Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book

Green Approaches in Medicinal Chemistry for Sustainable Drug Design


  • Author : Bimal K. Banik
  • Publisher : Elsevier
  • Release Date : 2020-04-09
  • Genre: Medical
  • Pages : 1044
  • ISBN 10 : 9780128175927

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design Excerpt :

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis

Contemporary Chemical Approaches for Green and Sustainable Drugs Book

Contemporary Chemical Approaches for Green and Sustainable Drugs


  • Author : Marianna Torok
  • Publisher : Elsevier
  • Release Date : 2022-08-26
  • Genre: Medical
  • Pages : 568
  • ISBN 10 : 9780128232712

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Contemporary Chemical Approaches for Green and Sustainable Drugs Excerpt :

Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate sustainable approaches into their work. Sections cover different aspects of green and sustainable drug development from design to disposal, including computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, this book provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs. This will be a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science. Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs Presents individual chapters written by renowned experts with diverse backgrounds Reflects research in practice through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project

Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book

Green Approaches in Medicinal Chemistry for Sustainable Drug Design


  • Author : Bimal K. Banik
  • Publisher : Elsevier
  • Release Date : 2020-03-27
  • Genre: Medical
  • Pages : 1044
  • ISBN 10 : 9780128175934

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design Excerpt :

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis

Green Toxicology Book

Green Toxicology


  • Author : Alexandra Maertens
  • Publisher : Royal Society of Chemistry
  • Release Date : 2022-02-16
  • Genre: Science
  • Pages : 292
  • ISBN 10 : 9781839164408

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Green Toxicology Excerpt :

Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Green Techniques for Organic Synthesis and Medicinal Chemistry Book

Green Techniques for Organic Synthesis and Medicinal Chemistry


  • Author : Wei Zhang
  • Publisher : John Wiley & Sons
  • Release Date : 2012-05-10
  • Genre: Science
  • Pages : 769
  • ISBN 10 : 9781118308653

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Green Techniques for Organic Synthesis and Medicinal Chemistry Excerpt :

An updated overview of the rapidly developing field of green engineering techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.

Green Sustainable Process for Chemical and Environmental Engineering and Science Book

Green Sustainable Process for Chemical and Environmental Engineering and Science


  • Author : Dr Inamuddin
  • Publisher : Elsevier
  • Release Date : 2020-11-18
  • Genre: Technology & Engineering
  • Pages : 312
  • ISBN 10 : 9780128218983

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Green Sustainable Process for Chemical and Environmental Engineering and Science Excerpt :

Green Solvents for Environmental Remediation provides an in-depth overview of environmental remediation by using eutectic solvents, ionic liquids, biosolvents, and switchable solvents, of ionic-liquids, biosolvents, Gas-expanded solvents Liquid polymers, supercritical fluids, Polymer-based green solvents, Switchable solvents, etc. This book offers all-types of green solvents for the removal of contaminations from the soil, air, and water. It summarizes in-depth literature on the application of various green solvents in the areas such as municipal water, extraction, bioremediation, phytoremediation, soil and sediment remediation, toxic gases removal, and various industrial effluents. A brief introduction, limitations, and advantages to the practical use of green solvents are also discussed. This book is authored by experts in a broad range of fields. It is an invaluable reference guide for the sustainable and environmentally friendly development of synthetic methodologies for environmental, analytical, engineering, and industrial technology. Provides an up-to-date research record on green solvents for environmental protection Includes latest advances in environmental remediation Outlines eco-friendly green solvents for toxic contaminants degradation and purification Covers all-types of green solvent-driven environmental remediation technologies Key references to obtain great results in environmental remediation using green solvents

Green Synthetic Approaches for Biologically Relevant Heterocycles Book

Green Synthetic Approaches for Biologically Relevant Heterocycles


  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release Date : 2021-03-20
  • Genre: Science
  • Pages : 646
  • ISBN 10 : 9780323851305

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Green Synthetic Approaches for Biologically Relevant Heterocycles Excerpt :

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability

Green Chemistry in the Pharmaceutical Industry Book

Green Chemistry in the Pharmaceutical Industry


  • Author : Peter J. Dunn
  • Publisher : John Wiley & Sons
  • Release Date : 2010-02-02
  • Genre: Science
  • Pages : 388
  • ISBN 10 : 3527629696

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Green Chemistry in the Pharmaceutical Industry Excerpt :

Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

Green and Sustainable Pharmacy Book

Green and Sustainable Pharmacy


  • Author : Klaus Kümmerer
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-06-16
  • Genre: Technology & Engineering
  • Pages : 313
  • ISBN 10 : 9783642051999

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Green and Sustainable Pharmacy Excerpt :

Within recent years pharmaceuticals have come into focus as contaminants of the environment (see for example Kümmerer, K. editor: Pharmaceuticals in the Environment). At the same time the issue of sustainable chemistry gained momentum. Bringing both together would result in sustainable pharmacy. Sustainable pharmacy is a totally new issue and approach. It addresses environmental, economical and social aspects of pharmacy. In the present stage the focus will be on environmental issues along the whole lifecycle of a pharmaceutical entity. That is dealing with resources and energy input but also with waste issues for example during the synthesis and production of an active pharmaceutical ingredient. Furthermore, it would also look on the compounds themselves and will aim to improve the degradability of the compounds after their use in the environment to reduce the environmental risk caused by pharmaceuticals in the environment. Another issue is the people using pharmaceuticals such as pharmacists, medical doctors and patients. How can they contribute to more efficient use of pharmaceuticals with less environmental burden and less risk for drinking water. The book "Sustainable Pharmacy" will address all these issues and will be the first one dealing with this important topic.

Green Chemistry Strategies for Drug Discovery Book

Green Chemistry Strategies for Drug Discovery


  • Author : Emily A. Peterson
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-06-11
  • Genre: Medical
  • Pages : 322
  • ISBN 10 : 9781782622659

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Green Chemistry Strategies for Drug Discovery Excerpt :

The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate. Written by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment. The Editors have taken a comprehensive approach to the topic, covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery and continuous processing. Moreover, important surrounding issues such as intellectual property are included. This book serves as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.

Sustainable Synthesis of Pharmaceuticals Book
Score: 5
From 1 Ratings

Sustainable Synthesis of Pharmaceuticals


  • Author : Mariette M. Pereira
  • Publisher : Royal Society of Chemistry
  • Release Date : 2018-03-26
  • Genre: Business & Economics
  • Pages : 286
  • ISBN 10 : 9781788010658

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Sustainable Synthesis of Pharmaceuticals Excerpt :

There is a growing interest in the development of sustainable processes for the synthesis of pharmaceuticals and this book bridges the divide between industrial examples and the fundamental chemistry. It explains the basic principles of using transition metal catalysis with several green approaches for the synthesis of pharmaceuticals. The topic is an important one for green chemistry and the chapters in this book on hydroformylation, green oxidation and olefin metathesis will also be of interest to both medicinal and organic chemists. Written by leading experts in the field, it provides a valuable and easy tool for scientists and industrialists who require information regarding this topic.

Sustainable Flow Chemistry Book

Sustainable Flow Chemistry


  • Author : Luigi Vaccaro
  • Publisher : John Wiley & Sons
  • Release Date : 2016-12-12
  • Genre: Science
  • Pages : 336
  • ISBN 10 : 9783527689101

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Sustainable Flow Chemistry Excerpt :

This ready reference not only presents the hot and emerging topic of modern flow chemistry, it is also unique in illustrating the important connection to sustainable chemistry. Focusing on more sustainable methods and applications, the text extensively covers every important field from reaction time optimization to waste minimization, and from safety improvements to microwave applications. In addition, green metrics are presented as a key aspect of the book, helping readers to evaluate the efficiency of flow technologies and their impact on the overall efficiency of a chemical process. An invaluable handbook for every chemist working in the laboratory, whether in academia or industry.

In Silico Methods for Drug Design and Discovery Book

In Silico Methods for Drug Design and Discovery


  • Author : Simone Brogi
  • Publisher : Frontiers Media SA
  • Release Date : 2020-10-09
  • Genre: Science
  • Pages : 504
  • ISBN 10 : 9782889660575

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In Silico Methods for Drug Design and Discovery Excerpt :

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Artificial Intelligence in Drug Design Book

Artificial Intelligence in Drug Design


  • Author : Alexander Heifetz
  • Publisher : Humana
  • Release Date : 2021-11-04
  • Genre: Medical
  • Pages : 529
  • ISBN 10 : 1071617869

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Artificial Intelligence in Drug Design Excerpt :

This volume looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique, Artificial Intelligence in Drug Design is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists and drug designers.