Enzyme Active Sites and their Reaction Mechanisms Book

Enzyme Active Sites and their Reaction Mechanisms


  • Author : Harry Morrison
  • Publisher : Academic Press
  • Release Date : 2020-12-02
  • Genre: Science
  • Pages : 280
  • ISBN 10 : 9780128231944

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Enzyme Active Sites and their Reaction Mechanisms Excerpt :

Enzyme Active Sites and their Reaction Mechanisms provides a one-stop reference on how enzymes "work." Here, Dr. Harry Morrison, PhD and Professor Emeritus at Purdue University, provides a detailed overview of the origin and function of forty enzymes, the chemical details of their active sites, their mechanisms of action, and associated cofactors. The enzymes featured highlight a step forward, along with possible areas of application, thus supporting new research in academic and industrial labs. Each chapter is written in a clear format, including a brief summary of enzyme function and structure, a detailed description of their mechanisms of action and associated co-factors. Offers a comprehensive, biochemical understanding of enzyme mechanisms and their reaction sites Supports new research in academic, medical and industrial labs, connecting discoveries powered by recent advances in technology and experimental approaches to areas of application Features short, carefully structured, actionable chapters on various enzyme classes, thus allowing for easy-use and searchability

Enzymatic Reaction Mechanisms Book
Score: 5
From 1 Ratings

Enzymatic Reaction Mechanisms


  • Author : Perry A. Frey
  • Publisher : Oxford University Press
  • Release Date : 2007-01-27
  • Genre: Science
  • Pages : 848
  • ISBN 10 : 0195352742

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Enzymatic Reaction Mechanisms Excerpt :

Books dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.

Mechanisms of Catalysis Book

Mechanisms of Catalysis


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 1991-01-28
  • Genre: Technology & Engineering
  • Pages : 459
  • ISBN 10 : 0080865968

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Mechanisms of Catalysis Excerpt :

The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.

Enzyme Inhibitors and Activators Book

Enzyme Inhibitors and Activators


  • Author : Murat Şentürk
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-03-29
  • Genre: Science
  • Pages : 268
  • ISBN 10 : 9789535130574

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Enzyme Inhibitors and Activators Excerpt :

Over the recent years, medicinal chemistry has become responsible for explaining interactions of chemical molecule processes such that many scientists in the life sciences from agronomy to medicine are engaged in medicinal research. This book contains an overview focusing on the research area of enzyme inhibitor and activator, enzyme-catalyzed biotransformation, usage of microbial enzymes, enzymes associated with programmed cell death, natural products as potential enzyme inhibitors, protease inhibitors from plants in insect pest management, peptidases, and renin-angiotensin system. The book provides an overview on basic issues and some of the recent developments in medicinal science and technology. Especially, emphasis is devoted to both experimental and theoretical aspect of modern medicine. The primary target audience for the book includes students, researchers, chemists, molecular biologists, medical doctors, pharmacologists, and professionals who are interested in associated areas. The textbook is written by international scientists with expertise in biochemistry, enzymology, molecular biology, and genetics, many of which are active in biochemical and pharmacological research. I would like to acknowledge the authors for their contribution to the book. We hope that the textbook will enhance the knowledge of scientists in the complexities of some medical approaches; it will stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications of pharmacology.

Comprehensive Natural Products II Book
Score: 5
From 3 Ratings

Comprehensive Natural Products II


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2010-03-05
  • Genre: Science
  • Pages : 7388
  • ISBN 10 : 9780080453828

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Comprehensive Natural Products II Excerpt :

This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas among the established natural products research community—which includes chemists, biochemists, biologists, botanists, and pharmacologists Informs and inspires students and newcomers to the field with accessible content in a range of delivery formats Includes 100% new content, with more than 6,000 figures (1/3 of these in color) and 40,000 references to the primary literature, for a thorough examination of the field Highlights new research and innovations concerning living organisms and their distinctive role in our understanding and improvement of human health, genomics, ecology/environment, and more Adds to the rich body of work that is the first edition, which will be available for the first time in a convenient online format giving researchers complete access to authoritative Natural Products content

Enzyme Inhibition and Bioapplications Book

Enzyme Inhibition and Bioapplications


  • Author : Rakesh Sharma
  • Publisher : BoD – Books on Demand
  • Release Date : 2012-05-09
  • Genre: Science
  • Pages : 332
  • ISBN 10 : 9789535105855

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Enzyme Inhibition and Bioapplications Excerpt :

Enzyme Inhibition and Bioapplications is a concise book on applied methods of enzymes used in drug testing. The present volume will serve the purpose of applied drug evaluation methods in research projects, as well as relatively experienced enzyme scientists who might wish to develop their experiments further. Chapters are arranged in the order of basic concepts of enzyme inhibition and physiological basis of cytochromes followed by new concepts of applied drug therapy; reliability analysis; and new enzyme applications from mechanistic point of view.

Chemistry 2e Book
Score: 1
From 1 Ratings

Chemistry 2e


  • Author : Paul Flowers
  • Publisher : Unknown
  • Release Date : 2019-02-14
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 194717262X

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Chemistry 2e Excerpt :

Enzymes and Their Inhibitors Book

Enzymes and Their Inhibitors


  • Author : H. John Smith
  • Publisher : CRC Press
  • Release Date : 2004-11-29
  • Genre: Medical
  • Pages : 328
  • ISBN 10 : 9780203414583

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Enzymes and Their Inhibitors Excerpt :

Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibitors: Drug Development provides a concise overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, functions, mechanisms, and kinetics of enzymes, including their use as disease markers, analytical reagents, and in industrial processes. Subsequent chapters discuss the different types of enzyme inhibitors and the principles involved in developing them into effective drugs. This outstanding text, also valuable as a professional reference, will be useful to all students of pharmacology and medicinal chemistry.

Novel Cofactors Book

Novel Cofactors


  • Author : Judith P. Klinman
  • Publisher : Gulf Professional Publishing
  • Release Date : 2001-10-19
  • Genre: Science
  • Pages : 474
  • ISBN 10 : 0120342588

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Novel Cofactors Excerpt :

A cofactor is a component part of many enzymes and functions by uniting with another molecule in order to become active. The use of cofactors to supplement the native amino acids of a protein is essential to maintain the chemical capabilities necessary for organisms to survive. This volume focuses on the significant advances of the past decade in identifying and describing new cofactors--either small molecules or those derived posttranslationally.

Structural and Functional Aspects of Enzyme Catalysis Book

Structural and Functional Aspects of Enzyme Catalysis


  • Author : H. Eggerer
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 218
  • ISBN 10 : 9783642817380

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Structural and Functional Aspects of Enzyme Catalysis Excerpt :

Enzymes perform the executive role in growth, energy conversion, and repair of a living organism. Their activity is adjusted to their en vironment within the cell, being turned off, switched on, or finely tuned by specific metabolites according to demands at the physiologi cal level. Each enzyme discovered in the long history of enzymology has revealed its own individuality. Even closely related members of a family differ in specificity, stability or regulatory properties. Despite these, at first sight overwhelming aspects of individuality, common factors of enzymic reactions have been recognized. Enzymes are stereospecific catalysts even when a nonspecific process would yield the same product. Knowledge of the detailed stereochemistry of an enzymic reaction helps to deduce reaction mechanisms and to ob tain insight into the specific binding of substrates at the active site. This binding close to catalytically competent groups is related to the enormous speed of enzyme-catalyzed reactions. The physical ba sis of rate-enhancement is understood in principle and further exploit ed in the design of small organic receptor molecules as model enzymes. These aspects of enzyme catalysis are discussed in Session 1. Session 2 emphasizes the dynamic aspects of enzyme substrate inter action. Substrate must diffuse from solution space to the enzyme's surface. This process is influenced and can be greatly facilitated by certain electrostatic propterties of enzymes. The dynamic events during catalysis are studied by relaxation kinetics or NMR techniques.

Theory and Experiment in Electrocatalysis Book

Theory and Experiment in Electrocatalysis


  • Author : Perla B. Balbuena
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-11-02
  • Genre: Science
  • Pages : 578
  • ISBN 10 : 9781441955944

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Theory and Experiment in Electrocatalysis Excerpt :

This review volume highlights advances in both theoretical and experimental techniques and points out both the progress made and the challenges to overcome in the near future. The topics cover a broad spectrum going from surface characterization, investigation of thermodynamics and kinetics mechanistic pathways, electrochemical experiments and theory, multi-scale modeling applied to synthesis and growth processes such as electrodeposition, and corrosion reactions arising from the nanosize of electrocatalysts that affect their lifetime and activity.

Protein Design and Structure Book

Protein Design and Structure


  • Author : Rossen Donev
  • Publisher : Academic Press
  • Release Date : 2022-05-06
  • Genre: Science
  • Pages : 432
  • ISBN 10 : 9780323992305

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Protein Design and Structure Excerpt :

Protein Design and Structure, Volume 130 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Protein Chemistry and Structural Biology series Includes the latest information on protein design and structure

Introduction to Enzyme and Coenzyme Chemistry Book

Introduction to Enzyme and Coenzyme Chemistry


  • Author : T. D. H. Bugg
  • Publisher : John Wiley & Sons
  • Release Date : 2012-05-29
  • Genre: Science
  • Pages : 280
  • ISBN 10 : 9781118348994

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Introduction to Enzyme and Coenzyme Chemistry Excerpt :

Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

Catalysis in Chemistry and Enzymology Book
Score: 4
From 1 Ratings

Catalysis in Chemistry and Enzymology


  • Author : William P. Jencks
  • Publisher : Courier Corporation
  • Release Date : 1987-01-01
  • Genre: Science
  • Pages : 836
  • ISBN 10 : 0486654605

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Catalysis in Chemistry and Enzymology Excerpt :

Exceptionally clear coverage of mechanisms for catalysis, forces in aqueous solution, carbonyl- and acyl-group reactions, practical kinetics, more.

Enzyme Kinetics  Catalysis and Control Book

Enzyme Kinetics Catalysis and Control


  • Author : Daniel L. Purich
  • Publisher : Elsevier
  • Release Date : 2010-06-16
  • Genre: Science
  • Pages : 920
  • ISBN 10 : 9780123809254

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Enzyme Kinetics Catalysis and Control Excerpt :

Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions