Genome Stability Book

Genome Stability


  • Author : Igor Kovalchuk
  • Publisher : Academic Press
  • Release Date : 2021-07-17
  • Genre: Science
  • Pages : 760
  • ISBN 10 : 9780323856805

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Genome Stability Excerpt :

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Genome Stability Book

Genome Stability


  • Author : James Haber
  • Publisher : Garland Science
  • Release Date : 2013-12-16
  • Genre: Science
  • Pages : 416
  • ISBN 10 : 9781317682318

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Genome Stability Excerpt :

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An

Genome Stability and Human Diseases Book

Genome Stability and Human Diseases


  • Author : Heinz-Peter Nasheuer
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-12-11
  • Genre: Medical
  • Pages : 340
  • ISBN 10 : 9048134714

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Genome Stability and Human Diseases Excerpt :

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Mobile Genetic Elements in Cellular Differentiation  Genome Stability  and Cancer Book

Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer


  • Author : Tammy A. Morrish
  • Publisher : Frontiers Media SA
  • Release Date : 2018-01-16
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889453894

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Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer Excerpt :

The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS). To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.

Systems Biology of Cancer Book

Systems Biology of Cancer


  • Author : Sam Thiagalingam
  • Publisher : Cambridge University Press
  • Release Date : 2015-04-09
  • Genre: Mathematics
  • Pages : 548
  • ISBN 10 : 9780521493390

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Systems Biology of Cancer Excerpt :

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Genome Instability in Cancer Development Book

Genome Instability in Cancer Development


  • Author : Erich A. Nigg
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-01-14
  • Genre: Medical
  • Pages : 512
  • ISBN 10 : 9781402037641

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Genome Instability in Cancer Development Excerpt :

Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke intense debate.

Genome and Disease Book

Genome and Disease


  • Author : Jean-Nicolas Volff
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2006-01-01
  • Genre: Medical
  • Pages : 246
  • ISBN 10 : 9783805580298

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Genome and Disease Excerpt :

Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human disease. Emphasis is given to the different types of genomic sequences involved in disease-related genomic rearrangements as well as to the various exogenous factors increasing the frequency of mutations. Several chapters are dedicated to the dysfunction of important cellular mechanisms like DNA repair and chromosome segregation, which may cause genomic instability and result in tumorigenesis. Important 'caretaker' genes controlling the stability of our genome have been identified through their defect in genomic instability syndromes, which are also extensively reviewed in this volume. This book provides an important update not only for investigators in biology and medicine, but also for physicians and anyone interested in the molecular basis of human disease.

Roles for the Saccharomyces Cerevisiae MLH1 Mismatch Repair Gene in Genome Stability and Genetic Recombination Book

Roles for the Saccharomyces Cerevisiae MLH1 Mismatch Repair Gene in Genome Stability and Genetic Recombination


  • Author : Juan Argueso Almeida
  • Publisher : Unknown
  • Release Date : 2004
  • Genre: Uncategoriezed
  • Pages : 296
  • ISBN 10 : CORNELL:31924094621632

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Roles for the Saccharomyces Cerevisiae MLH1 Mismatch Repair Gene in Genome Stability and Genetic Recombination Excerpt :

Mismatch repair (MMR) systems correct mismatches formed during DNA replication and genetic recombination and as the result of DNA damage. MMR is initiated by a conserved family of MutS (MSH) and MutL (MLH) homolog proteins. MLH1 is unique among these proteins because it is also required for high levels of crossing over which are necessary for the proper disjunction of homologous chromosomes during the first meiotic division.

Genome Stability Book

Genome Stability


  • Author : James Haber
  • Publisher : Garland Pub
  • Release Date : 2014
  • Genre: Science
  • Pages : 399
  • ISBN 10 : 0815344856

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Genome Stability Excerpt :

"Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and graduate students with a molecular biology and genetics background, researchers and practitioners, especially in cancer biology, will also appreciate the book as a reference"--Provided by publisher.

Somatic Genome Variation Book

Somatic Genome Variation


  • Author : Xiu-Qing Li
  • Publisher : John Wiley & Sons
  • Release Date : 2017-06-26
  • Genre: Science
  • Pages : 448
  • ISBN 10 : 9781118647066

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Somatic Genome Variation Excerpt :

Written by an international team of experts, Somatic Genome Variation presents a timely summary of the latest understanding of somatic genome development and variation in plants, animals, and microorganisms. Wide-ranging in coverage, the authors provide an updated view of somatic genomes and genetic theories while also offering interpretations of somatic genome variation. The text provides geneticists, bioinformaticians, biologist, plant scientists, crop scientists, and microbiologists with a valuable overview of this fascinating field of research.

DNA Repair and Replication Book

DNA Repair and Replication


  • Author : Roger J. A. Grand
  • Publisher : Garland Science
  • Release Date : 2018-09-03
  • Genre: Science
  • Pages : 368
  • ISBN 10 : 9780429876547

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DNA Repair and Replication Excerpt :

DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes, causes of damage, and methods of repair

Molecular Biology of the Cell Book
Score: 4.5
From 5 Ratings

Molecular Biology of the Cell


  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 0815332181

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Molecular Biology of the Cell Excerpt :

DNA Methylation and Complex Human Disease Book

DNA Methylation and Complex Human Disease


  • Author : Michel Neidhart
  • Publisher : Academic Press
  • Release Date : 2015-08-11
  • Genre: Science
  • Pages : 552
  • ISBN 10 : 9780127999203

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DNA Methylation and Complex Human Disease Excerpt :

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases