Hepatitis C in Developing Countries Book

Hepatitis C in Developing Countries


  • Author : Sanaa M. Kamal
  • Publisher : Academic Press
  • Release Date : 2017-11-23
  • Genre: Science
  • Pages : 278
  • ISBN 10 : 9780128032343

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Hepatitis C in Developing Countries Excerpt :

Hepatitis C in Developing Countries: Current and Future Challenges explores the current state of HCV in several countries, including Africa, Asia and South America. It maintains a dedicated focus on the epidemiology, clinical patterns, virologic diversity, coinfections, natural history and progression, complications, and response to standard of care (SOC) pegylated interferon and ribavirin therapy of HCV with recommendations specific to middle and low income countries. Readers will find detailed information on the burden of HCV infection from a global health and economic perspective, along with data from multicenter trials on DAAs that have enrolled patients infected with HCV non-genotype 1. Features coverage on the prevention of, or inhibition of, liver fibrosis, cirrhosis, and hepatocellular carcinoma Presents data from trials on patients with diverse ethnic backgrounds and those infected with genotypes 3, 4, 5, 6 Addresses the epidemiology, modes of transmission, socio-political aspects, genotypes, and co-infections of Hepatitis C

Hepatitis C in Developing Countries Book

Hepatitis C in Developing Countries


  • Author : Sanaa M. Kamal
  • Publisher : Academic Press
  • Release Date : 2017-11-23
  • Genre: Hepatitis C
  • Pages : 278
  • ISBN 10 : 0128032332

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Hepatitis C in Developing Countries Excerpt :

Hepatitis C in Developing Countries: Current and Future Challenges explores the current state of HCV in several countries, including Africa, Asia and South America. It maintains a dedicated focus on the epidemiology, clinical patterns, virologic diversity, coinfections, natural history and progression, complications, and response to standard of care (SOC) pegylated interferon and ribavirin therapy of HCV with recommendations specific to middle and low income countries. Readers will find detailed information on the burden of HCV infection from a global health and economic perspective, along with data from multicenter trials on DAAs that have enrolled patients infected with HCV non-genotype 1. Features coverage on the prevention of, or inhibition of, liver fibrosis, cirrhosis, and hepatocellular carcinoma Presents data from trials on patients with diverse ethnic backgrounds and those infected with genotypes 3, 4, 5, 6 Addresses the epidemiology, modes of transmission, socio-political aspects, genotypes, and co-infections of Hepatitis C

Guidelines for the Screening Care and Treatment of Persons with Chronic Hepatitis C Infection Updated Version April 2016 Book

Guidelines for the Screening Care and Treatment of Persons with Chronic Hepatitis C Infection Updated Version April 2016


  • Author : World Health Organization
  • Publisher : World Health Organization
  • Release Date : 2016-04-30
  • Genre: Medical
  • Pages : 140
  • ISBN 10 : 9789241549615

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Guidelines for the Screening Care and Treatment of Persons with Chronic Hepatitis C Infection Updated Version April 2016 Excerpt :

The field of HCV therapeutics continues to evolve rapidly and since the World Health Organization (WHO) issued its first Guidelines for the screening care and treatment of persons with hepatitis C infection in 2014 several new medicines have been approved by at least one stringent regulatory authority. These medicines called direct-acting antivirals (DAAs) are transforming the treatment of HCV enabling regimens that can be administered orally are of shorter duration (as short as eight weeks) result in cure rates higher than 90% and are associated with fewer serious adverse events than the previous interfere on containing regimens. WHO is updating its hepatitis C treatment guidelines to provide recommendations for the use of these new medicines. The objectives of these WHO guidelines are to provide updated evidence-based recommendations for the treatment of persons with hepatitis C infection using where possible all DAA-only combinations. The guidelines also provide recommendations on the preferred regimens based on a patient?s HCV genotype and clinical history and assess the appropriateness of continued use of certain medicines. This document also includes existing recommendations on screening for HCV infection and care of persons infected with HCV that were first issued in 2014. The key audience for these guidelines are policy-makers in low- and middle-income countries who formulate country-specific treatment guidelines and who plan infectious disease treatment programmes and services in addition to those people responsible for delivering treatment. The guidelines are appropriate for all countries including high-income countries.

Clinical Dilemmas in Viral Liver Disease Book

Clinical Dilemmas in Viral Liver Disease


  • Author : Graham R. Foster
  • Publisher : John Wiley & Sons
  • Release Date : 2020-03-19
  • Genre: Medical
  • Pages : 272
  • ISBN 10 : 9781119533443

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Clinical Dilemmas in Viral Liver Disease Excerpt :

The only evidence-based book to approach viral liver disease by focusing exclusively on the clinical dilemmas encountered by hepatologists and their medical teams Although viral hepatitis is a growing public health risk around the world, the World Health Organization (WHO) views the elimination of hepatitis infection over the next several as an achievable goal. Effective pharmaceutical therapies are now available, yet medical teams caring for patients with viral hepatitis are challenged when looking for answers to specific questions in the current medical literature. The second edition of Clinical Dilemmas in Viral Liver Disease provides evidence-based guidance for medical teams involved in diagnosing, treating, and managing patients with viral liver disease. This fully updated book explores developments in new treatments and new diagnostic approaches that are contributing to WHO goals of viral elimination. Brief, easily referenced chapters examine clearly defined topics, addressing the clinical questions and difficulties encountered by medical teams in day-to-day practice. Contributions by an international team of investigators and clinicians address clinical questions and issues which are seldom found in standard textbooks and online repositories. Offering practical guidance on the specific challenges and dilemmas of treating viral liver disease, this unique volume: Provides practical, evidence-based guidance on topical and controversial issues Addresses understudied questions that arise in day-to-day clinical practice Discusses the challenges surrounding global elimination programs Presents focused approach that is supported by current literature and expert opinion The second edition of Clinical Dilemmas in Viral Liver Disease is required reading for practicing and trainee hepatologists, gastroenterologists, transplant surgeons, virologists, and other practitioners involved in caring for patients with liver disease.

Eliminating the Public Health Problem of Hepatitis B and C in the United States Book

Eliminating the Public Health Problem of Hepatitis B and C in the United States


  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Release Date : 2016-06-01
  • Genre: Medical
  • Pages : 186
  • ISBN 10 : 9780309438025

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Eliminating the Public Health Problem of Hepatitis B and C in the United States Excerpt :

Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.

Guidelines on Hepatitis B and C Testing Book

Guidelines on Hepatitis B and C Testing


  • Author : World Health Organization
  • Publisher : Unknown
  • Release Date : 2018-02-06
  • Genre: Medical
  • Pages : 202
  • ISBN 10 : 924154998X

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Guidelines on Hepatitis B and C Testing Excerpt :

Testing and diagnosis of hepatitis B (HBV) and C (HCV) infection is the gateway for access to both prevention and treatment services, and is a crucial component of an effective response to the hepatitis epidemic. Early identification of persons with chronic HBV or HCV infection enables them to receive the necessary care and treatment to prevent or delay progression of liver disease. Testing also provides an opportunity to link people to interventions to reduce transmission, through counselling on risk behaviors and provision of prevention commodities (such as sterile needles and syringes) and hepatitis B vaccination. These are the first WHO guidelines on testing for chronic HBV and HCV infection and complement published guidance by WHO on the prevention, care and treatment of chronic hepatitis C and hepatitis B infection. These guidelines outline the public health approach to strengthening and expanding current testing practices for HBV and HCV, and are intended for use across age groups and populations.

Advances in Treatment of Hepatitis C and B Book

Advances in Treatment of Hepatitis C and B


  • Author : Naglaa Allam
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-03-08
  • Genre: Medical
  • Pages : 408
  • ISBN 10 : 9789535129936

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Advances in Treatment of Hepatitis C and B Excerpt :

As in many areas of medicine, treatment of viral hepatitis has seen an acceleration of change driven by new therapies and evolving technology. Thanks to the direct-acting antiviral agents (DAAs), the era of HCV eradication and cure has begun. As regards to hepatitis B therapy, potent antiviral drugs for suppression of viral replication are available, new research activities to enhance eradication are visible, and these may influence clinical practice in the coming years. This book covers the latest advances in hepatitis C and hepatitis B therapeutics as well as the emerging and investigational treatment strategies. "Advances in Treatment of Hepatitis C and Hepatitis B" book is an up-to-date source of information for physicians, residents, and advanced medical students seeking a broader understanding of treatment of viral hepatitis. The authors of the chapters come from many eminent centers around the world and are experts in their respective fields.

Hepatitis C Virus  From Molecular Virology to Antiviral Therapy Book

Hepatitis C Virus From Molecular Virology to Antiviral Therapy


  • Author : Ralf Bartenschlager
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-12
  • Genre: Medical
  • Pages : 346
  • ISBN 10 : 9783642273407

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Hepatitis C Virus From Molecular Virology to Antiviral Therapy Excerpt :

Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.

Viral Hepatitis  Chronic Hepatitis C Book

Viral Hepatitis Chronic Hepatitis C


  • Author : Resat Ozaras
  • Publisher : Springer
  • Release Date : 2019-06-21
  • Genre: Medical
  • Pages : 217
  • ISBN 10 : 9783030037574

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Viral Hepatitis Chronic Hepatitis C Excerpt :

This book presents up-to-date, practically oriented information on major topics in chronic hepatitis C. The coverage encompasses epidemiology; diagnosis, including molecular methods; treatment and challenges; and the management of co-infections. Readers will find guidance on pretherapeutic evaluation with respect to disease severity and extrahepatic manifestations. Resistance to antiviral treatment and its management are discussed, and the nature of optimal follow-up is addressed in detail. Treatment of HCV/HIV co-infection is considered separately, and the approach in special patient populations is thoroughly examined. Chronic Hepatitis C will be of high value for general practitioners and specialists in gastroenterology, infectious diseases, and internal medicine. It will be international in scope in terms of both authorship and appeal.

Saliva Protection and Transmissible Diseases Book

Saliva Protection and Transmissible Diseases


  • Author : Crispian Scully
  • Publisher : Academic Press
  • Release Date : 2017-07-19
  • Genre: Medical
  • Pages : 122
  • ISBN 10 : 9780128136829

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Saliva Protection and Transmissible Diseases Excerpt :

Saliva Protection and Transmissible Diseases provides a review of saliva protection, raising debate on micro-organisms potentially transmissible in saliva, and also considering the evidence on diseases that may be transmitted by kissing. Saliva is a complex body fluid essential to health, especially mastication, swallowing and speech, and hyposalivation can lead to dysfunction and even infection. More serious pathogens, such as herpes viruses and papillomaviruses can be conveyed by kissing, as can potentially lethal micro-organisms present in some saliva, such as meningococci, fungal organisms and Ebola viruses. Stipulates the defensive roles of saliva, an important topic not previously reviewed in-depth in literature Provides awareness that saliva also transmits infectious agents that can produce serious or even lethal diseases Gives understanding that kissing may be an at-risk practice

Hepatitis C Book

Hepatitis C


  • Author : Imran Shahid
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-10-10
  • Genre: Medical
  • Pages : 214
  • ISBN 10 : 9781789842074

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Hepatitis C Excerpt :

The propagation of hepatitis C from acute to chronic infection and afterward to end-stage liver diseases (hepatic fibrosis, cirrhosis, and hepatocellular carcinoma) involves a highly orchestrated series of molecular and cellular events, including a plethora of genes and cell signaling cascades. The treatment paradigms was revolutionized after the development and approval of all oral interferon-free direct-acting antivirals achieving higher sustained virologic response rates in treated individuals. This book pragmatically overviews the intricate interplay between viral and host factors during hepatitis C virus infection progression, as well as other hepatitis C-associated clinical implications. Hepatitis C - From Infection to Cure also provides up-to-date information about hepatitis C cures for clinicians, physicians, and healthcare providers with an ample understanding of the current treatment horizon, as well as other investigational and emerging treatment strategies. The authors with their valuable scientific contributions belong to many eminent institutes around the world and are much experienced in hepatitis C virology, pathology, and therapeutics.

CDC Yellow Book 2018  Health Information for International Travel Book

CDC Yellow Book 2018 Health Information for International Travel


  • Author : Centers for Disease Control and Prevention CDC
  • Publisher : Oxford University Press
  • Release Date : 2017-04-17
  • Genre: Medical
  • Pages : 672
  • ISBN 10 : 9780190628635

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CDC Yellow Book 2018 Health Information for International Travel Excerpt :

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Hepatitis C Book

Hepatitis C


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2000-10-09
  • Genre: Medical
  • Pages : 493
  • ISBN 10 : 0080533914

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Hepatitis C Excerpt :

The anticipated encore volume of the Biomedical Research Reports Series, Hepatitis C is the first book that offers comprehensive and up-to-date coverage of this "silent epidemic." The subject matter ranges from basic science to clinical medicine, with contributions from more than 30 international experts in the field. This important new book details the hepatitis C virus and the disease that it causes, including its prevalence, means of spread, symptoms, complications, natural history, prevention, and therapy. The editors, T. Jake Liang, M.D., and Jay H. Hoofnagle, M.D., are both hepatologists and clinical and laboratory researchers who are well known leaders in the hepatitis field. Their team of authors provide the latest information on key issues such as the role of hepatitis C in liver cancer and evolving therapy for hepatitis C, including special subgroups of patients such as children, patients with renal failure, patients undergoing liver transplantation, and patients with HIV coinfection. The book also addresses future directions in antiviral therapy of hepatitis C and the real challenges of developing a vaccine. Hepatitis C is the integrated reference book for all researchers, clinicians, and students dealing with this troubling virus. Key Features * Provides comprehensive coverage of hepatitis C, ranging from basic science to clinical application * Includes contributions from more than 30 international experts in the field * Supplies current recommendations on management of hepatitis C * Designed in an easy-to-use format with consistent organization * Includes extensive illustrations

HCV  The Journey from Discovery to a Cure Book

HCV The Journey from Discovery to a Cure


  • Author : Michael J. Sofia
  • Publisher : Springer Nature
  • Release Date : 2019-11-23
  • Genre: Science
  • Pages : 463
  • ISBN 10 : 9783030282073

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HCV The Journey from Discovery to a Cure Excerpt :

Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the development of a whole cell system to study the virus spurred the search for novel direct acting antiviral drugs to cure this disease. This global effort culminated in the development of direct acting antiviral drugs that led to cure rates approaching 100% in all patient populations after only 8-12 weeks of therapy. These efforts resulted in one of the greatest achievements in public health and provides the potential for eliminating HCV as a major disease worldwide. This volume is aimed at a broad audience of academic and industrial scientists interested in the discovery and development of drugs to treat viral diseases and those interested in reading about one of the most unique accomplishments in biomedical research. The volume will provide a one of a kind reference work that highlights the many efforts, from the discovery of the HCV virus, to the invention of breakthrough medicines and their use in the real world to cure patients. It is the companion book to the volume "HCV: The Journey from Discovery to a Cure - Volume II".

Consults in Obstetric Anesthesiology Book

Consults in Obstetric Anesthesiology


  • Author : Suzanne K. W. Mankowitz
  • Publisher : Springer
  • Release Date : 2018-11-15
  • Genre: Medical
  • Pages : 699
  • ISBN 10 : 9783319596808

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Consults in Obstetric Anesthesiology Excerpt :

This text addresses the need for a book specifically aimed at obstetric anesthesia and covers topics such as pulmonary, cardiac renal, hepatic, hematologic, neurologic, endocrine and other diseases. The real anesthetic challenge arises when patients present to Labor and Delivery with unusual or complicated medical problems and, in recent years, a few of the larger institutions have developed an Obstetric Anesthesiology Consultation Service to prepare for the management of these patients. While most pregnant women who present to Labor and Delivery require anesthetic intervention, they typically meet the anesthesiologist for the first time in labor. Since the majority of laboring women are healthy without significant comorbidities, this does not present much of a challenge to the anesthesiologist and the anesthetic management tends to be straight-forward with favorable outcomes. However, using this new model, the anesthesiologist has the opportunity to discuss the various treatment modalities and potentially suggest diagnostic testing to be performed prior to delivery, similar to the pre-operative testing that is done in other surgical environments.