Helicases from All Domains of Life Book

Helicases from All Domains of Life


  • Author : Renu Tuteja
  • Publisher : Academic Press
  • Release Date : 2018-09-21
  • Genre: Science
  • Pages : 298
  • ISBN 10 : 9780128146866

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Helicases from All Domains of Life Excerpt :

Helicases from All Domains of Life is the first book to compile information about helicases from many different organisms in a single volume. Research in the helicase field has been going on for a long time now, but the completion of so many genomes of these ubiquitous enzymes has made it difficult to keep up with new discoveries. As the huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make it difficult for the interested scholar to grasp a comprehensive view of the field, this book helps fill in the gaps. Presents updates on the functions and features of helicases across the different kingdoms Begins with a chapter on the evolutionary history of helicases Contains specific chapters on selected helicases of great importance from a biological/applicative point-of-view

The DNA Replication Machinery as Therapeutic Targets Book

The DNA Replication Machinery as Therapeutic Targets


  • Author : Andrew F. Gardner
  • Publisher : Frontiers Media SA
  • Release Date : 2019-09-19
  • Genre: Uncategoriezed
  • Pages : 144
  • ISBN 10 : 9782889459278

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The DNA Replication Machinery as Therapeutic Targets Excerpt :

In all organisms, the DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Inhibitors of replication proteins are commonly used in anti-cancer and anti-viral therapies. This eBook on “The DNA Replication Machinery as Therapeutic Targets” examines the normal functions of replication proteins as well as strategies to target each step during the replication process including DNA unwinding, DNA synthesis, and DNA damage bypass and repair. Articles discuss current strategies to develop drugs targeting DNA replication proteins as well as future outlooks and needs.

DNA Helicases and DNA Motor Proteins Book

DNA Helicases and DNA Motor Proteins


  • Author : Maria Spies
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-11-19
  • Genre: Medical
  • Pages : 299
  • ISBN 10 : 9781461450375

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DNA Helicases and DNA Motor Proteins Excerpt :

In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.

Metagenomic Systems Biology Book

Metagenomic Systems Biology


  • Author : Shailza Singh
  • Publisher : Springer Nature
  • Release Date : 2021-01-08
  • Genre: Science
  • Pages : 205
  • ISBN 10 : 9789811585623

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Metagenomic Systems Biology Excerpt :

The book serves as an amalgamation of knowledge and principles used in the area of systems and synthetic biology, and targets inter-disciplinary research groups. The readers from diversified areas would be benefited by the valuable resources and information available in one book. Microbiome projects with efficient data handling can fuel progress in the area of microbial synthetic biology by providing a ready to use plug and play chassis. Advances in gene editing technology such as the use of tailor made synthetic transcription factors will further enhance the availability of synthetic devices to be applied in the fields of environment, agriculture and health. The different chapters of the book reviews a broad range of topics, including food microbiome in ecology, use of microbiome in personalized medicine, machine learning in biomedicine. The book also describes ways to harness and exploit the incredible amounts of genomic data. The book is not only limited to medicine but also caters to the needs of environmentalists, biochemical engineers etc. It will be of interest to advanced students and researchers in life sciences, computational biology, microbiology and other inter-disciplinary areas.

Helicase Enzymes Part B Book

Helicase Enzymes Part B


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2022-08-15
  • Genre: Science
  • Pages : 538
  • ISBN 10 : 9780323997744

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Helicase Enzymes Part B Excerpt :

Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Updated release includes the latest information on Helicase Enzymes

Advances in Aquatic Invertebrate Stem Cell Research Book

Advances in Aquatic Invertebrate Stem Cell Research


  • Author : Loriano Ballarin
  • Publisher : MDPI
  • Release Date : 2022-01-28
  • Genre: Science
  • Pages : 398
  • ISBN 10 : 9783036516363

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Advances in Aquatic Invertebrate Stem Cell Research Excerpt :

This publication is based upon work from COST Action ’16203 MARISTEM Stem cells of marine/aquatic invertebrates: from basic research to innovative applications’, supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. www.cost.eu Aquatic invertebrates represent the largest biodiversity and the widest phylogenetic radiation on Earth, with more than 2 million known species. Up until a few years ago, their use as model organisms in biological research was limited by the paucity of omics data. Recently, the situation has rapidly changed and is still changing. Today, the genomes and various transcriptomes of many aquatic invertebrate species, as well as many recombinant proteins of invertebrate origin, are available. New technologies have revolutionized the available toolbox of research methodologies. This explains the rising interest of researchers in the use of aquatic invertebrates as reliable model organisms. In contrast to the prevalence of diverse oligopotent and unipotent stem cells in vertebrates, aquatic invertebrates (especially non-ecdysozoan invertebrates) exhibit multiple adult cell types with stem cell attributes characterized by multipotency and pluripotency; furthermore, these give rise to cell lineages characteristic of more than a single germ layer, sometimes with somatic and germ line potentials. In addition, unlike vertebrates, aquatic invertebrate adult stem cells are disseminated and widespread inside the animal body, are not associated with a regulatory microenvironment (niche) and do participate in aging and regeneration phenomena. These properties can help us to better understand the processes and phenomena in mammalian stem cell biology

Molecular Themes in DNA Replication Book

Molecular Themes in DNA Replication


  • Author : Lynne S Cox
  • Publisher : Royal Society of Chemistry
  • Release Date : 2009-10-31
  • Genre: Science
  • Pages : 315
  • ISBN 10 : 9781847559852

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Molecular Themes in DNA Replication Excerpt :

DNA replication, the process of copying one double stranded DNA molecule to form two identical copies, is highly conserved at the mechanistic level across evolution. Interesting in its own right as a fascinating feat of biochemical regulation and coordination, DNA replication is at the heart of modern advances in molecular biology. An understanding of the process at both the biological and chemical level is essential to developing new techniques in molecular biology. Insights into the process at the molecular level provide opportunities to modulate and intervene in replication. Rapidly dividing cells need to replicate their DNA prior to division, and targeting components of the replication process is a potentially powerful strategy in cancer treatment. Conversely, ageing may be associated with loss of replication activity and restoring it to cells may moderate some of the diseases associated with old age. Replication is, therefore, fundamental to a huge range of molecular biological and biochemical applications, and provides many potential targets for drug design. The fast pace of replication research, particularly in providing new structural insights, has outdated the majority of available texts. This learned, yet accessible, book contains the latest research written by those conducting it. It examines conserved themes providing a biological background for biochemical, chemical and pharmaceutical studies of this huge and exciting field. Rather than simply "itemising" the replication steps and the proteins involved, replication is tackled from a novel perspective. The book provides logical groupings of processes based upon biochemical similarities. The emphasis on mechanisms and the relationship between structure and function targets the chapters towards biochemists and biological chemists as well as molecular and cell biologists. The book highlights new insights into the replication process, from the assembly of pre-replication complexes, through polymerisation mec

Encyclopedia of Cell Biology Book

Encyclopedia of Cell Biology


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2015-08-07
  • Genre: Science
  • Pages : 3008
  • ISBN 10 : 9780123947963

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Encyclopedia of Cell Biology Excerpt :

The Encyclopedia of Cell Biology offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

RNA Helicases Book

RNA Helicases


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2012-11-13
  • Genre: Science
  • Pages : 584
  • ISBN 10 : 9780123972293

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RNA Helicases Excerpt :

This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes

DNA Replication Controls  Volume 1 Book

DNA Replication Controls Volume 1


  • Author : Eishi Noguchi
  • Publisher : MDPI
  • Release Date : 2018-04-27
  • Genre: Electronic books
  • Pages : 313
  • ISBN 10 : 9783038425687

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DNA Replication Controls Volume 1 Excerpt :

This book is a printed edition of the Special Issue "DNA Replication Controls" that was published in Genes

DNA Repair Book

DNA Repair


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-10-16
  • Genre: Science
  • Pages : 354
  • ISBN 10 : 9780128173978

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DNA Repair Excerpt :

DNA Repair, Volume 45 in The Enzymes series highlights new advances in the field, with this new volume presenting interesting chapters on DNA polymerase beta and other gap-filling enzymes in mammalian base excision repair, Translesion polymerases, mechanism and function, The Rev1-Pol? Mutasome: Structure and Interactions in Translesion Synthesis, Challenges for base excision repair enzymes: acquiring access to damaged DNA in chromatin Nucleotide excision repair, DNA damage recognition mechanisms in mammalian nucleotide excision repair, Advances in understanding DNA mismatch repair, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series

Joint Polish German Crystallographic Meeting  February 24   27  2020  Wroc  aw  Poland Book

Joint Polish German Crystallographic Meeting February 24 27 2020 Wroc aw Poland


  • Author : Anonim
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release Date : 2020-02-24
  • Genre: Science
  • Pages : 134
  • ISBN 10 : 9783110692914

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Joint Polish German Crystallographic Meeting February 24 27 2020 Wroc aw Poland Excerpt :

Zeitschrift für Kristallographie. Supplement Volume 40 presents the complete Abstracts of all contributions to the Joint Polish-German Crystallographic Meeting in Wroclaw (Poland) 2020: - Plenary Talks - Microsymposia - Poster Session Supplement Series of Zeitschrift für Kristallographie publishes Abstracts of international conferences on the interdisciplinary field of crystallography.

Protein Dimerization and Oligomerization in Biology Book

Protein Dimerization and Oligomerization in Biology


  • Author : Jacqueline M. Matthews
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-09-04
  • Genre: Medical
  • Pages : 170
  • ISBN 10 : 9781461432296

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Protein Dimerization and Oligomerization in Biology Excerpt :

This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.

Handbook of Molecular Microbial Ecology II Book

Handbook of Molecular Microbial Ecology II


  • Author : Frans J. de Bruijn
  • Publisher : John Wiley & Sons
  • Release Date : 2011-10-14
  • Genre: Science
  • Pages : 600
  • ISBN 10 : 9781118010532

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Handbook of Molecular Microbial Ecology II Excerpt :

The premiere two-volume reference on revelations from studying complex microbial communities in many distinct habitats Metagenomics is an emerging field that has changed the way microbiologists study microorganisms. It involves the genomic analysis of microorganisms by extraction and cloning of DNA from a group of microorganisms, or the direct use of the purified DNA or RNA for sequencing, which allows scientists to bypass the usual protocol of isolating and culturing individual microbial species. This method is now used in laboratories across the globe to study microorganism diversity and for isolating novel medical and industrial compounds. Handbook of Molecular Microbial Ecology is the first comprehensive two-volume reference to cover unculturable microorganisms in a large variety of habitats, which could not previously have been analyzed without metagenomic methodology. It features review articles as well as a large number of case studies, based largely on original publications and written by international experts. This second volume, Metagenomics in Different Habitats, covers such topics as: Viral genomes Metagenomics studies in a variety of habitats, including marine environments and lakes, soil, and human and animal digestive tracts Other habitats, including those involving microbiome diversity in human saliva and functional intestinal metagenomics; diversity of archaea in terrestrial hot springs; and microbial communities living at the surface of building stones Biodegradation Biocatalysts and natural products A special feature of this book is the highlighting of the databases and computer programs used in each study; they are listed along with their sites in order to facilitate the computer-assisted analysis of the vast amount of data generated by metagenomic studies. Such studies in a variety of habitats are described here, which present a large number of different system-dependent approaches in greatly differing habitats. Handbook of Molecular Microbial E

RNA Polymerases as Molecular Motors Book

RNA Polymerases as Molecular Motors


  • Author : Robert Landick
  • Publisher : Royal Society of Chemistry
  • Release Date : 2021-11-23
  • Genre: Science
  • Pages : 252
  • ISBN 10 : 9781839160660

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RNA Polymerases as Molecular Motors Excerpt :

To thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.