Exosomes Book


  • Author : Larry Edelstein
  • Publisher : Academic Press
  • Release Date : 2019-10-16
  • Genre: Science
  • Pages : 548
  • ISBN 10 : 9780128160541

Exosomes Excerpt :

Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomes in the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medical disciplines, as well as their role in cell-cell communication. It is intended to serve as a reference source for clinicians, physicians, and research scientists who wish to gain insight into the most recent advances in this rapidly growing field. The exosome revolution may well be the greatest advance in physiology and medicine since antibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is a major breakthrough in our understanding of how cells function. Provides readers with a broad and timely overview of exosomes in health and disease, closing with a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck. Summarizes the most recent laboratory and clinical findings on exosomes across numerous medical disciplines, thereby offering readers a broad-ranging and solid foundation for prospective investigative efforts Twenty-one chapters authored by a global team of peer-acknowledged experts, each representing a key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing

Diagnostic and Therapeutic Applications of Exosomes in Cancer Book

Diagnostic and Therapeutic Applications of Exosomes in Cancer

  • Author : Mansoor M. Amiji
  • Publisher : Academic Press
  • Release Date : 2018-05-09
  • Genre: Medical
  • Pages : 400
  • ISBN 10 : 9780128128046

Diagnostic and Therapeutic Applications of Exosomes in Cancer Excerpt :

Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer. Covers emerging pharmaceutical and diagnostic applications, including exosomes being tested as carriers of anticancer drugs, ongoing clinical trials, and exosomes as imaging agents for cancer diagnosis and treatment Brings together a team of highly regarded international authors who provide a full-rounded analysis Presents comprehensive coverage of the unique biophysical properties of exosomes Explores current and future possibilities

Exosomes in Cardiovascular Diseases Book

Exosomes in Cardiovascular Diseases

  • Author : Junjie Xiao
  • Publisher : Springer
  • Release Date : 2017-09-19
  • Genre: Science
  • Pages : 307
  • ISBN 10 : 9789811043970

Exosomes in Cardiovascular Diseases Excerpt :

The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.

Role of Exosomes in Biological Communication Systems Book

Role of Exosomes in Biological Communication Systems

  • Author : Faisal A. Alzahrani
  • Publisher : Springer Nature
  • Release Date : 2020-11-20
  • Genre: Medical
  • Pages : 373
  • ISBN 10 : 9789811565991

Role of Exosomes in Biological Communication Systems Excerpt :

This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.

Exosomes and MicroRNAs in Biomedical Science Book

Exosomes and MicroRNAs in Biomedical Science

  • Author : Hamed Mirzaei
  • Publisher : Morgan & Claypool Publishers
  • Release Date : 2022-04-21
  • Genre: Technology & Engineering
  • Pages : 237
  • ISBN 10 : 9781636393483

Exosomes and MicroRNAs in Biomedical Science Excerpt :

MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19–25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth

Exosomes and Microvesicles Book

Exosomes and Microvesicles

  • Author : Andrew F. Hill
  • Publisher : Humana Press
  • Release Date : 2016-12-10
  • Genre: Science
  • Pages : 228
  • ISBN 10 : 1493967266

Exosomes and Microvesicles Excerpt :

This volume covers methods for the analysis of extracellular vesicles (EV) that can be applied to isolated EVs from a wide variety of sources. This includes the use of electron microscopy, tunable resistance pulse sensing, and nanoparticle tracking analysis. The chapters in this book discuss EV cargoes containing proteins and genomic materials using a number of different approaches, and isolating EVs from platelets and neuronal cells and tissues. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and comprehensive, Exosomes and Microvesicles: Methods and Protocols is a valuable resource containing methodologies for anyone interested in researching EVs.

Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases Book
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Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases

  • Author : Jin Wang
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-07-12
  • Genre: Medical
  • Pages : 192
  • ISBN 10 : 9789535133353

Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases Excerpt :

The aim of this book is to provide an overview of the importance of exosomes in the biomedical field, which involves in novel implications of exosomes in diagnosis and treatment of cancer and infectious diseases. The book would definitely be an ideal source of scientific information of exosomes to researchers and scientists involved in biomedicine, biology, and other areas involving cancer and infectious diseases.

The Propagation of Neurodegenerative Diseases by Inflammation and Exosomes Book

The Propagation of Neurodegenerative Diseases by Inflammation and Exosomes

  • Author : Valerie Sackmann
  • Publisher : Linköping University Electronic Press
  • Release Date : 2019-10-16
  • Genre: Uncategoriezed
  • Pages : 60
  • ISBN 10 : 9789175190129

The Propagation of Neurodegenerative Diseases by Inflammation and Exosomes Excerpt :

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative diseases with rates increasing along with the ageing global population. Despite best efforts, we still do not understand the etiopathogenesis of these diseases and there are no effective disease-modifying treatments. Cognitive deficiencies or motor complications that emerge during AD and PD are thought to be the result of the accumulation of misfolded, aggregate-prone proteins, such as amyloid-? (A?) and tau or ?-synuclein (?-syn), respectively. Growing evidence suggests that prefibrillar oligomers of A? and ?-syn (oA? and o?-syn) are key contributors to the progression of these diseases. The progressive accumulation of these proteins leads to a gradual spread of pathology throughout interconnected brain regions, but the mechanisms by which this spreading occurs are still largely unknown. Neuroinflammation has been recognised as an important contributor to neurodegenerative disease. It is hypothesised that a pro-inflammatory environment initiated by the innate immune system, either through activation from A? itself or indirectly through neuronal injury signals in AD. These phenomena are thought to either cause or accelerate AD, such that an anti-inflammatory approach may be neuroprotective. In paper I, we investigated whether different inflammatory environments affected the transfer of oA? between neuron-like cells, in addition to investigating inter- and intracellular protein changes. This study demonstrated that an anti-inflammatory environment reduces the transfer of oA? between cells. We also provide evidence that these cells begin to take on the “phenotype” of the inflammatory milieu, while also demonstrating that the expression profile of endosomal/lysosomal and protein trafficking proteins is altered during these conditions. Small extracellular vesicles called exosomes, which are key players in cell to cell communication, have been proposed to play an influ

Mesenchymal Stem Cell Derived Exosomes Book

Mesenchymal Stem Cell Derived Exosomes

  • Author : Yaoliang Tang
  • Publisher : Academic Press
  • Release Date : 2015-09-02
  • Genre: Medical
  • Pages : 288
  • ISBN 10 : 9780128004975

Mesenchymal Stem Cell Derived Exosomes Excerpt :

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Emerging Concepts of Tumor Exosome   Mediated Cell Cell Communication Book

Emerging Concepts of Tumor Exosome Mediated Cell Cell Communication

  • Author : Huang-Ge Zhang
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-09-06
  • Genre: Medical
  • Pages : 220
  • ISBN 10 : 9781461436973

Emerging Concepts of Tumor Exosome Mediated Cell Cell Communication Excerpt :

In multicellular organisms, communication between cells involves secretion of proteins that bind to receptors on neighboring cells. While this has been well documented, another mode of intercellular communication has recently become the subject of increasing interest: the release of exosomes. In cancer, tumor exosomes are involved in various aspects of pathogenesis, including proliferation, immunosuppression, and metastasis. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. They are also being studied as prognostic markers for cancer.

RNA Exosome Book

RNA Exosome

  • Author : Torben Heick Jensen
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-06-29
  • Genre: Medical
  • Pages : 144
  • ISBN 10 : 9781441978417

RNA Exosome Excerpt :

The diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of this volume to introduce this fascinating protein complex as well as to give a timely and rich account of its many functions. The exosome was discovered more than a decade ago by Phil Mitchell and David Tollervey by its ability to trim the 3’end of yeast, S. cerevisiae, 5. 8S rRNA. In a historic account they laid out the events surrounding this identification and the subsequent birth of the research field. In the chapter by Kurt Januszyk and Christopher Lima the structural organization of eukaryotic exosomes and their evolutionary counterparts in bacteria and archaea are discussed in large part through presentation of structures.

Comprehensive Nanoscience and Nanotechnology Book

Comprehensive Nanoscience and Nanotechnology

  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-01-02
  • Genre: Technology & Engineering
  • Pages : 1886
  • ISBN 10 : 9780128122969

Comprehensive Nanoscience and Nanotechnology Excerpt :

Comprehensive Nanoscience and Technology, Second Edition allows researchers to navigate a very diverse, interdisciplinary and rapidly-changing field with up-to-date, comprehensive and authoritative coverage of every aspect of modern nanoscience and nanotechnology. Presents new chapters on the latest developments in the field Covers topics not discussed to this degree of detail in other works, such as biological devices and applications of nanotechnology Compiled and written by top international authorities in the field