Gap Junctions in the Nervous System Book

Gap Junctions in the Nervous System


  • Author : David C. Spray
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-06-29
  • Genre: Medical
  • Pages : 317
  • ISBN 10 : 9783662219355

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Gap Junctions in the Nervous System Excerpt :

This book deals with the types of gap junction proteins (connexins) and their distribution within the nervous system, the physiological properties of channels formed of each connexin, and the role of gap junction channels in functions of normal and pathological brain and peripheral nerve. Although glial tissue is emphasized, additional groups of chapters deal with neurons in the central nervous system and with the retina.

Gap Junctions in the Nervous System Book

Gap Junctions in the Nervous System


  • Author : David C. Spray
  • Publisher : Springer
  • Release Date : 2013-11-13
  • Genre: Medical
  • Pages : 317
  • ISBN 10 : 3662219379

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Gap Junctions in the Nervous System Excerpt :

A Cytoplasm Connexon or Hemichannel Cytoplasm external loop I - P. M. N-Termlnus Fig. 1. 1. Topology of gap junction channels. (A) Cap junction channels, extending from the cytoplasm of one cell to the cytoplasm of another, are formed by two connexons or hemichannels connected across extracellular space. (B) Each connexon is formed from six connexin subunits, each having four membrane-spanning domains and both amino and carboxyl termini within the cytoplasm. External/oops (I and II} are believed to provide the high affinity interactions between the hemichannels. 4 Gap }unctions in the Nervous System P-region of voltage sensitive nonjunctional molecules; these contributed disulfide 9 channels. And Delmar's group has ob bridges are presumably involved in intra tained evidence that intracellular acidifi connexin and inter-EL loop tertiary struc cation may result in a conformational ture. An old observation that should be change analogous to the ball and chain repeated stoichiometrically with modern techniques is that gap junction channels model of inactivation of voltage gated ionic can be split into connexons or hemi channels, whereby the carboxyl terminal channels using hyperosmotic disaccharide portion of connexin43 binds to CL, closing 23 solutions again implying that linkage is the channel. Higher order structure of the channel not covalent. is believed to consist of six connexins form ing the hemichannel or connexon in a 3.

Gap Junctions in the Brain Book

Gap Junctions in the Brain


  • Author : Ekrem Dere
  • Publisher : Academic Press
  • Release Date : 2012-12-12
  • Genre: Medical
  • Pages : 304
  • ISBN 10 : 9780124159273

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Gap Junctions in the Brain Excerpt :

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants. Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants

Gap Junctions in the Nervous System Book

Gap Junctions in the Nervous System


  • Author : David C. Spray
  • Publisher : Oxford University Press
  • Release Date : 1996
  • Genre: Science
  • Pages : 317
  • ISBN 10 : UOM:39015038171727

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Gap Junctions in the Nervous System Excerpt :

Gap Junction Channels and Hemichannels Book

Gap Junction Channels and Hemichannels


  • Author : Donglin Bai
  • Publisher : CRC Press
  • Release Date : 2016-08-05
  • Genre: Science
  • Pages : 305
  • ISBN 10 : 9781315352404

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Gap Junction Channels and Hemichannels Excerpt :

Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and hemichannel research has recently exploded and became one of the most active areas of cell biology. Numerous novel approaches and techniques have been developed, but there is no single book dedicated to the unique techniques and protocols employed for the research on these large pore channels. This book fills the gap and focuses on protocols, approaches and reviews of gap junction channels and connexin hemichannels. It will be a useful reference for graduate students, postdoctoral fellows and researchers. Anyone with an interest in gap junction channels and hemichannels will need this summary of state-of-the-art techniques and protocols.

Intercellular Communication in the Nervous System Book

Intercellular Communication in the Nervous System


  • Author : Robert Malenka
  • Publisher : Academic Press
  • Release Date : 2010-05-22
  • Genre: Science
  • Pages : 776
  • ISBN 10 : 9780123785725

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Intercellular Communication in the Nervous System Excerpt :

Intercellular communication is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their environment is the basis of growth and development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, diabetes, and neurological and psychiatric disorders. There is substantial drug development concentrating on this and intercellular communication is the basis of much of neuropharmacology. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be yielded. Neurotransmitters/receptors, synaptic structure and organization, gap junctions, neurotrophic factors and neuropeptides are all explored in this volume, as are the ways in which signaling controls neuroendocrinology, neuroimmunology and neuropharmacology. Intercellular Communication in the Nervous System provides a valuable desk reference for all scientists who consider signaling. * Chapters offer impressive scope with topics addressing neurotransmitters/receptors, synaptic structure and organization, neuropeptides, gap junctions, neuropharmacology and more * Richly illustrated in full color with over 200 figures * Contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge

Gap Junctions in the Nervous System Book

Gap Junctions in the Nervous System


  • Author : Renato Rozental
  • Publisher : Unknown
  • Release Date : 2000
  • Genre: Central nervous system
  • Pages : 341
  • ISBN 10 : OCLC:247123200

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Neurons Book

Neurons


  • Author : Gonzalo Emiliano Aranda Abreu
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-02-20
  • Genre: Medical
  • Pages : 128
  • ISBN 10 : 9781789851236

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Neurons Excerpt :

The brain is the most complex structure that exists in the universe, consisting of neurons whose function is to receive information through dendrites and transmit information through the axon. In neurosciences one of the main problems that exists are neurodegenerative diseases for which until now there has been no cure. This book is mainly focused on updating the information on the signaling process carried out in the development of axons. Topics such as axon guidance and its interaction with the extracellular matrix are discussed. Other important topics are semaphorins and their relationship with neurodegenerative diseases, and the neurobiology of the gap junction in the dorsal root ganglion. Finally, the topic of bioelectrical interfaces destined to regenerate damaged nerves is covered. The information in this book will be very important both for researchers who work with these issues and doctoral students who are involved in neuroscience.

Biophysics of Gap Junction Channels Book

Biophysics of Gap Junction Channels


  • Author : M.D. Peracchia
  • Publisher : CRC Press
  • Release Date : 2018-01-18
  • Genre: Medical
  • Pages : 413
  • ISBN 10 : 9781351078740

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Biophysics of Gap Junction Channels Excerpt :

This book provides a state of the art account of present knowledge of the biophysics of cell-to-cell channels. It is divided into two sections, one dealing with two-cell systems and the other with reconstitution systems.

Connexin Cell Communication Channels Book

Connexin Cell Communication Channels


  • Author : Ernesto Oviedo-Orta
  • Publisher : CRC Press
  • Release Date : 2013-03-22
  • Genre: Science
  • Pages : 380
  • ISBN 10 : 9781439862575

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Connexin Cell Communication Channels Excerpt :

Plasma membrane-associated channels known as gap junctions, along with their protein building blocks—connexins—have an important functional role in a range of immunological processes, including heart function, cell growth and specialization, and early development. Spanning basic science and potential clinical applications, Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology assembles and synthesizes four decades of the most important research carried out in this field. The book first provides a historical overview of the discovery of these membrane channels in cells and tissues of the immune system. It describes their general molecular and biological characteristics and examines how they participate in the evolution, organization, function, and regulation of leukocytes, as well as their interaction with other tissues. The next section examines immunologically related disease scenarios where gap junctions and connexins have been shown to play a fundamental role. The contributors explain how gap junctional communication participates in the establishment and maintenance of immunological properties such as antibody and cytokine production, as well as lymphocyte immune surveillance in both physiological and pathological conditions. The book explores the most important technical approaches used and how they have been specially adapted to answer key biological questions particular to the mobile nature of leukocytes. It also describes the most recent understanding of how gap junctions and connexins participate in antigen recognition, cross-presentation, lymphocyte activation, and in the assembly and function of the immunological synapse. Finally, the book focuses on the latest progress made on translating the knowledge gained to specific treatment modalities. Topics in this section include approaches for reducing scarring and cardiac arrhythmia, combating inflammation in the central nervous system, and enhancing epithelial tissue repair.

The world according to zebrafish  How neural circuits generate behaviour Book

The world according to zebrafish How neural circuits generate behaviour


  • Author : Gonzalo G. De Polavieja
  • Publisher : Frontiers E-books
  • Release Date : 2014-11-07
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889193288

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The world according to zebrafish How neural circuits generate behaviour Excerpt :

Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.

Astrocytes and Epilepsy Book

Astrocytes and Epilepsy


  • Author : Jacqueline A. Hubbard
  • Publisher : Academic Press
  • Release Date : 2016-07-05
  • Genre: Medical
  • Pages : 394
  • ISBN 10 : 9780128026243

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Astrocytes and Epilepsy Excerpt :

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron i

Molecular Biology of the Cell Book
Score: 4.5
From 5 Ratings

Molecular Biology of the Cell


  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 0815332181

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Molecular Biology of the Cell Excerpt :