The Human Hypothalamus Book

The Human Hypothalamus


  • Author : Dick F. Swaab
  • Publisher : Elsevier
  • Release Date : 2021-07-07
  • Genre: Science
  • Pages : 516
  • ISBN 10 : 9780128199749

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The Human Hypothalamus Excerpt :

The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer’s, Parkinson’s, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more. Summarizes research on how the hypothalamus relates to neurological disorders Contains neuropsychiatric, neurodegenerative, periodic and autonomic disorders Includes the neurobiology of, and treatment for, each disorder Covers depression, anxiety, OCD, PTSD, schizophrenia, autism, aggression, addiction, and more Provides coverage of sleep and pain

The Human Hypothalamus Book

The Human Hypothalamus


  • Author : Dick F. Swaab
  • Publisher : Elsevier
  • Release Date : 2021-09-06
  • Genre: Science
  • Pages : 745
  • ISBN 10 : 0128199733

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The Human Hypothalamus Excerpt :

The Handbooks of Neurology provide comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer's, Parkinson's, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more. Summarizes research on how the hypothalamus relates to neurological disorders Contains neuropsychiatric, neurodegenerative, periodic, and autonomic disorders Includes the neurobiology of, and treatment for, each disorder Covers depression, anxiety, OCD, PTSD, schizophrenia, autism, aggression, addiction and more Provides coverage of sleep and pain

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases Book

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases


  • Author : Akhlaq A. Farooqui
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-09-02
  • Genre: Medical
  • Pages : 401
  • ISBN 10 : 9781441966520

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Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases Excerpt :

Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane permeability, high calcium influx, and disruption of ion homeostasis. This type of cell death leads to membrane lysis and release of intracellular components that induce inflammatory reactions. Necrotic cell death normally occurs at the core of injury site. In contrast, apoptosis is an active process in which caspases (a group of endoproteases with specificity for aspartate residues in protein) are stimulated. Apoptotic cell death is accompanied by cell shrinkage, dynamic membrane blebbing, chromatin condensation, DNA laddering, loss of phospholipids asymmetry, low ATP levels, and mild calcium overload. This type of cell death normally occurs in penumbral region at the ischemic injury site and in different regions in various neurodegenerative diseases.

The Human Hypothalamus Book

The Human Hypothalamus


  • Author : Dick F. Swaab
  • Publisher : Elsevier
  • Release Date : 2021-08-15
  • Genre: Science
  • Pages : 807
  • ISBN 10 : 012819975X

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The Human Hypothalamus Excerpt :

The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the anterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus. Reviews the anatomy and physiology of the anterior hypothalamus Provides cytoarchitecture and chemoarchitecture from rodents Discusses hypothalamic related disorders of eating, sleeping, anxiety, and mood Covers how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus Explores the role of the hypothalamus in sexual behavior and gender identity

The American Psychiatric Association Publishing Textbook of Neuropsychiatry and Clinical Neurosciences  Sixth Edition Book

The American Psychiatric Association Publishing Textbook of Neuropsychiatry and Clinical Neurosciences Sixth Edition


  • Author : David B. Arciniegas, M.D.
  • Publisher : American Psychiatric Pub
  • Release Date : 2018-07-06
  • Genre: Medical
  • Pages : 674
  • ISBN 10 : 9781585624874

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The American Psychiatric Association Publishing Textbook of Neuropsychiatry and Clinical Neurosciences Sixth Edition Excerpt :

Preceded by The American Psychiatric Publishing textbook of neuropsychiatry and behavioral neurosciences / edited by Stuart C. Yudofsky, Robert E. Hales. 5th ed. c2008.

Molecular Aspects of Neurodegeneration  Neuroprotection  and Regeneration in Neurological Disorders Book

Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders


  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2020-09-07
  • Genre: Medical
  • Pages : 400
  • ISBN 10 : 9780128217016

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Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders Excerpt :

Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs. Provides a comprehensive overview of the molecular aspects of neurodegeneration, neuroprotection, and neuro-regeneration, along with therapeutic strategies for various types of neurological disorders Provides cutting-edge research information on the signal transduction processes associated with the neurochemistry of neurological disorders Discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential for treatments of neurological disorders

Neuroprogression in Psychiatric Disorders Book

Neuroprogression in Psychiatric Disorders


  • Author : A. Halaris
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2017-07-25
  • Genre: Medical
  • Pages : 182
  • ISBN 10 : 9783318060515

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Neuroprogression in Psychiatric Disorders Excerpt :

In this volume, international experts critically review cutting-edge advances in neuroprogression research. The relevance of these findings to psychiatric and neurological disorders is clarified. Potential etiopathological mechanisms of neuroprogression are described in detail. Special emphasis is placed on the role of the immune system in stress and stress-related disorders and brain-immune interactions. The epigenetic consequences of adverse experiences in early childhood, which may prelude major psychiatric disorders, are also considered. Recent research has not only provided evidence of neuroprogression in psychiatric and neurological disorders, but has shown that pharmacologic interventions have the potential to arrest this process. Advances in testing and imaging will lead to timely diagnosis and earlier treatment. Identification of neurological mechanisms alongside (epi-)genetic vulnerability markers will create truly personalized treatment programs. This book is a valuable resource for everyone who wishes to gain insight into the essential features of the neuroprogressive course of major psychiatric and neurological disorders. In particular, psychiatrists, neuroscientists and neurologists ¬ as well as immunologists, pharmacologists and molecular biologists - will find very informative chapters of direct relevance to their field.

Neurological and Psychiatric Disorders in Endocrine Diseases Book

Neurological and Psychiatric Disorders in Endocrine Diseases


  • Author : Gianluca Tamagno
  • Publisher : Frontiers Media SA
  • Release Date : 2015-07-16
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889195893

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Neurological and Psychiatric Disorders in Endocrine Diseases Excerpt :

Neurological and psychiatric disorders can occur in endocrine diseases either in the setting of the clinical manifestations of the same (i.e., hyper- or hyposecretion of hormones or peptides from the endocrine glands) or as events secondary to the pathogenetic mechanisms of the endocrinopathy (i.e., autommunity affecting endocrine glands and the brain). Also the medical or surgical treatment of the endocrine disease can sometimes determine the occurrence of neurological or psychiatric abnormalities. Moreover some genetic alterations can lead to syndromes affecting both the endocrine and the nervous system with a variety of possible manifestations. In the last couple of decades a number of associations between dysfunctions of the endocrine system and neurological or psychiatric manifestations have appeared and only in the minority of the cases this link has been fully elucidated. Often the neurological or psychiatric alterations still represent a relevant challenge for clinicians with regard to the management of the patients. The complexity of the topic and the limited availability of laboratory research models for the study of the endocrine system-nervous system cross-interaction are making the scientific progresses intricate and, sometimes, slow. A dedicated focus to such broad and often still obscure topic might help and clarify the current state-of-the-art in the field and direct the goals of future research.

Glutamate and Neuropsychiatric Disorders Book
Score: 5
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Glutamate and Neuropsychiatric Disorders


  • Author : Zoran M. Pavlovic
  • Publisher : Springer Nature
  • Release Date : 2022-04-10
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 9783030874803

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Glutamate and Neuropsychiatric Disorders Excerpt :

This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neur

Cluster Headache and other Trigeminal Autonomic Cephalgias Book

Cluster Headache and other Trigeminal Autonomic Cephalgias


  • Author : Massimo Leone
  • Publisher : Springer
  • Release Date : 2019-07-17
  • Genre: Medical
  • Pages : 264
  • ISBN 10 : 9783030124380

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Cluster Headache and other Trigeminal Autonomic Cephalgias Excerpt :

This book provides essential insights into the current state of knowledge regarding the main aspects of cluster headache and trigeminal autonomic cephalgias. The first chapters focus on classification and clinical features, together with familial and genetic aspects. Relevant animal models and the putative role of key nervous structures as the hypothalamus, brainstem, diencephalon and sphenopalatine ganglion are reviewed. Evidence gained from key molecules such as CGRP in animals and human headache models are discussed. The book subsequently presents information on the various aspects of the pathophysiology of trigeminal autonomic cephalalgias for example regarding the implication of the trigeminovascular system and the facial autonomic reflexes of the brainstem. Further, it shares insights from imaging studies including functional magnetic resonance imaging and more advanced techniques, as well as brain stimulation procedures. Further chapters describe the current st ate of knowledge concerning drug treatment and the various neurostimulation procedures. Trigeminal neuralgia is also presented, due its close relationship with some short-term trigeminal autonomic cephalgias: a great deal can be learned from a better understanding of their differences and similarities. The same approach is then applied to cluster headache and migraine. All chapters were written by respected experts in their fields, ensuring the book will provide an excellent source of up-to-date information and perspectives on trigeminal autonomic cephalgias and related disorders. As such, it will be of considerable value for students, clinicians and pain researchers alike.

Sleep Disorders and Sleep Deprivation Book
Score: 5
From 1 Ratings

Sleep Disorders and Sleep Deprivation


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2006-10-13
  • Genre: Medical
  • Pages : 424
  • ISBN 10 : 9780309101110

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Sleep Disorders and Sleep Deprivation Excerpt :

Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.

Dopamine and Glutamate in Psychiatric Disorders Book

Dopamine and Glutamate in Psychiatric Disorders


  • Author : Werner Schmidt
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-04-21
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 9781592598526

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Dopamine and Glutamate in Psychiatric Disorders Excerpt :

An illuminating summary of our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and the therapeutic strategies and possibilities for future treatment. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, and on the origin and progression of Parkinson's disease. Additional chapters offer novel insights into a variety of psychiatric diseases, including ADHD, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques.

Inflammation in Neuropsychiatric Disorders Book

Inflammation in Neuropsychiatric Disorders


  • Author : Rossen Donev
  • Publisher : Academic Press
  • Release Date : 2012
  • Genre: Science
  • Pages : 200
  • ISBN 10 : 9780123983145

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Inflammation in Neuropsychiatric Disorders Excerpt :

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics