Fibroblast Growth Factor 23 Book

Fibroblast Growth Factor 23

  • Author : Christian Faul
  • Publisher : Elsevier
  • Release Date : 2021-04-06
  • Genre: Medical
  • Pages : 376
  • ISBN 10 : 9780128180372

Fibroblast Growth Factor 23 Excerpt :

Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23. Provides a comprehensive collection of chapters on the diversity of FGF23's actions Highlights truly translational topics, from molecular signaling to physiology and mechanism of disease, discussing cell culture and animal models to study FGF23 Describes FGF23’s potential in the clinical setting as a biomarker or even drug target Presents leaders in the field who cover a wide spectrum of research backgrounds and expertise, including clinical and basic scientists who specialize in diseases, endocrinology, genetics, protein biochemistry, cell biology and physiology

Fibroblast Growth Factor 23 Book

Fibroblast Growth Factor 23

  • Author : Christian Faul
  • Publisher : Elsevier
  • Release Date : 2021-04-09
  • Genre: Medical
  • Pages : 376
  • ISBN 10 : 9780128180365

Fibroblast Growth Factor 23 Excerpt :

Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. This reference then defines the exciting research in recent years how a much wider spectrum of sources, targets and functions have been identified, showing that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues. This reference reaches a wide academic audience with a broad interest in biomedical sciences, including: Endocrinology: FGF23 initially identified as a bone-derived factor targeting the kidney Physiology: FGF23 as a regulator of phosphate metabolism and beyond Cell Biology: Mechanistic FGF23 research revealed novel concepts of FGF receptor signaling Biochemistry: Molecular crosstalk between FGF23 and klotho, from structure and binding to signal transduction Pharmacology: FGF23 and its receptors as potential drug targets to treat or prevent diseases, such as CKD, heart failure or COPD Basic Research: Cell culture and animal models as well as novel assays to study FGF23 production and effects Nephrology: FGF23 as a biomarker and cause for CKD and associated pathologies Internal Medicine: FGF23 as a biomarker and cause for various diseases involving the kidney, heart, lung and liver

Phosphate Metabolism Book

Phosphate Metabolism

  • Author : Shaul Massry
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-21
  • Genre: Medical
  • Pages : 636
  • ISBN 10 : 9781461342175

Phosphate Metabolism Excerpt :

We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.



  • Author : Atsushi Okawa
  • Publisher : Springer Nature
  • Release Date : 2020-05-14
  • Genre: Medical
  • Pages : 278
  • ISBN 10 : 9789811538551

OPLL Excerpt :

This publication brings together information on all aspects of OPLL - epidemiology, etiology, diagnosis, and treatment. It contains contributions by Japanese researchers and surgeons, including members of the Ministry of Health and Welfare Investigation Committee, and by American surgeons with expertise in the field. Until now, little has been published on the subject in English. This collection of reports is amply augmented with illustrations.

Endocrine FGFs and Klothos Book

Endocrine FGFs and Klothos

  • Author : Makoto Kuro-o
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-03-06
  • Genre: Science
  • Pages : 210
  • ISBN 10 : 9781461408871

Endocrine FGFs and Klothos Excerpt :

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

Chronic Kidney Disease Book

Chronic Kidney Disease

  • Author : Thomas Rath
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-02-21
  • Genre: Medical
  • Pages : 307
  • ISBN 10 : 9789535138433

Chronic Kidney Disease Excerpt :

Known worldwide, chronic kidney disease (CKD) is a disease that affects up to 4% of the population with increasing figures also in the developing countries. Life expectancy of patients affected by CKD is shortened compared to the overall population, and only a minority of patients reach end-stage renal disease (ESRD) with the need for dialysis or renal transplantation; death overtakes dialysis. In the 13 chapters, this book sheds light on the different aspects related to pathophysiology and clinical aspects of CKD, providing interesting insights into not only inflammation and cardiovascular risk but also the interplay of hormones and the functional aspects of endothelial function. In addition, chapters dealing with genetic aspects of polycystic kidney disease and also the clinical handling of patients with CKD and peritoneal dialysis will be beneficial for the open-minded reader.

Recent Advances in Dialysis Therapy in Japan Book

Recent Advances in Dialysis Therapy in Japan

  • Author : H. Nakamoto
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2018-07-24
  • Genre: Medical
  • Pages : 258
  • ISBN 10 : 9783318062984

Recent Advances in Dialysis Therapy in Japan Excerpt :

The number of dialysis patients, and their ages, continues to increase globally. This creates major issues such as rising medical costs in an aging population, how to best manage end-of-life care, and how to train the various practitioners involved in dialysis care. After the US and China, Japan occupies 3rd place with regard to the number of dialysis patients and is also widely regarded as a world leader in dialysis. This book contains selected articles – organized into 4 chapters - that discuss recent advances in dialysis therapy in Japan. Chapter 1 presents insights into causes, risk factors, disease associations, and possible implications for management of dialysis patients. Chapter 2 examines recent progress in hemodialysis treatment, and chapter 3 focuses on developments in peritoneal dialysis. The final chapter concentrates on recent advances in apheresis and current trends in practice, among other topics. This book is aimed at nephrologists, physicians, urologists, nurses, clinical engineers, pharmacists, and nutritionists. It is a significant contribution to furthering the progress of dialysis therapy worldwide.

Seldin and Giebisch s The Kidney Book

Seldin and Giebisch s The Kidney

  • Author : Robert J. Alpern
  • Publisher : Elsevier
  • Release Date : 2007-10-10
  • Genre: Science
  • Pages : 2928
  • ISBN 10 : 9780080559506

Seldin and Giebisch s The Kidney Excerpt :

A classic nephrology reference for over 20 years, Seldin & Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses from molecular biology and cell physiology to clinical issues regarding renal function and dysfunction. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebisch’s The Kidney is your number one source for information. * Offers the most comprehensive coverage of fluid and electrolyte regulation and dysregulation in 51 completely revised chapters unlike Brenner & Rector's The Kidney which devotes only 7 chapters to this topic. * Includes 3 sections, 31 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. Brenner & Rector's only devotes 5 chapters to these topics. * Previous three editions edited by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology. The title for the fourth edition has been changed to reflect their considerable work on previous editions and they have also written the forward for this edition. * Over 20 million adults over age 20 have chronic kidney disease with the number of people diagnosed doubling each decade making it America's ninth leading cause of death.

The Growth Plate Book

The Growth Plate

  • Author : Irving M. Shapiro
  • Publisher : IOS Press
  • Release Date : 2002
  • Genre: Computers
  • Pages : 312
  • ISBN 10 : 1586032402

The Growth Plate Excerpt :

Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.

Hypoparathyroidism Book


  • Author : Maria Luisa Brandi
  • Publisher : Springer
  • Release Date : 2015-02-24
  • Genre: Medical
  • Pages : 429
  • ISBN 10 : 9788847053762

Hypoparathyroidism Excerpt :

Hypoparathyroidism, a condition in which insufficient parathyroid hormone (PTH) is produced to maintain normocalcemia is associated with a variety of acute and chronic symptoms and complications due to hypocalcemia. Replacement therapy utilizing PTH has long been awaited, and this book is new and very timely as it coincides with the publication of results on the role of the PTH molecule in the pharmacological management of this disorder. This advance is sparking renewed interest in hypoparathyroidism, which is attributable to neck surgery in most cases and to inherited disorders in a minority. Hypoparathyroidism has been written by acknowledged experts in the field and provides essential, up-to-date information on the pathology, diagnosis, and treatment of the condition. It opens by addressing in detail the anatomy and physiology of the parathyroids and describing the epidemiology and clinical presentation of hypoparathyroidism. The full range of hypoparathyroid disorders are then discussed, including the various genetic forms, postoperative hypoparathyroidism, and other forms of acquired hypoparathyroidism. Individual chapters focus on refractory disease, the impact of the condition on bone, and the management of acute hypocalcemia. Both conventional treatment for hypoparathyroidism and the novel replacement therapy with PTH peptides are then thoroughly examined. Pseudohypoparathyroidism is also extensively discussed, with information on the various forms, differential diagnosis, and genetic testing. This book will be of interest to all endocrinologists, and also to surgeons and internal medicine physicians.

Dietary Phosphorus Book

Dietary Phosphorus

  • Author : Jaime Uribarri
  • Publisher : CRC Press
  • Release Date : 2017-09-27
  • Genre: Medical
  • Pages : 648
  • ISBN 10 : 9781351645843

Dietary Phosphorus Excerpt :

Phosphorus is an essential nutrient that occurs in almost all foods and is important for many normal physiological functions. In a typical Western diet, it is not harmful, but does adversely affect tissues in the body when consumed in excess or deficiency. This book provides a comprehensive review of various aspects of phosphorus in relation to human nutritional needs. Sections cover phosphorus nutrition and dietary issues; health risks associated with excess phosphorus intake that exceeds requirements; phosphorus intake in populations at risk; regulatory challenges and policy approaches; and environmental impacts of phosphates in the modern food supply. This book challenges the long held ideas that high dietary phosphorus intake beyond nutritional requirements is safe and the natural supply of phosphorus critical to agricultural and human food production is endless. Controversy surrounds the claim that largely unrestricted use of phosphorus in all aspects of food production from farm to fork increases dietary phosphorus intake and irretrievable environmental loss, both of which harm human and environmental health. The book editors have joined together experts in basic, medical, environmental, nutritional, and food science to explore the validity of these claims of harm from high intakes and the unchecked use of phosphorus in the global food supply. Despite the essential need for adequate phosphorus over all stages of plant, animal and human life, the growing evidence points to a worldwide increase in dietary phosphorus intake far beyond nutrient requirements, significant association with chronic disease risk even when renal function is not compromised, and the increase in environmental loss with crop run-off, animal husbandry, and unretrieved phosphorus from human waste. This current evidence alludes to a depleted, unsustainable natural supply of phosphorus, hazardous environmental pollution of lakes and waterways, and significant increases in the risk of kidney, s

Phosphate and Vitamin D in Chronic Kidney Disease Book

Phosphate and Vitamin D in Chronic Kidney Disease

  • Author : M.S. Razzaque
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2013-05-02
  • Genre: Medical
  • Pages : 164
  • ISBN 10 : 9783318023695

Phosphate and Vitamin D in Chronic Kidney Disease Excerpt :

The enormous progress made during the last decade has resulted in a better conceptual understanding of mineral ion metabolism in general. With regard to chronic kidney disease, the two most affected nutrients are phosphate and vitamin D. This book provides an overview of the physiological aspects of phosphate and vitamin D metabolism, and how their pathological dysregulation facilitates advancement of chronic kidney disease. It looks into the complex molecular and organ cross-talks during disease progression that range from the involvement of fibroblast growth factor (FGF23)-klotho system to impaired phosphate transport to hormonal dysfunctions of PTH and vitamin D. Each chapter clearly presents the clinically and biologically important problems and lists the key unsolved issues related to chronic kidney disease and beyond. Illustrations explaining multi-factorial and multi-organ interactions provide an easy outline for the reader to appreciate the complex biological pathways. For those without prior familiarity with the subject matter, this volume may serve as a quick reference to get updated information on phosphate and vitamin D metabolism.

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Book

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

  • Author : Juliet E. Compston
  • Publisher : John Wiley & Sons
  • Release Date : 2009-12-22
  • Genre: Science
  • Pages : 559
  • ISBN 10 : 9780470623985

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Excerpt :

EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in-depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online-only appendix of medicines used to treat bone disorders and their availability around the world.

Pediatric Nephrology Book
Score: 3
From 2 Ratings

Pediatric Nephrology

  • Author : Ellis D. Avner
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-08-20
  • Genre: Medical
  • Pages : 2059
  • ISBN 10 : 9783540763277

Pediatric Nephrology Excerpt :

Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.

Brush Border Membranes Book

Brush Border Membranes

  • Author : Ruth Porter
  • Publisher : John Wiley & Sons
  • Release Date : 2009-09-14
  • Genre: Medical
  • Pages : 192
  • ISBN 10 : 9780470718469

Brush Border Membranes Excerpt :

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.