Genes  Environment and Alzheimer s Disease Book

Genes Environment and Alzheimer s Disease


  • Author : Orly Lazarov
  • Publisher : Academic Press
  • Release Date : 2016-02-25
  • Genre: Medical
  • Pages : 448
  • ISBN 10 : 9780128028858

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Genes Environment and Alzheimer s Disease Excerpt :

Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Genes  Environment and Alzheimer s Disease Book

Genes Environment and Alzheimer s Disease


  • Author : Orly Lazarov
  • Publisher : Academic Press
  • Release Date : 2016-03-01
  • Genre: Uncategoriezed
  • Pages : 350
  • ISBN 10 : 0128028513

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Genes Environment and Alzheimer s Disease Excerpt :

Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer's disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer's disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer's disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Behavior Genetics of Cognition Across the Lifespan Book

Behavior Genetics of Cognition Across the Lifespan


  • Author : Deborah Finkel
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-07-09
  • Genre: Psychology
  • Pages : 300
  • ISBN 10 : 9781461474470

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Behavior Genetics of Cognition Across the Lifespan Excerpt :

Along with psychopathology, cognition has been one of the primary phenotypic focal points of the field of behavior genetics since its inception. Francis Galton’s 1874 examination of eminent families in Britain was among the earliest attempts to investigate whether cognitive achievements run in families. This volume presents current methodologies for understanding cognitive abilities that move beyond the outdated nature vs. nurture paradigm. Recent advances in both collection and statistical modeling of twin data, particularly longitudinal twin data, make this an especially advantageous moment to produce a work that presents a collection of the groundbreaking research on cognitive abilities across the lifespan. This volume presents an overview of the current state of quantitative and molecular genetic investigations into the many facets of cognitive performance and functioning across the lifespan.​

Aging Book

Aging


  • Author : Cindy S. Bergeman
  • Publisher : SAGE Publications
  • Release Date : 1997-04-30
  • Genre: Psychology
  • Pages : 159
  • ISBN 10 : 9781452249858

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Aging Excerpt :

Why do people age differently? Gerontological research has indicated that there are large individual differences in personality, cognitive functioning, physical health, psychological well-being and quality of life in old age. This book explores this variability. Following an overview of family, adoption and twin studies of genetic and environmental influences on ageing, the author examines such topics as: longevity and health research; cognitive functioning, personality and psychopathology; and social support, life events and family environment measures. The book concludes with a summary of finding from gerontological behavioural genetics.

Update on Dementia Book

Update on Dementia


  • Author : Davide Moretti
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-09-28
  • Genre: Medical
  • Pages : 558
  • ISBN 10 : 9789535126546

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Update on Dementia Excerpt :

The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Neurodegeneration  From Genetics to Molecules Book

Neurodegeneration From Genetics to Molecules


  • Author : Victoria Campos-Peña
  • Publisher : Frontiers Media SA
  • Release Date : 2016-11-15
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889450206

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Neurodegeneration From Genetics to Molecules Excerpt :

Chronic degenerative diseases are one of the major public health problems, particularly those affecting the nervous system. They are characterized by the degeneration of specific cell populations that include several pathologies which contribute significantly to morbidity and mortality in the elderly population. Therefore, in recent years, the study of neuroscience has gained significant importance. Most of these neurodegenerative disorders are the result of a complex interaction between genetic and environmental factors that generate progression and can even determine its severity. The presence of mutations in genes as LRRK2, SNCA, PARK7, PARK2 or PINK1 is associated with Parkinson's disease. Mutations in genes such as APP, PS1 and PS2 are associated with familial Alzheimer's disease; while HTT gene mutations are the cause of Huntington's disease. In most cases, this condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. It is known that these mutations can also alter the proteins function; however, it has not yet been possible to fully understand how some genetic changes cause the disease or influence the risk of developing these disorders. Most symptoms seen in these conditions occurs when specific nerve cells are damaged or die generating a loss in brain communication. Also many of these mutations generate aggregation of intracellular or extracellular proteins affecting cell function and eventually causing neuronal death. It is unclear whether the presence of these aggregates play an important role in nerve cell death during the development of neurodegenerative diseases, or if they are simply part of the response of cells to the disease. Other mutations affect the mitochondrial function generating alterations in energy production and promoting the formation of unstable molecules such as free radicals. Under normal conditions, the harmful effects caused by free radicals,

Environmental Factors in Neurodegenerative Diseases Book

Environmental Factors in Neurodegenerative Diseases


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2017-09-19
  • Genre: Science
  • Pages : 290
  • ISBN 10 : 9780128127650

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Environmental Factors in Neurodegenerative Diseases Excerpt :

Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

Challenging Genetic Determinism Book
Score: 4
From 1 Ratings

Challenging Genetic Determinism


  • Author : Louis Maheu
  • Publisher : McGill-Queen's Press - MQUP
  • Release Date : 2011-08-23
  • Genre: Science
  • Pages : 319
  • ISBN 10 : 9780773537804

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Challenging Genetic Determinism Excerpt :

Compelling essays on understanding the interplay of genes in society.

Genetic and Environmental Factors Affecting Alzheimer s Disease Pathogenic Mechanism Book

Genetic and Environmental Factors Affecting Alzheimer s Disease Pathogenic Mechanism


  • Author : Letizia Polito
  • Publisher : Unknown
  • Release Date : 2012
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:806196055

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Genetic and Environmental Factors Affecting Alzheimer s Disease Pathogenic Mechanism Excerpt :

Alzheimer's disease (AD) is the leading cause of senile dementia and the current lack of effective treatments provides a strong incentive for an improved therapeutic strategy. In particular, non-pharmacological treatments, such as calorie restriction (CR), were shown to be useful in delaying or preventing AD onset. This has given insight into the molecular pathways involved. Sirtuins (SIRTl-7) are evolutionary conserved enzymes that modulate life expectancy in simple organisms. In mammals, sirtuins are involved in pathways linked to age-related -.- - diseases, such as AD. In particular, they seem to be the molecular effectors of some beneficial effects mediated by external stimuli such as CR and physical activity. This thesis aims at investigating, for the first time, the involvement of all 7 sirtuins in AD. The relevance of sirtuin gene variation to AD risk was assessed by a combined mutation screening and case-control genetic study design. Sirtuin expression levels were also assessed in a transgenic mouse model of AD (APP23 mice) and within the application of a non-pharmacological approach (environmental enrichment-EE). Finally, the possible role of SIRTl in AD pathogenesis was better elucidated through in vitro studies. Overall, in vitro studies confirmed the neuroprotective role of SIRTl activator resveratrol in etiopathological contexts related to AD. Moreover, genetic studies have highlighted SIRT2 could be involved in modulating AD etiology. In particular, a common polymorphism in SIRT2 could be a weak genetic risk factor for AD. Finally, in vivo studies confirmed the beneficial effects of an EE protocol in delaying AD onset. However, despite sirtuin involvement in other environmental paradigms, no apparent modulation was registered under EE.

Alzheimer s Disease Book

Alzheimer s Disease


  • Author : Caroline McNeil
  • Publisher : DIANE Publishing
  • Release Date : 1997
  • Genre: Uncategoriezed
  • Pages : 60
  • ISBN 10 : 078813793X

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Alzheimer s Disease Excerpt :

This report was written for people who are interested in research on Alzheimer's disease. Briefly covers the following areas of research: neurotransmitters, the proteins, the genes, environmental suspects, the calcium hypothesis, metabolism, cognitive markers, biological markers, caregiving, managing symptoms, potential biomedical treatments, and much more. Technical terms are defined in the glossary. Each chapter ends with a list of review articles and other materials that provide more detail on other studies mentioned in the text. Illustrated.

Human Genome Epidemiology Book

Human Genome Epidemiology


  • Author : Muin J. Khoury
  • Publisher : Oxford University Press
  • Release Date : 2004
  • Genre: Medical
  • Pages : 549
  • ISBN 10 : 9780195146745

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Human Genome Epidemiology Excerpt :

Advances in genomics are expected to play a central role in medicine and public health in the future by providing a genetic basis for disease prediction and prevention. The transplantation of human gene discoveries into meaningful actions to improve health and prevent disease depends on scientific information from multiple disciplines, including epidemiology. This book describes the important role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It proceeds systematically from the fundamentals of genome technology and gene discovery, to epidemiologic approaches to gene characterization in the population, to the evaluation of genetic tests and their use in health services. These methodologic approaches are then illustrated with several disease-specific case studies. The book provides a scientific foundation that will help researchers, policy makers, and practitioners integrate genomics into medical and public health practice.

Genetics and Mental Illness Book

Genetics and Mental Illness


  • Author : L.L. Hall
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-06-29
  • Genre: Medical
  • Pages : 226
  • ISBN 10 : 9781489901705

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Genetics and Mental Illness Excerpt :

''Refreshing and informative....describe[s] the new complex research tools, directions and interpretations in a lucid and understandable fashion.'' --- Lancet, North American edition ''Beautifully crafted...The most significant contribution of this book involves its integration of areas that are not typically considered in genetic overviews.'' --- American Scientist, 1998 ''This book does an extraordinary job of making sense out of the many complex and controversial issues surrounding psychiatric genetics...It is worth the price.'' --- Journal of Genetic Counseling, Vol. 6, No. 3, 1997 This collection of essays clearly examines the complex nature of mental illness, focusing on the theory and state of the art of psychiatric genetics. This insightful volume is the first to present the diverse viewpoints of investigators, policy analysts, and psychiatric patients. Contributors explore the roles of genes in mental illness and describe various clinical, ethical, and social implications of psychiatric genetics. Additional discussions include trends in psychiatric genetic research, nature versus nurture in behavioral genetics, basic statistical principles of linkage analysis, and the many social domains relevant to psychiatric genetics.

Cognitive Enhancement Book

Cognitive Enhancement


  • Author : Shira Knafo
  • Publisher : Academic Press
  • Release Date : 2014-12-20
  • Genre: Psychology
  • Pages : 392
  • ISBN 10 : 9780124171251

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Cognitive Enhancement Excerpt :

Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors addresses the gap that exists in research on the topic, gathering multidisciplinary knowledge and tools that help the reader understand the basics of cognitive enhancement. It also provides assistance in designing procedures and pharmacological approaches to further the use of novel cognitive enhancers, a field that offers potential benefit to a variety of populations, including those with neurologic and psychiatric disorders, mild aging-related cognitive impairment, and those who want to improve intellectual performance. The text builds on our knowledge of the molecular/cellular basis of cognitive function, offering the technological developments that may soon enhance cognition. Separate sections cover enhancement drugs, environmental conditions, and genetic factors in terms of both human and animal studies, including both healthy/young and aging/diseased individuals. Provides a multidisciplinary knowledge, enabling a further understanding of cognitive enhancement Offers coverage of the pharmacologic, environmental, and genetic factors relevant to the topic Discusses cognitive enhancement from the perspective of both healthy and diseased or aging populations Topics are discussed in terms of both human and animal studies