Guidebook to Protein Toxins and Their Use in Cell Biology Book
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Guidebook to Protein Toxins and Their Use in Cell Biology


  • Author : Rino Rappuoli
  • Publisher : OUP Oxford
  • Release Date : 1997-05-29
  • Genre: Medical
  • Pages : 274
  • ISBN 10 : 9780191547287

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Guidebook to Protein Toxins and Their Use in Cell Biology Excerpt :

Many bacteria, animals, and plants produce toxins that can prove lethal to other organisms. Toxins are a form of "biological warfare" that helps their producer to survive and so confer an evolutionary advantage. They display an extraordinary range of complexity, from the formic acid provided by ants to bacterial proteins composed of thousands of amino acids. This Guidebook considers the more complex protein and peptide toxins and groups them according to their mode of action. Topics covered include: membrane-permeabilizing toxins; toxins affecting signal transduction and protein synthesis; cytoskeleton-affecting toxins; toxins affecting the immune and inflammatory response. This class of biomolecules will be of interest to a wide range of researchers in cell biology, neuroscience, and toxicology.

The Comprehensive Sourcebook of Bacterial Protein Toxins Book

The Comprehensive Sourcebook of Bacterial Protein Toxins


  • Author : Joseph E. Alouf
  • Publisher : Elsevier
  • Release Date : 2005-12-20
  • Genre: Science
  • Pages : 1072
  • ISBN 10 : 9780080456980

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The Comprehensive Sourcebook of Bacterial Protein Toxins Excerpt :

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology Includes the major toxins of both basic and clinical interest are described in depth Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology Evolutionary and functional aspects of bacterial toxins evaluated and summarized Toxin applications in cell biology presented Therapy (cancer therapy, dystonias) discussed Vaccines (native and genetically engineered vaccines) featured Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

Bacterial Protein Toxins Book

Bacterial Protein Toxins


  • Author : K. Aktories
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-14
  • Genre: Medical
  • Pages : 700
  • ISBN 10 : 9783662059715

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Bacterial Protein Toxins Excerpt :

In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

Guidebook to Molecular Chaperones and Protein Folding Catalysts Book

Guidebook to Molecular Chaperones and Protein Folding Catalysts


  • Author : Mary-Jane Gething
  • Publisher : OUP Oxford
  • Release Date : 1997-11-27
  • Genre: Medical
  • Pages : 580
  • ISBN 10 : 9780191547270

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Guidebook to Molecular Chaperones and Protein Folding Catalysts Excerpt :

The precise shape of a protein is a crucial factor in its function. How do proteins become folded into the right conformation? Molecular chaperones and protein folding catalysts bind to developing polypeptides in the cytoplasm and ensure correct folding and transport. This Guidebook catalogues the latest information on nearly 200 of these molecules, including the important class of heat shock proteins; each entry is written by leading researchers in the field.

Guidebook to the Extracellular Matrix  Anchor  and Adhesion Proteins Book

Guidebook to the Extracellular Matrix Anchor and Adhesion Proteins


  • Author : Thomas Kreis
  • Publisher : Unknown
  • Release Date : 1999
  • Genre: Science
  • Pages : 568
  • ISBN 10 : 0198599587

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Guidebook to the Extracellular Matrix Anchor and Adhesion Proteins Excerpt :

This new edition collects up-to-date information on the purification, activities, antibodies and genes for proteins found in the extracellular matrix and those known to be involved in cell-cell contact and adhesion. It includes new research on the structure of proteins and their diverse roles in cell communication and metabolite exchange. Like other books in this series, this practical volume is equally useful for specialists and those new to the field, providing a succint survey of the most important work drawn from a wide range of sources.

Bacterial Toxins Book

Bacterial Toxins


  • Author : Otto Holst
  • Publisher : Springer Science & Business Media
  • Release Date : 2000
  • Genre: Medical
  • Pages : 379
  • ISBN 10 : 9781592590520

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Bacterial Toxins Excerpt :

The interest of investigators across a broad spectrum of scientific dis- plines has been steadily stimulated by the field of bacterial toxin research, an area that makes use of a large variety of biological, chemical, physicochemical, and medically oriented approaches. Researchers studying bacterial toxins need to be acquainted with all these disciplines in order to work effectively in the field. To date, there has been no published collection offering detailed descr- tions of the techniques and methods needed by researchers operating across the field’sdiverse areas. The present volume Bacterial Toxins: Methods and Pro- cols, is intended to fill this gap. Bacterial Toxins: Methods and Protocols consists of two sections: one on protein toxins (15 chapters) and one on endotoxins (5 chapters). Each s- tion is introduced by an overview article (Chapters 1 and 16). The protocols collected represent state-of-the-art techniques that each have high impact on future bacterial toxin research. All methods are described by authors who have regularly been using the protocol in their own laboratories. Included in each chapter is a brief introduction to the method being described.

Toxic Plant Proteins Book

Toxic Plant Proteins


  • Author : J. Michael Lord
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-07-20
  • Genre: Science
  • Pages : 270
  • ISBN 10 : 9783642121760

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Toxic Plant Proteins Excerpt :

Many plants produce enzymes collectively known as ribosome-inactivating proteins (RIPs). RIPs catalyze the removal of an adenine residue from a conserved loop in the large ribosomal RNA. The adenine residue removed by this depurination is crucial for the binding of elongation factors. Ribosomes modified in this way are no longer able to carry out protein synthesis. Most RIPs exist as single polypeptides (Type 1 RIPs) which are largely non-toxic to mammalian cells because they are unable to enter them and thus cannot reach their ribosomal substrate. In some instances, however, the RIP forms part of a heterodimer where its partner polypeptide is a lectin (Type 2 RIPs). These heterodimeric RIPs are able to bind to and enter mammalian cells. Their ability to reach and modify ribosomes in target cells means these proteins are some of the most potently cytotoxic poisons found in nature, and are widely assumed to play a protective role as part of the host plant’s defenses. RIPs are able to further damage target cells by inducing apoptosis. In addition, certain plants produce lectins lacking an RIP component but which are also cytotoxic. This book focuses on the structure/function and some potential applications of these toxic plant proteins.

Perspectives in Molecular Toxinology Book

Perspectives in Molecular Toxinology


  • Author : A. Ménez
  • Publisher : John Wiley & Sons
  • Release Date : 2002-05-17
  • Genre: Science
  • Pages : 516
  • ISBN 10 : 0471495034

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Perspectives in Molecular Toxinology Excerpt :

Covering the most recent advances in our understanding of toxins from venomous animals and microbes as well as that of their targets, this book expertly addresses the many intriguing and unsolved questions concerning; proteomics studies of the "toxinome", intimate modes of toxin actions, molecular basis of specificity, pleiotropic properties of toxins and structural biology of toxins. Through twenty-seven chapters the authors discuss the role of structural genomics in toxinology, how toxins are subject to accelerated evolution, how toxins can be exploited as models for the design of new drugs, and what the future holds for the treatment of snake bites. In order to address these challenging aspects, the authors have posed crystal-clear questions. Based on the most precise knowledge the attendant reasoning shows how toxinology has become an important area of biochemistry and is directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering and many other disciplines.

Chimeric Toxins Book
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Chimeric Toxins


  • Author : Haya Lorberboum-Galski
  • Publisher : CRC Press
  • Release Date : 2002-05-30
  • Genre: Medical
  • Pages : 292
  • ISBN 10 : 9780203216477

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Chimeric Toxins Excerpt :

Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action are common to many of these toxins and represent general pathways for the interaction of a number of biomolecules with target cells, such as binding to specific surface receptors, internalizati

Recent Advances in Marine Biotechnology  Vol  6 Book

Recent Advances in Marine Biotechnology Vol 6


  • Author : Milton Fingerman
  • Publisher : CRC Press
  • Release Date : 2002-01-01
  • Genre: Science
  • Pages : 272
  • ISBN 10 : 9781482279832

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Recent Advances in Marine Biotechnology Vol 6 Excerpt :

The marine environment has been, and continues to be, a fruitful source of novel chemical compounds that are not found in terrestrial and freshwater organisms. Many of these substances show potential biomedical applications, which could lead to development of new pharmaceutical products. Research on the utilization of natural products from marine organisms is growing by leaps and bounds; one important reason why being that, investigators, through new diving technologies, are becoming able to explore at greater depths. Studies of these marine natural products include investigations of neuronal membrane-active toxins, ion channel blockers, antitumor and antiviral agents, and anti-inflammatory molecules. This volume is the sixth in the ongoing series.

Nuclear Magnetic Resonance Book

Nuclear Magnetic Resonance


  • Author : G A Webb
  • Publisher : Royal Society of Chemistry
  • Release Date : 2007-10-31
  • Genre: Science
  • Pages : 550
  • ISBN 10 : 9781847553843

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Nuclear Magnetic Resonance Excerpt :

As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Strict and Facultative Anaerobes Book

Strict and Facultative Anaerobes


  • Author : Michiko M. Nakano
  • Publisher : CRC Press
  • Release Date : 2004-10-20
  • Genre: Science
  • Pages : 390
  • ISBN 10 : 0849333172

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Strict and Facultative Anaerobes Excerpt :

Strict and Facultative Anaerobes: Medical and Environmental Aspects reviews all aspects of anaerobic bacteria, highlighting their environmental and medical importance. The first three chapters focus on taxonomy, anaerobic metabolism and the genetic regulation of anaerobic processes in strict and facultative anaerobes. The next section includes an examination of the physiological traits of anaerobic bacteria that enable them to be beneficial in one situation but hazardous to human and animal health in others. Other topics include the anaerobic nature of infections, latency, anaerobic biofilms, and toxin production. The final section reviews iron, selenate, and arsenate reduction, as well as oxidation of halogenated organics, ammonium oxidation, and acetogenesis. This important book provides detailed coverage of the wide-ranging capabilities of anaerobic bacteria. It examines their basic biology and chemistry, medical importance, and applications in biotechnology and environmental science. It is an essential reference for everyone interested in anaerobic bacteria, environmental biology, medical microbiology, and industrial bacteriology.

Genomics  Proteomics and Vaccines Book

Genomics Proteomics and Vaccines


  • Author : Guido Grandi
  • Publisher : John Wiley & Sons
  • Release Date : 2004-08-13
  • Genre: Science
  • Pages : 336
  • ISBN 10 : 9780470093924

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Genomics Proteomics and Vaccines Excerpt :

While the sequence of the human genome sequence has hit the headlines, extensive exploitation of this for practical applications is still to come. Genomic and post-genomic technologies applied to viral and bacterial pathogens, which are almost equally important from a scientific perspective, have the potential to be translated into useful products and processes much more rapidly. Genomics, Proteomics and Vaccines introduces the history of vaccinology and discusses how vaccines are expected to evolve in the future. It describes the relevant technologies, including genome sequencing and analysis, DNA microarrays, 2D electrophoresis and 2D chromatography, mass spectrometry and high-throughput protein expression and purification. The book also features examples of the exploitation of genomics and post-genomics in vaccine discovery, and contains useful descriptions of the biology and pathogenesis of clinically important bacterial pathogens. This book should be of interest to all those working in vaccine discovery and development in pharmaceutical and biotechnology companies as well as in academic institutions

Cell Biology E Book Book

Cell Biology E Book


  • Author : Thomas D. Pollard
  • Publisher : Elsevier Health Sciences
  • Release Date : 2016-11-01
  • Genre: Science
  • Pages : 908
  • ISBN 10 : 9780323400022

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Cell Biology E Book Excerpt :

The much-anticipated 3rd edition of Cell Biology delivers comprehensive, clearly written, and richly illustrated content to today’s students, all in a user-friendly format. Relevant to both research and clinical practice, this rich resource covers key principles of cellular function and uses them to explain how molecular defects lead to cellular dysfunction and cause human disease. Concise text and visually amazing graphics simplify complex information and help readers make the most of their study time. Clearly written format incorporates rich illustrations, diagrams, and charts. Uses real examples to illustrate key cell biology concepts. Includes beneficial cell physiology coverage. Clinically oriented text relates cell biology to pathophysiology and medicine. Takes a mechanistic approach to molecular processes. Major new didactic chapter flow leads with the latest on genome organization, gene expression and RNA processing. Boasts exciting new content including the evolutionary origin of eukaryotes, super resolution fluorescence microscopy, cryo-electron microscopy, gene editing by CRISPR/Cas9, contributions of high throughput DNA sequencing to understand genome organization and gene expression, microRNAs, IncRNAs, membrane-shaping proteins, organelle-organelle contact sites, microbiota, autophagy, ERAD, motor protein mechanisms, stem cells, and cell cycle regulation. Features specially expanded coverage of genome sequencing and regulation, endocytosis, cancer genomics, the cytoskeleton, DNA damage response, necroptosis, and RNA processing. Includes hundreds of new and updated diagrams and micrographs, plus fifty new protein and RNA structures to explain molecular mechanisms in unprecedented detail.

Bacterial Toxins Book

Bacterial Toxins


  • Author : Klaus Aktories
  • Publisher : John Wiley & Sons
  • Release Date : 2008-09-26
  • Genre: Science
  • Pages : 334
  • ISBN 10 : 9783527614608

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Bacterial Toxins Excerpt :

This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance. A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.