Handbook of Pharmacogenomics and Stratified Medicine Book

Handbook of Pharmacogenomics and Stratified Medicine


  • Author : Sandosh Padmanabhan
  • Publisher : Academic Press
  • Release Date : 2014-04-28
  • Genre: Science
  • Pages : 1118
  • ISBN 10 : 9780123868831

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Handbook of Pharmacogenomics and Stratified Medicine Excerpt :

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, pro

Handbook of Personalized Medicine Book

Handbook of Personalized Medicine


  • Author : Ioannis S. Vizirianakis
  • Publisher : CRC Press
  • Release Date : 2014-02-12
  • Genre: Medical
  • Pages : 1562
  • ISBN 10 : 9789814411196

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Handbook of Personalized Medicine Excerpt :

This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.

Handbook of Biomarkers and Precision Medicine Book

Handbook of Biomarkers and Precision Medicine


  • Author : Claudio Carini
  • Publisher : CRC Press
  • Release Date : 2019-04-16
  • Genre: Mathematics
  • Pages : 1025
  • ISBN 10 : 9780429574627

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Handbook of Biomarkers and Precision Medicine Excerpt :

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Handbook of Biomarkers and Precision Medicine Book

Handbook of Biomarkers and Precision Medicine


  • Author : Claudio Carini
  • Publisher : CRC Press
  • Release Date : 2019-04-16
  • Genre: Mathematics
  • Pages : 631
  • ISBN 10 : 9780429576737

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Handbook of Biomarkers and Precision Medicine Excerpt :

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Handbook of Personalized Medicine Book

Handbook of Personalized Medicine


  • Author : Ioannis S. Vizirianakis
  • Publisher : CRC Press
  • Release Date : 2014-02-12
  • Genre: Medical
  • Pages : 1560
  • ISBN 10 : 9789814411202

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Handbook of Personalized Medicine Excerpt :

This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.

Pharmacogenomics Book

Pharmacogenomics


  • Author : Yui-Wing Francis Lam
  • Publisher : Academic Press
  • Release Date : 2018-11-27
  • Genre: Medical
  • Pages : 442
  • ISBN 10 : 9780128126271

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Pharmacogenomics Excerpt :

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition, provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as pharmacogenomic data technologies, clinical testing strategies, cost-effectiveness, and pharmacogenomic education and practice guidelines. The importance of ethnicity is also discussed, which highlights phar,acogenomic diversity across Latin American populations. With chapters written by interdisciplinary experts and insights into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation. Provides viewpoints that focus on the scientific and translational challenges and opportunities associated with advancing the field of pharmacogenomics Highlights progress in both the research and clinical areas of pharmacogenomics, as well as relevant implementation experience, challenges, and perspectives on direct-to-consumer genetic testing Includes, where applicable, discussion points, review questions, and cases for self-assessment purposes and to facilitate in-depth discussion

Handbook of Drug Monitoring Methods Book

Handbook of Drug Monitoring Methods


  • Author : Amitava Dasgupta
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-10-23
  • Genre: Medical
  • Pages : 441
  • ISBN 10 : 9781588297808

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Handbook of Drug Monitoring Methods Excerpt :

In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

Pharmacoepigenetics Book

Pharmacoepigenetics


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-06-04
  • Genre: Medical
  • Pages : 983
  • ISBN 10 : 9780128139400

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Pharmacoepigenetics Excerpt :

Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Textbook of Personalized Medicine Book

Textbook of Personalized Medicine


  • Author : Kewal K. Jain
  • Publisher : Springer
  • Release Date : 2014-11-26
  • Genre: Medical
  • Pages : 430
  • ISBN 10 : 1489983341

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Textbook of Personalized Medicine Excerpt :

Personalized medicine, which simply means selection of treatment best suited for an individual, involves integration and translation of several new technologies in clinical care of patients. The scope is much broader than indicated by the term genomic medicine because many non-genomic factors are taken into consideration in developing personalized medicine. Basic technologies for personalized medicine, of which molecular diagnostics has the biggest share, are mentioned briefly and appropriate references are given for further information. Commercial aspects are discussed briefly in a chapter and detailed analysis of markets and companies involved in personalized medicine is presented in a special report on this topic. There is increasing interest in personalized medicine. Considerable advances have taken place in molecular biology and biotechnology to make personalized medicine a viable option, but some misconceptions still exist, both in the academic and commercial sectors. There is lack of a suitable source of information that provides both the fundamentals as well as applications of personalized medicine. As the latest version of the first monograph on personalized medicine published in 1998, this volume, Textbook of Personalized Medicine, summarizes the author’s efforts during the past decade, as well as reviews selected studies done during this period in a readable format for the physicians and scientists. It is hoped that physicians, pharmacists, scientists and interested lay readers with basic scientific knowledge will find this book useful.

Mastering Pharmacogenomics  A Nurse s Handbook for Success Book

Mastering Pharmacogenomics A Nurse s Handbook for Success


  • Author : Dale Halsey Lea
  • Publisher : Sigma Theta Tau
  • Release Date : 2015-01-14
  • Genre: Medical
  • Pages : 264
  • ISBN 10 : 9781938835704

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Mastering Pharmacogenomics A Nurse s Handbook for Success Excerpt :

Pharmacogenomics, the study of the role of genetics in drug response, has developed into a critical new area in battling disease and improving outcomes. As our knowledge of the human genome grows, and with the advent of next-generation sequencing technologies, the role of genetic research is evolving to guide therapy and prevent many diseases and mitigate side-effects of current treatments. As a pivotal member of the healthcare team, nurses must acquire competency in pharmacogenomics to deliver optimal patient care in the 21st century. Mastering Pharmacogenomics provides nursing professionals with a foundational knowledge of human genetics and genomics that can be applied in optimizing drug therapy and patient care delivery. Coverage includes: Essential pharmacogenomics competencies for registered nurses Genomics technologies and resources Critical properties of drug response and disposition Covered specialties include obstetrics and prenatal patients, pediatrics, older adult patients, and oncology Ethics and patient careFuture developments in technology and delivery

Preclinical Development Handbook Book

Preclinical Development Handbook


  • Author : Shayne Cox Gad
  • Publisher : Wiley-Interscience
  • Release Date : 2008-03-14
  • Genre: Medical
  • Pages : 1080
  • ISBN 10 : 0470248467

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Preclinical Development Handbook Excerpt :

A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * In vitro mammalian cytogenetics tests * Phototoxicity * Carcinogenicity studies * The pharmacogenomics of personalized medicine * Bridging studies * Toxicogenomics and toxicoproteomics Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This is a hands-on guide for pharmaceutical scientists involved in preclinical testing,enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

Pharmacogenomics and Precision Medicine  An Issue of the Clinics in Laboratory Medicine  E Book Book

Pharmacogenomics and Precision Medicine An Issue of the Clinics in Laboratory Medicine E Book


  • Author : Kristen Reynolds
  • Publisher : Elsevier Health Sciences
  • Release Date : 2016-08-16
  • Genre: Medical
  • Pages : 177
  • ISBN 10 : 9780323462808

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Pharmacogenomics and Precision Medicine An Issue of the Clinics in Laboratory Medicine E Book Excerpt :

This issue of the Clinics in Laboratory Medicine on “Pharmacogenomics is being edited by Drs. Roland Valdes and Kristen Reynolds and will cover a wide variety of topics, including but not limited to, fundamentals of pharmacology, a review of pharmacogenetics guidelines, pharmacogenetic testing in pain management, pharmacogenetics of pain management, clinical and economic impact of pharmacogenetic genotyping analysis, exosome analysis in lab medicine, and implementation of pharmacogenetics in developing countries.

Handbook of Children s Rights Book

Handbook of Children s Rights


  • Author : Martin D. Ruck
  • Publisher : Taylor & Francis
  • Release Date : 2016-12-08
  • Genre: Psychology
  • Pages : 618
  • ISBN 10 : 9781317660040

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Handbook of Children s Rights Excerpt :

While the notion of young people as individuals worthy or capable of having rights is of relatively recent origin, over the past several decades there has been a substantial increase in both social and political commitment to children’s rights as well as a tendency to grant young people some of the rights that were typically accorded only to adults. In addition, there has been a noticeable shift in orientation from a focus on children’s protection and provision to an emphasis on children’s participation and self-determination. With contributions from a wide range of international scholars, the Handbook of Children’s Rights brings together research, theory, and practice from diverse perspectives on children’s rights. This volume constitutes a comprehensive treatment of critical perspectives concerning children’s rights in their various forms. Its contributions address some of the major scholarly tensions and policy debates comprising the current discourse on children’s rights, including the best interests of the child, evolving capacities of the child, states’ rights versus children’s rights, rights of children versus parental or family rights, children as citizens, children’s rights versus children’s responsibilities, and balancing protection and participation. In addition to its multidisciplinary focus, the handbook includes perspectives from social science domains in which children’s rights scholarship has evolved largely independently due to distinct and seemingly competing assumptions and disciplinary approaches (e.g., childhood studies, developmental psychology, sociology of childhood, anthropology, and political science). The handbook also brings together diverse methodological approaches to the study of children’s rights, including both quantitative and qualitative perspectives, and policy analysis. This comprehensive, cosmopolitan, and timely volume serves as an important reference for both scholarly and policy-driven interest in th

Handbook of Clinical Adult Genetics and Genomics Book

Handbook of Clinical Adult Genetics and Genomics


  • Author : Shweta Dhar
  • Publisher : Academic Press
  • Release Date : 2020-04-10
  • Genre: Science
  • Pages : 534
  • ISBN 10 : 9780128173459

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Handbook of Clinical Adult Genetics and Genomics Excerpt :

Handbook of Clinical Adult Genetics and Genomics: A Practice-Based Approach provides a thorough overview of genetic disorders that are commonly encountered in adult populations and supports the full translation of adult genetic and genomic modalities into clinical practice. Expert chapter authors supplement foundational knowledge with case-based strategies for the evaluation and management of genetic disorders in each organ system and specialty area. Topics discussed include employing genetic testing technologies, reporting test results, genetic counseling for adult patients, medical genetics referrals, issues of complex inheritance, gene therapy, and diagnostic and treatment criteria for developmental, cardiovascular, gastrointestinal, neuropsychiatric, pulmonary issues, and much more. Employs clinical case studies to demonstrate how to evaluate, diagnosis and treat adult patients with genetic disorders Offers a practical framework for establishing an adult genetics clinic, addressing infrastructure, billing, counseling, and challenges unique to adult clinical genetics Features chapter contributions from authors at leading adult genetics institutions in the US and abroad

The Oxford Handbook of Substance Use and Substance Use Disorders Book

The Oxford Handbook of Substance Use and Substance Use Disorders


  • Author : Kenneth J. Sher
  • Publisher : Oxford University Press
  • Release Date : 2016
  • Genre: Psychology
  • Pages : 793
  • ISBN 10 : 9780199381708

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The Oxford Handbook of Substance Use and Substance Use Disorders Excerpt :

"The Oxford Handbook of Substance Use and Substance Use Disorders provides comprehensive reviews of key areas of inquiry into the fundamental nature of substance use and SUDs, their features, causes, consequences, course, treatment, and prevention"--