Handbook of Microdialysis Book

Handbook of Microdialysis


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2007-02-02
  • Genre: Psychology
  • Pages : 712
  • ISBN 10 : 9780080469669

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Handbook of Microdialysis Excerpt :

Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The authors are all well known researchers in Neuroscience and experts in the use of Microdialysis. Organized into two parts of seven sections, the Handbook of Microdialysis critically examines recent developments in the field through a variety of chapters written by an internationally acclaimed group of authors. It is the first comprehensive handbook covering the technology of Microdialysis and its applications in Neuroscience. * Presents microdialysis methods and interpretation including the technical aspects of microdialysis as a sampling technique followed by the analytical chemical methods * Discusses the role of microdialysis in pharmacology, drug development and models of CNS pathology * Includes clinical applications of microdialysis

Handbook of Non Invasive Methods and the Skin  Second Edition Book

Handbook of Non Invasive Methods and the Skin Second Edition


  • Author : Jorgen Serup
  • Publisher : CRC Press
  • Release Date : 2006-02-23
  • Genre: Medical
  • Pages : 1056
  • ISBN 10 : 9781420003307

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Handbook of Non Invasive Methods and the Skin Second Edition Excerpt :

Firmly established as the leading international reference in this field, Non-Invasive Methods and the Skin broke new ground with its comprehensive coverage of methods used in both clinical and experimental dermatology. Completely revised and updated, containing more than twice as much information, the Second Edition continues the tradition. The authors' thorough research and clear organization make this book a baseline reference for those using noninvasive biophysical methods to study the skin. Arranged by physical modality and structured to provide educational and practical information, the second edition, like its predecessor, will prove to be of value to young researchers and senior scientists alike. The coverage of major evaluation and measurement methods share a consistent format, including scope, sources of error, application, and validity. This edition incorporates 69 revised chapters with more than 90 new chapters covering topics such as computer technique, imaging techniques, skin friction, barrier functions, and more. New chapters provide coverage of: computers, computer techniques, and image analysis imaging techniques, including clinical photography legal situations and guidelines behind instrumental use skin friction barrier functions important new techniques such as in vitro confocal microscopy, OCT, and Raman spectroscopy veterinary/animal research use of methods The truly interdisciplinary, international panel of contributors includes experts from the specialties of dermatology, bioengineering, pathology, manufacturing engineering, medical physics, pharmacology, microbiology, neurology, surgery, obstetrics and gynecology, cardiovascular research, and pharmacy from academic institutions and hospitals in countries such as Denmark, Germany, the United Kingdom, the United States, Japan, Israel, Taiwan, and Singapore. The revision is extensive and covers a broad spectrum of methods while providing the same caliber of authoritative information that made th

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Book

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics


  • Author : Michelle A. Rudek
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-01-10
  • Genre: Medical
  • Pages : 836
  • ISBN 10 : 9781461491354

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Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Excerpt :

There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development

Handbook of Episodic Memory Book

Handbook of Episodic Memory


  • Author : Ekrem Dere
  • Publisher : Elsevier
  • Release Date : 2008-09-04
  • Genre: Psychology
  • Pages : 628
  • ISBN 10 : 0080932363

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Handbook of Episodic Memory Excerpt :

Episodic memory is the name of the kind of memory that records personal experiences instead of the mere remembering of impersonal facts and rules. This type of memory is extremely sensitive to ageing and disease so an understanding of the mechanisms of episodic memory might lead to the development of therapies suited to improve memory in some patient populations. Episodic memory is unique in that it includes an aspect of self-awareness and helps us to remember who we are in terms of what we did and what we have been passed through and what we should do in the future. This book brings together a renowned team of contributors from the fields of cognitive psychology, neuropsychology and behavioural and molecular neuroscience. It provides a detailed and comprehensive overview of recent developments in understanding human episodic memory and animal episodic-like memory in terms of concepts, methods, mechanisms, neurobiology and pathology. The work presented within this book will have a profound effect on the direction that future research in this topic will take. - The first and most current comprehensive handbook on what we know about episodic memory, the memory of events, time, place, and emotion, and a key feature of awareness and consciousness - Articles summarize our understanding of the mechanisms of episodic memory as well as surveying the neurobiology of epsidodic memory in patients, animal studies and functional imaging work - Includes 34 heavily illustrated chapters in two sections by the leading scientists in the field

Handbook of Anxiety and Fear Book
Score: 5
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Handbook of Anxiety and Fear


  • Author : D. Caroline Blanchard
  • Publisher : Elsevier
  • Release Date : 2011-09-02
  • Genre: Psychology
  • Pages : 450
  • ISBN 10 : 0080559522

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Handbook of Anxiety and Fear Excerpt :

This Handbook brings together and integrates comprehensively the core approaches to fear and anxiety. Its four sections: Animal models; neural systems; pharmacology; and clinical approaches, provide a range of perspectives that interact to produce new light on these important and sometimes dysfunctional emotions. Fear and anxiety are analyzed as patterns that have evolved on the basis of their adaptive functioning in response to threat. These patterns are stringently selected, providing a close fit with environmental situations and events; they are highly conservative across mammalian species, producing important similarities, along with some systematic differences, in their human expression in comparison to that of nonhuman mammals. These patterns are described, with attention to both adaptive and maladaptive components, and related to new understanding of neuroanatomic, neurotransmitter, and genetic mechanisms. Although chapters in the volume acknowledge important differences in views of fear and anxiety stemming from animal vs. human research, the emphasis of the volume is on a search for an integrated view that will facilitate the use of animal models of anxiety to predict drug response in people; on new technologies that will enable direct evaluation of biological mechanisms in anxiety disorders; and on strengthening the analysis of anxiety disorders as biological phenomena. • Integrates animal and human research on fear and anxiety • Presents emerging and developing fields of human anxiety research including imaging of anxiety disorders, the genetics of anxiety, the pharmacology of anxiolysis, recent developments in classification of anxiety disorders, linking these to animal work • Covers basic research on innate and conditioned responses to threat • Presents work from the major laboratories, on fear learning and extinction • Reviews research on an array of neurotransmitter and neuromodulator systems related to fear and anxiety • Compares models,

Handbook of Capillary Electrophoresis  Second Edition Book
Score: 5
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Handbook of Capillary Electrophoresis Second Edition


  • Author : James P. Landers
  • Publisher : CRC Press
  • Release Date : 1996-12-23
  • Genre: Medical
  • Pages : 894
  • ISBN 10 : 084932498X

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Handbook of Capillary Electrophoresis Second Edition Excerpt :

Because new information was discovered at an incredible rate since the publication of the successful first edition of this Handbook, this fully updated second edition covers all areas of interest in the field of capillary electrophoresis (CE). A relatively new technology, CE is a principle method for studying the physicochemical properties of proteins, peptides, and other macromolecules. Where applicable, the 30 chapters provide basic underlying theories as well as application-oriented aspects of each technique.Keep up with all the developments in this growing field with the Handbook of Capillary Electrophoresis, Second Edition - a complete guide to the fundamentals of CE and the latest research. The chapters are organized into five units: Modes: Presents a theoretical development of the basic principles governing separation with several modes, including CEC, and discusses their practical aspects. Analyte: Applies CE to the analysis of a specific class of analytes, including organic and inorganic ions, pharmaceuticals, glycoconjugates, peptides, proteins, and DNA fragments. Fundamental Aspects of CE: Technique-oriented information for the practitioner, including the importance of the sample matrix, on-line preconcentration of samples, modes of detection, and specific aspects of CE data analysis. Applications of CE: Includes single cell analysis, CE in DNA sequencing, CE as a clinical diagnostic tool, identifying and quantifying drugs, and for characterizing interacting species. Specialized Aspects of CE: Discusses interfacing CE with mass spectrometry, high-volume throughput continuous CE, microchip CE, control of EOF, and much more. The Handbook of Capillary Electrophoresis, Second Edition, pulls together diverse areas and applications of CE, resulting in an excellent tool for scientists involved in biotechnology and clinical chemistry, as well as the pharmaceutical, bioscience, chemical, and instrument-manufacturing industries. With an applications-oriented focus,

In Vivo Glucose Sensing Book

In Vivo Glucose Sensing


  • Author : David D. Cunningham
  • Publisher : John Wiley & Sons
  • Release Date : 2009-11-19
  • Genre: Science
  • Pages : 472
  • ISBN 10 : 0470567309

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In Vivo Glucose Sensing Excerpt :

In Vivo Glucose Sensing is a key reference for scientists and engineers working on the development of glucose sensing technologies for the management of diabetes and other medical conditions. It discusses the analytical chemistry behind the strategies currently used for measuring glucose in vivo. It focuses on analyzing samples in the real world and discusses the biological complexities that make glucose sensing difficult. Covering current implantable devices, next-generation implantable sensing methods, and non-invasive methods for measuring glucose, this book concludes with an overview of possible applications other than diabetes.

Biosensors and Invasive Monitoring in Clinical Applications Book

Biosensors and Invasive Monitoring in Clinical Applications


  • Author : Emma P. Córcoles
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-04-23
  • Genre: Technology & Engineering
  • Pages : 80
  • ISBN 10 : 9783319003603

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Biosensors and Invasive Monitoring in Clinical Applications Excerpt :

This volume examines the advances of invasive monitoring by means of biosensors and microdialysis. Physical and physiological parameters are commonly monitored in clinical settings using invasive techniques due to their positive outcome in patients’ diagnosis and treatment. Biochemical parameters, however, still rely on off-line measurements and require large pieces of equipment. Biosensing and sampling devices present excellent capabilities for their use in continuous monitoring of patients’ biochemical parameters. However, certain issues remain to be solved in order to ensure a more widespread use of these techniques in today’s medical practices.

Handbook of Neuroendocrinology Book

Handbook of Neuroendocrinology


  • Author : George Fink
  • Publisher : Academic Press
  • Release Date : 2012
  • Genre: Medical
  • Pages : 871
  • ISBN 10 : 9780123750976

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Handbook of Neuroendocrinology Excerpt :

Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Book

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics


  • Author : William D. Figg
  • Publisher : Springer Science & Business Media
  • Release Date : 2004-03-26
  • Genre: Medical
  • Pages : 623
  • ISBN 10 : 9781592597345

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Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Excerpt :

Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.

Biomedical Photonics Handbook Book
Score: 5
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Biomedical Photonics Handbook


  • Author : Tuan Vo-Dinh
  • Publisher : CRC Press
  • Release Date : 2003-03-26
  • Genre: Medical
  • Pages : 1872
  • ISBN 10 : 0203008995

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Biomedical Photonics Handbook Excerpt :

A wide variety of biomedical photonic technologies have been developed recently for clinical monitoring of early disease states; molecular diagnostics and imaging of physiological parameters; molecular and genetic biomarkers; and detection of the presence of pathological organisms or biochemical species of clinical importance. However, available information on this rapidly growing field is fragmented among a variety of journals and specialized books. Now researchers and medical practitioners have an authoritative and comprehensive source for the latest research and applications in biomedical photonics. Over 150 leading scientists, engineers, and physicians discuss state-of-the-art instrumentation, methods, and protocols in the Biomedical Photonics Handbook. Editor-in-Chief Tuan Vo-Dinh and an advisory board of distinguished scientists and medical experts ensure that each of the 65 chapters represents the latest and most accurate information currently available.

The Wiley Blackwell Handbook of Psychoneuroimmunology Book

The Wiley Blackwell Handbook of Psychoneuroimmunology


  • Author : Alexander W. Kusnecov
  • Publisher : Wiley-Blackwell
  • Release Date : 2013-12-31
  • Genre: Psychology
  • Pages : 552
  • ISBN 10 : 9781119979517

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The Wiley Blackwell Handbook of Psychoneuroimmunology Excerpt :

This comprehensive resource details the history, methodology anddevelopment of research into psychoneuroimmunology, balancing itwith meticulous coverage of both the clinical aspects and practicalapplications of the subject. A much-needed reference including overviews of key advances inthe field Discusses how psychoneuroimmunological research is conceivedand executed Includes contributions from a wealth of experts in thefield Forward by Robert Ader and Nicholas Cohen, founders of thediscipline Authoritative and interdisciplinary in scope - integratingbiological and behavioral science

Biomedical Photonics Handbook  Second Edition Book

Biomedical Photonics Handbook Second Edition


  • Author : Tuan Vo-Dinh
  • Publisher : CRC Press
  • Release Date : 2014-07-29
  • Genre: Medical
  • Pages : 889
  • ISBN 10 : 9781420085143

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Biomedical Photonics Handbook Second Edition Excerpt :

Shaped by Quantum Theory, Technology, and the Genomics Revolution The integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. The second volume, Biomedical Diagnostics, focuses on biomedical diagnostic technologies and their applications from the bench to the bedside. Represents the Collective Work of over 150 Scientists, Engineers, and Clinicians Designed to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies. What’s New in This Edition: A wide variety of photonic biochemical sensing technologies have already been developed for clinical monitoring of physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics and metabolomics allow sensing of early disease state biomarkers, thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease, imaging single molecules and in situ diagnostics at the single cell level. In addition to these state-of-the art advancements, the second edition

Preclinical Development Handbook Book

Preclinical Development Handbook


  • Author : Shayne Cox Gad
  • Publisher : John Wiley & Sons
  • Release Date : 2008-03-21
  • Genre: Medical
  • Pages : 1352
  • ISBN 10 : 9780470249024

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Preclinical Development Handbook Excerpt :

A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

The Handbook of Biomarkers Book

The Handbook of Biomarkers


  • Author : Kewal K. Jain
  • Publisher : Humana Press
  • Release Date : 2017-09-16
  • Genre: Science
  • Pages : 760
  • ISBN 10 : 9781493974313

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The Handbook of Biomarkers Excerpt :

Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications. To aid in this imperative research, Prof. Kewal K. Jain’s Handbook of Biomarkers, Second Edition features a full revision and additional chapters to thoroughly describe many different types of biomarkers and their discovery using various "-omics" technologies, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers, Second Edition serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important trends in healthcare today.