Host Response to Biomaterials Book

Host Response to Biomaterials

  • Author : Stephen F Badylak
  • Publisher : Academic Press
  • Release Date : 2015-05-08
  • Genre: Technology & Engineering
  • Pages : 460
  • ISBN 10 : 9780128005002

Host Response to Biomaterials Excerpt :

Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices

Biosurfaces Book


  • Author : Kantesh Balani
  • Publisher : John Wiley & Sons
  • Release Date : 2015-01-23
  • Genre: Technology & Engineering
  • Pages : 392
  • ISBN 10 : 9781118950647

Biosurfaces Excerpt :

Ideal as a graduate textbook, this title is aimed at helpingdesign effective biomaterials, taking into account the complexinteractions that occur at the interface when a synthetic materialis inserted into a living system. Surface reactivity,biochemistry, substrates, cleaning, preparation, and coatingsare presented, with numerous case studies and applicationsthroughout. Highlights include: Starts with concepts and works up to real-life applicationssuch as implantable devices, medical devices, prosthetics, and drugdelivery technology Addresses surface reactivity, requirements for surface coating,cleaning and preparation techniques, and characterization Discusses the biological response to coatings Addresses biomaterial-tissue interaction Incorporates nanomechanical properties and processingstrategies

Immunomodulatory Biomaterials Book

Immunomodulatory Biomaterials

  • Author : Stephen F. Badylak
  • Publisher : Woodhead Publishing
  • Release Date : 2021-07-30
  • Genre: Medical
  • Pages : 294
  • ISBN 10 : 9780128214565

Immunomodulatory Biomaterials Excerpt :

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tiss

The Immune Response to Implanted Materials and Devices Book

The Immune Response to Implanted Materials and Devices

  • Author : Bruna Corradetti
  • Publisher : Springer
  • Release Date : 2016-11-30
  • Genre: Technology & Engineering
  • Pages : 241
  • ISBN 10 : 9783319454337

The Immune Response to Implanted Materials and Devices Excerpt :

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Biomaterials in Regenerative Medicine and the Immune System Book

Biomaterials in Regenerative Medicine and the Immune System

  • Author : Laura Santambrogio
  • Publisher : Springer
  • Release Date : 2015-09-04
  • Genre: Technology & Engineering
  • Pages : 280
  • ISBN 10 : 9783319180458

Biomaterials in Regenerative Medicine and the Immune System Excerpt :

The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses.

Biomaterials and Immune Response Book

Biomaterials and Immune Response

  • Author : Nihal Engin Vrana
  • Publisher : CRC Press
  • Release Date : 2018-07-20
  • Genre: Medical
  • Pages : 328
  • ISBN 10 : 9781351377553

Biomaterials and Immune Response Excerpt :

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Regenerative Medicine Applications in Organ Transplantation Book

Regenerative Medicine Applications in Organ Transplantation

  • Author : Giuseppe Orlando
  • Publisher : Academic Press
  • Release Date : 2013-10-11
  • Genre: Technology & Engineering
  • Pages : 1050
  • ISBN 10 : 9780123985200

Regenerative Medicine Applications in Organ Transplantation Excerpt :

Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions

Engineering Biomaterials for Regenerative Medicine Book

Engineering Biomaterials for Regenerative Medicine

  • Author : Sujata K. Bhatia
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-11-10
  • Genre: Technology & Engineering
  • Pages : 354
  • ISBN 10 : 1461410800

Engineering Biomaterials for Regenerative Medicine Excerpt :

Regeneration of tissues and organs remains one of the great challenges of clinical medicine, and physicians are constantly seeking better methods for tissue repair and replacement. Tissue engineering and regenerative medicine have been investigated for virtually every organ system in the human body, and progress is made possible by advances in materials science, polymer chemistry, and molecular biology. This book reviews the current status of biomaterials for regenerative medicine, and highlights advances in both basic science and clinical practice. The latest methods for regulating the biological and chemical composition of biomaterials are described, together with techniques for modulating mechanical properties of engineered constructs. Contributors delineate methods for guiding the host response to implantable materials, and explain the use of biologically-inspired materials for optimal biological functionality and compatibility. The book culminates in a discussion of the clinical applications of regenerative medicine. By integrating engineering and clinical medicine, Engineering Biomaterials for Regenerative Medicine examines how tissue engineering and regenerative medicine can be translated into successful therapies to bridge the gap between laboratory and clinic. The book will aid materials scientists and engineers in identifying research priorities to fulfill clinical needs, and will also enable physicians to understand novel biomaterials that are emerging in the clinic. This integrated approach also gives engineering students a sense of the excitement and relevance of materials science in the development of novel therapeutic strategies.

Biologically responsive Hybrid Biomaterials Book
Score: 5
From 1 Ratings

Biologically responsive Hybrid Biomaterials

  • Author : Esmaiel Jabbari
  • Publisher : World Scientific
  • Release Date : 2010
  • Genre: Medical
  • Pages : 430
  • ISBN 10 : 9789814295680

Biologically responsive Hybrid Biomaterials Excerpt :

Conjugation of synthetic materials with cell-responsive biologically-active molecules, in addition to providing structural support and release of biomolecules in the regenerating region, can provide the signaling factors required to initiate the cascade of cell migration, adhesion, differentiation, maturation, growth factor modulation, maintenance of matrix integrity, and tissue morphogenesis. Nanoparticles conjugated with ligands that preferentially interact with cell surface receptors in the tumor environment have the potential to drastically improve bioavailability, selectivity and residence time of the chemotherapeutic agent in the tumor microenvironment, while limiting their peripheral toxicity. Multivalent presentation of tumor-associated antigens on a targeted delivery system containing T and B cell epitopes can result in strong, long-lasting, self-adjuvant immunity against cancer and other diseases in vaccination. These examples demonstrate that cell-responsive conjugate biomaterials have profoundly impacted the medical field. This book is divided into three sections. In the first section, synthesis and characterization, conformation, structure-activity, self-assembly, and host response of conjugate hybrid biomaterials are covered. The second section is dedicated to the applications of conjugate biomaterials in drug delivery and vaccination while the last section is devoted to tissue engineering applications including cell adhesion, control of the stem cell niche, cartilage regeneration, neural and vascular tissue engineering, and dynamic cell culture systems for functionalized biomaterials. There is no doubt that biologically-responsive conjugate biomaterials play a key role in the design of biologics and medical devices, and this pioneering reference book provides a comprehensive review on synthesis, characterization, structure-activity, 3D assembly/fabrication, host response and the emerging applications of conjugate hybrid biomaterials.

In Situ Tissue Regeneration Book

In Situ Tissue Regeneration

  • Author : Sang Jin Lee
  • Publisher : Academic Press
  • Release Date : 2016-07-17
  • Genre: Medical
  • Pages : 458
  • ISBN 10 : 9780128025000

In Situ Tissue Regeneration Excerpt :

In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. Explores the body’s ability to mobilize endogenous stem cells to the site of injury Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume Features chapter authors and editors who are authorities in this emerging field Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

An Introduction to Biomaterials Book
Score: 3.5
From 2 Ratings

An Introduction to Biomaterials

  • Author : Jeffrey O. Hollinger
  • Publisher : CRC Press
  • Release Date : 2005-12-21
  • Genre: Medical
  • Pages : 586
  • ISBN 10 : 0849322820

An Introduction to Biomaterials Excerpt :

The complexity of biological systems and the need to design and develop biomedical therapies poses major challenges to professionals in the biomedical disciplines. An Introduction to Biomaterials emphasizes applications of biomaterials for patient care. Containing chapters prepared by leading authorities on key biomaterial types, this book underscores the process of biomaterial design, development directed toward clinical application, and testing that leads to therapies for clinical targets. The authors provide a lucid perspective on the standards available and the logic behind the standards in which biomaterials address clinical needs. This volume includes chapters on consensus standards and regulatory approaches to testing paradigms, followed by an analysis of specific classes of biomaterials. The book closes with sections on clinical topics that integrate materials sciences and patient applications.

Biomaterials Science Book

Biomaterials Science

  • Author : William R Wagner
  • Publisher : Academic Press
  • Release Date : 2020-05-23
  • Genre: Medical
  • Pages : 1616
  • ISBN 10 : 9780128161388

Biomaterials Science Excerpt :

The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for most chapters

Biomaterials Book


  • Author : Véronique Migonney
  • Publisher : John Wiley & Sons
  • Release Date : 2014-10-13
  • Genre: Science
  • Pages : 248
  • ISBN 10 : 9781119043676

Biomaterials Excerpt :

Discovered in the 20th century, biomaterials have contributed to many of the incredible scientific and technological advancements made in recent decades. This book introduces and details the tenets of biomaterials, their relevance in a various fields, practical applications of their products, and potential advancements of the years to come. A comprehensive resource, the text covers the reasons that certain properties of biomaterials contribute to specific applications, and students and researchers will appreciate this exhaustive textbook.

Safety of Silicone Breast Implants Book

Safety of Silicone Breast Implants

  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2000-01-06
  • Genre: Medical
  • Pages : 560
  • ISBN 10 : 9780309132756

Safety of Silicone Breast Implants Excerpt :

The Dow Corning case raised serious questions about the safety of silicone breast implants and about larger issues of medical device testing and patient education. Safety of Silicone Breast Implants presents a well-documented, thoughtful exploration of the safety of these devices, drawing conclusions from the available research base and suggesting further questions to be answered. This book also examines the sensitive issues surrounding women's decisions about implants. In reaching conclusions, the committee reviews: The history of the silicone breast implant and the development of its chemistry. The wide variety of U.S.-made implants and their regulation by the Food and Drug Administration. Frequency and consequences of local complications from implants. The evidence for and against links between implants and autoimmune disorders, connective tissue disease, neurological problems, silicone in breast milk, or a proposed new syndrome. Evidence that implants may be associated with lower frequencies of breast cancer. Safety of Silicone Breast Implants provides a comprehensive, well-organized review of the science behind one of the most significant medical controversies of our time.

Bone Augmentation by Anatomical Region Book

Bone Augmentation by Anatomical Region

  • Author : Zvi Artzi
  • Publisher : John Wiley & Sons
  • Release Date : 2020-05-15
  • Genre: Medical
  • Pages : 560
  • ISBN 10 : 9781119427902

Bone Augmentation by Anatomical Region Excerpt :

Comprehensively describes bone augmentation techniques and their application to the different anatomical regions of the upper and lower jaws. Bone Augmentation by Anatomical Region is a unique, evidence-based guide focusing on each specific anatomical region – anterior maxilla, posterior maxilla, anterior mandible, and posterior mandible – in order to emphasize the correct implemented procedures needed to successfully perform oral osseous reconstruction. Numerous ridge augmentation techniques are covered, including: horizontal and vertical guided bone regeneration, autologous block transplantation, interpositional bone grafting, allogeneic blocks, sandwich technique, split-expansion ridge technique, and sinus floor grafting. Non-augmented approaches such as forced socket site extrusion and the installation of digitally printed implants are also presented and discussed. Guides readers on tackling bone augmentation via anatomical region of the jaws and their related surrounding muscles, vascularization and innervation Presents innovative augmentation techniques for the anterior maxilla, posterior maxilla, anterior mandible, and posterior mandible Includes clinical photographs in each section and a decision tree to help readers select the appropriate surgical modality Bone Augmentation by Anatomical Region is a specialist resource suitable for dentists who practice implant dentistry, oral surgeons, oral and maxillofacial surgeons, periodontists, and postgraduate dental students in the above-mentioned disciplines. Please note Due to recently developments, part of Chapter 2 Biologic Conditions for Bone Growth and Maintenance: Managing the Oxidative Stress has been amended which will be available in all future reprints. All electronic versions have been updated.