Endothelial Signaling in Vascular Dysfunction and Disease Book

Endothelial Signaling in Vascular Dysfunction and Disease


  • Author : Shampa Chatterjee
  • Publisher : Academic Press
  • Release Date : 2021-01-20
  • Genre: Science
  • Pages : 274
  • ISBN 10 : 9780128163825

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Endothelial Signaling in Vascular Dysfunction and Disease Excerpt :

Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable. This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease. Discusses the most relevant discoveries in endothelial biology and their link to manifestations of clinical disease Presents history and diagrams in each section to highlight the original biological discovery and its link of clinical manifestations of vascular disease Includes recent findings on the relationship between endothelial signaling, chemotherapy and radiation induced endothelial dysfunction

Endothelial Signaling in Vascular Dysfunction and Disease Book

Endothelial Signaling in Vascular Dysfunction and Disease


  • Author : Shampa Chatterjee, PhD
  • Publisher : Academic Press
  • Release Date : 2021-02-05
  • Genre: Science
  • Pages : 278
  • ISBN 10 : 9780128161968

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Endothelial Signaling in Vascular Dysfunction and Disease Excerpt :

Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable. This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease. Discusses the most relevant discoveries in endothelial biology and their link to manifestations of clinical disease Presents history and diagrams in each section to highlight the original biological discovery and its link of clinical manifestations of vascular disease Includes recent findings on the relationship between endothelial signaling, chemotherapy and radiation induced endothelial dysfunction

The Endothelium Book

The Endothelium


  • Author : Michel Félétou
  • Publisher : Morgan & Claypool Publishers
  • Release Date : 2011
  • Genre: Medical
  • Pages : 281
  • ISBN 10 : 9781615041237

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The Endothelium Excerpt :

"The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. "--Publisher.

Endothelium and Cardiovascular Diseases Book

Endothelium and Cardiovascular Diseases


  • Author : Protasio Lemos Da Luz
  • Publisher : Academic Press
  • Release Date : 2018-02-03
  • Genre: Medical
  • Pages : 758
  • ISBN 10 : 9780128125519

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Endothelium and Cardiovascular Diseases Excerpt :

Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes

Senescence and Senescence Related Disorders Book

Senescence and Senescence Related Disorders


  • Author : Wang Zhiwei
  • Publisher : BoD – Books on Demand
  • Release Date : 2013-02-20
  • Genre: Medical
  • Pages : 162
  • ISBN 10 : 9789535109976

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Senescence and Senescence Related Disorders Excerpt :

Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders. This book discusses in detail senescence and its related diseases by distinguished researchers and practicing clinicians. The cumulative knowledge from the studies could lead to developing new approaches for anti-senescence interventions.

Mechanisms of Vascular Disease Book

Mechanisms of Vascular Disease


  • Author : Robert Fitridge
  • Publisher : University of Adelaide Press
  • Release Date : 2011
  • Genre: Medical
  • Pages : 589
  • ISBN 10 : 9781922064004

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Mechanisms of Vascular Disease Excerpt :

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Endothelial Dysfunction Book

Endothelial Dysfunction


  • Author : Helena Lenasi
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-10-24
  • Genre: Medical
  • Pages : 432
  • ISBN 10 : 9781789842531

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Endothelial Dysfunction Excerpt :

The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades Book

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades


  • Author : Wolfgang B. Liedtke, MD, PH.D.
  • Publisher : CRC Press
  • Release Date : 2006-09-29
  • Genre: Science
  • Pages : 467
  • ISBN 10 : 9781420005844

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TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades Excerpt :

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Regulation of Endothelial Barrier Function Book

Regulation of Endothelial Barrier Function


  • Author : Sarah Y. Yuan
  • Publisher : Morgan & Claypool Publishers
  • Release Date : 2010-09-30
  • Genre: Science
  • Pages : 143
  • ISBN 10 : 9781615041206

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Regulation of Endothelial Barrier Function Excerpt :

The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular tissues. In addition to regulating blood delivery and perfusion, a major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a semipermeable barrier that controls blood-tissue exchange of fluids, nutrients, and metabolic wastes while preventing pathogens or harmful materials in the circulation from entering into tissues. During host defense against infection or tissue injury, endothelial barrier dysfunction occurs as a consequence as well as cause of inflammatory responses. Plasma leakage disturbs fluid homeostasis and impairs tissue oxygenation, a pathophysiological process contributing to multiple organ dysfunction associated with trauma, infection, metabolic disorder, and other forms of disease. In this book, we provide an updated overview of microvascular endothelial barrier structure and function in health and disease. The discussion is initiated with the basic physiological principles of fluid and solute transport across microvascular endothelium, followed by detailed information on endothelial cell-cell and cell-matrix interactions and the experimental techniques that are employed to measure endothelial permeability. Further discussion focuses on the signaling and molecular mechanisms of endothelial barrier responses to various stimulations or drugs, as well as their relevance to several common clinical conditions. Taken together, this book provides a comprehensive analysis of microvascular endothelial cell and molecular pathophysiology. Such information will assist scientists and clinicians in advanced basic and clinical research for improved health care. Table of Contents: Acknowledgments / Introduction / Structure and Function of Exchange Microvessels / Methods for Measuring Perm

Endothelial Dysfunction and Inflammation Book

Endothelial Dysfunction and Inflammation


  • Author : Shauna Dauphinee
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-09-24
  • Genre: Medical
  • Pages : 234
  • ISBN 10 : 9783034601689

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Endothelial Dysfunction and Inflammation Excerpt :

Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.

Cardiovascular Signaling in Health and Disease Book

Cardiovascular Signaling in Health and Disease


  • Author : Narasimham L. Parinandi
  • Publisher : Springer Nature
  • Release Date : 2022-10-22
  • Genre: Sports & Recreation
  • Pages : 535
  • ISBN 10 : 9783031083099

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Cardiovascular Signaling in Health and Disease Excerpt :

This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases. This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.

Pediatric Hypertension Book

Pediatric Hypertension


  • Author : Joseph Flynn
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-06-26
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 9781627034906

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Pediatric Hypertension Excerpt :

The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.

Molecular Biology of the Cell Book
Score: 4.5
From 5 Ratings

Molecular Biology of the Cell


  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 0815332181

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Molecular Biology of the Cell Excerpt :

Cardiology Explained Book

Cardiology Explained


  • Author : Euan A. Ashley
  • Publisher : Remedica
  • Release Date : 2004
  • Genre: Medical
  • Pages : 257
  • ISBN 10 : 9781901346220

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Cardiology Explained Excerpt :

One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.

Regulation of Vascular Smooth Muscle Function Book

Regulation of Vascular Smooth Muscle Function


  • Author : Raouf A. Khalil
  • Publisher : Morgan & Claypool Publishers
  • Release Date : 2010
  • Genre: Medical
  • Pages : 62
  • ISBN 10 : 9781615041800

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Regulation of Vascular Smooth Muscle Function Excerpt :

In book the role of Ca2+ and other signaling pathways of Vascular smooth muscle (VSM) contraction will be discussed. VSM contraction plays an important role in the regulation of vascular resistance and blood pressure, and its dysregulation may lead to vascular diseases such as hypertension and coronary artery disease. Under physiological conditions, agonist activation of VSM results in an initial phasic contraction followed by a tonic contraction. The initial agonist-induced contraction is generally believed to be due to Ca2+ release from the intracellular stores. Although VSM is unique in that it can sustain contraction with minimal energy expense, the mechanisms involved in the maintained VSM contraction are not clearly understood.