Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics Book

Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics


  • Author : Alexander A. Vinks
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-23
  • Genre: Medical
  • Pages : 466
  • ISBN 10 : 9780387756134

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Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics Excerpt :

Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.

Antimicrobial Pharmacodynamics in Theory and Clinical Practice Book

Antimicrobial Pharmacodynamics in Theory and Clinical Practice


  • Author : Nightingale
  • Publisher : CRC Press
  • Release Date : 2001-09-25
  • Genre: Medical
  • Pages : 432
  • ISBN 10 : 9780824741822

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Antimicrobial Pharmacodynamics in Theory and Clinical Practice Excerpt :

This up-to-the-minute reference explores the pharmacodynamics of antimicrobials as well as the absorption, distribution, metabolism, and elimination of the major classes of antimicrobials-covering new agents such as ketolide antibiotics and highlighting the pharmacodynamic relationship between drug concentration and antimicrobial activity, as well as the relationship of pharmacodynamics to bacterial resistance. Contains specific examples and practical applications for the design of effective dosing regimens! Written by recognized experts in the field, Antimicrobial Pharmacodynamics in Theory and Clinical Practice describes the pharmacodynamic properties of all major classes of antibiotics parameters for microbiological activity of antimicrobial agents such as minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) serum/tissue protein binding and penetration rates differences between in vivo and in vitro postantibiotic effects (PAE) and more! With nearly 1000 references, tables, drawings, and illustrations, Antimicrobial Pharmacodynamics in Theory and Clinical Practice is a state-of-the-art reference for infectious disease specialists, pulmonologists, pharmacists, pharmacologists, microbiologists, biological chemists, epidemiologists, internists, and students in these disciplines.

Antibiotic Pharmacokinetic Pharmacodynamic Considerations in the Critically Ill Book

Antibiotic Pharmacokinetic Pharmacodynamic Considerations in the Critically Ill


  • Author : Andrew A. Udy
  • Publisher : Springer
  • Release Date : 2017-09-18
  • Genre: Medical
  • Pages : 275
  • ISBN 10 : 9789811053368

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Antibiotic Pharmacokinetic Pharmacodynamic Considerations in the Critically Ill Excerpt :

This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.

Antibiotic Pharmacodynamics Book

Antibiotic Pharmacodynamics


  • Author : John C. Rotschafer
  • Publisher : Humana Press
  • Release Date : 2016-03-23
  • Genre: Medical
  • Pages : 666
  • ISBN 10 : 1493933213

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Antibiotic Pharmacodynamics Excerpt :

This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab. Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.

Introduction to Pharmacokinetics and Pharmacodynamics Book
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Introduction to Pharmacokinetics and Pharmacodynamics


  • Author : Thomas N. Tozer
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2006
  • Genre: Medical
  • Pages : 326
  • ISBN 10 : 0781751497

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Introduction to Pharmacokinetics and Pharmacodynamics Excerpt :

This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.

Anesthetic Pharmacology Book

Anesthetic Pharmacology


  • Author : Alex S. Evers
  • Publisher : Cambridge University Press
  • Release Date : 2011-03-10
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9781139497022

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Anesthetic Pharmacology Excerpt :

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Continuous Renal Replacement Therapy Book

Continuous Renal Replacement Therapy


  • Author : John Kellum
  • Publisher : Oxford University Press
  • Release Date : 2009-12-03
  • Genre: Medical
  • Pages : 288
  • ISBN 10 : 9780199889389

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Continuous Renal Replacement Therapy Excerpt :

In the past decade, CRRT has moved from a niche therapy within specific specialty centers to the standard of care for management of critically ill patients with acute renal failure. Continuous Renal Replacement Therapy provides concise, evidence-based, to-the-point bedside guidance about this treatment modality, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice. Organized into sections on Theory; Pratice; Special Situations; and Organizational Issues, Continuous Renal Replacement Therapy provides a complete view of CRRT theory and practice. Generous tables summarize and highlight key points, and key studies and trials are listed in each chapter.

Antimicrobial Stewardship Book

Antimicrobial Stewardship


  • Author : Matthew Laundy
  • Publisher : Oxford University Press
  • Release Date : 2016-08-18
  • Genre: Uncategoriezed
  • Pages : 176
  • ISBN 10 : 9780198758792

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Antimicrobial Stewardship Excerpt :

Antimicrobial resistance (AMR) challenges the treatment of clinical infections. Despite the decline in infectious diseases mortality rates, infections are more difficult to eliminate or contain in the host, resulting in poorer outcomes to treatment, longer hospital inpatient stays, and increased mortality. Written by international experts in the field and supported by the review of the available evidence, including example case studies, Antimicrobial Stewardship provides a practical how-to guide on this growing area. Divided into three sections, the first sets the scene, looking at the key problems of antimicrobial resistance. Section two examines and identifies the key components of an antimicrobial stewardship program. Finally, the book explores specialist areas of antimicrobial stewardship ranging from antimicrobial pharmacokinetics and dynamics, to near patient testing, and infection biomarkers. Antimicrobial Stewardship will be a valuable and practical resource for infection trainees, as well as specialists from the medical, pharmacy, and nursing professions.

Antibiotic Optimization Book

Antibiotic Optimization


  • Author : Robert C. Owens
  • Publisher : CRC Press
  • Release Date : 2004-11-04
  • Genre: Medical
  • Pages : 688
  • ISBN 10 : 9781135534462

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Antibiotic Optimization Excerpt :

This book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi

Antibacterial Therapy  Achievements  Problems and Future Perspectives Book

Antibacterial Therapy Achievements Problems and Future Perspectives


  • Author : W.-D. Busse
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 78
  • ISBN 10 : 9783642608032

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Antibacterial Therapy Achievements Problems and Future Perspectives Excerpt :

At a symposium in Wuppertal held on 26 September 1995, Dr. Karl-Georg Metzger was honored, on the occasion of his retirement, for his scientific contributions and involvement in antibacterial drug research and develop ment within Bayer AG. In 1963 Dr. Metzger was the first "molecular micro biologist" to join Bayer in the field of antibacterial research. Karl-Georg Metzger studied physics and biology at the University of Mainz from 1950 to 1953 and continued his scientific education, with a grant from the Deutsche Forschungsgemeinschaft, in Frankfurt on Main (1953-1956). From 1956 to 1958, under Professor Kaplan, he worked on his DNA following treatment of PhD, studying on "Energy conduction along bacteria with UV light and X-rays and the formation of mutations". He was awarded his PhD in 1959. From 1958 to 1963 he was research assistant in ra diobiology development at the Institute of Genetics in Cologne. During the following years he became fascinated by the emerging fields of molecular biology and gene technology. He worked together with the molecular gen eticists W. Harms and M. Delbriick, who built up one of the most renowned institutes in the world, in Cologne. ''An incredibly interesting time:' Dr. Metzger remembers, in which he got to know a whole series of Nobel prize winners from Niels Bohr to Watson and Crick and Joshua Lederberg, the first to recombine genotypes of bacteria.

Principles of Pharmacology Book

Principles of Pharmacology


  • Author : David E. Golan
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2011-12-15
  • Genre: Medical
  • Pages : 954
  • ISBN 10 : 9781608312702

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Principles of Pharmacology Excerpt :

Now in its third edition, Principles of Pharmacology presents content in a conceptual framework that maximizes understanding and retention and minimizes rote memorization. It takes students "beyond the disease" and deep into physiologic, biochemical, and pathophysiologic systems where drugs activate or inhibit these systems by interacting with molecular and cellular targets. This unique approach ensures understanding of the mechanisms of drug actions on the body, and ultimately, in treating the human patient. Ideal for introductory pharmacology courses that emphasize critical thinking, molecular understanding, systems-based integration, and clinical preparation, the text: Features chapter-opening clinical cases and questions to establish a context for the discussion and the answers that follow Presents signature drug summary tables, updated and organized by mechanism of action, with information on clinical applications, adverse effects, contraindications, and therapeutic considerations Incorporates NEW full-color illustrations throughout, suiting the needs of visual learners and more effectively presenting concepts covered in the narrative Integrates timely content, including recently approved drugs as well as current research on drug mechanisms of action Delivers course and review material appropriate for students through a uniquely collaborative authorship consisting of medical students, residents, and faculty

Fundamentals of Anaesthesia Book

Fundamentals of Anaesthesia


  • Author : Colin Pinnock
  • Publisher : Cambridge University Press
  • Release Date : 2002-12
  • Genre: Medical
  • Pages : 963
  • ISBN 10 : 052169079X

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Fundamentals of Anaesthesia Excerpt :

The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.

Antibiotics Simplified Book

Antibiotics Simplified


  • Author : Jason C. Gallagher
  • Publisher : Jones & Bartlett Publishers
  • Release Date : 2009-10-05
  • Genre: Medical
  • Pages : 158
  • ISBN 10 : 9781449659608

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Antibiotics Simplified Excerpt :

Antibiotics Simplified is a succinct guide designed to bridge knowledge gained in basic sciences courses with clinical practice in infectious diseases. Introductory chapters explain the rationale behind the treatment of infectious diseases, describe a system for selecting antimicrobial agents and briefly review basic microbiology. Later chapters present relevant characteristics of drug classes, emphasizing clinical pearls for individual agents, and also include content on antifungals. The concise nature of the text allows for emphasis on key points, allowing readers to extract the most important characteristics of anti-infective drugs from the larger mass of material that they learn from detailed pharmacology textbooks. This is an ideal handbook for students as well as practicing clinicians and pharmacists.