Innovative Brain Tumor Therapy Book

Innovative Brain Tumor Therapy


  • Author : Gerardo Caruso
  • Publisher : Woodhead Publishing
  • Release Date : 2014-10-10
  • Genre: Medical
  • Pages : 196
  • ISBN 10 : 9781908818744

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Innovative Brain Tumor Therapy Excerpt :

Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.

Innovative Brain Tumor Therapy Book

Innovative Brain Tumor Therapy


  • Author : Gerardo Caruso
  • Publisher : Woodhead Pub Limited
  • Release Date : 2014-10-10
  • Genre: Science
  • Pages : 180
  • ISBN 10 : 190756859X

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Innovative Brain Tumor Therapy Excerpt :

Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.

Nanotherapy for Brain Tumor Drug Delivery Book

Nanotherapy for Brain Tumor Drug Delivery


  • Author : Vivek Agrahari
  • Publisher : Humana
  • Release Date : 2021-12-15
  • Genre: Medical
  • Pages : 298
  • ISBN 10 : 1071610546

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Nanotherapy for Brain Tumor Drug Delivery Excerpt :

This volume provides a guide on nanoformulations and other drug delivery approaches for both academic and industry scientists. The chapters in this book cover diverse topics and techniques in nanoparticle drug delivery, gene therapy, neurosurgical brain implant, exosomes, MRI-guided focused ultrasound (MRgFUS), and advanced preclinical glioblastoma multiforme animal models. Some chapters discuss state-of-the-art and innovative nanomedicines for glioblastoma, surface-modified nanoparticle drug carriers for brain cancer treatment, focused ultrasound (FUS)-mediated blood-brain barrier disruption for enhanced drug delivery to brain tumors; gene therapy delivery approaches to treat brain cancer, and a liposome-template hydrogel nanoparticles (LHNPs) as a powerful CRISPR/Cas9 delivery vehicle. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Nanotherapy for Brain Tumor Drug Delivery is a valuable resource for the scientific community working on this important therapeutic field, and will help fast-track the clinical translation of revolutionary nanotechnologies for treating brain tumors.

Intracranial Gliomas Part III   Innovative Treatment Modalities Book

Intracranial Gliomas Part III Innovative Treatment Modalities


  • Author : M.F. Chernov
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2018-07-10
  • Genre: Medical
  • Pages : 222
  • ISBN 10 : 9783318060638

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Intracranial Gliomas Part III Innovative Treatment Modalities Excerpt :

At present most intracranial gliomas are considered incurable with current treatment strategies, and the search for new modalities that may effectively control tumor growth continues. The chapters in this volume describe basic principles and therapeutic possibilities of several innovative techniques, including photodynamic therapy, laser-induced interstitial thermotherapy, stereotactic cryodestruction, high-intensity focused ultrasound ablation, boron neutron capture therapy, proton and carbon ion irradiation, targeted therapy, immunotherapy, gene therapy, local chemotherapy, and alternating electric fields therapy. Potential applications of extracellular vesicles and nanotechnology for management of gliomas are highlighted as well. Many of these methods have already demonstrated antitumor efficacy in clinical testing, whereas others are still under development. The materials presented in this book are mainly directed at clinicians treating patients with brain tumors, as well as clinical and basic researchers working in the field of neuro-oncology.

Handbook of Brain Tumor Chemotherapy Book

Handbook of Brain Tumor Chemotherapy


  • Author : Herbert B. Newton
  • Publisher : Academic Press
  • Release Date : 2006
  • Genre: Medical
  • Pages : 510
  • ISBN 10 : 0120884100

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Handbook of Brain Tumor Chemotherapy Excerpt :

The book provides a broad overview of the current "state-of-the-art" in the use of chemotherapy for primary and metastatic brain tumors and includes information on traditional (e.g., alkylating agents, spindle poisons, topoisomerase inhibitors, etc) and non-traditional (e.g., intra-arterial approaches, blood-brain barrier disruption, etc) forms of chemotherapy. In addition, newer molecular-based chemotherapeutic agents (e.g., tyrosine kinase inhibitors, ras pathway inhibitors, PI3 kinase inhibitors, mTOR inhibitors, angiogenesis inhibitors, etc) are included. Well-founded in basic science and pharmacology, the chapters provide an overview of relevant background material in critical areas such as drug pharmacology and mechanisms of action, molecular biology (e.g., critical oncogenes, tumor suppressor genes), signal transduction pathways, angiogenesis pathways, and developmental pharmacology.

Glioblastoma Resistance to Chemotherapy  Molecular Mechanisms and Innovative Reversal Strategies Book

Glioblastoma Resistance to Chemotherapy Molecular Mechanisms and Innovative Reversal Strategies


  • Author : Ramasamy Paulmurugan
  • Publisher : Academic Press
  • Release Date : 2021-06-25
  • Genre: Science
  • Pages : 828
  • ISBN 10 : 9780128215685

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Glioblastoma Resistance to Chemotherapy Molecular Mechanisms and Innovative Reversal Strategies Excerpt :

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood. Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance

Tumors of the Brain and Spine Book

Tumors of the Brain and Spine


  • Author : Franco DeMonte
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-10
  • Genre: Medical
  • Pages : 364
  • ISBN 10 : 9780387292021

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Tumors of the Brain and Spine Excerpt :

Tumors of the Brain and Spine focuses primarily on approaches to the treatment of benign, primary low-grade to high-grade, and metastatic tumors in the brain and spine, as practiced by surgeons and clinicians at the University of Texas M. D. Anderson Cancer Center. The book is written mainly for the primary care oncologist, general neurologist, and general neurosurgeon. Discussion of treatment coverage focuses on neurosurgery, chemotherapy, and radiation therapy, singly and in combination. Also included are chapters on symptom management, molecular genetics and neuropathology of intracranial tumors, leptomeningeal dissemination of systemic cancer, epidemiology of brain tumors, and innovative treatment strategies.

Targeted Radionuclide Therapy Book

Targeted Radionuclide Therapy


  • Author : Tod W. Speer
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2012-03-28
  • Genre: Medical
  • Pages : 608
  • ISBN 10 : 9781451153262

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Targeted Radionuclide Therapy Excerpt :

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Brain Tumor Imaging Book

Brain Tumor Imaging


  • Author : Elke Hattingen
  • Publisher : Springer
  • Release Date : 2015-09-02
  • Genre: Medical
  • Pages : 161
  • ISBN 10 : 9783642450402

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Brain Tumor Imaging Excerpt :

This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.

Handbook of Brain Tumor Chemotherapy  Molecular Therapeutics  and Immunotherapy Book

Handbook of Brain Tumor Chemotherapy Molecular Therapeutics and Immunotherapy


  • Author : Herbert B. Newton
  • Publisher : Academic Press
  • Release Date : 2018-03-28
  • Genre: Medical
  • Pages : 848
  • ISBN 10 : 9780128121016

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Handbook of Brain Tumor Chemotherapy Molecular Therapeutics and Immunotherapy Excerpt :

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Innovative Medicine Book

Innovative Medicine


  • Author : Kazuwa Nakao
  • Publisher : Springer
  • Release Date : 2015-10-13
  • Genre: Medical
  • Pages : 339
  • ISBN 10 : 9784431556510

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Innovative Medicine Excerpt :

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

MRI Guided Focused Ultrasound Surgery Book

MRI Guided Focused Ultrasound Surgery


  • Author : Ferenc A. Jolesz
  • Publisher : CRC Press
  • Release Date : 2007-09-26
  • Genre: Medical
  • Pages : 216
  • ISBN 10 : 9781420019933

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MRI Guided Focused Ultrasound Surgery Excerpt :

MRI-Guided Focused Ultrasound Surgery will be the first publication on this new technology, and will present a variety of current and future clinical applications in tumor ablation treatment. This source helps surgeons and specialists evaluate, analyze, and utilize MRI-guided focused ultrasound surgery - bridging the gap between phase 3 clinical tr

Glioblastoma Book

Glioblastoma


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2022-11-26
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:1125677458

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Glioblastoma Excerpt :

Emerging Electromagnetic Technologies for Brain Diseases Diagnostics  Monitoring and Therapy Book

Emerging Electromagnetic Technologies for Brain Diseases Diagnostics Monitoring and Therapy


  • Author : Lorenzo Crocco
  • Publisher : Springer
  • Release Date : 2018-03-10
  • Genre: Technology & Engineering
  • Pages : 241
  • ISBN 10 : 9783319750071

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Emerging Electromagnetic Technologies for Brain Diseases Diagnostics Monitoring and Therapy Excerpt :

This timely book presents innovative technologies for use in the diagnosis, monitoring, and treatment of brain disease. These technologies offer exciting possibilities in the medical field owing to their low-cost, portability and safety. The authors address cerebrovascular diseases such as stroke, ischemia, haemorrhage, and vasospasm, these diseases having an ever-increasing societal relevance due to the global ageing population. The authors describe the potential of novel techniques such as microwave imaging and present innovative modalities for treatment of brain tumours using electromagnetic fields and nano-composites, as well as for monitoring brain temperature during surgery. Finally, Emerging Electromagnetic Technologies for Brain Diseases Diagnostics, Monitoring and Therapy addresses the perspectives which arise from multi-modal multi-spectral EM modalities, which make a synergic use of the different portions of the electromagnetic spectrum. This text will be of interest to readers from various different areas, given the fundamental interdisciplinarity of the subject matter. This includes researchers or practitioners in the field of electrical engineering, applied physicists, and applied mathematicians working on imaging applications for biomedical and electromagnetic technologies. Neurologists and radiologists may also find this book of interest, as may graduate students in these areas.

Advancing Nuclear Medicine Through Innovation Book

Advancing Nuclear Medicine Through Innovation


  • Author : National Research Council
  • Publisher : National Academies Press
  • Release Date : 2007-09-11
  • Genre: Medical
  • Pages : 173
  • ISBN 10 : 0309134153

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Advancing Nuclear Medicine Through Innovation Excerpt :

Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.