Fundamentals of Molecular Structural Biology Book

Fundamentals of Molecular Structural Biology


  • Author : Subrata Pal
  • Publisher : Academic Press
  • Release Date : 2019-08-13
  • Genre: Science
  • Pages : 518
  • ISBN 10 : 9780128148563

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Fundamentals of Molecular Structural Biology Excerpt :

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease

Fundamentals of Molecular Structural Biology Book

Fundamentals of Molecular Structural Biology


  • Author : Subrata Pal
  • Publisher : Academic Press
  • Release Date : 2019-09-02
  • Genre: Science
  • Pages : 518
  • ISBN 10 : 9780128148556

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Fundamentals of Molecular Structural Biology Excerpt :

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease

Algorithms in Structural Molecular Biology Book

Algorithms in Structural Molecular Biology


  • Author : Bruce R. Donald
  • Publisher : MIT Press
  • Release Date : 2011-06-01
  • Genre: Science
  • Pages : 464
  • ISBN 10 : 9780262297844

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Algorithms in Structural Molecular Biology Excerpt :

An overview of algorithms important to computational structural biology that addresses such topics as NMR and design and analysis of proteins. Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules. Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility. The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field.

Fundamentals of Protein NMR Spectroscopy Book

Fundamentals of Protein NMR Spectroscopy


  • Author : Gordon S. Rule
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-02-16
  • Genre: Science
  • Pages : 532
  • ISBN 10 : 9781402035005

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Fundamentals of Protein NMR Spectroscopy Excerpt :

NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR pulse sequences. A modular analysis of NMR pulse sequence building blocks also provides a basis for understanding and developing novel pulse programs. This text not only covers topics from chemical shift assignment to protein structure refinement, as well as the analysis of protein dynamics and chemical kinetics, but also provides a practical guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing. End of chapter exercises are included to emphasize important concepts. Fundamentals of Protein NMR Spectroscopy not only offer students a systematic, in-depth, understanding of modern NMR spectroscopy and its application to biomolecular systems, but will also be a useful reference for the experienced investigator.

Fundamentals of Protein Structure and Function Book

Fundamentals of Protein Structure and Function


  • Author : Engelbert Buxbaum
  • Publisher : Springer
  • Release Date : 2015-11-27
  • Genre: Science
  • Pages : 521
  • ISBN 10 : 9783319199207

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Fundamentals of Protein Structure and Function Excerpt :

This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.

Fundamentals of Molecular Biology Book
Score: 4
From 1 Ratings

Fundamentals of Molecular Biology


  • Author : Jayanta K. Pal
  • Publisher : Oxford University Press, USA
  • Release Date : 2009
  • Genre: Science
  • Pages : 374
  • ISBN 10 : 0195697812

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Fundamentals of Molecular Biology Excerpt :

Fundamentals of Molecular Biology focuses on explaining the basic concepts and techniques in molecular biology and their applications.

Diagnostic Molecular Biology Book
Score: 5
From 1 Ratings

Diagnostic Molecular Biology


  • Author : Chang-Hui Shen
  • Publisher : Academic Press
  • Release Date : 2019-04-02
  • Genre: Science
  • Pages : 471
  • ISBN 10 : 9780128028674

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Diagnostic Molecular Biology Excerpt :

Diagnostic Molecular Biology describes the fundamentals of molecular biology in a clear, concise manner to aid in the comprehension of this complex subject. Each technique described in this book is explained within its conceptual framework to enhance understanding. The targeted approach covers the principles of molecular biology including the basic knowledge of nucleic acids, proteins, and genomes as well as the basic techniques and instrumentations that are often used in the field of molecular biology with detailed procedures and explanations. This book also covers the applications of the principles and techniques currently employed in the clinical laboratory. • Provides an understanding of which techniques are used in diagnosis at the molecular level • Explains the basic principles of molecular biology and their application in the clinical diagnosis of diseases • Places protocols in context with practical applications

Biophysical Chemistry Book

Biophysical Chemistry


  • Author : Dagmar Klostermeier
  • Publisher : CRC Press
  • Release Date : 2018-01-02
  • Genre: Medical
  • Pages : 770
  • ISBN 10 : 9781482252248

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Biophysical Chemistry Excerpt :

Biophysical Chemistry explores the concepts of physical chemistry and molecular structure that underlie biochemical processes. Ideally suited for undergradate students and scientists with backgrounds in physics, chemistry or biology, it is also equally accessible to students and scientists in related fields as the book concisely describes the fundamental aspects of biophysical chemistry, and puts them into a biochemical context. The book is organized in four parts, covering thermodynamics, kinetics, molecular structure and stability, and biophysical methods. Cross-references within and between these parts emphasize common themes and highlight recurrent principles. End of chapter problems illustrate the main points explored and their relevance for biochemistry, enabling students to apply their knowledge and to transfer it to laboratory projects. Features: Connects principles of physical chemistry to biochemistry Emphasizes the role of organic reactions as tools for modification and manipulation of biomolecules Includes a comprehensive section on the theory of modern biophysical methods and their applications

Molecular Biology Book

Molecular Biology


  • Author : David P. Clark
  • Publisher : Elsevier
  • Release Date : 2012-03-20
  • Genre: Science
  • Pages : 928
  • ISBN 10 : 9780123785954

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Molecular Biology Excerpt :

Molecular Biology, Second Edition, examines the basic concepts of molecular biology while incorporating primary literature from today’s leading researchers. This updated edition includes Focuses on Relevant Research sections that integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world. The new Academic Cell Study Guide features all the articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text. Animations provided deal with topics such as protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE. The text also includes updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA. An updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images. This text is designed for undergraduate students taking a course in Molecular Biology and upper-level students studying Cell Biology, Microbiology, Genetics, Biology, Pharmacology, Biotechnology, Biochemistry, and Agriculture. NEW: "Focus On Relevant Research" sections integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world. NEW: Academic Cell Study Guide features all articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text. NEW: Animations provided include topics in protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE Updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA Updated ancillary package includes flashca

Fundamentals of Molecular Evolution Book

Fundamentals of Molecular Evolution


  • Author : Dan Graur
  • Publisher : Sinauer Associates Incorporated
  • Release Date : 2000-01
  • Genre: Medical
  • Pages : 481
  • ISBN 10 : 0878932666

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Fundamentals of Molecular Evolution Excerpt :

Genes, genetic codes, and mutation. Dynamics of genes in populations. Evolutionary change in nucleotide sequences. Rates and patterns of nucleotide substitution. Molecular phylogenetics. Gene duplication, exon shuffling, and concerted evolution. Evolution by transposition. Genome evolution. Spatial and temporal frameworks of the evolutionary process. Basics of probability.

Molecular Simulations Book
Score: 5
From 1 Ratings

Molecular Simulations


  • Author : Saman Alavi
  • Publisher : VCH
  • Release Date : 2020-06-03
  • Genre: Uncategoriezed
  • Pages : 344
  • ISBN 10 : 9783527341054

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Molecular Simulations Excerpt :

Addressing the need of chemistry, biology and engineering students to understand and perform their own molecular simulations, the author introduces the fundamentals of molecular modeling for a broad, practice-oriented audience and presents versatile practical applications. The book presents a thorough overview of the underlying concepts.

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design Book

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design


  • Author : Om Silakari
  • Publisher : Academic Press
  • Release Date : 2020-11-05
  • Genre: Business & Economics
  • Pages : 396
  • ISBN 10 : 9780128205471

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Concepts and Experimental Protocols of Modelling and Informatics in Drug Design Excerpt :

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design discusses each experimental protocol utilized in the field of bioinformatics, focusing especially on computer modeling for drug development. It helps the user in understanding the field of computer-aided molecular modeling (CAMM) by presenting solved exercises and examples. The book discusses topics such as fundamentals of molecular modeling, QSAR model generation, protein databases and how to use them to select and analyze protein structure, and pharmacophore modeling for drug targets. Additionally, it discusses data retrieval system, molecular surfaces, and freeware and online servers. The book is a valuable source for graduate students and researchers on bioinformatics, molecular modeling, biotechnology and several members of biomedical field who need to understand more about computer-aided molecular modeling. Presents exercises with solutions to aid readers in validating their own protocol Brings a thorough interpretation of results of each exercise to help readers compare them to their own study Explains each parameter utilized in the algorithms to help readers understand and manipulate various features of molecules and target protein to design their study

Fundamentals of Molecular Virology  2nd Edition Book

Fundamentals of Molecular Virology 2nd Edition


  • Author : Nicholas H. Acheson
  • Publisher : Wiley Global Education
  • Release Date : 2011-08-01
  • Genre: Science
  • Pages : 500
  • ISBN 10 : 9781118213827

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Fundamentals of Molecular Virology 2nd Edition Excerpt :

Designed for students learning about viruses for the first time at the undergraduate or graduate level, Fundamentals of Molecular Virology is presented in a style which relates to today's students and professors. This book is also a valuable, up-to-date source of information for graduate students, postdoctoral fellows and research scientists working with viruses. Chapters contributed by prominent virologists were edited to conform to a clear and accessible style. The text provides a thorough presentation of basic and contemporary concepts in virology for a student's first exposure to the field.

Protein Nucleic Acid Interactions Book

Protein Nucleic Acid Interactions


  • Author : Phoebe A. Rice
  • Publisher : Royal Society of Chemistry
  • Release Date : 2008-05-22
  • Genre: Science
  • Pages : 397
  • ISBN 10 : 9780854042722

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Protein Nucleic Acid Interactions Excerpt :

The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid 1980s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite frequently. High-resolution structures of protein-RNA complexes were relatively rare until the last decade. Propelled by advances in technology as well as the realization of RNA's importance to biology, the number of example structures has ballooned in recent years. New insights are now being gained from comparative studies only recently made possible due to the size of the database, as well as from careful biochemical and biophysical studies. As a result of the explosion of research in this area, it is no longer possible to write a comprehensive review. Instead, current review articles tend to focus on particular subtopics of interest. This makes it difficult for newcomers to the field to attain a solid understanding of the basics. One goal of this book is therefore to provide in-depth discussions of the fundamental principles of protein-nucleic acid interactions as well as to illustrate those fundamentals with up-to-date and fascinating examples for those who already possess some familiarity with the field. The book also aims to bridge the gap between the DNA- and the RNA- views of nucleic acid - protein recognition, which are often treated as separate fields. However, this is a false dichotomy because protein - DNA and protein - RNA interactions share many general principles. This book therefore includes relevant examples from both sides, and frames discussions of the fundamentals in terms that are relevant to both. The monograph approaches the study of protein-nucleic acid interactions in two distinctive ways. First, DNA-protein and RNA-protein interactions are presented together. Second, the first half of the book develops the principles of

Molecular and Cellular Biology of Viruses Book

Molecular and Cellular Biology of Viruses


  • Author : Phoebe Lostroh
  • Publisher : Garland Science
  • Release Date : 2019-05-06
  • Genre: Science
  • Pages : 501
  • ISBN 10 : 9780429664304

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Molecular and Cellular Biology of Viruses Excerpt :

Viruses interact with host cells in ways that uniquely reveal a great deal about general aspects of molecular and cellular structure and function. Molecular and Cellular Biology of Viruses leads students on an exploration of viruses by supporting engaging and interactive learning. All the major classes of viruses are covered, with separate chapters for their replication and expression strategies, and chapters for mechanisms such as attachment that are independent of the virus genome type. Specific cases drawn from primary literature foster student engagement. End-of-chapter questions focus on analysis and interpretation with answers being given on the website (half for students, all for instructors). Examples come from the most-studied and medically important viruses such as HIV, influenza, and poliovirus. Plant viruses and bacteriophages are also included. There are chapters on the overall effect of viral infection on the host cell. Coverage of the immune system is focused on the interplay between host defenses and viruses, with a separate chapter on medical applications such as anti-viral drugs and vaccine development. The final chapter is on virus diversity and evolution, incorporating contemporary insights from metagenomic research. Key selling feature: Readable but rigorous coverage of the molecular and cellular biology of viruses Molecular mechanisms of all major groups, including plant viruses and bacteriophages, illustrated by example Host-pathogen interactions at the cellular and molecular level emphasized throughout Medical implications and consequences included Quality illustrations available to instructors Extensive questions and answers for each chapter