Handbook of Pharmacogenomics and Stratified Medicine Book

Handbook of Pharmacogenomics and Stratified Medicine


  • Author : Sandosh Padmanabhan
  • Publisher : Academic Press
  • Release Date : 2014-04-28
  • Genre: Science
  • Pages : 1118
  • ISBN 10 : 9780123868831

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Handbook of Pharmacogenomics and Stratified Medicine Excerpt :

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, pro

The SAGE Handbook of Social Studies in Health and Medicine Book

The SAGE Handbook of Social Studies in Health and Medicine


  • Author : Susan C. Scrimshaw
  • Publisher : SAGE
  • Release Date : 2021-12-01
  • Genre: Social Science
  • Pages : 704
  • ISBN 10 : 9781529761948

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The SAGE Handbook of Social Studies in Health and Medicine Excerpt :

With new chapters on key topics such as mental health, the environment, race, ethnicity and health, and pharmaceuticals, this new edition maintains its multidisciplinary framework and bridges the gap between health policy and the sociology of health. It builds upon the success of the first by encompassing a range of issues, studies, and disciplines. The broad coverage of topics in addition to new chapters present an engagement with contemporary issues, resulting in a valuable teaching aid. This second edition brings together a diverse range of leading international scholars with contributors from Australia, Puerto-Rico, USA, Guatemala, Germany, Sri Lanka, Botswana, UK, South Sudan, Mexico, South Korea, Canada and more. The second edition of this Handbook remains a key resource for undergraduates, post-graduates, and researchers across multidisciplinary backgrounds including: medicine, health and social care, sociology, and anthropology. PART ONE: Culture, Society and Health PART TWO: Lived Experiences PART THREE: Health Care Systems, Access and Use PART FOUR: Health in Environmental and Planetary Context

Drug Design Book
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Drug Design


  • Author : Arli Aditya Parikesit
  • Publisher : BoD – Books on Demand
  • Release Date : 2021-06-16
  • Genre: Medical
  • Pages : 159
  • ISBN 10 : 9781789847529

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Drug Design Excerpt :

Right before the COVID-19 pandemic declared by the World Health Organization (WHO), life sciences have incited novel areas of studies that revolutionize the health sector. They are the studies of structural bioinformatics, pharmacogenomics, and metabolomics. The structural bioinformatics field is the very foundation of drug design research, as it provides insight into the molecular simulations and interactions between the biomolecules and the drug candidates. Secondly, pharmacogenomics is the starting point of any efforts in developing personalized medicine. Lastly, metabolomics provides instrumentation to elicit biomarkers for various diseases and health conditions. These studies have enabled current accelerated effort in COVID-19 research, as well as other communicable and non-communicable diseases.

Pharmacoepigenetics Book

Pharmacoepigenetics


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-06-04
  • Genre: Medical
  • Pages : 983
  • ISBN 10 : 9780128139400

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Pharmacoepigenetics Excerpt :

Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Pharmacogenomics in Drug Discovery and Development Book

Pharmacogenomics in Drug Discovery and Development


  • Author : Qing Yan
  • Publisher : Springer Nature
  • Release Date : 2022-10-08
  • Genre: Medical
  • Pages : 617
  • ISBN 10 : 9781071625736

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Pharmacogenomics in Drug Discovery and Development Excerpt :

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

The Genetics of African Populations in Health and Disease Book

The Genetics of African Populations in Health and Disease


  • Author : Muntaser E. Ibrahim
  • Publisher : Cambridge University Press
  • Release Date : 2019-12-19
  • Genre: History
  • Pages : 351
  • ISBN 10 : 9781107072022

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The Genetics of African Populations in Health and Disease Excerpt :

A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.

Oxford Textbook of Global Public Health Book

Oxford Textbook of Global Public Health


  • Author : Roger Detels
  • Publisher : Oxford University Press
  • Release Date : 2021-10-29
  • Genre: Medical
  • Pages : 1888
  • ISBN 10 : 9780192548771

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Oxford Textbook of Global Public Health Excerpt :

The Oxford Textbook of Global Public Health is the ultimate resource on the subject of public health and epidemiology. It offers a global and comprehensive perspective on wide-ranging public health needs and priorities in modern health care. Thoroughly revised and updated for the seventh edition, the book is split into three main topics. 'The Scope of Public Health' covers the development of the discipline, determinants of health and disease, and policies, law, and ethics. The second volume focuses on The Methods of Public Health, including the science of epidemiology, social science techniques, and environmental techniques. Finally, The Practice of Public Health is fully explored, with sections on specific public health problems, ways of prevention and control, the varying needs of different populations, and the functions of public health services and professionals. Three new editors have joined for this edition, Liming Li (China), Fran Baum (Australia), and Alastair H Leyland (UK), complimenting Quarraisha Abdool Karim (South Africa) and Roger Detels (USA), for a truly global perspective on public health. Featuring over 225 contributors from countries all over the world ensures that the book covers public health from all aspects, with vastly different health systems and priorities. Featuring new chapters on gender identity and gender-based violence, environmental health and climate change, genomics and epidemiology, and emerging and re-emerging infectious diseases, the seventh edition of the Oxford Textbook of Global Public Health remains the most comprehensive text on the subject and is a vital resource for public health practitioners and trainees, clinical epidemiologists, and students in the field.

Oxford American Handbook of Cardiology Book

Oxford American Handbook of Cardiology


  • Author : Jeffrey Bender
  • Publisher : Oxford University Press
  • Release Date : 2010-10-27
  • Genre: Medical
  • Pages : 706
  • ISBN 10 : 9780195389692

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Oxford American Handbook of Cardiology Excerpt :

The Oxford American Handbook of Cardiology captures the latest knowledge in the rapidly expanding field of cardiovascular medicine and delivers essential, practical advice for clinical cardiologists.

Personalized Psychiatry Book

Personalized Psychiatry


  • Author : Bernhard Baune
  • Publisher : Academic Press
  • Release Date : 2019-10-16
  • Genre: Medical
  • Pages : 604
  • ISBN 10 : 9780128131770

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Personalized Psychiatry Excerpt :

Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

Food as Medicine Book

Food as Medicine


  • Author : Maurice M. Iwu
  • Publisher : CRC Press
  • Release Date : 2016-11-25
  • Genre: Medical
  • Pages : 384
  • ISBN 10 : 9781498706100

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Food as Medicine Excerpt :

This comprehensive book documents African plants used for functional and medicinal foods. It contains more than 60 detailed monographs of African foods, describing foods with various characteristics such as prebiotic, probiotic, satiety, immune modulation, stress-reduction, sports performance, mental acuity, sleep-supporting, metabolic syndrome, antioxidant, and unsaturated fats. Plant description, botanical names and synonyms, plant part used, habitat and distribution, folk use, nutritional content, and chemistry are all fully detailed. The book highlights indigenous African food processing technologies up to the modern era.

Studies in Natural Products Chemistry Book

Studies in Natural Products Chemistry


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2018-08-31
  • Genre: Science
  • Pages : 559
  • ISBN 10 : 9780444641809

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Studies in Natural Products Chemistry Excerpt :

Studies in Natural Products Chemistry, Volume 59, the latest in the series, covers the synthesis, or testing and recording, of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, this book is a welcomed resource. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

High Throughput Screening Methods Book

High Throughput Screening Methods


  • Author : Joshua A Bittker
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-12-05
  • Genre: Medical
  • Pages : 396
  • ISBN 10 : 9781782626770

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High Throughput Screening Methods Excerpt :

High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.

Frontiers in Clinical Drug Research   Anti Infectives  Volume 8 Book

Frontiers in Clinical Drug Research Anti Infectives Volume 8


  • Author : Atta-ur-Rahman
  • Publisher : Bentham Science Publishers
  • Release Date : 2021-12-07
  • Genre: Science
  • Pages : 367
  • ISBN 10 : 9789815039429

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Frontiers in Clinical Drug Research Anti Infectives Volume 8 Excerpt :

Frontiers in Clinical Drug Research – Anti infectives is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the book series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research – Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology. The eighth volume of this series presents comprehensive reviews of interest to readers interested in the treatment of inflammatory diseases, new antiviral agents and strategies, specific antiprotozoal drugs that work against leishmania and helminths, and a study on potential agents against American foulbrood in honey bees. The 7 reviews included in this volume are: - Monoclonal antibodies as therapeutic agents for inflammatory diseases - Pharmacotherapy of emerging antiviral agents - Antiviral activity of vitamin D and COVID-19: current understanding - Anti-infectives to combat leishmaniasis - Anthelmintic drug discovery: current situation and future perspectives - Therapeutic targets for emerging Zika virus infection and vaccines in clinical trials - Agro-industrial waste: new source of raw material for the control of American foulbrood in honey bees.

Neuroanatomy of the Mouse Book

Neuroanatomy of the Mouse


  • Author : Hannsjörg Schröder
  • Publisher : Springer Nature
  • Release Date : 2020-02-28
  • Genre: Medical
  • Pages : 350
  • ISBN 10 : 9783030198985

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Neuroanatomy of the Mouse Excerpt :

This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse’s central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories.

Smart Nanotechnology with Applications Book

Smart Nanotechnology with Applications


  • Author : Cherry Bhargava
  • Publisher : CRC Press
  • Release Date : 2020-12-16
  • Genre: Technology & Engineering
  • Pages : 305
  • ISBN 10 : 9781000262483

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Smart Nanotechnology with Applications Excerpt :

This comprehensive reference text discusses advance concepts and applications in the field of nanotechnology. The text presents a detailed discussion of key important concepts including nanomaterials and nanodevices, nano-bio interface, nanoscale memories, and semiconductor nanotechnology. It discusses applications of nanotechnology in the fields of aerospace engineering, cosmetic industry, pharmaceutical science, food industry, and the textile industry. The text will be useful for senior undergraduate and graduate students in the field of electrical engineering, electronics engineering, nanotechnology, and pharmaceutical science. Discussing fundamental, advanced concepts and their applications in a single volume, this text will be useful as a reference text for senior undergraduate and graduate students in the field of electrical engineering, electronics engineering, nanotechnology, and pharmaceutical science. It comprehensively discusses important concepts such as nano-robotics, carbon-based nanomaterials, and nanoscale memories. The text discusses advanced concepts of nanotechnology and its applications in the fields of textile, pharmaceutical sciences, aerospace, and food industry. It will be an ideal reference text for senior undergraduate and graduate students in the field of electrical engineering, electronics engineering, nanotechnology, and nanoscience.