Freeze Drying of Pharmaceutical and Food Products Book

Freeze Drying of Pharmaceutical and Food Products


  • Author : Tse-Chao Hua
  • Publisher : Elsevier
  • Release Date : 2010-07-30
  • Genre: Technology & Engineering
  • Pages : 280
  • ISBN 10 : 9781845697471

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Freeze Drying of Pharmaceutical and Food Products Excerpt :

Freeze-drying is an important preservation technique for heat-sensitive pharmaceuticals and foods. Products are first frozen, then dried in a vacuum at low temperature by sublimation and desorption, rather than by the application of heat. The resulting items can be stored at room temperature for long periods. This informative text addresses both principles and practice in this area. The first chapter introduces freeze-drying. The authors then review the fundamentals of the technique, heat-mass transfer analyses, modelling of the drying process and the equipment employed. Further chapters focus on freeze-drying of food, freeze-drying of pharmaceuticals and the protective agents and additives applied. The final chapter covers the important subjects of disinfection, sterilization and process validation. Freeze-drying of pharmaceutical and food products is an essential reference for food, pharmaceutical and refrigeration engineers and scientists with an interest in preservation techniques. It will also be of use to students in these fields. Addresses the principles and practices used in this important preservation technique Explains the fundamentals of heat-mass transfer analysis, modelling and the equipment used Discusses the importance of disinfection, sterilization and process validation

Freeze Drying of Pharmaceutical Products Book

Freeze Drying of Pharmaceutical Products


  • Author : Davide Fissore
  • Publisher : CRC Press
  • Release Date : 2019-10-24
  • Genre: Medical
  • Pages : 192
  • ISBN 10 : 9780429666735

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Freeze Drying of Pharmaceutical Products Excerpt :

Freeze Drying of Pharmaceutical Products provides an overview of the most recent and cutting-edge developments and technologies in the field, focusing on formulation developments and process monitoring and considering new technologies for process development. This book contains case studies from freeze dryer manufacturers and pharmaceutical companies for readers in industry and academia. It was contributed to by lyophilization experts to create a detailed analysis of the subject matter, organically presenting recent advancements in freeze-drying research and technology. It discusses formulation design, process optimization and control, new PAT-monitoring tools, multivariate image analysis, process scale-down and development using small-scale freeze-dryers, use of CFD for equipment design, and development of continuous processes. This book is for industry professionals, including chemical engineers and pharmaceutical scientists.

Freeze Drying Lyophilization Of Pharmaceutical   Biological Products  Revised and Expanded Book

Freeze Drying Lyophilization Of Pharmaceutical Biological Products Revised and Expanded


  • Author : Louis Rey
  • Publisher : CRC Press
  • Release Date : 2004-01-21
  • Genre: Medical
  • Pages : 634
  • ISBN 10 : 9780203021323

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Freeze Drying Lyophilization Of Pharmaceutical Biological Products Revised and Expanded Excerpt :

Thoroughly acquainting the reader with freeze-drying fundamentals, Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products, Second Edition carves practical guidelines from the very latest theoretical research, technologies, and industrial procedures. It delineates the best execution of steps from closure preparation and regulatory control of products to equipment sterilization and process validation. With 13 new chapters providing state-of-the-art information, the book unveils innovations currently advancing the field, including LYOGUARD® packaging for bulk freeze-drying and the irradiation of pharmaceutical and biological products.

Spray Freeze Drying of Foods and Bioproducts Book

Spray Freeze Drying of Foods and Bioproducts


  • Author : Padma Ishwarya, S.
  • Publisher : CRC Press
  • Release Date : 2022
  • Genre: Medical
  • Pages : 343
  • ISBN 10 : 1003019315

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Spray Freeze Drying of Foods and Bioproducts Excerpt :

Spray-freeze-drying (SFD) is a synergistic drying technology that imbibes in it the merits of both spray drying and freeze-drying, whilst overcoming the limitations of these predecessor technologies. SFD produces uniquely powdered food and pharmaceutical products with porous microstructure and superior quality attributes. Owing to its atomization step and ultra-low-temperature operation, SFD is a competent drying technique for the production of valuable but sensitive bioactive components. Despite the costs and complexities involved, SFD has a competitive edge over the conventional drying techniques in providing distinctive product attributes. The applications of spray-freeze-drying in the area of food and bioproducts span across the product categories of instant food powders, dry flavors, active pharmaceutical ingredients, poorly water-soluble drugs, probiotics, proteins, enzymes and vaccines. Spray-Freeze-Drying of Foods and Bioproducts: Theory, Applications and Perspectives is the first exclusive title on this interesting drying technique. It provides a comprehensive understanding of the fundamentals of SFD and its food and pharmaceutical applications. The scope of this book, comprising 12 chapters, has been organizedunder four major headings: fundamentals of process-stages, applications with case-studies, recent advancements and the processing bottlenecks and solutions. Key Features Provides examples and case studies of nuances and intricacies associated with each stage of the spray-freeze-drying process Highlights the applications of spray-freeze-drying in the production of food products including soluble coffee, dairy powders, probiotics and flavors Serves as a ready-reckoner of characterization methods for spray-freeze-dried products Contains 200+ illustrations and tabulations The contents of this book are organized to cater to the knowledge needs of students, academicians, researchers and professionals in the food and pharmaceutical industry.

Freeze Drying of Pharmaceutical Products Book

Freeze Drying of Pharmaceutical Products


  • Author : Davide Fissore
  • Publisher : CRC Press
  • Release Date : 2019-10-24
  • Genre: Medical
  • Pages : 201
  • ISBN 10 : 9780429664014

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Freeze Drying of Pharmaceutical Products Excerpt :

Freeze Drying of Pharmaceutical Products provides an overview of the most recent and cutting-edge developments and technologies in the field, focusing on formulation developments and process monitoring and considering new technologies for process development. This book contains case studies from freeze dryer manufacturers and pharmaceutical companies for readers in industry and academia. It was contributed to by lyophilization experts to create a detailed analysis of the subject matter, organically presenting recent advancements in freeze-drying research and technology. It discusses formulation design, process optimization and control, new PAT-monitoring tools, multivariate image analysis, process scale-down and development using small-scale freeze-dryers, use of CFD for equipment design, and development of continuous processes. This book is for industry professionals, including chemical engineers and pharmaceutical scientists.

Drying Technologies for Biotechnology and Pharmaceutical Applications Book

Drying Technologies for Biotechnology and Pharmaceutical Applications


  • Author : Satoshi Ohtake
  • Publisher : John Wiley & Sons
  • Release Date : 2020-06-02
  • Genre: Medical
  • Pages : 394
  • ISBN 10 : 9783527341122

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Drying Technologies for Biotechnology and Pharmaceutical Applications Excerpt :

A comprehensive source of information about modern drying technologies that uniquely focus on the processing of pharmaceuticals and biologicals Drying technologies are an indispensable production step in the pharmaceutical industry and the knowledge of drying technologies and applications is absolutely essential for current drug product development. This book focuses on the application of various drying technologies to the processing of pharmaceuticals and biologicals. It offers a complete overview of innovative as well as standard drying technologies, and addresses the issues of why drying is required and what the critical considerations are for implementing this process operation during drug product development. Drying Technologies for Biotechnology and Pharmaceutical Applications discusses the state-of-the-art of established drying technologies like freeze- and spray- drying and highlights limitations that need to be overcome to achieve the future state of pharmaceutical manufacturing. The book also describes promising next generation drying technologies, which are currently used in fields outside of pharmaceuticals, and how they can be implemented and adapted for future use in the pharmaceutical industry. In addition, it deals with the generation of synergistic effects (e.g. by applying process analytical technology) and provides an outlook toward future developments. -Presents a full technical overview of well established standard drying methods alongside various other drying technologies, possible improvements, limitations, synergies, and future directions -Outlines different drying technologies from an application-oriented point of view and with consideration of real world challenges in the field of drug product development -Edited by renowned experts from the pharmaceutical industry and assembled by leading experts from industry and academia Drying Technologies for Biotechnology and Pharmaceutical Applications is an important book for pharma engineers, proce

Freeze Drying Technology in Foods Book

Freeze Drying Technology in Foods


  • Author : Valentina Prosapio
  • Publisher : MDPI
  • Release Date : 2021-08-31
  • Genre: Technology & Engineering
  • Pages : 98
  • ISBN 10 : 9783036500683

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Freeze Drying Technology in Foods Excerpt :

This Special Issue provides an update on the most recent research and developments in the area of freeze-drying technology in foods. It presents a combination of experimental and modeling studies, offering an overview of oncoming challenges and opportunities on the topic.

Phytotechnology Book

Phytotechnology


  • Author : Wanderley Pereira Oliveira
  • Publisher : CRC Press
  • Release Date : 2022-02-16
  • Genre: Science
  • Pages : 411
  • ISBN 10 : 9781000530612

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Phytotechnology Excerpt :

Herbal products have traditionally been used in several industrial sectors and have gained a notable reputation in recent years due to the current trend in society, which seeks natural, healthier, and more sustainable products. The processing of these products, however, is multiplex but important for the production of a high-quality standardised product. Phytotechnology: A Sustainable Platform for the Development of Herbal Products highlights the complex, multidisciplinary process of phytopharmaceutical technology used to create herbal remedies. Organised into four parts, various experts in the field clearly and objectively address the fundamental and technological concepts involved in the manufacturing of high-quality herbal products. Additional Features Emphasises how herbal products have traditionally been used in several industrial sectors, including pharmaceutical science, food, cosmetics, chemical engineering, and agroindustry Provides a much-needed update of the current information regarding phytopharmaceutical technology and focuses on industrial applications Written using a multidisciplinary approach, to include all subjects involved in the processing of herbal products The information presented is valuable reference material for professionals of different specialties who wish to enter this fascinating and innovative area.

Encyclopedia of Food and Health Book

Encyclopedia of Food and Health


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2015-08-26
  • Genre: Technology & Engineering
  • Pages : 4006
  • ISBN 10 : 9780123849533

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Encyclopedia of Food and Health Excerpt :

The Encyclopedia of Food and Health provides users with a solid bridge of current and accurate information spanning food production and processing, from distribution and consumption to health effects. The Encyclopedia comprises five volumes, each containing comprehensive, thorough coverage, and a writing style that is succinct and straightforward. Users will find this to be a meticulously organized resource of the best available summary and conclusions on each topic. Written from a truly international perspective, and covering of all areas of food science and health in over 550 articles, with extensive cross-referencing and further reading at the end of each chapter, this updated encyclopedia is an invaluable resource for both research and educational needs. Identifies the essential nutrients and how to avoid their deficiencies Explores the use of diet to reduce disease risk and optimize health Compiles methods for detection and quantitation of food constituents, food additives and nutrients, and contaminants Contains coverage of all areas of food science and health in nearly 700 articles, with extensive cross-referencing and further reading at the end of each chapter

Ice Templating and Freeze Drying for Porous Materials and Their Applications Book

Ice Templating and Freeze Drying for Porous Materials and Their Applications


  • Author : Haifei Zhang
  • Publisher : John Wiley & Sons
  • Release Date : 2018-05-16
  • Genre: Science
  • Pages : 400
  • ISBN 10 : 9783527807413

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Ice Templating and Freeze Drying for Porous Materials and Their Applications Excerpt :

Filling a gap in the literature, this is the first book to focus on the fabrication of functional porous materials by using ice templating and freeze drying. Comprehensive in its scope, the volume covers such techniques as the fabrication of porous polymers, porous ceramics, biomimic strong composites, carbon nanostructured materials, nanomedicine, porous nanostructures by freeze drying of colloidal or nanoparticle suspensions, and porous materials by combining ice templating and other techniques. In addition, applications for each type of material are also discussed. Of great benefit to those working in the freeze-drying field and researchers in porous materials, materials chemistry, engineering, and the use of such materials for various applications, both in academia and industry.

Food Processing Technology Book

Food Processing Technology


  • Author : P J Fellows
  • Publisher : Woodhead Publishing
  • Release Date : 2016-10-04
  • Genre: Technology & Engineering
  • Pages : 1152
  • ISBN 10 : 9780081005231

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Food Processing Technology Excerpt :

Food Processing Technology: Principles and Practice, Fourth Edition, has been updated and extended to include the many developments that have taken place since the third edition was published. The new edition includes an overview of the component subjects in food science and technology, processing stages, important aspects of food industry management not otherwise considered (e.g. financial management, marketing, food laws and food industry regulation), value chains, the global food industry, and over-arching considerations (e.g. environmental issues and sustainability). In addition, there are new chapters on industrial cooking, heat removal, storage, and distribution, along with updates on all the remaining chapters. This updated edition consolidates the position of this foundational book as the best single-volume introduction to food manufacturing technologies available, remaining as the most adopted standard text for many food science and technology courses. Updated edition completely revised with new developments on all the processing stages and aspects of food industry management not otherwise considered (e.g. financial management, marketing, food laws, and food industry regulation), and more Introduces a range of processing techniques that are used in food manufacturing Explains the key principles of each process, including the equipment used and the effects of processing on micro-organisms that contaminate foods Describes post-processing operations, including packaging and distribution logistics Includes extra textbook elements, such as videos and calculations slides, in addition to summaries of key points in each chapter

Good Pharmaceutical Freeze Drying Practice Book

Good Pharmaceutical Freeze Drying Practice


  • Author : Peter Cameron
  • Publisher : CRC Press
  • Release Date : 1997-06-30
  • Genre: Medical
  • Pages : 320
  • ISBN 10 : 9781482207842

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Good Pharmaceutical Freeze Drying Practice Excerpt :

This text is devoted to pharmaceutical freeze-drying in all its forms and in all its technological variations. Whether you freeze-dry nonsterile tablets or you lyophilize injectables, this book covers all the technological and regulatory requirements. Written by a panel of leading practitioners in the pharmaceutical industry -- production experts, regulatory inspectors, technical consultants, and equipment suppliers -- the information is relevant, usable, and timely. Practical, "how to" chapters serve as training aids, and each section stands on its own as a concise, easy-to-access resource for both managers and technicians.

Freeze drying of Pharmaceuticals and Biopharmaceuticals Book
Score: 4
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Freeze drying of Pharmaceuticals and Biopharmaceuticals


  • Author : Felix Franks
  • Publisher : Royal Society of Chemistry
  • Release Date : 2008
  • Genre: Medical
  • Pages : 220
  • ISBN 10 : 9780854041510

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Freeze drying of Pharmaceuticals and Biopharmaceuticals Excerpt :

Aimed at product and process developers in the biopharmaceutical industry and academia, this is the first book to describe freeze-drying, as related to the pharmaceutical industry.

Freeze Drying Book

Freeze Drying


  • Author : Peter Haseley
  • Publisher : John Wiley & Sons
  • Release Date : 2018-05-07
  • Genre: Science
  • Pages : 434
  • ISBN 10 : 9783527343065

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Freeze Drying Excerpt :

This completely updated and enlarged third edition of the classic text adopts a practical approach to describe the fundamentals of freeze-drying, backed by many explanatory examples. Following an introduction to the fundamentals, the book goes on to discuss process and plant automation as well as methods to transfer pilot plant qualifications and process data to production. An entire section is devoted to a large range of different pharmaceutical, biological, and medical products. New to this edition are chapters on antibodies, freeze-dry microscopy, TEMPRIS, microwave freeze-drying, spray freeze-drying, and PAT. Their many years of experience in freeze-drying enable the authors to supply valuable criteria for the selection of laboratory, pilot and production plants, discussing the advantages, drawbacks and limitations of different plant designs. Alongside guidelines for the evaluation and qualification of plants and processes, the author also includes a troubleshooting section.

Designing the Internal Porous Structure of Soluble Coffee Particles to Improve Freeze Drying and Functionality  Band 22  Book

Designing the Internal Porous Structure of Soluble Coffee Particles to Improve Freeze Drying and Functionality Band 22


  • Author : Patrick Levin
  • Publisher : Cuvillier Verlag
  • Release Date : 2023-01-10
  • Genre: Technology & Engineering
  • Pages : 154
  • ISBN 10 : 9783736967267

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Designing the Internal Porous Structure of Soluble Coffee Particles to Improve Freeze Drying and Functionality Band 22 Excerpt :

The objective of this work was the understanding of the internal pore structure creation of instant coffee. It includes the question which parameters are influencing the pore structure and mapping the applicable ranges. The influence of these structural parameters on the drying kinetics were investigated in experiment and modeling, finding the optimal approach to increase the drying kinetics. The reconstitution behavior of the dried powder structures was analyzed to link the process optimization to product quality aspects. The instant coffee was structured in a scraped surface heat exchanger and with different freezing methods, where samples were gassed with nitrogen and carbon dioxide. The amount of gassing, the total solids content, the coolant temperature, the scraping speed, temperature cycling and the freezing rate of the slurry during hardening were shown to influence the morphology of the samples, where total solids content, gassing, temperature cycling and freezing rate showed a dominant influence in the investigated range on structure parameters like open porosity, closed porosity and the median pore diameter, obtained after drying. It could be shown that the pore diameter has the biggest potential to improve drying and reconstitution kinetics