In Silico Immunology Book

In Silico Immunology

  • Author : Darren D.R. Flower
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-04-16
  • Genre: Medical
  • Pages : 451
  • ISBN 10 : 9780387392417

In Silico Immunology Excerpt :

This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care.

Immunoinformatics Book


  • Author : Darren R. Flower
  • Publisher : Springer Science & Business Media
  • Release Date : 2007
  • Genre: Allergy and Immunology
  • Pages : 438
  • ISBN 10 : 9781603271189

Immunoinformatics Excerpt :

Immunoinformatics: Predicting Immunogenicity In Silico is a primer for researchers interested in this emerging and exciting technology and provides examples in the major areas within the field of immunoinformatics. This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology. The volume is conveniently divided into four sections. The first section, Databases, details various immunoinformatic databases, including IMGT/HLA, IPD, and SYEPEITHI. In the second section, Defining HLA Supertypes, authors discuss supertypes of GRID/CPCA and hierarchical clustering methods, Hla-Ad supertypes, MHC supertypes, and Class I Hla Alleles. The third section, Predicting Peptide-MCH Binding, includes discussions of MCH binders, T-Cell epitopes, Class I and II Mouse Major Histocompatibility, and HLA-peptide binding. Within the fourth section, Predicting Other Properties of Immune Systems, investigators outline TAP binding, B-cell epitopes, MHC similarities, and predicting virulence factors of immunological interest. Immunoinformatics: Predicting Immunogenicity In Silico merges skill sets of the lab-based and the computer-based science professional into one easy-to-use, insightful volume.

Computational Immunology Book
Score: 5
From 2 Ratings

Computational Immunology

  • Author : Josep Bassaganya-Riera
  • Publisher : Academic Press
  • Release Date : 2015-10-21
  • Genre: Medical
  • Pages : 210
  • ISBN 10 : 9780128037157

Computational Immunology Excerpt :

Computational Immunology: Models and Tools encompasses the methodological framework and application of cutting-edge tools and techniques to study immunological processes at a systems level, along with the concept of multi-scale modeling. The book's emphasis is on selected cases studies and application of the most updated technologies in computational modeling, discussing topics such as computational modeling and its usage in immunological research, bioinformatics infrastructure, ODE based modeling, agent based modeling, and high performance computing, data analytics, and multiscale modeling. There are also modeling exercises using recent tools and models which lead the readers to a thorough comprehension and applicability. The book is a valuable resource for immunologists, computational biologists, bioinformaticians, biotechnologists, and computer scientists, as well as all those who wish to broaden their knowledge in systems modeling. Offers case studies with different levels of complexity Provides a detailed view on cutting-edge tools for modeling that are useful to experimentalists with limited computational skills Explores the usage of simulation for hypothesis generation, helping the reader to understand the most valuable points on experimental setting

Immunoinformatics Book


  • Author : Namrata Tomar
  • Publisher : Humana
  • Release Date : 2021-03-26
  • Genre: Medical
  • Pages : 409
  • ISBN 10 : 1071603914

Immunoinformatics Excerpt :

This book covers a wide range of diverse immunoinformatics research topics, involving tools and databases of potential epitope prediction, HLA gene analysis, MHC characterizing, in silico vaccine design, mathematical modeling of host-pathogen interactions, and network analysis of immune system data. In that way, this fully updated volume explores the enormous value of computational tools and models in immunology research. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of key insights and detailed implementation advice to encourage successful results in the lab. Authoritative and practical, Immunoinformatics, Third Edition serves as an ideal guide for scientists working at the intersection of bioinformatics, mathematical modelling, and statistics for the study of immune systems biology.

Immunological Bioinformatics Book

Immunological Bioinformatics

  • Author : Ole Lund
  • Publisher : MIT Press
  • Release Date : 2005-06-17
  • Genre: Computers
  • Pages : 312
  • ISBN 10 : 0262122804

Immunological Bioinformatics Excerpt :

Using bioinformatics methods to generate a systems-level view of the immune system; description of the main biological concepts and the new data-driven algorithms. Despite the fact that advanced bioinformatics methodologies have not been used as extensively in immunology as in other subdisciplines within biology, research in immunological bioinformatics has already developed models of components of the immune system that can be combined and that may help develop therapies, vaccines, and diagnostic tools for such diseases as AIDS, malaria, and cancer. In a broader perspective, specialized bioinformatics methods in immunology make possible for the first time a systems-level understanding of the immune system. The traditional approaches to immunology are reductionist, avoiding complexity but providing detailed knowledge of a single event, cell, or molecular entity. Today, a variety of experimental bioinformatics techniques connected to the sequencing of the human genome provides a sound scientific basis for a comprehensive description of the complex immunological processes. This book offers a description of bioinformatics techniques as they are applied to immunology, including a succinct account of the main biological concepts for students and researchers with backgrounds in mathematics, statistics, and computer science as well as explanations of the new data-driven algorithms in the context of biological data that will be useful for immunologists, biologists, and biochemists working on vaccine design. In each chapter the authors show interesting biological insights gained from the bioinformatics approach. The book concludes by explaining how all the methods presented in the book can be integrated to identify immunogenic regions in microorganisms and host genomes.

Conceptual Modelling in Computational Immunology Book

Conceptual Modelling in Computational Immunology

  • Author : Martina Husáková
  • Publisher : Tomáš Bruckner
  • Release Date : 2015-09-10
  • Genre: Computers
  • Pages : 174
  • ISBN 10 : 9788087924020

Conceptual Modelling in Computational Immunology Excerpt :

Computational immunology offers in silico strategies for understanding of complex processes occurring in the natural immune system of a living organism that are difficult to explore by traditional in vivo or in vitro techniques. The monograph introduces conceptual languages and approaches for modelling biological processes. The Agent Modelling Language is investigated for conceptualisation of immune processes. AML-based diagrams represent properties and processes occurring in a lymph node.

Encyclopedia of Bioinformatics and Computational Biology Book

Encyclopedia of Bioinformatics and Computational Biology

  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2018-08-21
  • Genre: Medical
  • Pages : 3284
  • ISBN 10 : 9780128114322

Encyclopedia of Bioinformatics and Computational Biology Excerpt :

Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

Immunity Book


  • Author : Alfred I. Tauber
  • Publisher : Oxford University Press
  • Release Date : 2017
  • Genre: Medical
  • Pages : 303
  • ISBN 10 : 9780190651244

Immunity Excerpt :

" Senior scholar Alfred Tauber argues in this bold account that common approaches to the study of immunology are inherently flawed in its strict dichotomy of the self and non-self, or external invaders. The relationship between what is self and what is non-self is in reality a complex, dymanic, relational one. Autonomous agents are constantly in the midst of dialectical exchanges in which immunity mediates both noxious and benign encounters. Namely: rather than serving to defend an independent entity, immunity participates in an eco-system. Contemporary transplantation biology and autoimmunity have demonstrated phenomena that upset rigid adherence to the self/non-self dichotomy. Placing tolerant immune mechanisms within a broad ecological context has highlighted the balance of co-operative and competitive relationships in which immunity functions. By understanding immunity this way, as a 'symbiotic turn, ' we come to see that immune reactivity (rejection or tolerance) is a second-order response to the cognitive functions of the immune system. Organisms have a complex capacity to respond to environment, and, through Tauber's insignts, we appreciate them more fully when we grasp the flexibility of the borders of organisms. After first providing an overview of the history of immunology, and explaining why the dominant understanding of it is incomplete and limiting, Tauber argues for this new approach to immunology and explains how it will usher in a new biology in which symbiosis is the rule, not the exception. "--

Issues in Immunology Research  2013 Edition Book

Issues in Immunology Research 2013 Edition

  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-05-01
  • Genre: Medical
  • Pages : 1230
  • ISBN 10 : 9781490109848

Issues in Immunology Research 2013 Edition Excerpt :

Issues in Immunology Research / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Immunochemistry. The editors have built Issues in Immunology Research: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Immunochemistry in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Immunology Research / 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

In Silico Inference of Immunological Relationship Between Protein Antigens Based on Their Cytotoxic T lymphocyte Epitope Repertoires Book

In Silico Inference of Immunological Relationship Between Protein Antigens Based on Their Cytotoxic T lymphocyte Epitope Repertoires

  • Author : Werner Smidt
  • Publisher : Unknown
  • Release Date : 2013
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:956374573

In Silico Inference of Immunological Relationship Between Protein Antigens Based on Their Cytotoxic T lymphocyte Epitope Repertoires Excerpt :

The importance of Cytotoxic T-Cell (CTL) reponses during the course of intracellular infections has received a lot of attention during the past few decades. CTLs respond to epitopes presented by the Major Histocompatibility Complex (MHC) originating from intracellular proteins for which they have an appropriate T-Cell Receptor (TCR) for. This response is crucial for the control of pathogens such as Influenza, Hepatitis, HIV and others by destroying the cell in which the pathogen replicates. Due to the extreme polymorphism of MHC molecules, Computational Immunology techniques have been developed to detect potential MHC ligands and as a consequence, potential CTL epitopes. The polymorphism factor needs to be taken into account especially when concerning the design of vaccines with a CTL response component to maximize population coverage. Tools have been constructed that combine the predictions tools concerning major steps in this pathway, that is, proteasomal cleavage, Transporter associated with Antigen Presentation (TAP) affinity, Major Histocompatibility Complex (MHC) affinity and Immunogenicity. In this study, a novel method is developed to combine the different steps in the pathway, which includes the development of a novel TAP predictor. Furthermore, by using a BLOSUM-based score in conjunction with the epitope prediction results, a novel CTL epitopebased clustering method was developed. Two pathogens with major CTL epitope components, but vastly different mutation rates were chosen to infer whether the aforementioned methods can be used to detect potential CTL epitopes and group sequences together based on shared immunogenicity.

Computational Immunology Book

Computational Immunology

  • Author : Shyamasree Ghosh
  • Publisher : CRC Press
  • Release Date : 2020-02-17
  • Genre: Medical
  • Pages : 172
  • ISBN 10 : 9781351023481

Computational Immunology Excerpt :

Computational Immunology: Applications focuses on different mathematical models, statistical tools, techniques, and computational modelling that helps in understanding complex phenomena of the immune system and its biological functions. The book also focuses on the latest developments in computational biology in designing of drugs, targets, biomarkers for early detection and prognosis of a disease. It highlights the applications of computational methods in deciphering the complex processes of the immune system and its role in health and disease. This book discusses the most essential topics, including Next generation sequencing (NGS) and computational immunology Computational modelling and biology of diseases Drug designing Computation and identification of biomarkers Application in organ transplantation Application in disease detection and therapy Computational methods and applications in understanding of the invertebrate immune system Shyamasree Ghosh (MSc, PhD, PGDHE, PGDBI) Scientific Officer (F), is currently working in the School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, DAE, Govt of India, graduated from the prestigious Presidency College Kolkata in 1998. She was awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.

Tumor Immunology and Cancer Vaccines Book

Tumor Immunology and Cancer Vaccines

  • Author : Samir Khleif
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-07-16
  • Genre: Medical
  • Pages : 398
  • ISBN 10 : 9780387275451

Tumor Immunology and Cancer Vaccines Excerpt :

- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field