Epigenetics of Cancer Prevention Book

Epigenetics of Cancer Prevention


  • Author : Anupam Bishayee
  • Publisher : Academic Press
  • Release Date : 2018-11-27
  • Genre: Medical
  • Pages : 442
  • ISBN 10 : 9780128125663

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Epigenetics of Cancer Prevention Excerpt :

Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and resveratrol, and organ specific epigenetic targets related to diverse types of cancer, for example prostate, colorectal, breast, lung and skin cancers. Additionally, it encompasses a discussion on research methods and limitations to study epigenetics and epigenomics of chemopreventive drugs and personalized cancer treatment with phytochemicals. The book is ideal for cancer researchers, health care professionals and all individuals who are interested in cancer prevention research and its clinical applications, especially in natural remedies. Lists natural agents, including nutraceuticals, and their effects on normal or tumor genome Addresses various epigenetic systems and mechanisms in the regulation and support of the mammalian genome Discusses how various parts of dietary phytochemicals can influence or modify epigenetic mechanisms in several types of cancer

Nutrition  Functional and Sensory Properties of Foods Book

Nutrition Functional and Sensory Properties of Foods


  • Author : Chi-Tang Ho
  • Publisher : Royal Society of Chemistry
  • Release Date : 2013-03-13
  • Genre: Technology & Engineering
  • Pages : 480
  • ISBN 10 : 9781849737685

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Nutrition Functional and Sensory Properties of Foods Excerpt :

The link between nutrition, food and health is well established and the global interest in these areas generates new information every day. This book pulls together the latest research on flavour chemistry and nutritional and functional properties of food. Topics covered in flavour chemistry begin with an overview of the analysis, occurrence and formation mechanism of furan, a food-borne carcinogen, then focuses on analysis of melamine, the uses of enzymes to modify flavours of wines and protein as a process flavour precursor and finally includes information on the volatile compounds in an array of food products and ingredients such as coriander, chamomile, saffron and dry fermented sausage. Coverage in the nutritional and functional properties of food section is wide range and includes reviews of the hot topics such as the metabolism of dietary phenolic acids, the use of emulsions for the oral delivery of bioactive phytochemicals and the impact on epigenetics in cancer prevention. Written by international experts in the field and edited to a high standard, this title will provide a unique reference for researchers and other professionals in the industry and academia, particularly those directly involved in food science.

Epigenetic Mechanisms in Cancer Book

Epigenetic Mechanisms in Cancer


  • Author : Sabita Saldanha
  • Publisher : Academic Press
  • Release Date : 2017-11-16
  • Genre: Medical
  • Pages : 392
  • ISBN 10 : 9780128134603

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Epigenetic Mechanisms in Cancer Excerpt :

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes. Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc. Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis Features contributions by leading experts in the field Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs

Environmental Epigenetics Book

Environmental Epigenetics


  • Author : L. Joseph Su
  • Publisher : Springer
  • Release Date : 2015-05-18
  • Genre: Medical
  • Pages : 321
  • ISBN 10 : 9781447166788

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Environmental Epigenetics Excerpt :

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Epigenetics in Cancer Prevention Book

Epigenetics in Cancer Prevention


  • Author : Mukesh Verma
  • Publisher : Unknown
  • Release Date : 2003
  • Genre: Science
  • Pages : 330
  • ISBN 10 : STANFORD:36105026613799

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Epigenetics in Cancer Prevention Excerpt :

This volume addresses the question of how knowledge of epigenetic phenomena like DNA methylation and acetylation can be applied to early cancer detection and risk assessment. The objectives of the papers include defining the terminology used in epigenetics.

Cancer Epigenetics for Precision Medicine Book

Cancer Epigenetics for Precision Medicine


  • Author : Ramona G. Dumitrescu
  • Publisher : Humana Press
  • Release Date : 2018-10-12
  • Genre: Medical
  • Pages : 298
  • ISBN 10 : 149398750X

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Cancer Epigenetics for Precision Medicine Excerpt :

This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in this book further delve into this field and cover topics such as epigenome-based precision medicine in lung cancer; interplay between genetic and epigenetic changes in breast cancer subtypes; genetic regulation of PDCD1 gene in cancer immunology; and pyrosequencing methylation analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Cancer Epigenetics for Precision Medicine: Methods and Protocols is a valuable resource to help researchers and scientists identify these specific biomarkers and work towards the prevention, diagnosis, and prognosis of different cancers in the future.

Nutrition and Cancer Prevention Book

Nutrition and Cancer Prevention


  • Author : Thomas Prates Ong
  • Publisher : Royal Society of Chemistry
  • Release Date : 2019-12-03
  • Genre: Medical
  • Pages : 434
  • ISBN 10 : 9781788013413

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Nutrition and Cancer Prevention Excerpt :

Cancer is a major global public health problem. Among different environmental and lifestyle factors contributing to cancer risk, diet is a key one. On the one hand, obesity and increased consumption of red and processed meat, ethanol, sugar and saturated fatty acids are associated with increased cancer risk. On the other hand, consumption of micronutrients such as vitamin D, selenium, zinc, folate and bioactive compounds from fruits and vegetables is associated with decreased risk. Written by an influential, international team of experts, this book presents and discusses current topics on nutrition and cancer prevention. It covers both nutritional influences on different cancers plus specific chapters on the commonly occurring cancers. Nutritional genomics-based studies show that some dietary components modulate carcinogenesis through complex cellular and molecular mechanisms. A better understanding of these different cellular and molecular mechanisms is needed to establish efficient dietary recommendations for cancer prevention. This book will provide such an understanding, serving as an important book for all those working in nutritional health, food science and cancer research.

Epigenetics and Cancer Book

Epigenetics and Cancer


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2010-11-23
  • Genre: Medical
  • Pages : 314
  • ISBN 10 : 0123808650

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Epigenetics and Cancer Excerpt :

Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects

Personalized Epigenetics Book

Personalized Epigenetics


  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release Date : 2015-04-28
  • Genre: Science
  • Pages : 610
  • ISBN 10 : 9780128004364

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Personalized Epigenetics Excerpt :

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

The Genetics of Cancer Book

The Genetics of Cancer


  • Author : B.A. Ponder
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 221
  • ISBN 10 : 9789401106771

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The Genetics of Cancer Excerpt :

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

Epigenetic Epidemiology Book

Epigenetic Epidemiology


  • Author : Karin B. Michels
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-01-02
  • Genre: Medical
  • Pages : 448
  • ISBN 10 : 9789400724952

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Epigenetic Epidemiology Excerpt :

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

Emerging Epigenetics in Cancer Chemoprevention by Dietary Phytochemicals Book

Emerging Epigenetics in Cancer Chemoprevention by Dietary Phytochemicals


  • Author : Chengyue Zhang
  • Publisher : Unknown
  • Release Date : 2017
  • Genre: Cancer
  • Pages : 193
  • ISBN 10 : OCLC:990285821

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Emerging Epigenetics in Cancer Chemoprevention by Dietary Phytochemicals Excerpt :

Cancer chemoprevention is defined as the strategy to block or slow the onset of premalignant tumors and using relatively nontoxic chemical substance. Recently, accumulating experimental evidence has suggested that epigenetic alterations are involved in cancer development. The scope of epigenetics lies on the molecular interface between genetics and environmental factors; external factors switch genes on and off by influencing how cells read the genes. DNA methylation, histone covalent modification and remodeling, miRNA-mediated gene silencing represent the major mechanisms that play important role in epigenetic control of gene expression. This thesis focused on elucidating the epigenetic mechanisms in cancer prevention by dietary phytochemicals. Nrf2 is a master regulator of the antioxidant response and xenobiotic metabolism through the regulation of a wide range of antioxidant and phase II detoxification genes. The cellular protective role of Nrf2 points its potential as a primary target in chemoprevetion. Our group has reported that within tumor development in the transgenic adenocarcinoma of mouse prostate (TRAMP) model, there is a progressive loss of expression of Nrf2 and its downstream target genes, which is associated CpG hypermethylation in the promoter region. Using TRAMP C1 cells, we demonstrated that sulforaphane is a potent demethylation agent and it restores the epigenetically silenced Nrf2 gene through DNA demethylation. JB6 cells are derived from normal skin epidermis. We found that hypermethylation of Nrf2 promoter also exists in the transformation sensitive JB6 P+ cell line. The epigenetic reactivation of the Nrf2 signaling pathway by Tanshinone IIA could potentially contribute to the attenuation of JB6 P+ cellular transformation under the challenge of TPA, a tumor promoter. On the other hand, histone modification, in particular acetylation of H3K27 residue, is implicated in the transcription activation of pro-survival, pro-proliferative, and pro-in

Epigenetics in Precision Medicine Book

Epigenetics in Precision Medicine


  • Author : Jose Luis Garcia-Gimenez
  • Publisher : Elsevier
  • Release Date : 2021-11-22
  • Genre: Medical
  • Pages : 614
  • ISBN 10 : 9780323858052

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Epigenetics in Precision Medicine Excerpt :

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease. Provides a thorough grounding in epigenetics-driven precision medicine, with emphasis on developing and implementing early diagnosis and prognosis biomarkers, and supporting patient stratification Empowers researchers and clinicians to incorporate epigenetics in new disease research, drug discovery, and clinical practice Features chapter contributions from international leaders in the field

Molecular mechanisms and physiology of disease Book

Molecular mechanisms and physiology of disease


  • Author : Nilanjana Maulik
  • Publisher : Springer
  • Release Date : 2014-05-31
  • Genre: Medical
  • Pages : 505
  • ISBN 10 : 9781493907069

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Molecular mechanisms and physiology of disease Excerpt :

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Introduction to Epigenetics Book

Introduction to Epigenetics


  • Author : Renato Paro
  • Publisher : Springer Nature
  • Release Date : 2021-03-23
  • Genre: Science
  • Pages : 215
  • ISBN 10 : 9783030686703

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Introduction to Epigenetics Excerpt :

This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease