The Innate Immune System Book

The Innate Immune System


  • Author : Tom Monie
  • Publisher : Academic Press
  • Release Date : 2017-02-16
  • Genre: Medical
  • Pages : 228
  • ISBN 10 : 9780081007587

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The Innate Immune System Excerpt :

The Innate Immune System: A Compositional and Functional Perspective focuses on the components and functionality of the innate immune system, detailing how they work in their own right, and then progressing to cover their relevance to disease and how they interface with the adaptive response. Despite the growing appreciation of the importance of the innate immune system, many classical immunology books still focus predominantly on the adaptive immune response. Not only is this unbalanced, but it fails to reflect the growing synergy between the activation and function of the innate response and the final nature of adaptive response. This book fills the gap in knowledge that is needed to fully understand and appreciate the topic. Provides a clear, but simple picture of the main principle of innate immunity and the interlink with adaptive responses Fulfills an unmet need in the area of innate immunity Gives a constructive and progressive approach to introducing and explaining the key players in the innate immune response Introduces and explains the key players in the innate immune response with a constructive and progressive approach Presents the components of the innate response and shows how these interrelated areas connect with one another from a functional perspective Enables the reader to gradually increase their level of understanding and knowledge without the risk of becoming confused, thereby ensuring they fully comprehend the integrated signaling pathways

Molecular Biology of the Cell Book
Score: 4.5
From 5 Ratings

Molecular Biology of the Cell


  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 0815332181

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Molecular Biology of the Cell Excerpt :

Janeway s Immunobiology Book

Janeway s Immunobiology


  • Author : Kenneth Murphy
  • Publisher : Garland Science
  • Release Date : 2010-06-22
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 0815344570

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Janeway s Immunobiology Excerpt :

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Innate Immunity Book

Innate Immunity


  • Author : Yves Carton
  • Publisher : Iste Press - Elsevier
  • Release Date : 2019-11-15
  • Genre: Natural immunity
  • Pages : 324
  • ISBN 10 : 9781785483080

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Innate Immunity Excerpt :

Innate immunity is a new branch of immunology, confirmed by three Nobel Prize winners in 2011. It is the first line of defense against pathogens and is in a way the preliminary step of adaptive immunity which occurs later, and only present in vertebrates. This book examines the way in which innate immunity was discovered in invertebrates. As a starting point, it looks at the work of Louis Pasteur on silkworm disease and the findings of Ilya Metchnikov, discoverer of phagocytosis. It also investigates André Paillot, who in 1920 demonstrated the existence of humoral immunity in insects, unrelated to the type of immunity that was initially thought to be present in all vertebrates. Finally, Innate Immunity shows how the group directed by Jules Hoffmann found strong similarities between the innate immunity response of insects and mammals. The discovery of a receptor protein in Drosophila, which is also found in humans, was what led to Jules Hoffmann being awarded the Nobel Prize in 2011. Presents the transformations experienced by the domains of innate immunity Shows the lineage of these results Bridges the gap between innate immunity of invertebrates and that of vertebrates

The Innate Immune Response to Noninfectious Stressors Book

The Innate Immune Response to Noninfectious Stressors


  • Author : Massimo Amadori
  • Publisher : Academic Press
  • Release Date : 2016-02-23
  • Genre: Medical
  • Pages : 276
  • ISBN 10 : 9780128019740

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The Innate Immune Response to Noninfectious Stressors Excerpt :

The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans Covers the crucial issue of the immune response to endocrine disruptors Includes immunological parameters as reporter system of environmental adaptation Provides many illustrative examples to foster reader understanding

Innate Immunity  Resistance and Disease Promoting Principles Book

Innate Immunity Resistance and Disease Promoting Principles


  • Author : G. Hartmann
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2013-06-05
  • Genre: Science
  • Pages : 138
  • ISBN 10 : 9783318023480

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Innate Immunity Resistance and Disease Promoting Principles Excerpt :

Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.

Innate Immunity Book

Innate Immunity


  • Author : Jonathan Ewbank
  • Publisher : Springer Science & Business Media
  • Release Date : 2008
  • Genre: Medical
  • Pages : 458
  • ISBN 10 : 9781588297464

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Innate Immunity Excerpt :

Immunologists today are interested in all of the diverse cell-types involved in host defense and have a deeper appreciation of the importance of innate immune mechanisms as a first line of protection against pathogens. This volume thus discusses the isolation and functional characterization of cells involved in innate immunity in mouse and man, including mast cells and eosinophils. Other focuses include natural killer cells, methods in statistics, in vivo imaging, genome engineering, and mutagenesis and culture that are adapted to the study of innate immunity in these hosts. These are complemented with a series of chapters dealing with alternative models: plants, worms, mosquitoes, flies, and fish. Together, these approaches and models are being used to dissect the complex interplay between hosts and pathogens and contribute to developing strategies to help fight infection. With chapters written by experts on the cutting-edge of this technology, Innate Immunity is an essential reference for immunologists, histologists, geneticists, and molecular biologists.

Antibody Fc  Book

Antibody Fc


  • Author : Margaret Ackerman
  • Publisher : Academic Press
  • Release Date : 2013-08-06
  • Genre: Medical
  • Pages : 358
  • ISBN 10 : 9780123948182

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Antibody Fc Excerpt :

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system

Experimental Approaches For The Investigation Of Innate Immunity  The Human Innate Immunity Handbook Book

Experimental Approaches For The Investigation Of Innate Immunity The Human Innate Immunity Handbook


  • Author : Richard Bucala
  • Publisher : World Scientific
  • Release Date : 2016-01-15
  • Genre: Medical
  • Pages : 180
  • ISBN 10 : 9789814678742

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Experimental Approaches For The Investigation Of Innate Immunity The Human Innate Immunity Handbook Excerpt :

The recent explosion of information in innate immune pathways for recognition, effect or responses, and genetic regulation has given impetus to investigations into analogous pathways in the human immune response, which in turn has produced attendant insights into both normal physiology and immunopathology. This volume presents a compendium of methods and protocols for the investigation of human innate immunity with application to the study of normal immune function, immunosenescence, autoimmunity and infectious diseases. Among the topics covered are quantitative flow cytometry for Toll-like receptor expression and function; multidimensional single cell mass cytometry (CyTOF) in complex immune interactions and tumor immunity; imaging techniques such as Imagestream high resolution microscopy coupled to flow cytometry, immune cell infiltration of organotypic, biomimetic organs; high-throughput single cell secretion profiling; multiplexed transcriptomic profiling; microsatellite and microRNA methodologies, RNA interference; and the latest bioinformatics and biostatistical methodologies, including in-depth statistical modeling, genetic mapping, and systems approaches.

Autophagy Regulation of Innate Immunity Book

Autophagy Regulation of Innate Immunity


  • Author : Jun Cui
  • Publisher : Springer Nature
  • Release Date : 2019-11-14
  • Genre: Medical
  • Pages : 203
  • ISBN 10 : 9789811506062

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Autophagy Regulation of Innate Immunity Excerpt :

This book discusses novel concepts and discoveries concerning the regulation of innate immunity by autophagy and autophagy-related proteins. In the past decade, there have been major advances in our understanding of the molecular mechanisms of autophagy and its physiological functions. This book highlights emerging studies on the underlying mechanisms of autophagy regulation of innate immunity, including inflammation, antiviral immunity and anti-bacterial responses and the signaling pathways that prompt or inhibit the initiation and progression of related diseases. It also offers new ideas and strategies for future drugs based on manipulating autophagy, especially selective autophagy mediated by cargo receptors. Providing a comprehensive overview of the autophagy regulation of innate immunity, it is a valuable resource for graduate students and researchers in the fields of immunology, cell biology and translational medicine.

Innate Immunity in Aquatic Vertebrates Book

Innate Immunity in Aquatic Vertebrates


  • Author : Leon Grayfer
  • Publisher : Frontiers Media SA
  • Release Date : 2020-01-17
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889634279

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Innate Immunity in Aquatic Vertebrates Excerpt :

Innate Immunity and Inflammation Book

Innate Immunity and Inflammation


  • Author : Ruslan Medzhitov
  • Publisher : Unknown
  • Release Date : 2014-10-01
  • Genre: Medical
  • Pages : 240
  • ISBN 10 : 1621820297

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Innate Immunity and Inflammation Excerpt :

The innate immune system is rapidly activated in response to infection and injury. It is a generic rather than pathogen-specific response that recruits immune cells, promotes inflammation, and mobilizes the adaptive immune system. Excessive or chronic inflammation may cause tissue damage, so a careful balance is required to restore homeostasis. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the cellular and molecular mechanisms involved in innate immunity and all types of inflammation. The contributors examine the cell types that make up the innate immune system, their use of pattern recognition receptors (e.g., Toll-like receptors) to identify pathogens and damaged tissues, and how they trigger signaling pathways that culminate in inflammation, pathogen destruction, and tissue repair. The numerous chemical signals and factors involved in innate immunity and inflammation are described, as are those that keep inflammation in check. The authors also discuss the diseases that can result when these processes go awry, such as rheumatoid arthritis and cancer. This volume is therefore a valuable reference for all immunologists, cell biologists, and medical scientists wishing to understand these protective processes and their implications for human health and disease.

Innate Immunity in Health and Disease Book

Innate Immunity in Health and Disease


  • Author : Shailendra K. Saxena
  • Publisher : BoD – Books on Demand
  • Release Date : 2021-08-25
  • Genre: Medical
  • Pages : 414
  • ISBN 10 : 9781838807658

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Innate Immunity in Health and Disease Excerpt :

The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.

Current Topics in Innate Immunity II Book

Current Topics in Innate Immunity II


  • Author : John D. Lambris
  • Publisher : Springer
  • Release Date : 2013-10-25
  • Genre: Medical
  • Pages : 354
  • ISBN 10 : 1461429528

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Current Topics in Innate Immunity II Excerpt :

Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases.