Huntington s Disease Book

Huntington s Disease


  • Author : Oliver Quarrell
  • Publisher : Oxford University Press
  • Release Date : 2008-02-28
  • Genre: Health & Fitness
  • Pages : 165
  • ISBN 10 : 9780199212019

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Huntington s Disease Excerpt :

Huntington's disease affects 1 person in 10,000 but this figure is an underestimate because the immediate carer, spouse/partner and the close relatives at risk of developing this condition in the future are also affected. The new edition has been revised to include important new developments that have occurred in the field in recent years.

Neurobiology of Huntington   s Disease Book

Neurobiology of Huntington s Disease


  • Author : Donald C. Lo
  • Publisher : CRC Press
  • Release Date : 2010-07-02
  • Genre: Science
  • Pages : 338
  • ISBN 10 : 9781420008258

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Neurobiology of Huntington s Disease Excerpt :

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Can You Help Me  Book

Can You Help Me


  • Author : Thomas D. Bird MD
  • Publisher : Oxford University Press
  • Release Date : 2019-02-01
  • Genre: Medical
  • Pages : 240
  • ISBN 10 : 9780190684235

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Can You Help Me Excerpt :

Can You Help Me?: Living in the Turbulent World of Huntington Disease shares the surprising, insightful, challenging, and even encouraging stories of patients and their families who live with Huntington Disease. Having seen patients for more than 40 years, Dr Thomas Bird, a pioneer neurogeneticist, adds a human touch to this genetic brain disease that devastates persons during mid-life when they can least afford it. With a brief history of Huntington Disease and the occasional scientific detail, the true heart of the book is the human experience of the disorder: · The man who cannot stay out of prison because he is addicted to being a burglar. · Another man shoots and kills his roommate while watching television and cannot explain why he did it. · The woman with Huntington Disease copes with her depression by using Texas line dancing. · A twelve year old girl with juvenile Huntington Disease who can barely walk and talk, but her classmates rally around with touching and heartfelt support. · And the 72 year old man with late onset Huntington Disease and severe depression is made worse by ECT, but improved (for a while) with Transcranial Magnetic Stimulation. These are just some of the compelling stories of people of all ages and in all walks of life who feel trapped by a progressive degenerative brain disease from which there is no escape.

Learning to Live with Huntington s Disease Book

Learning to Live with Huntington s Disease


  • Author : Sandy Sulaiman
  • Publisher : Jessica Kingsley Publishers
  • Release Date : 2007
  • Genre: Family & Relationships
  • Pages : 178
  • ISBN 10 : 9781843104872

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Learning to Live with Huntington s Disease Excerpt :

Huntington's Disease (HD), is a hereditary illness passed on via a defective gene. This book offers one family's poignant story of coping with the symptoms, the diagnosis and the effects of HD. It also presents the struggles and strengths of the whole family when one member loses their future to a terminal illness.

Huntington s Disease Book

Huntington s Disease


  • Author : Gillian Bates
  • Publisher : Oxford Monographs on Medical G
  • Release Date : 2014
  • Genre: Medical
  • Pages : 513
  • ISBN 10 : 9780199929146

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Huntington s Disease Excerpt :

Preceded by Huntington's disease / [edited by] Gillian Bates, Peter S. Harper, Lesley Jones. 3rd ed. 2002.

Food for Huntingtons Disease Book

Food for Huntingtons Disease


  • Author : M. Mohamed Essa
  • Publisher : Unknown
  • Release Date : 2018-09-16
  • Genre: Uncategoriezed
  • Pages : 235
  • ISBN 10 : 1536138541

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Food for Huntingtons Disease Excerpt :

Food and Huntingtons Disease is another book in a series of books related to the benefits of food on brain function. This book designates the possible beneficial effects of edible natural products and their active materials on Huntingtons disease. This is a progressive neurodegenerative disease that could cause uncontrolled movements, cognitive difficulties and emotional disturbances. The aim of this book and its series is to create awareness in general audiences about the dietary perception to reduce the occurrence of Huntingtons disease. This may enable a better understanding and possibly reduce the cost on medical bills for patients (approximately $4500/year/person) and the insurance companies. Literature revealed that this disturbing neurodegenerative disorder has a higher prevalence in Europe (3-7 in 100,000), North America (4-5 in 100,000), and Australia than in Asian countries. Studies suggest that mutation in the HD gene and the repeat expansion play an important role in the pathophysiology of this disease. The genetic defect underlying Huntingtons disease is unstable, caused by an abnormal CAG expansion within the first exon of the Huntingtin gene (HTT), leading to an expanded polyglutamine (polyQ) track in the HTT protein. This disease is an inherited one. Even though the prevalence rate is moderate, scientists predict that a lot of people possess the possibility of carrying this disease. Mitochondrial dysfunction and oxidative stress could very highly play a role in this disease. In the last decade, the benefits of food on many diseases including brain diseases were explored. This book aims to summarize the recent updates on the benefit of natural edible materials and their active principles on the prevention or delaying of the progression or the management of this disease. The editors feel highly obligated to all the contributors for this initiative. Undeniably, they believe that the information provided in this book would raise the awareness of the read

SPEC     Handbook of Clinical Neurology  Volume 144  Huntington Disease  12 Month Access  eBook Book

SPEC Handbook of Clinical Neurology Volume 144 Huntington Disease 12 Month Access eBook


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2017-09-22
  • Genre: Medical
  • Pages : 312
  • ISBN 10 : 9780128019030

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SPEC Handbook of Clinical Neurology Volume 144 Huntington Disease 12 Month Access eBook Excerpt :

Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms. This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington’s disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource. Includes coverage of both basic science and clinical aspects of the disease, as well as treatment, experimental therapeutics, and biomarkers Provides an essential resource for the non-neurologist, including necessary background for understanding the disease before making a more detailed study proposal Provides an interdisciplinary approach that can be applied in everyday clinic and research efforts Features chapters edited by leaders in the field around the globe—the broadest expert coverage available

Hyperkinetic Movement Disorders Book

Hyperkinetic Movement Disorders


  • Author : Alberto Albanese
  • Publisher : John Wiley & Sons
  • Release Date : 2012-03-07
  • Genre: Medical
  • Pages : 252
  • ISBN 10 : 9781444346169

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Hyperkinetic Movement Disorders Excerpt :

Hyperkinetic movement disorders comprise a range of diseases characterized by unwanted and uncontrollable, or poorly controllable, involuntary movements. The phenomenology of these disorders is quite variable encompassing chorea, tremor, dystonia, myoclonus, tics, other dyskinesias, jerks and shakes. Discerning the underlying condition can be very difficult given the range and variability of symptoms. But recognizing the phenomenology and understanding the pathophysiology are essential to ensure appropriate treatment. Hyperkinetic Movement Disorders provides a clinical pathway for effective diagnosis and management of these disorders. The stellar international cast of authors distils the evidence so you can apply it into your practice. The judicious use of diagnostic criteria algorithms rating scales management guidelines Provides a robust framework for clear patient management. Throughout the text, QR codes* provide smartphone access to case-study videos of hyperkinetic symptoms. Purchase includes an enhanced Wiley Desktop Edition.* This is an interactive digital version featuring: all text and images in fully searchable form integrated videos of presentations View a sample video: www.wiley.com/go/albanese highlighting and note taking facilities book marking linking to additional references Hyperkinetic Movement Disorders provides you with the essential visual and practical tools you need to effectively diagnose and treat your patients. *Full instructions for using QR codes and for downloading your digital Wiley DeskTop Edition are inside the book.

Neuroprotective Natural Products Book
Score: 5
From 1 Ratings

Neuroprotective Natural Products


  • Author : Goutam Brahmachari
  • Publisher : John Wiley & Sons
  • Release Date : 2017-06-19
  • Genre: Medical
  • Pages : 372
  • ISBN 10 : 9783527341863

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Neuroprotective Natural Products Excerpt :

Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.

Inside the O Briens Book
Score: 4
From 58 Ratings

Inside the O Briens


  • Author : Lisa Genova
  • Publisher : Simon and Schuster
  • Release Date : 2015-04-07
  • Genre: Fiction
  • Pages : 368
  • ISBN 10 : 9781476717838

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Inside the O Briens Excerpt :

A New York Times bestseller ▪ A Library Journal Best Books of 2015 Pick ▪ A St. Louis Post-Dispatch Best Books of 2015 Pick ▪A GoodReads Top Ten Fiction Book of 2015 ▪ A People Magazine Great Read From New York Times bestselling author and neuroscientist Lisa Genova comes a “heartbreaking…very human novel” (Matthew Thomas, author of We Are Not Ourselves) that does for Huntington’s disease what her debut novel Still Alice did for Alzheimer’s. Joe O’Brien is a forty-three-year-old police officer from the Irish Catholic neighborhood of Charlestown, Massachusetts. A devoted husband, proud father of four children in their twenties, and respected officer, Joe begins experiencing bouts of disorganized thinking, uncharacteristic temper outbursts, and strange, involuntary movements. He initially attributes these episodes to the stress of his job, but as these symptoms worsen, he agrees to see a neurologist and is handed a diagnosis that will change his and his family’s lives forever: Huntington’s disease. Huntington’s is a lethal neurodegenerative disease with no treatment and no cure, and each of Joe’s four children has a 50 percent chance of inheriting their father’s disease. While watching her potential future in her father’s escalating symptoms, twenty-one-year-old daughter Katie struggles with the questions this test imposes on her young adult life. As Joe’s symptoms worsen and he’s eventually stripped of his badge and more, Joe struggles to maintain hope and a sense of purpose, while Katie and her siblings must find the courage to either live a life “at risk” or learn their fate. Praised for writing that “explores the resilience of the human spirit” (San Francisco Chronicle), Lisa Genova has once again delivered a novel as powerful and unforgettable as the human insights at its core.

Huntington s Disease Book

Huntington s Disease


  • Author : Stephanie E. Clipper
  • Publisher : Unknown
  • Release Date : 1998
  • Genre: Huntington's chorea
  • Pages : 44
  • ISBN 10 : OCLC:39520885

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The Neuropathology of Huntington   s Disease  Classical Findings  Recent Developments and Correlation to Functional Neuroanatomy Book

The Neuropathology of Huntington s Disease Classical Findings Recent Developments and Correlation to Functional Neuroanatomy


  • Author : Udo Rüb
  • Publisher : Springer
  • Release Date : 2015-09-29
  • Genre: Medical
  • Pages : 146
  • ISBN 10 : 9783319192857

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The Neuropathology of Huntington s Disease Classical Findings Recent Developments and Correlation to Functional Neuroanatomy Excerpt :

This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.

Huntington s Chorea Book

Huntington s Chorea


  • Author : Michael R. Hayden
  • Publisher : Springer Verlag
  • Release Date : 1981
  • Genre: Medical
  • Pages : 222
  • ISBN 10 : UOM:39015000270481

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Huntington s Chorea Excerpt :