Genetic Diseases of the Kidney Book

Genetic Diseases of the Kidney

  • Author : Richard P. Lifton
  • Publisher : Academic Press
  • Release Date : 2009-02-25
  • Genre: Science
  • Pages : 848
  • ISBN 10 : 0080924271

Genetic Diseases of the Kidney Excerpt :

Genetic approaches have revolutionized our understanding of the fundamental causes of human disease by permitting the identification of specific genes in which variation causes or contributes to susceptibility to, or protection from, disease. More than 2,000 disease genes have been identified in the last 20 years, providing important new insight into the pathophysiology of diseases in every field of medicine. Genetic Diseases of the Kidney offers expert insight into the role of genetic abnormalities in the pathogenesis of abnormal kidney function and kidney disease. Genetic abnormalities are carefully presented within the appropriate physiologic context so that readers will understand not only which genes are linked to which diseases but also which pathways lead from a genetic “disturbance” to the systemic appearance of disease. * Lays the essential foundation of mammalian genetics principles for medical professionals with little or no background in genetics * Analyzes specific renal diseases – both monogenic disorders confined to the kidney and systemic diseases with renal involvement – and explains their genetic causes *World-renowned editors and authors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension)

Genetics of Kidney Diseases Book

Genetics of Kidney Diseases

  • Author : Harvest F. Gu
  • Publisher : Frontiers Media SA
  • Release Date : 2020-05-22
  • Genre: Uncategoriezed
  • Pages : 119
  • ISBN 10 : 9782889637379

Genetics of Kidney Diseases Excerpt :

Molecular and Genetic Basis of Renal Disease Book

Molecular and Genetic Basis of Renal Disease

  • Author : David B. Mount
  • Publisher : Elsevier Health Sciences
  • Release Date : 2008-01-01
  • Genre: Medical
  • Pages : 604
  • ISBN 10 : 9781416002529

Molecular and Genetic Basis of Renal Disease Excerpt :

This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the nephron as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included. Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.

Cystogenesis Book


  • Author : Jong Hoon Park
  • Publisher : Springer
  • Release Date : 2016-10-12
  • Genre: Medical
  • Pages : 126
  • ISBN 10 : 9789811020414

Cystogenesis Excerpt :

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Polycystic Kidney Disease Book

Polycystic Kidney Disease

  • Author : Jinghua Hu
  • Publisher : CRC Press
  • Release Date : 2019-10-24
  • Genre: Medical
  • Pages : 391
  • ISBN 10 : 9780429888946

Polycystic Kidney Disease Excerpt :

This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies. Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems

Biomarkers of Kidney Disease Book

Biomarkers of Kidney Disease

  • Author : Charles L. Edelstein
  • Publisher : Academic Press
  • Release Date : 2016-11-08
  • Genre: Science
  • Pages : 632
  • ISBN 10 : 9780128030356

Biomarkers of Kidney Disease Excerpt :

Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation, and preeclampsia. New chapters include biomarkers of cardiovascular disease in patients with CKD, biomarkers of Polycystic Kidney Disease, and biomarkers and the role of nanomedicine. Explores both the practical and conceptual steps performed in the discovery of biomarkers in kidney disease Presents a comprehensive account of newer biomarker discover strategies, such as metabolomics and proteomics, all illustrated by clear examples Offers clear translational presentations by the top basic and clinical researchers in each specific renal disease, including AKI, transplantation, cancer, CKD, PKD, diabetic nephropathy, preeclampsia, and glomerular disease

Diagnostic Pathology  Kidney Diseases E Book Book

Diagnostic Pathology Kidney Diseases E Book

  • Author : Matthew R Lindberg
  • Publisher : Elsevier Health Sciences
  • Release Date : 2019-05-24
  • Genre: Medical
  • Pages : 1176
  • ISBN 10 : 9780323711500

Diagnostic Pathology Kidney Diseases E Book Excerpt :

Comprehensive and up to date, the third edition of Diagnostic Pathology: Kidney Diseases, written by Robert B. Colvin, MD and Anthony Chang, MD, expertly covers all aspects of common and rare renal diseases and their variants. This easy-to-use, point-of-care reference offers a state-of-the-art, concise presentation of major pathological, clinical, pathophysiological, and genetic information for more than 240 diagnoses, making it an ideal resource for pathologists and nephrologists to improve knowledge and skills. Significantly revised information throughout ensures that you remain current with everything new regarding the pathology and pathogenesis of nonneoplastic kidney diseases. New content with over 20 new chapters covering idiopathic non-lupus full-house nephropathy, hemophagocytic glomerulonephritis, cryofibrinogenemic glomerulopathy, metabolic syndrome and obesity-related glomerular disease, Whipple disease, systemic Castleman disease, nephropathies due to direct acting antivirals for HCV, checkpoint inhibitors, EGFR antagonists, illicit drugs and opioids, Tums glomerulopathy, vancomycin-induced cast nephropathy, transcript analysis of renal biopsies, new forms of amyloidosis, and mass spectroscopy Updated and validated pathologic classifications systems reflect details on new genetic, therapeutic, and pathologic information, including IgA nephropathy, lupus nephritis, vasculitis, and transplant pathology More than 3,300 outstanding, annotated images, including gross and microscopic pathology, a wide range of stains, and detailed medical illustrations, make this an invaluable diagnostic aid for every practicing pathologist, nephrologist, resident, or fellow Time-saving reference features include consistently templated chapters, bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index Internationally recognized authors, many new to this edition, provide fresh perspectives on multiple topics, with a parti

Kidney Development  Disease  Repair and Regeneration Book

Kidney Development Disease Repair and Regeneration

  • Author : Melissa Helen Little
  • Publisher : Academic Press
  • Release Date : 2015-08-06
  • Genre: Medical
  • Pages : 614
  • ISBN 10 : 9780128004388

Kidney Development Disease Repair and Regeneration Excerpt :

Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

The Kidney Book

The Kidney

  • Author : Peter D. Vize
  • Publisher : Elsevier
  • Release Date : 2003-03-14
  • Genre: Science
  • Pages : 592
  • ISBN 10 : 0080521541

The Kidney Excerpt :

Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads into exploring the genetic regulation of this complex process but also began to unravel the molecular basis of many forms of congenital kidney disease. This book is a comprehensive study on these findings and the only book available with such in depth coverage of the kidney. Hundreds of color figures depicting key events in all aspects of kidney development Full coverage of the genetic and cellular basis of kidney development Analysis of the genetic basis of the major congenital kidney diseases

The Genetics of Renal Disease Book

The Genetics of Renal Disease

  • Author : Frances Flinter
  • Publisher : Oxford Monographs on Medical G
  • Release Date : 2003
  • Genre: Language Arts & Disciplines
  • Pages : 600
  • ISBN 10 : UOM:39015058871636

The Genetics of Renal Disease Excerpt :

Renal genetic disorders may become apparent at any time in life and recognition of specific renal disorders is important in allowing accurate genetic counselling. Active counselling requires knowledge about the natural history of the disorder, an understanding of the genetic component and mode of inheritance, risk of the disorder in other family members, information about patient attitudes towards family planning and the possibility of pre-natal diagnosis. The Genetics of Renal Disease covers these issues in detail. The book provides a comprehensive account of both the hereditary nephropathies and more generalised disorders which may affect the renal tract. It includes comprehensive guidelines from an international group of authors on renal function and development, choromosomal disorders, dysmorphic syndromes, inherited predisposition to kidney cancer and gene therapy for renal cancer. Specific chapters deal with individual renal tract disorders such as an extensive discussion of Alport's disease, cystic renal diseases, the Bardet-Biedl and Alstrom syndromes. Each section gives a brief description of the clinical and pathological features of a particular disorder, followed by a review of the genetics of the disorder including incidence, inheritance of familial occurrence, genetic linkage and gene assignment, and prenatal diagnosis and carrier detection. Original studies are extensively quoted and are referenced at the end of each section. There are a great many dysmorphic syndromes which involve the urinary tract. These are incorporated within the book. Aimed primarily at clinical and medical geneticists, this book will also appeal to researchers into genetic kidney disease and genetic counsellors as well as nephrologists with an interest in this area.

Clinical Paediatric Dietetics Book

Clinical Paediatric Dietetics

  • Author : Vanessa Shaw
  • Publisher : John Wiley & Sons
  • Release Date : 2008-04-15
  • Genre: Medical
  • Pages : 483
  • ISBN 10 : 9780470680100

Clinical Paediatric Dietetics Excerpt :

This standard work for practising dietitians and students has beenrevised to reflect the growing importance of nutritional support inmany paediatric conditions and the numerous advances which haveoccurred since the first edition was published in 1994. Fullycomprehensive and covering all disorders of the body systemsrelating to nutrition, it includes enteral and parenteral feeding,the nutrition and feeding of premature infants, diseases of organsystems, lipid disorders, nutrition for children with feedingdifficulties, burns, obesity and failure to thrive. The second edition has expanded the range of disorders andtreatments described, with additional information on nutritionalassessment, inborn errors of metabolism, food allergy andintolerance, immunodeficiency syndromes and gastroenterology.Arranged under headings of disorders of organ systems rather thantype of diet, and with much information presented in tabular form,the manual is easy to use. Dietary restrictions due either tocustoms, religious beliefs or environmental conditions which mayaffect the nutritional adequacy of the diet of the growing childare also discussed.

Diabetes and Kidney Disease Book

Diabetes and Kidney Disease

  • Author : Edgar V. Lerma
  • Publisher : Springer
  • Release Date : 2014-05-09
  • Genre: Medical
  • Pages : 256
  • ISBN 10 : 9781493907939

Diabetes and Kidney Disease Excerpt :

Diabetes and Kidney Disease reviews the most up-to-date research on diabetic nephropathy, the current understanding of its pathophysiology, renal structural alterations and clinical features and summarizes recent evidence-based clinical treatment modalities for the prevention and management of diabetic kidney disease. General clinical aspects are covered, as well as an overview to the novel approaches being designed by leading researchers in the field. A convenient compendium for physicians involved in the care of diabetic patients with varying degrees of kidney involvement, Diabetes and Kidney Disease is also a handy resource for medical residents and students interested in the current status and future approaches to reducing the burden of diabetes and diabetic kidney disease.

Thriving with Kidney Disease Book

Thriving with Kidney Disease

  • Author : Walter A. Hunt
  • Publisher : Johns Hopkins University Press
  • Release Date : 2022-02-22
  • Genre: Health & Fitness
  • Pages : 272
  • ISBN 10 : 1421442906

Thriving with Kidney Disease Excerpt :

In this latest edition, Hunt adds new sections on emerging subjects, including; coping skills for caregivers; kidney disease in children; environmental causes of chronic kidney failure; conservative care for those who wish to decline treatment; related conditions like gout, depression, and sleep disturbances; diet after transplantation; how best to work with your care team; insurance issues; potential new treatmentsA useful guide for the healthcare professionals who work with individuals with kidney problems.

Chronic Kidney Disease  Dialysis  and Transplantation E Book Book

Chronic Kidney Disease Dialysis and Transplantation E Book

  • Author : Jonathan Himmelfarb
  • Publisher : Elsevier Health Sciences
  • Release Date : 2018-11-06
  • Genre: Medical
  • Pages : 768
  • ISBN 10 : 9780323531726

Chronic Kidney Disease Dialysis and Transplantation E Book Excerpt :

Contains expanded content on economics and outcomes of treatment, as well as acute kidney injury. Covers hot topics such as the genetic causes of chronic kidney disease, ethical challenges and palliative care, and home hemodialysis. Discusses the latest advances in hypertensive kidney disease, vitamin D deficiency, diabetes management, transplantation, and more. Provides a clear visual understanding of complex information with high-quality line drawings, photographs, and diagnostic and treatment algorithms.

Renal Vascular Disease Book

Renal Vascular Disease

  • Author : Andrew C. Novick
  • Publisher : Harcourt College Pub
  • Release Date : 1996
  • Genre: Atherosclerosis
  • Pages : 539
  • ISBN 10 : UOM:39015037844605

Renal Vascular Disease Excerpt :

This is a reference text covering all aspects of renal disease, including: pathology, clinical features, imaging, hypertension, atherosclerotic disease, medical and surgical treatment.