Influence of Stress on Cell Growth and Product Formation Book

Influence of Stress on Cell Growth and Product Formation


  • Author : Karl Schügerl
  • Publisher : Springer
  • Release Date : 2003-06-30
  • Genre: Science
  • Pages : 190
  • ISBN 10 : 9783540478652

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Influence of Stress on Cell Growth and Product Formation Excerpt :

Stresses which arise in bioreactors can influence process performance considerably. Recent molecular biological investigations indicate that stress caused by fluid dynamical effects and extreme values of process variables and toxic substances cause similar responses in the cells. These molecular fundamentals, as well as quantitative evaluation of fluid dynamical stresses and, their effects on microorganisms, animal and plant cells and proteins are treated in this volume.

Disposable Bioreactors II Book

Disposable Bioreactors II


  • Author : Dieter Eibl
  • Publisher : Springer
  • Release Date : 2013-12-17
  • Genre: Science
  • Pages : 292
  • ISBN 10 : 9783642451584

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Disposable Bioreactors II Excerpt :

Dynamic Single-Use Bioreactors Used in Modern Liter- and m3- Scale Biotechnological Processes: Engineering Characteristics and Scaling Up, by Christian Löffelholz, Stephan C. Kaiser, Matthias Kraume, Regine Eibl , Dieter Eibl. Orbitally Shaken Single-Use Bioreactors, by Wolf Klöckner, Sylvia Diederichs, Jochen Büchs. Therapeutic Human Cells: Manufacture for Cell Therapy/Regenerative Medicine by Christian van den Bos, Robert Keefe, Carmen Schirmaier, Michael McCaman. Fast Single-Use VLP Vaccine Productions Based on Insect Cells and the Baculovirus Expression Vector System: Influenza as Case Study by Regine Eibl, Nina Steiger, Sabine Wellnitz, Tiago Vicente, Corinne John, Dieter Eibl. Microbial High Cell Density Fermentations in a Stirred Single-Use Bioreactor by Thomas Dreher, Bart Walcarius, Ute Husemann, Franziska Klingenberg, Christian Zahnow, Thorsten Adams, Davy de Wilde, Peter Casteels, Gerhard Greller. Quorus Bioreactor: A New Perfusion-Based Technology for Microbial Cultivation by Sheena J. Fraser, Christian Endres. Cultivation of Marine Microorganisms in Single-Use Systems by Friederike Hillig, Maciej Pilarek, Stefan Junne, Peter Neubauer. Flexible Biomanufacturing Processes that Address the Needs of the Future by Bernhard Diel, Christian Manzke, Thorsten Peuker. An Approach to Quality and Security of Supply for Single-Use Bioreactors by Magali Barbaroux, Susanne Gerighausen, Heiko Hackel. A Risk Analysis for Production Processes with Disposable Bioreactors by Tobias Merseburger, Ina Pahl, Daniel Müller, Markus Tanner.

Plant Tissue Culture Engineering Book
Score: 5
From 2 Ratings

Plant Tissue Culture Engineering


  • Author : S. Dutta Gupta
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-07-10
  • Genre: Science
  • Pages : 480
  • ISBN 10 : 9781402036941

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Plant Tissue Culture Engineering Excerpt :

It is my privilege to contribute the foreword for this unique volume entitled: “Plant Tissue Culture Engineering,” edited by S. Dutta Gupta and Y. Ibaraki. While there have been a number of volumes published regarding the basic methods and applications of plant tissue and cell culture technologies, and even considerable attention provided to bioreactor design, relatively little attention has been afforded to the engineering principles that have emerged as critical contributions to the commercial applications of plant biotechnologies. This volume, “Plant Tissue Culture Engineering,” signals a turning point: the recognition that this specialized field of plant science must be integrated with engineering principles in order to develop efficient, cost effective, and large scale applications of these technologies. I am most impressed with the organization of this volume, and the extensive list of chapters contributed by expert authors from around the world who are leading the emergence of this interdisciplinary enterprise. The editors are to be commended for their skilful crafting of this important volume. The first two parts provide the basic information that is relevant to the field as a whole, the following two parts elaborate on these principles, and the last part elaborates on specific technologies or applications.

Bioreactors for Tissue Engineering Book

Bioreactors for Tissue Engineering


  • Author : Julian Chaudhuri
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-01-16
  • Genre: Medical
  • Pages : 376
  • ISBN 10 : 9781402037412

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Bioreactors for Tissue Engineering Excerpt :

For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.

Handbook of Marine Microalgae Book

Handbook of Marine Microalgae


  • Author : Se-Kwon Kim
  • Publisher : Academic Press
  • Release Date : 2015-04-30
  • Genre: Science
  • Pages : 604
  • ISBN 10 : 9780128011249

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Handbook of Marine Microalgae Excerpt :

Handbook of Microalgae: Biotechnology Advances offers complete coverage of marine microalgae, including biology, production techniques, biotechnological applications, economic perspectives of applications, and environmental effects of marine microalgae blooms. With contributions from world experts, Handbook of Microalgae: Biotechnology Advances focuses on microalgae from an organism perspective to offer a complete picture from evolution to biofuel. Focuses on a comprehensive approach from an organism point of view Contains full coverage of all aspects of microalgae from biology through biotechnological and biomedical applications Includes biological properties of commercial algal species Provides microalgae screening and identification methods, culturing methods and new aspects of processing

Micro  and Macroparticle enhanced cultivation of filamentous Lentzea aerocolonigenes for increased rebeccamycin production Book

Micro and Macroparticle enhanced cultivation of filamentous Lentzea aerocolonigenes for increased rebeccamycin production


  • Author : Kathrin Schrinner
  • Publisher : Cuvillier Verlag
  • Release Date : 2020-12-28
  • Genre: Science
  • Pages : 142
  • ISBN 10 : 9783736963504

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Micro and Macroparticle enhanced cultivation of filamentous Lentzea aerocolonigenes for increased rebeccamycin production Excerpt :

The filamentous actinomycete Lentzea aerocolonigenes produces the antitumor antibiotic rebeccamycin. However, the complex morphology of actinomycetes leads to challenges during the cultivation often accompanied by low product titers. In the recent past, the to date low rebeccamycin titers were increased by particle addition to cultivations of L. aerocolonigenes. In this thesis the addition of micro-, macro- and adsorbent particles to cultivations of L. aerocolonigenes were investigated in more detail. Furthermore, the scale-up to a bubble-free bioreactor was conducted. The addition of glass microparticles (x50 = 7.9 μm, 10 g L-1) to shake flask cultivations increased the rebeccamycin titer up to 3.6-fold compared to an unsupplemented approach. Pellet slices showed the incorporation of microparticles. With different surface modifications of the microparticles, specific incorporation patterns of the microparticles appeared. The incorporation of microparticles causes looser and smaller pellets allowing an increased nutrient and oxygen supply in the pellet core. With addition of larger (glass) macroparticles (ø = 0.2 – 2.1 mm, 100 g L-1) mechanical stress was induced on the biopellets. The additional supplementation of 5 g L-1 soy lecithin and glass beads (ø = 969 μm, 100 g L-1) resulted in a rebeccamycin titer of 388 mg L-1, one of the highest rebeccamycin titers ever achieved. For the scale-up of L. aerocolonigenes cultivations a bubble-free membrane aeration system was developed. The tubular membrane aeration system can additionally be pressurized to increase the oxygen transfer. First cultivations of L. aerocolonigenes successfully provided 18 mg L-1 rebeccamycin, a concentration similar to that of unsupplemented shake flask cultivations. XAD adsorbent particles were added to cultivations to facilitate rebeccamycin recovery. However, the XAD particles additionally increased the rebeccamycin titer which was likely to be caused by the adsorption of the rebeccamy

Disposable Bioprocessing Systems Book

Disposable Bioprocessing Systems


  • Author : Sarfaraz K. Niazi
  • Publisher : CRC Press
  • Release Date : 2016-04-19
  • Genre: Medical
  • Pages : 322
  • ISBN 10 : 9781000218749

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Disposable Bioprocessing Systems Excerpt :

Written by a researcher with experience designing, establishing, and validating biological manufacturing facilities worldwide, this is the first comprehensive introduction to disposable systems for biological drug manufacturing. It reviews the current state of the industry; tackles questions about safety, costs, regulations, and waste disposal; and guides readers to choose disposable components that meet their needs. This practical manual covers disposable containers, mixing systems, bioreactors, connectors and transfers, controls and sensors, downstream processing systems, filling and finishing systems, and filters. The author also shares his predictions for the future, calling disposable bioprocessing technology a "game changer."

Plant Biotechnology and Molecular Markers Book

Plant Biotechnology and Molecular Markers


  • Author : S. Srivastava
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-01-16
  • Genre: Science
  • Pages : 400
  • ISBN 10 : 9781402032134

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Plant Biotechnology and Molecular Markers Excerpt :

The genesis of the volume, Plant Biotechnology and Molecular Markers, has been the occasion of the retirement of Professor Sant Saran Bhojwani from the Department of Botany, University of Delhi. For Professor Bhojwani, retirement only means relinquishing the chair as being a researcher and a teacher which has always been a way of life to him. Professor Bhojwani has been an ardent practitioner of modern plant biology and areas like Plant Biotechnology and Molecular Breeding have been close to his heart. The book contains original as well as review articles contributed by his admirers and associates who are experts in their area of research. While planning this contributory book our endeavour has been to incorporate articles that cover the entire gamut of Plant Biotechnology, and also applications of Molecular Markers. Besides articles on in vitro fertilization and micropropagation, there are articles on forest tree improvement through genetic engineering. Considering the importance of conservation of our precious natural wealth, one article deals with cryopreservation of plant material. Chapter on molecular marker considers DNA indexing as markers of clonal fidelity of in vitro regenerated plants and prevention against bio-piracy. A couple of write-ups also cover stage-specific gene markers, DNA polymorphism and genetic engineering, including raising of stress tolerant plants to sustain productivity and help in reclamation of degraded land.

Bioreactors Book

Bioreactors


  • Author : Carl-Fredrik Mandenius
  • Publisher : John Wiley & Sons
  • Release Date : 2016-02-16
  • Genre: Science
  • Pages : 520
  • ISBN 10 : 9783527683376

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Bioreactors Excerpt :

In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

Cell and Tissue Reaction Engineering Book

Cell and Tissue Reaction Engineering


  • Author : Regine Eibl
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-09-30
  • Genre: Science
  • Pages : 363
  • ISBN 10 : 9783540681823

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Cell and Tissue Reaction Engineering Excerpt :

The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.

Computational Fluid Dynamics Book

Computational Fluid Dynamics


  • Author : Oleg Minin
  • Publisher : BoD – Books on Demand
  • Release Date : 2011-07-05
  • Genre: Computers
  • Pages : 410
  • ISBN 10 : 9789533071695

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Computational Fluid Dynamics Excerpt :

This book is planned to publish with an objective to provide a state-of-art reference book in the area of computational fluid dynamics for CFD engineers, scientists, applied physicists and post-graduate students. Also the aim of the book is the continuous and timely dissemination of new and innovative CFD research and developments. This reference book is a collection of 14 chapters characterized in 4 parts: modern principles of CFD, CFD in physics, industrial and in castle. This book provides a comprehensive overview of the computational experiment technology, numerical simulation of the hydrodynamics and heat transfer processes in a two dimensional gas, application of lattice Boltzmann method in heat transfer and fluid flow, etc. Several interesting applications area are also discusses in the book like underwater vehicle propeller, the flow behavior in gas-cooled nuclear reactors, simulation odour dispersion around windbreaks and so on.

Bioreactor System Design Book
Score: 5
From 2 Ratings

Bioreactor System Design


  • Author : Juan A. Asenjo
  • Publisher : CRC Press
  • Release Date : 1994-11-17
  • Genre: Science
  • Pages : 648
  • ISBN 10 : 0824790022

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Bioreactor System Design Excerpt :

Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such as strain and media selection, that have an overwhelming influence on all further operations, is emphasized.;This work is intended for biochemical, chemical and bioprocess engineers; biotechnologists; industrial biochemists; micro- and molecular biologists; food scientists; and upper-level undergraduate and graduate students in these disciplines.

Plant Biotechnology Book

Plant Biotechnology


  • Author : Jaime Hill
  • Publisher : Scientific e-Resources
  • Release Date : 2019-01-21
  • Genre: Uncategoriezed
  • Pages : 328
  • ISBN 10 : 9781839471865

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Plant Biotechnology Excerpt :

Biotechnology, is the manipulation of biological organisms to make products that benefit human beings. Biotechnology contributes to such diverse areas as food production, waste disposal, mining and medicine. Plant biotechnology may be defined as the art, science and application of knowledge obtained from the study of life sciences to create technological improvements and change the genetics of plants in order to produce desired characteristics in plant species. This can be accomplished through many different techniques ranging from simply selecting plants with desirable characteristics for propagation, to more complex molecular techniques. Genetic engineering deals with synthesis of artificial gene, repair of gene, combining of DNA from two organism and manipulating the artificial gene together with the recombinant DNA for the improvement of microbes in plants as well as other living being. Genetic engineering opens a totally new dimension for bioprospecting. The search for new genes and their application is the primary objective of the biotech industry. Gene technology now enable humans to integrate revolutionary new properties in to cultivated plants through inter-specific or inter-generic gene transfer which was not possible through classical approach of crop improvement. This book covers all important aspects of practical utility in field of genetic manipulation by different areas of Plant Biotechnology Techniques.

Biocatalysis and Biocatalytic Technologies Book

Biocatalysis and Biocatalytic Technologies


  • Author : Gennadiĭ Efremovich Zaikov
  • Publisher : Nova Publishers
  • Release Date : 2006
  • Genre: Science
  • Pages : 82
  • ISBN 10 : 1600210414

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Biocatalysis and Biocatalytic Technologies Excerpt :

This book covers the application, both actual and potential, of biological catalysts (including whole cells or isolated components thereof, natural and modified enzymes and catalytic antibodies) for the synthesis, interconversion or degradation of chemical species.

Handbook of Industrial Chemistry and Biotechnology Book

Handbook of Industrial Chemistry and Biotechnology


  • Author : James A. Kent
  • Publisher : Springer
  • Release Date : 2017-08-01
  • Genre: Science
  • Pages : 2278
  • ISBN 10 : 9783319522876

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Handbook of Industrial Chemistry and Biotechnology Excerpt :

This widely respected and frequently consulted reference work provides a wealth of information and guidance on industrial chemistry and biotechnology. Industries covered span the spectrum from salt and soda ash to advanced dyes chemistry, the nuclear industry, the rapidly evolving biotechnology industry, and, most recently, electrochemical energy storage devices and fuel cell science and technology. Other topics of surpassing interest to the world at large are covered in chapters on fertilizers and food production, pesticide manufacture and use, and the principles of sustainable chemical practice, referred to as green chemistry. Finally, considerable space and attention in the Handbook are devoted to the subjects of safety and emergency preparedness. It is worth noting that virtually all of the chapters are written by individuals who are embedded in the industries whereof they write so knowledgeably.