Haschek and Rousseaux s Handbook of Toxicologic Pathology Book

Haschek and Rousseaux s Handbook of Toxicologic Pathology


  • Author : Wanda M. Haschek
  • Publisher : Academic Press
  • Release Date : 2021-10-20
  • Genre: Medical
  • Pages : 1152
  • ISBN 10 : 9780128218297

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Haschek and Rousseaux s Handbook of Toxicologic Pathology Excerpt :

Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Volume 1 of the Fourth Edition covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Completely revised with a number of new chapters, Volume 1 of the Handbook of Toxicologic Pathology is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Handbook of Toxicologic Pathology Book

Handbook of Toxicologic Pathology


  • Author : Wanda M. Haschek
  • Publisher : Elsevier
  • Release Date : 2013-10-22
  • Genre: Medical
  • Pages : 1127
  • ISBN 10 : 9781483288611

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Handbook of Toxicologic Pathology Excerpt :

This is the first comprehensive reference work on toxicologic pathology, an emerging field that integrates the mechanisms of toxic injury with the resulting pathology. Chapters deal systematically with organ-specific toxic injury, describing the mechanisms of injury, morphological expression of the injury, and evaluation of the pathology. Additional chapters introduce the field to the uninitiated and address such topics as techniques used for morphological evaluation, risk assessment, and regulatory aspects. The Handbook of Toxicologic Pathology will quickly establish itself as the classic reference work in this field for years to come. Comprehensive, "user friendly" reference text on toxicologic pathology Large, easy-to-use 8 1/2" x 11", double-column format Systematic approach to each organ or system More than 500 illustrations and 90 tables complement the text Over 2,000 references for easy access to the primary literature Unique chapters written by leading authorities

Haschek and Rousseaux s Handbook of Toxicologic Pathology  Volume 2 Book

Haschek and Rousseaux s Handbook of Toxicologic Pathology Volume 2


  • Author : Wanda M. Haschek
  • Publisher : Academic Press
  • Release Date : 2022-02-01
  • Genre: Medical
  • Pages : 950
  • ISBN 10 : 9780323910521

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Haschek and Rousseaux s Handbook of Toxicologic Pathology Volume 2 Excerpt :

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Two, Fourth Edition is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Sections discuss Toxicologic Pathology in Product Discovery and Safety Assessment, Safety Assessment and Data Interpretation, and Food and the Environment: Selected Toxic Agents. Completely revised with new chapters, this book is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Provides new chapters on gene therapy, stem cells, regenerative medicine, genome editing, and in-depth discussions of timely topics in toxicologic pathology Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Haschek and Rousseaux s Handbook of Toxicologic Pathology Book

Haschek and Rousseaux s Handbook of Toxicologic Pathology


  • Author : Wanda M. Haschek
  • Publisher : Academic Press
  • Release Date : 2013-05-01
  • Genre: Medical
  • Pages : 3054
  • ISBN 10 : 9780124157651

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Haschek and Rousseaux s Handbook of Toxicologic Pathology Excerpt :

Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Clinical Toxicology Testing Book

Clinical Toxicology Testing


  • Author : Barbarajean Magnani
  • Publisher : Unknown
  • Release Date : 2020
  • Genre: Toxicity testing
  • Pages : null
  • ISBN 10 : 1941096514

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Clinical Toxicology Testing Excerpt :

"A comprehensive overview of clinical laboratory toxicology services and analytes"--

A Comprehensive Guide to Toxicology in Preclinical Drug Development Book

A Comprehensive Guide to Toxicology in Preclinical Drug Development


  • Author : Ali S. Faqi
  • Publisher : Academic Press
  • Release Date : 2012-11-16
  • Genre: Medical
  • Pages : 885
  • ISBN 10 : 9780123878151

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A Comprehensive Guide to Toxicology in Preclinical Drug Development Excerpt :

A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. Chapters written by world-renowned contributors who are experts in their fields Includes the latest research in preclinical drug testing and international guidelines Covers preclinical toxicology in small molecules and biologics in one single source

Fundamentals of Toxicologic Pathology Book

Fundamentals of Toxicologic Pathology


  • Author : Wanda M. Haschek
  • Publisher : Academic Press
  • Release Date : 2009-11-23
  • Genre: Medical
  • Pages : 714
  • ISBN 10 : 0080919324

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Fundamentals of Toxicologic Pathology Excerpt :

Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology Second Edition updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists. 25% brand new information, fully revised throughout New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology New color photomicrographs detailing specific toxicant-induced diseases in animals Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels

Haschek and Rousseaux s Handbook of Toxicologic Pathology  Volume 2 Book

Haschek and Rousseaux s Handbook of Toxicologic Pathology Volume 2


  • Author : Wanda M. Haschek
  • Publisher : Academic Press
  • Release Date : 2022-06-15
  • Genre: Medical
  • Pages : 950
  • ISBN 10 : 0128210478

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Haschek and Rousseaux s Handbook of Toxicologic Pathology Volume 2 Excerpt :

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Two, Fourth Edition is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Sections discuss Toxicologic Pathology in Product Discovery and Safety Assessment, Safety Assessment and Data Interpretation, and Food and the Environment: Selected Toxic Agents. Completely revised with new chapters, this book is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Provides new chapters on gene therapy, stem cells, regenerative medicine, genome editing, and in-depth discussions of timely topics in toxicologic pathology Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Handbook of Toxicology  Second Edition Book

Handbook of Toxicology Second Edition


  • Author : Michael J. Derelanko
  • Publisher : CRC Press
  • Release Date : 2001-08-29
  • Genre: Medical
  • Pages : 1440
  • ISBN 10 : 1420042076

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Handbook of Toxicology Second Edition Excerpt :

LOCATE FREQUENTLY USED INFORMATION EASILY AND QUICKLY Working in the laboratory or office, you use a diverse assortment of basic information to design, conduct, and interpret toxicology studies and to perform risk assessments. The Second Edition of the best-selling Handbook of Toxicology gives you the information you need in a single reference source. NEW IN THIS EDITION: Expanded coverage of inhalation toxicology, neurotoxicology, and histopathology Additional regulatory chapters dealing with pesticides, medical devices, consumer products, and world-wide notification of new chemicals Areas of toxicology missing from the first edition such as ecotoxicology and in vitro toxicology A chapter providing extensive overview of the toxicology of metals Two chapters on basic male and female endocrinology and related toxicology Information on differences in physiological and biochemical parameters between children and adults References to Web site sources of valuable information Over 200 new tables and figures THE SINGLE SOURCE FOR THE INFORMATION YOU USE MOST FREQUENTLY Updated and expanded, this unique book includes practical reference information useful to toxicologists in the chemical and pharmaceutical industries, contract laboratories, regulatory agencies, and academia. To help you find information quickly and easily, data is arranged by toxicology subspecialty and each chapter begins with a detailed listing of information presented. Containing over 700 tables and figures, Handbook of Toxicology, Second Edition gives you a single source for the information you use most often.

Environmental Toxicants Book
Score: 5
From 1 Ratings

Environmental Toxicants


  • Author : Morton Lippmann
  • Publisher : John Wiley & Sons
  • Release Date : 2009-03-26
  • Genre: Science
  • Pages : 1200
  • ISBN 10 : 0470442883

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Environmental Toxicants Excerpt :

Provides the most current information and research available for performing risk assessments on exposed individuals and populations, giving guidance to public health authorities, primary care physicians, and industrial managers Reviews current knowledge on human exposure to selected chemical agents and physical factors in the ambient environment Updates and revises the previous edition, in light of current scientific literature and its significance to public health concerns Includes new chapters on: airline cabin exposures, arsenic, endocrine disruptors, and nanoparticles

Haschek and Rousseaux s Handbook of Toxicologic Pathology Book

Haschek and Rousseaux s Handbook of Toxicologic Pathology


  • Author : Wanda M. Haschek
  • Publisher : Academic Press
  • Release Date : 2002
  • Genre: Medical
  • Pages : 1706
  • ISBN 10 : UOM:39015053184597

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Haschek and Rousseaux s Handbook of Toxicologic Pathology Excerpt :

Volume 1: General Toxicologic Pathology -- Preface. -- Contributors. -- Part A: Basics of Toxicologic Pathology -- Toxicologic Pathology: An Introduction. -- Biochemical Basis of Toxicity. -- Morphologic Manifestation of Toxic Cell Injury. -- Organelle Biochemistry and Regulation of Cell Death. -- Carcinogenesis. -- Applied Clinical Pathology in Preclinical Toxicology Testing. -- Nomenclature. -- Part B: The Practice of Toxicologic Pathology -- Basic Techniques. -- Managing Pitfalls in Toxicologic Pathology. -- Special Techniques in Toxicologic Pathology. -- Application of New Technologies to Toxicologic Pathology. -- Issues in Laboratory Animal Science for the Toxicologic Pathologist. -- New Animal Models in Toxicology. -- Pathology Issues in the Design of Toxicology Studies. -- Use and Misuse of Statistics in the Design and Interpretation of Studies. -- Preparation of the Report for a Toxicology/Pathology Study. -- Part C: Selected Topics in Toxicologic Pathology -- Risk Assessment: ...

Pathology of the Developing Mouse Book

Pathology of the Developing Mouse


  • Author : Brad Bolon
  • Publisher : CRC Press
  • Release Date : 2015-04-24
  • Genre: Medical
  • Pages : 446
  • ISBN 10 : 9781420070095

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Pathology of the Developing Mouse Excerpt :

Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

Environmental Pathology Book

Environmental Pathology


  • Author : N. Karle Mottet
  • Publisher : Oxford University Press, USA
  • Release Date : 1985
  • Genre: Medical
  • Pages : 460
  • ISBN 10 : UOM:39015009528616

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Environmental Pathology Excerpt :

Fundamental Neuropathology for Pathologists and Toxicologists Book

Fundamental Neuropathology for Pathologists and Toxicologists


  • Author : Brad Bolon
  • Publisher : John Wiley & Sons
  • Release Date : 2011-08-08
  • Genre: Science
  • Pages : 648
  • ISBN 10 : 9781118002230

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Fundamental Neuropathology for Pathologists and Toxicologists Excerpt :

This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology – including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).

Toxicologic Pathology Book

Toxicologic Pathology


  • Author : Pritam S. Sahota
  • Publisher : CRC Press
  • Release Date : 2018-08-31
  • Genre: Medical
  • Pages : 1224
  • ISBN 10 : 9780429997457

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Toxicologic Pathology Excerpt :

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.