Hyperpolarized and Inert Gas MRI Book

Hyperpolarized and Inert Gas MRI


  • Author : Mitchell S. Albert
  • Publisher : Academic Press
  • Release Date : 2016-11-17
  • Genre: Medical
  • Pages : 332
  • ISBN 10 : 9780128037041

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Hyperpolarized and Inert Gas MRI Excerpt :

Hyperpolarized and Inert Gas MRI: Theory and Applications in Research and Medicine is the first comprehensive volume published on HP gas MRI. Since the 1990’s, when HP gas MRI was invented by Dr. Albert and his colleagues, the HP gas MRI field has grown dramatically. The technique has proven to be a useful tool for diagnosis, disease staging, and therapy evaluation for obstructive lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. HP gas MRI has also been developed for functional imaging of the brain and is presently being developed for molecular imaging, including molecules associated with lung cancer, breast cancer, and Alzheimer’s disease. Taking into account the ongoing growth of this field and the potential for future clinical applications, the book pulls together the most relevant and cutting-edge research available in HP gas MRI into one resource. Presents the most comprehensive, relevant, and accurate information on HP gas MRI Co-edited by the co-inventor of HP gas MRI, Dr. Albert, with chapter authors who are the leading experts in their respective sub-disciplines Serves as a foundation of understanding of HP gas MRI for researchers and clinicians involved in research, technology development, and clinical use with HP gas MRI Covers all hyperpolarized gases, including helium, the gas with which the majority of HP gas MRI has been conducted

Investigation of Lung Structure function Relationships Using Hyperpolarized Noble Gases Book

Investigation of Lung Structure function Relationships Using Hyperpolarized Noble Gases


  • Author : Robert P. Thomen
  • Publisher : Unknown
  • Release Date : 2016
  • Genre: Electronic dissertations
  • Pages : 197
  • ISBN 10 : OCLC:954150431

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Investigation of Lung Structure function Relationships Using Hyperpolarized Noble Gases Excerpt :

Magnetic Resonance Imaging (MRI) is an application of the nuclear magnetic resonance (NMR) phenomenon to non-invasively generate 3D tomographic images. MRI is an emerging modality for the lung, but it suffers from low sensitivity due to inherent low tissue density and short T2*. Hyperpolarization is a process by which the nuclear contribution to NMR signal is greatly enhanced to more than 100,000 times that of samples in thermal equilibrium. The noble gases 3He and 129Xe are most often hyperpolarized by transfer of light angular momentum through the electron of a vaporized alkali metal to the noble gas nucleus (called Spin Exchange Optical Pumping). The enhancement in NMR signal is so great that the gas itself can be imaged via MRI, and because noble gases are chemically inert, they can be safely inhaled by a subject, and the gas distribution within the interior of the lung can be imaged. The mechanics of respiration is an elegant physical process by which air is is brought into the distal airspaces of the lungs for oxygen/carbon dioxide gas exchange with blood. Therefore proper description of lung function is intricately related to its physical structure, and the basic mechanical operation of healthy lungs -- from pressure driven airflow, to alveolar airspace gas kinetics, to gas exchange by blood/gas concentration gradients, to elastic contraction of parenchymal tissue -- is a process decidedly governed by the laws of physics. This dissertation will describe experiments investigating the relationship of lung structure and function using hyperpolarized (HP) noble gas MRI. In particular HP gases will be applied to the study of several pulmonary diseases each of which demonstrates unique structure-function abnormalities: asthma, cystic fibrosis, and chronic obstructive pulmonary disease. Successful implementation of an HP gas acquisition protocol for pulmonary studies is an involved and stratified undertaking which requires a solid theoretical foundation in NMR and h

MRI of the Lung Book

MRI of the Lung


  • Author : Hans-Ulrich Kauczor
  • Publisher : Springer
  • Release Date : 2018-11-28
  • Genre: Medical
  • Pages : 518
  • ISBN 10 : 9783319426174

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MRI of the Lung Excerpt :

This book provides a comprehensive overview of how to use MRI for the imaging of lung disease. Special emphasis is placed on routine applications and the clinical impact of MRI in each setting. In addition, current technological developments are reviewed and information presented on dedicated applications of MRI in preclinical and translational research, clinical trials, and specialized institutions. During the past two decades, significant advances in the technology have enabled MRI to enter and mature in the clinical arena of chest imaging. Standard protocols are now readily available on MR scanners, and MRI is recommended as the first- or second-line imaging modality for a variety of lung diseases, not limited to cystic fibrosis, pulmonary hypertension, and lung cancer. The benefits and added value of MRI originate from its ability to both visualize lung structure and provide information on different aspects of lung function, such as perfusion, respiratory motion, ventilation, and gas exchange. On this basis, novel quantitative surrogates for lung function and therapy control (imaging biomarkers) are generated. The second edition of MRI of the Lung has been fully updated to take account of recent advances. It is written by an internationally balanced team of renowned authors representing all major groups in the field.

Pulmonary Functional Imaging Book

Pulmonary Functional Imaging


  • Author : Yoshiharu Ohno
  • Publisher : Springer Nature
  • Release Date : 2020-12-11
  • Genre: Medical
  • Pages : 360
  • ISBN 10 : 9783030435394

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Pulmonary Functional Imaging Excerpt :

This book reviews the basics of pulmonary functional imaging using new CT and MR techniques and describes the clinical applications of these techniques in detail. The intention is to equip readers with a full understanding of pulmonary functional imaging that will allow optimal application of all relevant techniques in the assessment of a variety of diseases, including COPD, asthma, cystic fibrosis, pulmonary thromboembolism, pulmonary hypertension, lung cancer and pulmonary nodule. Pulmonary functional imaging has been promoted as a research and diagnostic tool that has the capability to overcome the limitations of morphological assessments as well as functional evaluation based on traditional nuclear medicine studies. The recent advances in CT and MRI and in medical image processing and analysis have given further impetus to pulmonary functional imaging and provide the basis for future expansion of its use in clinical applications. In documenting the utility of state-of-the-art pulmonary functional imaging in diagnostic radiology and pulmonary medicine, this book will be of high value for chest radiologists, pulmonologists, pulmonary surgeons, and radiation technologists.

Chest MRI  An Issue of Magnetic Resonance Imaging Clinics of North America  Book

Chest MRI An Issue of Magnetic Resonance Imaging Clinics of North America


  • Author : Prachi P. Agarwal
  • Publisher : Elsevier Health Sciences
  • Release Date : 2015-06-14
  • Genre: Medical
  • Pages : 241
  • ISBN 10 : 9780323376068

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Chest MRI An Issue of Magnetic Resonance Imaging Clinics of North America Excerpt :

Chest MRI is explored in this important issue in MRI Clinics of North America. Articles include: MRI of Mediastinal Masses; State of the art: MR Imaging of the Thymus; Novel MR Applications for Pleural Evaluation; MRI Imaging of Chest Wall Tumors; MR Imaging of the Lungs with Hyperpolarized Gases: Technique and Applications; Lung Cancer Assessment with MR Imaging: An Update; PET/MRI in Chest Diseases; Imaging Pulmonary Arterial Thromboembolism: Challenges and Opportunities; MR Imaging of the Thoracic Aorta; MR Imaging of Thoracic Veins; State of the Art MR Imaging in Vascular Thoracic Outlet Syndrome; Pediatric Chest MR Applications, and more!

Fluorine Magnetic Resonance Imaging Book

Fluorine Magnetic Resonance Imaging


  • Author : Ulrich Flogel
  • Publisher : CRC Press
  • Release Date : 2016-10-26
  • Genre: Medical
  • Pages : 462
  • ISBN 10 : 9781315340937

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Fluorine Magnetic Resonance Imaging Excerpt :

Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.

Functional Imaging of the Lungs Using Magnetic Resonance Imaging of Inert Fluorinated Gases Book

Functional Imaging of the Lungs Using Magnetic Resonance Imaging of Inert Fluorinated Gases


  • Author : Marcus Couch
  • Publisher : Unknown
  • Release Date : 2016
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:1280684346

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Functional Imaging of the Lungs Using Magnetic Resonance Imaging of Inert Fluorinated Gases Excerpt :

Fluorine-19 (19F) magnetic resonance imaging (MRI) of the lungs using inhaled inert fluorinated gases can potentially provide high quality anatomical and functional images of the lungs. This technique is able to visualize the distribution of the inhaled gas, similar to hyperpolarized (HP) helium-3 (3He) and xenon-129 (129Xe) MRI. Inert fluorinated gases have the advantages of being nontoxic, abundant, and inexpensive compared to HP gases. Due to the high gyromagnetic ratio of 19F, there is sufficient thermally polarized signal for imaging, and averaging within a single breath-hold is possible due to short longitudinal relaxation times. Since inert fluorinated gases do not need to be hyperpolarized prior to their use in MRI, this eliminates the need for an expensive polarizer and expensive isotopes. Inert fluorinated gas MRI of the lungs has been studied extensively in animals since the 1980s, and more recently in healthy volunteers and patients with lung diseases. This thesis focused on the development of static breath-hold inert fluorinated gas MR imaging techniques, as well as the development functional imaging biomarkers in humans and animal models of pulmonary disease. Optimized ultrashort echo time (UTE) 19F MR imaging was performed in healthy volunteers, and images from different gas breathing techniques were quantitatively compared. 19F UTE MR imaging was then quantitatively compared to 19F gradient echo imaging in both healthy volunteers and in a resolution phantom. A preliminary comparison to HP 3He MR imaging is also presented, along with preliminary 19F measurements of the apparent diffusion coefficient (ADC) and iv gravitational gradients of ventilation in healthy volunteers. The potential of inert fluorinated gas MRI in detecting pulmonary diseases was further explored by performing ventilation mapping in animal models of inflammation and fibrosis. Overall, interest in pulmonary 19F MRI of inert fluorinated gases is increasing, and numerous sites around

Magnetic Resonance Imaging Book

Magnetic Resonance Imaging


  • Author : Lachezar Manchev
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-07-17
  • Genre: Medical
  • Pages : 116
  • ISBN 10 : 9781789238211

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Magnetic Resonance Imaging Excerpt :

Diagnostic imaging has undergone many changes over the last several years. Technical developments have defined Magnetic Resonance Imaging (MRI) as the leading diagnostic modality in different diseases. MRI is definitive and sensitive and the current requirements of medicine call for radiologists to be proficient in its use. This book provides complete and detailed information about the fast-developing field of MRI from physicians, radiologists, and other clinical specialists. It is a practical guide to using MRI in areas such as cardiology and pulmonology, among others.

Magnetic Materials and Technologies for Medical Applications Book

Magnetic Materials and Technologies for Medical Applications


  • Author : Alexander Tishin
  • Publisher : Woodhead Publishing
  • Release Date : 2021-11-18
  • Genre: Technology & Engineering
  • Pages : 662
  • ISBN 10 : 9780128225332

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Magnetic Materials and Technologies for Medical Applications Excerpt :

The study of electromagnetic fields in the treatment of various diseases is not a new one; however, we are still learning how magnetic fields impact the human body and its organs. Many novel magnetic materials and technologies could potentially transform medicine. Magnetic Materials and Technologies for Medical Applications explores these current and emerging technologies. Beginning with foundational knowledge on the basics of magnetism, this book then details the approaches and methods used in the creation of novel magnetic materials and devices. This book also discusses current technologies and applications, as well as the commercial aspects of introducing new technologies to the field. This book serves as an excellent introduction for early career researchers or a reference to more experienced researchers who wish to stay abreast of current trends and developing technologies in the field. This book could also be used by clinicians working in medicine and companies interested in establishing new medical technologies. Each chapter provides novel tasks for future scientific and technology research studies. Outlines the basics of magnetism for enhanced understanding of its applications in medicine Covers novel magnetic devices as well as technologies still under development, including magnetic brain stimulation, biosensors, and nanoparticles for drug delivery Explores commercial opportunities and obstacles to market entry for new magnetic materials and technologies for the medical field

Imaging of the Airways Book

Imaging of the Airways


  • Author : David P. Naidich
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2005
  • Genre: Medical
  • Pages : 216
  • ISBN 10 : 0781757681

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Imaging of the Airways Excerpt :

Written by recognized authorities on thoracic imaging, this volume is the first to examine all modalities—both noninvasive and invasive—for visualizing the airways. Emphasis is placed on correlating CT images with bronchoscopy, to aid in interpreting CT findings and in performing interventional bronchoscopic procedures. After a review of airway imaging techniques and anatomy, the book presents correlating CT and bronchoscopic images for a wide range of pathologic entities. Detailed chapters examine the trachea and central bronchi, the diagnosis of bronchiectasis, and the use of CT in diagnosing small airway disease. A chapter on functional imaging of the airways is also included.

Annual Reports on NMR Spectroscopy Book

Annual Reports on NMR Spectroscopy


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-08-10
  • Genre: Science
  • Pages : 200
  • ISBN 10 : 9780081026694

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Annual Reports on NMR Spectroscopy Excerpt :

Annual Reports on NMR Spectroscopy, Volume 95, provides an in-depth accounting of progress in nuclear magnetic resonance (NMR) spectroscopy and its many applications. In recent years, no other technique has gained as much significance. It is used in all branches of science in which precise structural determination is required, and in which the nature of interactions and reactions in solution is being studied. This book has established itself as a premier resource for both specialists and non-specialists who are looking to become familiar with new techniques and applications pertaining to NMR spectroscopy. Serves as the premier resource for learning the new techniques and applications of NMR spectroscopy Provides a key reference for chemists and physicists using NMR spectroscopy to study the structure and dynamics of molecules Covers all aspects of molecular science, including MRI (Magnetic Resonance Imaging)

Gas Phase NMR Book

Gas Phase NMR


  • Author : Michał Jaszuński
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-02-18
  • Genre: Gas chromatography
  • Pages : 400
  • ISBN 10 : 9781782621614

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Gas Phase NMR Excerpt :

NMR MRI with Hyperpolarized Gas and High Tc SQUID  Book

NMR MRI with Hyperpolarized Gas and High Tc SQUID


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2000
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:873776969

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NMR MRI with Hyperpolarized Gas and High Tc SQUID Excerpt :

A method and apparatus for the detection of nuclear magnetic resonance (NMR) signals and production of magnetic resonance imaging (MRI) from samples combines the use of hyperpolarized inert gases to enhance the NMR signals from target nuclei in a sample and a high critical temperature (Tc) superconducting quantum interference device (SQUID) to detect the NMR signals. The system operates in static magnetic fields of 3 mT or less (down to 0.1 mT), and at temperatures from liquid nitrogen (77K) to room temperature. Sample size is limited only by the size of the magnetic field coils and not by the detector. The detector is a high Tc SQUID magnetometer designed so that the SQUID detector can be very close to the sample, which can be at room temperature.

Functional Imaging of the Chest Book

Functional Imaging of the Chest


  • Author : Hans-Ulrich Kauczor
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 230
  • ISBN 10 : 9783642186219

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Functional Imaging of the Chest Excerpt :

For a long time, imaging of the chest was based on the use of either radiography, demonstrating lung morphology, or scintigraphy, looking at lung function. However, as a result of recent developments in CT and MRI technology it is now possible to perform dedicated investigations of different aspects of lung function, such as ventilation, perfusion, gas exchange, and respiratory mechanics. This volume, written by acknowledged experts in the field, provides a well-illustrated and comprehensive review of these novel approaches to functional imaging of the chest. It will be of great assistance to all who are establishing such strategies in the research or clinical arenas for the diagnostic work-up and follow-up of patients with lung diseases.

Biomedical Photonics Handbook  Second Edition Book

Biomedical Photonics Handbook Second Edition


  • Author : Tuan Vo-Dinh
  • Publisher : CRC Press
  • Release Date : 2014-07-29
  • Genre: Medical
  • Pages : 889
  • ISBN 10 : 9781420085143

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Biomedical Photonics Handbook Second Edition Excerpt :

Shaped by Quantum Theory, Technology, and the Genomics Revolution The integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. The second volume, Biomedical Diagnostics, focuses on biomedical diagnostic technologies and their applications from the bench to the bedside. Represents the Collective Work of over 150 Scientists, Engineers, and Clinicians Designed to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies. What’s New in This Edition: A wide variety of photonic biochemical sensing technologies have already been developed for clinical monitoring of physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics and metabolomics allow sensing of early disease state biomarkers, thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease, imaging single molecules and in situ diagnostics at the single cell level. In addition to these state-of-the art advancements, the second edition