Growth Factors and Their Receptors in Cell Differentiation  Cancer and Cancer Therapy Book

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy


  • Author : Gajanan V Sherbet
  • Publisher : Elsevier
  • Release Date : 2011-07-14
  • Genre: Science
  • Pages : 368
  • ISBN 10 : 9780123878199

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Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy Excerpt :

Annotation G.V. Sherbet provides insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. The book focuses on the relationships and convergence of growth factors and their receptors in development and pathogenesis.

Holland Frei Cancer Medicine Book

Holland Frei Cancer Medicine


  • Author : Robert C. Bast, Jr.
  • Publisher : John Wiley & Sons
  • Release Date : 2017-03-10
  • Genre: Medical
  • Pages : 2008
  • ISBN 10 : 9781119000846

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Holland Frei Cancer Medicine Excerpt :

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Growth Factors and their Receptors in Cancer Metastasis Book

Growth Factors and their Receptors in Cancer Metastasis


  • Author : Wen G. Jiang
  • Publisher : Springer
  • Release Date : 2010-12-05
  • Genre: Medical
  • Pages : 303
  • ISBN 10 : 9048157579

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Growth Factors and their Receptors in Cancer Metastasis Excerpt :

about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).

Oxford Textbook of Oncology Book

Oxford Textbook of Oncology


  • Author : David J. Kerr
  • Publisher : Oxford University Press
  • Release Date : 2016-01-28
  • Genre: Medical
  • Pages : 832
  • ISBN 10 : 9780191065118

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Oxford Textbook of Oncology Excerpt :

Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Therapeutic Strategies in Cancer Biology and Pathology Book

Therapeutic Strategies in Cancer Biology and Pathology


  • Author : Gajanan V. Sherbet
  • Publisher : Elsevier
  • Release Date : 2013
  • Genre: Medical
  • Pages : 288
  • ISBN 10 : 0124165702

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Therapeutic Strategies in Cancer Biology and Pathology Excerpt :

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies. Identifies molecular targets and their accessibility for therapeutic intervention Provides information on biological features of tumor development and dissemination Background information provided for each topic

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis Book

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis


  • Author : Padma V. Devarajan
  • Publisher : Springer Nature
  • Release Date : 2019-11-09
  • Genre: Medical
  • Pages : 560
  • ISBN 10 : 9783030291686

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Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis Excerpt :

This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular tar

Blood Cell Biochemistry Book

Blood Cell Biochemistry


  • Author : Anthony D. Whetton
  • Publisher : Springer Science & Business Media
  • Release Date : 1996-08-31
  • Genre: Medical
  • Pages : 419
  • ISBN 10 : UOM:39015041066294

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Blood Cell Biochemistry Excerpt :

Volume 7 explores the role of receptors and growth factors in the control of hematopoiesis and the immune system. This work features color plates and numerous illustrations.

Genetic Recombination in Cancer Book

Genetic Recombination in Cancer


  • Author : Gajanan V. Sherbet
  • Publisher : Academic Press
  • Release Date : 2003
  • Genre: Medical
  • Pages : 245
  • ISBN 10 : 012639881X

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Genetic Recombination in Cancer Excerpt :

Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells * Examines the role of genetic recombination in cancer including cancer invasion and metastasis * Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers

The Genetics of Cancer Book

The Genetics of Cancer


  • Author : Gajanan V. Sherbet
  • Publisher : Unknown
  • Release Date : 1997
  • Genre: Medical
  • Pages : 338
  • ISBN 10 : 0126398755

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The Genetics of Cancer Excerpt :

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Key Features The contents include: * Clonal evolution of the metastasis phenotype * Cell Cycle regulation * Apoptosis in tumour growth and metastasis * Angiogenesis in cancer * Cell surface glycoproteins and their receptors * Proteinases and their inhibitors in cancer invasion * Oncogenes and cancer metastasis * Developmental genes * Tumour suppressor genes * Metastasis suppressor genes * Dominant metastasis-associated genes

Molecular Approach to Cancer Management Book

Molecular Approach to Cancer Management


  • Author : Gajanan V. Sherbet
  • Publisher : Academic Press
  • Release Date : 2017
  • Genre: Cancer
  • Pages : 352
  • ISBN 10 : 0128128968

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Molecular Approach to Cancer Management Excerpt :

Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy. Covers all relevant topics with a defined aim of targeted therapy Encompasses the basic aspects of cancer invasion and metastasis Discusses signaling systems operating in normal cells and their deregulation in cancer cells Directs attention to the foci in signaling systems that can be targeted with a new and conventional drug-based approach

Engineering Strategies for Regenerative Medicine Book

Engineering Strategies for Regenerative Medicine


  • Author : Tiago G. Fernandes
  • Publisher : Academic Press
  • Release Date : 2019-11-14
  • Genre: Science
  • Pages : 284
  • ISBN 10 : 9780128166703

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Engineering Strategies for Regenerative Medicine Excerpt :

Engineering Strategies for Regenerative Medicine considers how engineering strategies can be applied to accelerate advances in regenerative medicine. The book provides relevant and up-to-date content on key topics, including the interdisciplinary integration of different aspects of stem cell biology and technology, diverse technologies, and their applications. By providing massive amounts of data on each individual, recent scientific advances are rapidly accelerating medicine. Cellular, molecular and genetic parameters from biological samples combined with clinical information can now provide valuable data to scientists, clinicians and ultimately patients, leading to the development of precision medicine. Equally noteworthy are the contributions of stem cell biology, bioengineering and tissue engineering that unravel the mechanisms of disease, regeneration and development. Considers how engineering strategies can accelerate novel advances in regenerative medicine Takes an interdisciplinary approach, integrating different aspects of research, technology and application Provides up-to-date coverage on this rapidly developing area of medicine Presents insights from an experienced and cross-disciplinary group of researchers and practitioners with close links to industry

The Cytokine Handbook Book

The Cytokine Handbook


  • Author : Angus W. Thomson
  • Publisher : Gulf Professional Publishing
  • Release Date : 2003
  • Genre: Medical
  • Pages : 878
  • ISBN 10 : 0126896631

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The Cytokine Handbook Excerpt :

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics. Key Features * Covers all main cytokines and chemokines * Written by experts * Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome * The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters * Includes major emphasis on clinical applications * Extensively illustrated with tables and figures

Insulin and IGFs Book
Score: 3
From 1 Ratings

Insulin and IGFs


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2009-03-10
  • Genre: Science
  • Pages : 760
  • ISBN 10 : 0080922155

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Insulin and IGFs Excerpt :

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on insulin and IGFs. *Longest running series published by Academic Press *Contributions by leading international authorities

Tumour Angiogenesis Book

Tumour Angiogenesis


  • Author : R. John Bicknell
  • Publisher : Oxford University Press, USA
  • Release Date : 1997
  • Genre: Medical
  • Pages : 416
  • ISBN 10 : UOM:39015041324271

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Tumour Angiogenesis Excerpt :

It is now widely recognised that the growth of solid tumours is angiogenesis dependent. The inhibition of tumour angiogenesis offers a novel anti-cancer therapeutic strategy. In this first book to be devoted solely to tumour angiogenesis each chapter is written by leading world experts and the twenty seven chapters taken together cover all aspects of the field.

Molecular Mechanisms In Cellular Growth and Differentiation Book

Molecular Mechanisms In Cellular Growth and Differentiation


  • Author : A.R. Bellve
  • Publisher : Academic Press
  • Release Date : 2012-12-02
  • Genre: Science
  • Pages : 388
  • ISBN 10 : 9780323152730

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Molecular Mechanisms In Cellular Growth and Differentiation Excerpt :

Molecular Mechanisms in Cellular Growth and Differentiation describes the cellular differentiation and development. It emphasizes the pattern formation, specifically the genesis of spatial relationships, among the parts of a vertebrate or invertebrate organism, embryonic or adult. Organized into five parts, this book deals with the major steps leading from growth factor-receptor interactions, through transduction and modulation mechanisms, to proliferative response. It also discusses the relation of growth factors and their receptors to oncogenes and to protooncogenes. It also elucidates the roles of growth factors and receptors in cell differentiation and development, particularly, in pattern formation. The homeotic systems regulated intracellularly and the two differentiation systems thought to involve sequence-specific DNA-binding proteins in conjunction with small molecules are also explored.