Genomic Control Process Book

Genomic Control Process

  • Author : Isabelle Peter
  • Publisher : Academic Press
  • Release Date : 2015-01-21
  • Genre: Science
  • Pages : 460
  • ISBN 10 : 9780124047464

Genomic Control Process Excerpt :

Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type Demonstrates the causal power of system-level understanding of genomic control process Conceptually organizes a constellation of complex and diverse biological phenomena Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome

Decoding the Genomic Control of Immune Reactions Book

Decoding the Genomic Control of Immune Reactions

  • Author : Gregory R. Bock
  • Publisher : John Wiley & Sons
  • Release Date : 2007-04-04
  • Genre: Science
  • Pages : 232
  • ISBN 10 : 0470062118

Decoding the Genomic Control of Immune Reactions Excerpt :

This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend. Specific problems addressed include the following: What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance? Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues? Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses? Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.

Genomic Regulatory Systems Book

Genomic Regulatory Systems

  • Author : Eric H. Davidson
  • Publisher : Elsevier
  • Release Date : 2001-01-24
  • Genre: Science
  • Pages : 261
  • ISBN 10 : 0080525598

Genomic Regulatory Systems Excerpt :

The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest. The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist. * Contents Include * Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression * Regulation of Direct Cell-Type Specification in Early Development * The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts * Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans

Genomic Signal Processing and Statistics Book

Genomic Signal Processing and Statistics

  • Author : Edward R. Dougherty
  • Publisher : Hindawi Publishing Corporation
  • Release Date : 2005
  • Genre: Science
  • Pages : 456
  • ISBN 10 : 9789775945075

Genomic Signal Processing and Statistics Excerpt :

Recent advances in genomic studies have stimulated synergetic research and development in many cross-disciplinary areas. Processing the vast genomic data, especially the recent large-scale microarray gene expression data, to reveal the complex biological functionality, represents enormous challenges to signal processing and statistics. This perspective naturally leads to a new field, genomic signal processing (GSP), which studies the processing of genomic signals by integrating the theory of signal processing and statistics. Written by an international, interdisciplinary team of authors, this invaluable edited volume is accessible to students just entering this emergent field, and to researchers, both in academia and in industry, in the fields of molecular biology, engineering, statistics, and signal processing. The book provides tutorial-level overviews and addresses the specific needs of genomic signal processing students and researchers as a reference book. The book aims to address current genomic challenges by exploiting potential synergies between genomics, signal processing, and statistics, with special emphasis on signal processing and statistical tools for structural and functional understanding of genomic data. The first part of this book provides a brief history of genomic research and a background introduction from both biological and signal-processing/statistical perspectives, so that readers can easily follow the material presented in the rest of the book. In what follows, overviews of state-of-the-art techniques are provided. We start with a chapter on sequence analysis, and follow with chapters on feature selection, classification, and clustering of microarray data. We then discuss the modeling, analysis, and simulation of biological regulatory networks, especially gene regulatory networks based on Boolean and Bayesian approaches. Visualization and compression of gene data, and supercomputer implementation of genomic signal processing systems are also

Cardiovascular Genetics and Genomics Book

Cardiovascular Genetics and Genomics

  • Author : Dan M. Roden
  • Publisher : John Wiley & Sons
  • Release Date : 2009-04-01
  • Genre: Medical
  • Pages : 288
  • ISBN 10 : 1444311778

Cardiovascular Genetics and Genomics Excerpt :

This comprehensive and concise presentation of genetic factors in cardiovascular disease and their response to therapy consolidates knowledge of this high-interest and emerging topic. Covering broad areas of contemporary genomic medicine and specific cardiovascular diseases, this book is a must for anyone seeking to better understand this rapidly developing field.

Echinoderms Book


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-04-02
  • Genre: Science
  • Pages : 550
  • ISBN 10 : 9780128170731

Echinoderms Excerpt :

Echinoderms, Volume 151, the latest release in the Methods in Cell Biology series, highlights advances in the field, with this update presenting chapters on Echinoderm Genome Databases, analysis of gene regulatory networks, using ATAC-seq and RNA-seq to increase resolution in GRN connectivity, multiplex cis-regulatory analysis, experimental approaches GRN/signal pathways, BACs, analysis of chromatin accessibility using ATAC-seq, analysis of sea urchin proteins /Click IT, CRISPR/Cas9-mediated genome editing in sea urchins, super-resolution and in toto imaging of echinoderm embryos, and methods for analysis of intracellular ion signals in sperm, eggs and embryos. Presents clear, concise protocols provided by experts who have established the echinoderms as a model systems Highlights new advances in the field, with this update presenting interesting chapters on echinoderms

Genomic Approaches for Cross Species Extrapolation in Toxicology Book

Genomic Approaches for Cross Species Extrapolation in Toxicology

  • Author : William H. Benson
  • Publisher : CRC Press
  • Release Date : 2006-12-13
  • Genre: Mathematics
  • Pages : 216
  • ISBN 10 : 9781420043648

Genomic Approaches for Cross Species Extrapolation in Toxicology Excerpt :

The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from

Post Genomic Perspectives in Modeling and Control of Breathing Book

Post Genomic Perspectives in Modeling and Control of Breathing

  • Author : Jean Champagnat
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-06-28
  • Genre: Medical
  • Pages : 342
  • ISBN 10 : 9780387270234

Post Genomic Perspectives in Modeling and Control of Breathing Excerpt :

Post Genomic Perspectives in Modeling and Control of Breathing is comprised of the proceedings of the IXth Oxford Conference on Modeling and Control of Breathing, held September 13-16, 2003 in Paris, France. This publication is placed within the general framework of post-genomic neurobiology, pathology, and the precise example of the rhythmic respiratory neural assembly being used to understand how genetic networks have been selected and conserved in the vertebrate brain. Specific topics include: ion channels and synapses responsible for respiratory rhythmogenesis and plasticity; pre- and post-natal development of the respiratory rhythm; chemosensory transduction and chemo-afferent signalling. These valuable insights open new avenues as to why the genetic codes underlying a vital function such as breathing have been selected, conserved, or optimized during evolution – a major issue of post-genomic biology. This critical issue will be considered from both top-down and bottom-up integrative modeling standpoints, with a view to elucidating the functional genomics linking discrete molecules to the integrated system that regulates breathing.

Phenotypic Switching Book

Phenotypic Switching

  • Author : Herbert Levine
  • Publisher : Academic Press
  • Release Date : 2020-06-10
  • Genre: Medical
  • Pages : 762
  • ISBN 10 : 9780128179970

Phenotypic Switching Excerpt :

Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies Features a diverse range of chapter contributions from international leaders in the field

Statistical Methods in Genetic Epidemiology Book

Statistical Methods in Genetic Epidemiology

  • Author : Duncan C. Thomas
  • Publisher : Oxford University Press
  • Release Date : 2004-01-29
  • Genre: Medical
  • Pages : 464
  • ISBN 10 : 0199748055

Statistical Methods in Genetic Epidemiology Excerpt :

This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.

Molecular Biology of the Cell Book
Score: 4.5
From 5 Ratings

Molecular Biology of the Cell

  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 0815332181

Molecular Biology of the Cell Excerpt :

The Encyclopaedia of Sports Medicine  Genetic and Molecular Aspects of Sports Performance Book

The Encyclopaedia of Sports Medicine Genetic and Molecular Aspects of Sports Performance

  • Author : Claude Bouchard
  • Publisher : John Wiley & Sons
  • Release Date : 2011-08-02
  • Genre: Medical
  • Pages : 424
  • ISBN 10 : 9781444348293

The Encyclopaedia of Sports Medicine Genetic and Molecular Aspects of Sports Performance Excerpt :

This is the latest volume in the IOC Encyclopaedia of Sports Medicine series, summarizing the evidence from all relevant sources on the genetic and molecular basis of sports and other human physical performance. The initial chapters address the basic science of genomics and genetics and the regulation of gene expression. Additional chapters provide authoritative information on the genetics of complex performance phenotypes, the contributions of small animal research, family and twin studies, and ethnic comparisons. A final section addresses the issue of the contribution of specific genes and molecular markers as related to endurance, strength and power, and responsiveness to specific conditioning programs. This latest volume in the Encyclopaedia of Sports Medicine Series from the Medical Commission of the International Olympic Committee is a must for sports and exercise scientists who require a thorough guide to the most cutting edge science in this expanding field.

The Theory of Evolution Book

The Theory of Evolution

  • Author : Samuel M. Scheiner
  • Publisher : University of Chicago Press
  • Release Date : 2020-04-03
  • Genre: Science
  • Pages : 464
  • ISBN 10 : 9780226671338

The Theory of Evolution Excerpt :

Darwin’s nineteenth-century writings laid the foundations for modern studies of evolution, and theoretical developments in the mid-twentieth century fostered the Modern Synthesis. Since that time, a great deal of new biological knowledge has been generated, including details of the genetic code, lateral gene transfer, and developmental constraints. Our improved understanding of these and many other phenomena have been working their way into evolutionary theory, changing it and improving its correspondence with evolution in nature. And while the study of evolution is thriving both as a basic science to understand the world and in its applications in agriculture, medicine, and public health, the broad scope of evolution—operating across genes, whole organisms, clades, and ecosystems—presents a significant challenge for researchers seeking to integrate abundant new data and content into a general theory of evolution. This book gives us that framework and synthesis for the twenty-first century. The Theory of Evolution presents a series of chapters by experts seeking this integration by addressing the current state of affairs across numerous fields within evolutionary biology, ranging from biogeography to multilevel selection, speciation, and macroevolutionary theory. By presenting current syntheses of evolution’s theoretical foundations and their growth in light of new datasets and analyses, this collection will enhance future research and understanding.

Essays on Developmental Biology Book

Essays on Developmental Biology

  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2016-03-09
  • Genre: Science
  • Pages : 770
  • ISBN 10 : 9780128029763

Essays on Developmental Biology Excerpt :

In 2016 Current Topics in Developmental Biology (CTDB) will celebrate its 50th or “golden anniversary. To commemorate the founding of CTDB by Aron Moscona (1921-2009) and Alberto Monroy (1913-1986) in 1966, a two-volume set of CTDB (volumes 116 and 117), entitled Essays on Development, will be published by Academic Press/Elsevier in early 2016. The volumes are edited by Paul M. Wassarman, series editor of CTDB, and include contributions from dozens of outstanding developmental biologists from around the world. Overall, the essays provide critical reviews and discussion of developmental processes for a variety of model organisms. Many essays relate the history of a particular area of research, others personal experiences in research, and some are quite philosophical. Essays on Development provides a window onto the rich landscape of contemporary research in developmental biology and should be useful to both students and investigators for years to come. Covers the area of developmental processes for a variety of model organisms International board of authors Part of two 50th Anniversary volumes proving a comprehensive set of reviews edited by Serial Editor Paul M. Wassarman

Creative Complex Systems Book

Creative Complex Systems

  • Author : Kazuo Nishimura
  • Publisher : Springer Nature
  • Release Date : 2021-10-26
  • Genre: Business & Economics
  • Pages : 425
  • ISBN 10 : 9789811644573

Creative Complex Systems Excerpt :

In recent years, problems such as environmental and economic crises and pandemics caused by new viruses have been occurring on a global scale. Globalization brings about benefits, but it can increase the potential risks of “systemic problems”, leading to system-wide disruptions. The coronavirus pandemic, declared on March 11, 2020, by the World Health Organization, has revealed social disparities in the form of a higher risk of death for people of low-socioeconomic status and has caused massive destruction of the economy and of globalization itself. Extensive efforts to cope with these challenges have often led to the emergence of additional problems due to the chain of hidden causation. What can be done to protect against such emerging challenges? Despite the resulting complexity, once these individual problems are considered as different aspects of a single whole, seemingly contradictory issues can become totally understandable, as they can be integrated into a single coherent framework. This is the integrationist approach in contrast to the reductionist approach. Situations of this kind are truly relevant to understanding the question, “What are creative complex systems?” This book features contributions by members and colleagues of the Kyoto University International Research Unit of Integrated Complex System Science. It broadens our outlook from the traditional view of stability, in which global situations are eventually stabilized after the impact of destruction, to “creative” complex systems.