Glioblastoma Resistance to Chemotherapy  Molecular Mechanisms and Innovative Reversal Strategies Book

Glioblastoma Resistance to Chemotherapy Molecular Mechanisms and Innovative Reversal Strategies


  • Author : Ramasamy Paulmurugan
  • Publisher : Academic Press
  • Release Date : 2021-06-25
  • Genre: Science
  • Pages : 828
  • ISBN 10 : 9780128215685

GET BOOK
Glioblastoma Resistance to Chemotherapy Molecular Mechanisms and Innovative Reversal Strategies Excerpt :

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood. Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance

Resistance to Targeted Therapies Against Adult Brain Cancers Book

Resistance to Targeted Therapies Against Adult Brain Cancers


  • Author : Amanda Tivnan
  • Publisher : Springer
  • Release Date : 2018-07-04
  • Genre: Medical
  • Pages : 260
  • ISBN 10 : 3319835319

GET BOOK
Resistance to Targeted Therapies Against Adult Brain Cancers Excerpt :

This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance Book

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance


  • Author : Andrew Freywald
  • Publisher : Academic Press
  • Release Date : 2020-12-04
  • Genre: Science
  • Pages : 308
  • ISBN 10 : 9780128213117

GET BOOK
Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance Excerpt :

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

Inflammation and Cancer Book

Inflammation and Cancer


  • Author : Bharat B. Aggarwal
  • Publisher : Springer
  • Release Date : 2014-05-12
  • Genre: Medical
  • Pages : 490
  • ISBN 10 : 9783034808378

GET BOOK
Inflammation and Cancer Excerpt :

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Re Irradiation  New Frontiers Book

Re Irradiation New Frontiers


  • Author : Carsten Nieder
  • Publisher : Springer
  • Release Date : 2016-10-25
  • Genre: Medical
  • Pages : 364
  • ISBN 10 : 9783319418254

GET BOOK
Re Irradiation New Frontiers Excerpt :

This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.

Resistance to Targeted Therapies Against Adult Brain Cancers Book

Resistance to Targeted Therapies Against Adult Brain Cancers


  • Author : Amanda Tivnan
  • Publisher : Springer
  • Release Date : 2016-11-26
  • Genre: Medical
  • Pages : 260
  • ISBN 10 : 9783319465050

GET BOOK
Resistance to Targeted Therapies Against Adult Brain Cancers Excerpt :

This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

Keto for Cancer Book

Keto for Cancer


  • Author : Miriam Kalamian
  • Publisher : Chelsea Green Publishing
  • Release Date : 2017
  • Genre: COOKING
  • Pages : 400
  • ISBN 10 : 9781603587013

GET BOOK
Keto for Cancer Excerpt :

A Comprehensive Guide for Patients and Practitioners Although evidence supporting the benefits of ketogenic diet therapies continues to mount, there is little to guide those who wish to adopt this diet as a metabolic therapy for cancer. Keto for Cancer fills this need. Inspired by the work of Dr. Thomas N. Seyfried, PhD, nutritionist Miriam Kalamian has written the first book to lay out comprehensive guidelines that specifically address the many challenges associated with cancer, and particularly the deep nutritional overhaul involved with the ketogenic diet. Kalamian, a leading voice in the keto movement, is driven by passion from her own experience in using the ketogenic diet for her young son. Her book addresses the nuts and bolts of adopting the diet, from deciding whether keto is the right choice to developing a personal plan for smoothly navigating the keto lifestyle. It is invaluable for both beginners and seasoned users of the ketogenic diet, as well as for health-care professionals who need a toolkit to implement this targeted metabolic therapy. The book guides readers to a deeper understanding of the therapeutic potential of the ketogenic diet--which extends well beyond simply starving cancer--emphasizing the powerful impact the diet has on the metabolism of cancer cells. Nutritional nuances are explored in sections such as "Fasting Protocols" and "Know What's in the Foods You Eat" while meal templates and tracking tools are provided in "Preparing Keto Meals." Kalamian also discusses important issues such as self-advocacy. Readers of Keto for Cancer are empowered to "get off the bench and get in the game." To that end, Kalamian offers tips on how to critically examine cancer-care options then incorporate what resonates into a truly personalized treatment plan.

Brain Mimetic Hydrogel Platform for Investigation of Glioblastoma Drug Resistance Book

Brain Mimetic Hydrogel Platform for Investigation of Glioblastoma Drug Resistance


  • Author : Weikun Xiao
  • Publisher : Unknown
  • Release Date : 2019
  • Genre: Uncategoriezed
  • Pages : 213
  • ISBN 10 : OCLC:1102367198

GET BOOK
Brain Mimetic Hydrogel Platform for Investigation of Glioblastoma Drug Resistance Excerpt :

Glioblastoma (GBM) is the most lethal and malignant cancer originating from the central nervous system. Even with intense treatment involving surgery and radio-chemotherapy, median survival after prognosis remains within 12 months, as GBM constantly develops resistance to common therapies. Many novel therapies developed for GBM have shown promising results in in-vitro studies, but unfortunately failed in actual clinical practices, partially because traditional model systems failed to recapitulate the microenvironment surrounding GBM tumors. Therefore, we posit that unique brain extracellular matrix (ECM) facilitates therapeutic resistance in GBM. To study this problem, we investigated ECM deposition in GBM patient samples and fabricated brain-mimetic, orthogonally tunable hydrogel system in which to culture patient-derived GBM cells in 3-dimensional manner. To validate our novel ex-vivo culture system, genomic sequencing and gene expression profiling were performed for comparison with traditional in-vitro culture and animal xenograft models. At the same time, cell viability, proliferation and markers for cancer stem cell were assessed. Our model system was used to study the therapeutic response of GBM cells to commonly used therapeutics and to investigate resistance mechanisms. We found GBM cells displayed drug response kinetics comparable to in-vivo xenograft models. We also found novel molecular mechanisms describing how unique brain matrix facilitates therapeutic resistance through corresponding receptors in our 3D culture models. By utilizing novel engineered platforms to study drug resistance, we are able to uncover mechanisms that could not be observed through traditional methods.

The Heterogeneity of Cancer Metabolism Book

The Heterogeneity of Cancer Metabolism


  • Author : Anne Le
  • Publisher : Springer
  • Release Date : 2018-06-26
  • Genre: Medical
  • Pages : 183
  • ISBN 10 : 9783319777368

GET BOOK
The Heterogeneity of Cancer Metabolism Excerpt :

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Handbook of Brain Tumor Chemotherapy  Molecular Therapeutics  and Immunotherapy Book

Handbook of Brain Tumor Chemotherapy Molecular Therapeutics and Immunotherapy


  • Author : Herbert B. Newton
  • Publisher : Academic Press
  • Release Date : 2018-03-28
  • Genre: Medical
  • Pages : 848
  • ISBN 10 : 9780128121016

GET BOOK
Handbook of Brain Tumor Chemotherapy Molecular Therapeutics and Immunotherapy Excerpt :

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Tumor Microenvironment and Cellular Stress Book

Tumor Microenvironment and Cellular Stress


  • Author : Constantinos Koumenis
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-23
  • Genre: Medical
  • Pages : 290
  • ISBN 10 : 9781461459156

GET BOOK
Tumor Microenvironment and Cellular Stress Excerpt :

The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

Glioma Book

Glioma


  • Author : Ibrahim Omerhodzic
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-01-16
  • Genre: Medical
  • Pages : 258
  • ISBN 10 : 9781789849530

GET BOOK
Glioma Excerpt :

The past three decades have been marked with huge enthusiasm from scientists and professionals in an effort to find a cure for glioma disease. Methods to confirm the kinds and grades of glioma have taken a path from classical macro- to microscopic pathohystological confirmation of tumors, through morphological-histological, molecular, and genetic diagnosis. Surgically, progress was made possible with the development and use of technological aids, for example neuronavigation, cortical mapping, electrocorticography, neuromonitoring, functional and intraoperative MRI, magnetoencephalography, etc. Great hope was placed on the extension of tumor resection and popular supratotal resection. Significant progress has been made generally in glioma treatment with the use of modern radiotherapy and new chemotherapeutics. What do we want to see for the future? By way of stem cells, a specific medicine will be produced, individualized for the particular patient, and by using a microcapsule it will be implanted into the brain zone affected by the tumor by way of robot surgery and injection needle. This is not at all an unrealistic expectation in the next decade or two.

Radiobiology of Glioblastoma Book

Radiobiology of Glioblastoma


  • Author : Luigi Pirtoli
  • Publisher : Springer
  • Release Date : 2016-06-06
  • Genre: Medical
  • Pages : 305
  • ISBN 10 : 9783319283050

GET BOOK
Radiobiology of Glioblastoma Excerpt :

This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators.

Methods to Increase Temozolomide Sensitivity in Glioblastoma Multiforme Book

Methods to Increase Temozolomide Sensitivity in Glioblastoma Multiforme


  • Author : Vanessa Loraine Thibado
  • Publisher : Unknown
  • Release Date : 2011
  • Genre: Brain
  • Pages : 137
  • ISBN 10 : OCLC:768243799

GET BOOK
Methods to Increase Temozolomide Sensitivity in Glioblastoma Multiforme Excerpt :

Glioblastoma multiforme (GBM) is the most malignant and frequent primary brain tumor in adults. These tumors expand quickly and tend to recur despite surgery, radiation, and chemotherapy treatments. Alkylating agents, such as Temozolomide (TMZ), are currently the chemotherapy drugs of choice. Resistance to alkylating agents via direct DNA repair by O6-methylguanine methyltransferase (MGMT) has arisen as a significant barrier to effective treatment. Poly(ADP-ribose) polymerase-1 (PARP-1) is activated by binding to DNA breaks, and has functions related to the DNA repair done by MGMT. Therefore, inhibition of PARP-1 has been associated with increased sensitivity to DNA-alkylating agents. The goal of this research was to characterize several PARP and MGMT manipulating treatments in four glioblastoma cell lines. Clinically relevant silencing methods were investigated and dose response assays were used for determining the efficacy of treatments. Research studies such as this are important in the identification of therapies that can overcome drug resistance, lessen cytotoxic side effects, and ultimately improve the prognosis of glioblastoma patients.