Genomics  Circuits  and Pathways in Clinical Neuropsychiatry Book

Genomics Circuits and Pathways in Clinical Neuropsychiatry


  • Author : Thomas Lehner
  • Publisher : Academic Press
  • Release Date : 2016-06-07
  • Genre: Science
  • Pages : 796
  • ISBN 10 : 9780128005309

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Genomics Circuits and Pathways in Clinical Neuropsychiatry Excerpt :

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Cell Biology and Translational Medicine  Volume 9 Book

Cell Biology and Translational Medicine Volume 9


  • Author : Kursad Turksen
  • Publisher : Springer Nature
  • Release Date : 2020-08-27
  • Genre: Science
  • Pages : 163
  • ISBN 10 : 9783030549176

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Cell Biology and Translational Medicine Volume 9 Excerpt :

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the ninth volume of a continuing series.

Neurobiology of Bipolar Disorder Book

Neurobiology of Bipolar Disorder


  • Author : Joao Luciano de Quevedo
  • Publisher : Academic Press
  • Release Date : 2020-11-25
  • Genre: Medical
  • Pages : 470
  • ISBN 10 : 9780128191835

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Neurobiology of Bipolar Disorder Excerpt :

The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Umphred s Neurological Rehabilitation   E Book Book

Umphred s Neurological Rehabilitation E Book


  • Author : Rolando T. Lazaro
  • Publisher : Elsevier Health Sciences
  • Release Date : 2019-12-05
  • Genre: Medical
  • Pages : 1168
  • ISBN 10 : 9780323641944

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Umphred s Neurological Rehabilitation E Book Excerpt :

UPDATED! Color photos and line drawings clearly demonstrate important concepts and clinical conditions students will encounter in practice. NEW and EXPANDED! Additional case studies illustrate how concepts apply to practice. Updated chapters incorporate the latest advances and the newest information in neurological rehabilitation strategies. NEW and UNIQUE! New chapter on concussion has been added. Separate and expanded chapters on two important topics: Balance and Vestibular.

Stress and Mental Disorders Book

Stress and Mental Disorders


  • Author : Richard McCarty
  • Publisher : Oxford University Press
  • Release Date : 2020-04-01
  • Genre: Psychology
  • Pages : 384
  • ISBN 10 : 9780190697273

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Stress and Mental Disorders Excerpt :

Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.

Developing Therapeutics for Alzheimer s Disease Book

Developing Therapeutics for Alzheimer s Disease


  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release Date : 2016-05-27
  • Genre: Medical
  • Pages : 676
  • ISBN 10 : 9780128021644

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Developing Therapeutics for Alzheimer s Disease Excerpt :

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

Treatment of Stress Response Syndromes Book

Treatment of Stress Response Syndromes


  • Author : Mardi J. Horowitz
  • Publisher : American Psychiatric Pub
  • Release Date : 2020-09-06
  • Genre: Medical
  • Pages : 108
  • ISBN 10 : 9781615373673

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Treatment of Stress Response Syndromes Excerpt :

Stress is a universal condition. However, severe stress related to loss, trauma, and/or terror necessitates an integrated approach, one that was pioneered nearly 20 years ago with the publication of Treatment of Stress Response Syndromes. This classic text has been updated and revised for our times, reflecting changes in DSM-5, which introduced a new category of diagnoses called trauma- and stressor-related disorders. This new edition updates treatment recommendations for these disorders and emphasizes formulation for determining appropriate therapeutic strategies. The author's method is assessment-based and does not compartmentalize its recommendations into treatment modalities such as cognitive-behavioral therapy, prolonged exposure, or cognitive processing therapy. Instead, the book takes an integrative and transtheoretical approach that emphasizes repeated assessments, resulting in treatment plans that are individualized, flexible, and more responsive to patient changes. Clinicians plan interventions based on the current state of mind of patients as they progress through the processing of traumatic events. The new edition reflects evolution in the field, including the following: The cross-theoretical approach helps practitioners integrate previously acquired clinical concepts without limiting them to one treatment modality or school of thought, enhancing their ability to respond to patient needs. Assessment can be used throughout all phases of treatment, which leads to the possibility of enhancing emotional control, advancing attachment models, and consolidating identity. Because of the financial constraints of insurance coverage or military troop availability, many treatment guidelines for PTSD focus on brief therapy; however, this book stresses the need for therapies of the length required to provide full benefit to patients and to lead to personality growth. In addition, the inclusion of illustrative cases anchors techniques to pragmatic actions, engaging rea

Mental Health Informatics Book

Mental Health Informatics


  • Author : Jessica D. Tenenbaum
  • Publisher : Springer Nature
  • Release Date : 2021-11-18
  • Genre: Medical
  • Pages : 534
  • ISBN 10 : 9783030705589

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Mental Health Informatics Excerpt :

This textbook provides a detailed resource introducing the subdiscipline of mental health informatics. It systematically reviews the methods, paradigms, tools and knowledge base in both clinical and bioinformatics and across the spectrum from research to clinical care. Key foundational technologies, such as terminologies, ontologies and data exchange standards are presented and given context within the complex landscape of mental health conditions, research and care. The learning health system model is utilized to emphasize the bi-directional nature of the translational science associated with mental health processes. Descriptions of the data, technologies, paradigms and products that are generated by and used in each process and their limitations are discussed. Mental Health Informatics: Enabling a Learning Mental Healthcare System is a comprehensive introductory resource for students, educators and researchers in mental health informatics and related behavioral sciences. It is an ideal resource for use in a survey course for both pre- and post-doctoral training programs, as well as for healthcare administrators, funding entities, vendors and product developers working to make mental healthcare more evidence-based.

Animal Genetics and Diseases  Advances in Farming and Livestock Systems Book

Animal Genetics and Diseases Advances in Farming and Livestock Systems


  • Author : Mark S. Fife
  • Publisher : Frontiers Media SA
  • Release Date : 2020-02-14
  • Genre: Uncategoriezed
  • Pages : 192
  • ISBN 10 : 9782889635238

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Animal Genetics and Diseases Advances in Farming and Livestock Systems Excerpt :

The new Animal Genetics and Disease 2017 conference committee organized a Research Topic for the proceedings of this inaugural conference. The meeting brought together specialists working on the interface between genomics, genetic engineering, and infectious disease, with the aims of improving animal and human health and welfare. This conference was funded by Advanced Courses and Scientific Conference at the Wellcome Genome Campus, Hinxton, UK. The conference will highlight breakthroughs in genomic technologies that are rapidly increasing our understanding of the fundamental role that host and pathogen genetics play in infections and epidemics. This Research Topic focuses on how infections spread and how they further affect the productivity of livestock systems and food supply chains. Thanks to technological advances, we now have the tools for real-time surveillance of zoonoses affecting wildlife, farm animals and animal-to-human disease transmission.

Neurofeedback and Neuromodulation Techniques and Applications Book

Neurofeedback and Neuromodulation Techniques and Applications


  • Author : Robert Coben
  • Publisher : Academic Press
  • Release Date : 2010-11-25
  • Genre: Psychology
  • Pages : 450
  • ISBN 10 : 012382236X

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Neurofeedback and Neuromodulation Techniques and Applications Excerpt :

The study of neurofeedback and neuromodulation offer a window into brain physiology and function, suggesting innovative approaches to the improvement of attention, anxiety, pain, mood and behavior. Resources for understanding what neurofeedback and neuromodulation are, how they are used, and to what disorders and patients they can be applied are scarce, and this volume serves as an ideal tool for clinical researchers and practicing clinicians in both neuroscience and psychology to understand techniques, analysis, and their applications to specific patient populations and disorders. The top scholars in the field have been enlisted, and contributions offer both the breadth needed for an introductory scholar and the depth desired by a clinical professional. Includes the practical application of techniques to use with patients Includes integration of neurofeedback with neuromodulation techniques Discusses what the technique is, for which disorders it is effective, and the evidence basis behind its use Written at an appropriate level for clinicians and researchers

Bradley s Neurology in Clinical Practice E Book Book

Bradley s Neurology in Clinical Practice E Book


  • Author : Joseph Jankovic
  • Publisher : Elsevier Health Sciences
  • Release Date : 2021-03-23
  • Genre: Medical
  • Pages : 2400
  • ISBN 10 : 9780323642620

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Bradley s Neurology in Clinical Practice E Book Excerpt :

A practical, dynamic resource for practicing neurologists, clinicians and trainees, Bradley and Daroff's Neurology in Clinical Practice, Eighth Edition, offers a straightforward style, evidence-based information, and robust interactive content supplemented by treatment algorithms and images to keep you up to date with all that’s current in this fast-changing field. This two-volume set is ideal for daily reference, featuring a unique organization by presenting symptom/sign and by specific disease entities—allowing you to access content in ways that mirror how you practice. More than 150 expert contributors, led by Drs. Joseph Jankovic, John C. Mazziotta, Scott L. Pomeroy, and Nancy J. Newman, provide up-to-date guidance that equips you to effectively diagnose and manage the full range of neurological disorders. Covers all aspects of today’s neurology in an easy-to-read, clinically relevant manner. Allows for easy searches through an intuitive organization by both symptom and grouping of diseases. Features new and expanded content on movement disorders, genetic and immunologic disorders, tropical neurology, neuro-ophthalmology and neuro-otology, palliative care, pediatric neurology, and new and emerging therapies. Offers even more detailed videos that depict how neurological disorders manifest, including EEG and seizures, deep brain stimulation for PD and tremor, sleep disorders, movement disorders, ocular oscillations, EMG evaluation, cranial neuropathies, and disorders of upper and lower motor neurons, as well as other neurologic signs.

Textbook of Clinical Neuropsychology Book

Textbook of Clinical Neuropsychology


  • Author : Joel E. Morgan
  • Publisher : Taylor & Francis
  • Release Date : 2017-12-06
  • Genre: Psychology
  • Pages : 3689
  • ISBN 10 : 9781351985987

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Textbook of Clinical Neuropsychology Excerpt :

The first edition of the Textbook of Clinical Neuropsychology set a new standard in the field in its scope, breadth, and scholarship. The second edition comprises authoritative chapters that will both enlighten and challenge readers from across allied fields of neuroscience, whether novice, mid-level, or senior-level professionals. It will familiarize the young trainee through to the accomplished professional with fundamentals of the science of neuropsychology and its vast body of research, considering the field’s historical underpinnings, its evolving practice and research methods, the application of science to informed practice, and recent developments and relevant cutting edge work. Its precise commentary recognizes obstacles that remain in our clinical and research endeavors and emphasizes the prolific innovations in interventional techniques that serve the field’s ultimate aim: to better understand brain-behavior relationships and facilitate adaptive functional competence in patients. The second edition contains 50 new and completely revised chapters written by some of the profession's most recognized and prominent scholar-clinicians, broadening the scope of coverage of the ever expanding field of neuropsychology and its relationship to related neuroscience and psychological practice domains. It is a natural evolution of what has become a comprehensive reference textbook for neuropsychology practitioners.

Historical Roots of Psychopathology Book

Historical Roots of Psychopathology


  • Author : Diogo Telles Correia
  • Publisher : Frontiers Media SA
  • Release Date : 2016-08-12
  • Genre: Psychology
  • Pages : 62
  • ISBN 10 : 9782889199334

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Historical Roots of Psychopathology Excerpt :

New advances of the neuroscience supported by a refined, reliable and valid phenotyping (e.g., at the level of symptoms and not at the level of disorders), are bringing some promising results. The mapping of clinical phenomenology on specific brain dysfunction is now becoming plausible and the resulting functional psychopathology may in the future significantly replace the present nosology (Jablensky, 2010). Nevertheless, as Andreasen (2007) points out: “Applying technology without companionship of wise clinicians with specific expertise in psychopathology will be a lonely, sterile and perhaps fruitless enterprise.” Some of the chapters of this Ebook deal with aspects which are essential to the historical understanding of mental symptoms and disorders.

Mental and Behavioral Dysfunction in Movement Disorders Book

Mental and Behavioral Dysfunction in Movement Disorders


  • Author : Marc-André Bédard
  • Publisher : Springer Science & Business Media
  • Release Date : 2003-03-27
  • Genre: Medical
  • Pages : 561
  • ISBN 10 : 9781592593262

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Mental and Behavioral Dysfunction in Movement Disorders Excerpt :

A state-of-the-art review of the many cognitive, affective, and behavioral dysfunctions associated with movement disorders. These dysfunctions include depression, dementia, psychosis, sleep disorders arising from Parkinson's and Huntington's disease, Tourette's syndrome, as well as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and many other related disorders. The authors describe these behavioral syndromes and their neurophysiological and neuropathological substratum, as well as their diagnostic criteria and therapeutic guidelines. The cognitive and affective dysfunctions are spelled out in detail.

Psychiatric Genetics Book

Psychiatric Genetics


  • Author : Thomas Schulze
  • Publisher : Oxford University Press
  • Release Date : 2018-04-06
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9780190222000

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Psychiatric Genetics Excerpt :

Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of "take home" points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.