iPSCs from Diverse Species Book

iPSCs from Diverse Species


  • Author : Alexander Birbrair
  • Publisher : Academic Press
  • Release Date : 2020-09-29
  • Genre: Science
  • Pages : 272
  • ISBN 10 : 9780323851855

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iPSCs from Diverse Species Excerpt :

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs from Diverse Species, Volume 2 addresses how induced pluripotent stem cells (iPSCs) can be derived from different species. The volume teaches the reader about modern state-of-the-art methodologies to derive iPSCs from distinct species. This volume will cover how to derive iPSCs from species like nonhuman primates, horses, dogs, pigs, rats, rabbits, and others. It also discusses the importance of iPSCs in species conservation. Detailed description on methods used to obtain iPSCs from humans and other species expands the knowledge and understanding of stem cell biology and provides a potent tool to model diseases. The volume is written for researchers and scientists in stem cell biology, and regenerative medicine and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of iPSC technology Covers iPCSs from the following species: humans, monkeys, horses, dogs, pigs, rats, rabbits, and more Consists of contributions from stem cell leaders around the world

The SAGE Encyclopedia of Stem Cell Research Book

The SAGE Encyclopedia of Stem Cell Research


  • Author : Eric E. Bouhassira
  • Publisher : SAGE Publications
  • Release Date : 2015-06-15
  • Genre: Medical
  • Pages : 1517
  • ISBN 10 : 9781483347677

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The SAGE Encyclopedia of Stem Cell Research Excerpt :

The SAGE Encyclopedia of Stem Cell Research, Second Edition is filled with new procedures and exciting medical breakthroughs, including executive orders from the Obama administration reversing barriers to research imposed under the Bush administration, court rulings impacting NIH funding of research based on human embryonic stem cells, edicts by the Papacy and other religious leaders, and the first success in cloning human stem cells. Stem cell biology is clearly fueling excitement and potential in traditional areas of developmental biology and in the field of regenerative medicine, where they are believed to hold much promise in addressing any number of intractable medical conditions. This updated second edition encyclopedia will expand on information that was given in the first edition and present more than 270 new and updated articles that explore major topics in ways accessible to nonscientists, thus bringing readers up-to-date with where stem cell biology stands today, including new and evolving ethical, religious, legal, social, and political perspectives. This second edition reference work will serve as a universal resource for all public and academic libraries. It is an excellent foundation for anyone who is interested in the subject area of stem cell biology. Key Features: Reader’s Guide, Further Readings, Cross References, Chronology, Resource Guide, Index A Glossary will elucidate stem cell terminology for the nonscientist Statistics and selected reprints of major journal articles that pertain to milestones achieved in stem cell research Documents from Congressional Hearings on stem cells and cloning Reports to the President’s Council on Bioethics, and more

iPSCs from Diverse Species Book

iPSCs from Diverse Species


  • Author : Alexander Birbrair
  • Publisher : Academic Press
  • Release Date : 2020-10-19
  • Genre: Science
  • Pages : 272
  • ISBN 10 : 9780128222287

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iPSCs from Diverse Species Excerpt :

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs from Diverse Species, Volume 2 addresses how induced pluripotent stem cells (iPSCs) can be derived from different species. The volume teaches the reader about modern state-of-the-art methodologies to derive iPSCs from distinct species. This volume will cover how to derive iPSCs from species like nonhuman primates, horses, dogs, pigs, rats, rabbits, and others. It also discusses the importance of iPSCs in species conservation. Detailed description on methods used to obtain iPSCs from humans and other species expands the knowledge and understanding of stem cell biology and provides a potent tool to model diseases. The volume is written for researchers and scientists in stem cell biology, and regenerative medicine and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of iPSC technology Covers iPCSs from the following species: humans, monkeys, horses, dogs, pigs, rats, rabbits, and more Consists of contributions from stem cell leaders around the world

Phenotyping of Human iPSC derived Neurons Book

Phenotyping of Human iPSC derived Neurons


  • Author : Elizabeth D. Buttermore
  • Publisher : Academic Press
  • Release Date : 2022-09-30
  • Genre: Medical
  • Pages : 374
  • ISBN 10 : 9780128222782

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Phenotyping of Human iPSC derived Neurons Excerpt :

Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification. Discusses techniques and new technology for iPSC culturing and neuronal differentiation to establish best practices in the lab Outlines considerations for phenotypic assay development Provides information about the successes, failures, and implications of phenotyping and screening with iPSC-derived neurons Describes how

IPSCs in Tissue Engineering Book

IPSCs in Tissue Engineering


  • Author : Alexander Birbrair
  • Publisher : Elsevier
  • Release Date : 2021-08-17
  • Genre: Science
  • Pages : 430
  • ISBN 10 : 9780128238097

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IPSCs in Tissue Engineering Excerpt :

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs in Tissue Engineering, Volume 11 addresses how induced pluripotent stem cells (iPSCs) are being used to advance tissue engineering. Somatic cells can be reprogrammed into iPSCs by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This book will address the advances in research of how iPSCs are being used for the generation of different tissues and organs such as the lungs, trachea, salivary glands, skeletal muscle, liver, intestine, kidney, even the brain, and much more. This volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and tissue engineering and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics Covers the engineering of the following organs: lungs, trachea, salivary glands, skeletal muscle, liver, intestine, kidney, even the brain, and more Is contributed from stem cell leaders around the world

Advanced Therapies in Regenerative Medicine Book

Advanced Therapies in Regenerative Medicine


  • Author : Jan-Thorsten Schantz
  • Publisher : World Scientific Publishing Company
  • Release Date : 2015-03-30
  • Genre: Science
  • Pages : 300
  • ISBN 10 : 9789814630665

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Advanced Therapies in Regenerative Medicine Excerpt :

Regenerative medicine is a fast developing field which has led to a paradigm shift in treatment of various diseases. Clinician-scientists worldwide constantly develop novel approaches in various medical specialties (surgery, internal medicine, oncology, neurology, gynecology, pediatrics, etc.) using gene therapy approaches, innovative biomaterials or stem cell based therapies. It is difficult even for experts to find out what has already reached a clinical stage. The aim of the second volume in this series is to provide the reader with a current update on the latest therapeutic developments. As such, both patients and doctors will find the information contained within this manual to be useful and relevant. The editors are both international leaders in the field of regenerative medicine, and both possess a broad spectrum of experience from basic research to clinical application and commercialization.

Stem Cells Book

Stem Cells


  • Author : Muireann Quigley
  • Publisher : World Scientific
  • Release Date : 2012
  • Genre: Medical
  • Pages : 297
  • ISBN 10 : 9789814374255

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Stem Cells Excerpt :

Fast-moving and ever-changing, stem cell science and research presents ongoing ethical and legal challenges in many countries. Each development and innovation throws up new challenges. This is the case even where new developments initially seem to solve old dilemmas. Sometimes it becomes evident that new science does not in fact solve old problems and, for that reason, the ethical issues remain. In recognition of this, this book presents innovative and creative analyses of a range of ethical and legal challenges raised by stem cell research and its potential and actual application. The editors of this collection have brought together experts from ethics and law to bring fresh perspectives on the use of and research on stem cells. The chapters in this collection range across a number of different issues in the debate on stem cells, from the ethical dilemmas of conducting stem cell research to those of the clinical application of stem cell technology. Each chapter gives an in-depth and comprehensive analysis of the ethical or legal issues at stake. The early chapters give engaging new expositions on the permissibility of using embryos in stem cell research, in particular challenging our views about how we view and OCyconstructOCO the embryo in debates regarding stem cells. Later chapters move on to actual and potential clinical uses of stem cells and present novel arguments about these.

Stem Cells Book

Stem Cells


  • Author : Muireann Quigley
  • Publisher : World Scientific
  • Release Date : 2012-03-27
  • Genre: Science
  • Pages : 296
  • ISBN 10 : 9789814458085

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Stem Cells Excerpt :

Fast-moving and ever-changing, stem cell science and research presents ongoing ethical and legal challenges in many countries. Each development and innovation throws up new challenges. This is the case even where new developments initially seem to solve old dilemmas. Sometimes it becomes evident that new science does not in fact solve old problems and, for that reason, the ethical issues remain. In recognition of this, this book presents innovative and creative analyses of a range of ethical and legal challenges raised by stem cell research and its potential and actual application. The editors of this collection have brought together experts from ethics and law to bring fresh perspectives on the use of and research on stem cells. The chapters in this collection range across a number of different issues in the debate on stem cells, from the ethical dilemmas of conducting stem cell research to those of the clinical application of stem cell technology. Each chapter gives an in-depth and comprehensive analysis of the ethical or legal issues at stake. The early chapters give engaging new expositions on the permissibility of using embryos in stem cell research, in particular challenging our views about how we view and ‘construct’ the embryo in debates regarding stem cells. Later chapters move on to actual and potential clinical uses of stem cells and present novel arguments about these. Contents:New Frontiers in Stem Cell Science & Ethics: Current Technology & Future Challenges (Muireann Quigley, Sarah Chan and John Harris)The Monopoly of Moral Status in Debate on Embryonic Stem Cell Research (Sorcha Uí Chonnachtaigh)The Construction of the Embryo and Implications for Law (Sheelagh McGuinness)Legal Regulation of Human Stem Cell Technology (Loane Skene)Human Embryos in Stem Cell Research: Property and Recompense (Sarah Devaney)Against the Discarded–Created Distinction in Embryonic Stem Cell Research (Katrien Devolder)Stem Cell Therapies & Benefiting from the Fruits

The New Eugenics Book

The New Eugenics


  • Author : Conrad B. Quintyn Ph.D.
  • Publisher : Archway Publishing
  • Release Date : 2020-12-17
  • Genre: Science
  • Pages : 424
  • ISBN 10 : 9781480899216

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The New Eugenics Excerpt :

The specter of early twentieth-century eugenics—with its goal of preventing the “unfit” from reproducing through forced sterilization—still haunts us in this era of genetic engineering. Conrad B. Quintyn, an associate professor of biological anthropology at Bloomsburg University, Bloomsburg, Pennsylvania, calls this the new eugenics era because geneticists have begun to explore ways to prevent and repair defective genes in all humans. In this book, he considers whether genetic engineering will exacerbate social injustices and/or lead to a public safety issue. For instance, in 2012, virologists in the U.S. and the Netherlands genetically engineered avian (bird) flu to be more transmissible between mammals. These scientists argued that virus transmission between mammals enables us to make vaccines to prevent pandemics. They never considered what would happen if the virus accidentally escaped the laboratory. Meanwhile, some scientists are experimenting with “designer babies,” altering genes to remove diseases and even programming certain traits. Join the author as he considers whether scientists are playing God as well as the risks we face by altering genetics in The New Eugenics.

Current Topics in iPSCs Technology Book

Current Topics in iPSCs Technology


  • Author : Alexander Birbrair
  • Publisher : Academic Press
  • Release Date : 2022-01-18
  • Genre: Science
  • Pages : 636
  • ISBN 10 : 9780323983983

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Current Topics in iPSCs Technology Excerpt :

Current Topics in iPSCs provides a deep analysis of the underlying fundamentals that support short and mid-term developments and milestones in the business of mesenchymal stem cell therapies. This volume explores the next frontier of MSC therapies and how the transformational potential of therapeutic adult cells will be realised in all therapy areas. The impacts of clinical and economic benefits are dissected throughout each of the chapters. Written by thought leaders in the field for those curious about the interface of science and business. Explores the strategy at the forefront of the science of mesenchymal stem cells Provides an overview of all therapy areas where MSC and MSC-derived products can be used therapeutically Depicts transformational changes in healthcare that enable the implementation of MSC-powered technology platforms

Cell Therapy Book

Cell Therapy


  • Author : Dwaine F. Emerich
  • Publisher : Springer
  • Release Date : 2017-08-25
  • Genre: Medical
  • Pages : 328
  • ISBN 10 : 9783319571539

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Cell Therapy Excerpt :

This volume provides a comprehensive, state-of-the art review of the field of cell therapy. The volume begins with an overview of the breadth of the field and then turns to overviews of imaging technologies that can aid in both safety and efficacy evaluations. The book then turns to numerous contributions detailing the rapidly growing field of stem cell therapies. These sections cover our understanding of the natural roles of stem cells in biology and human disease and then touches on several of the more prominent areas where stem cells are moving rapidly into clinical evaluation including neurodegenerative diseases, muscular dystrophy, cardiac repair, and diabetes. The volume concludes with contributions from experts in oncology, ophthalmology, stem cells, 3-D printing, and biomaterials where the convergence of expertise is leading to unprecedented insights into how to minutely control the in vivo fate and function of transplanted and/or endogeneously mobilized cells. Finally, the book provides insights into the pivotal relationship between academic and industrial partnerships. This volume is designed to touch on the major areas where the field will make its greatest and most immediate clinical impacts. This text will provide a useful resource for physicians and researchers interested in the rapidly changing filed of cell therapy.

The End of Sex and the Future of Human Reproduction Book

The End of Sex and the Future of Human Reproduction


  • Author : Henry T. Greely
  • Publisher : Harvard University Press
  • Release Date : 2016-05-30
  • Genre: Law
  • Pages : 392
  • ISBN 10 : 9780674728967

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The End of Sex and the Future of Human Reproduction Excerpt :

Within twenty, maybe forty, years most people in developed countries will stop having sex for the purpose of reproduction. Instead, prospective parents will be told as much as they wish to know about the genetic makeup of dozens of embryos, and they will pick one or two for implantation, gestation, and birth. And it will be safe, lawful, and free. In this work of prophetic scholarship, Henry T. Greely explains the revolutionary biological technologies that make this future a seeming inevitability and sets out the deep ethical and legal challenges humanity faces as a result. “Readers looking for a more in-depth analysis of human genome modifications and reproductive technologies and their legal and ethical implications should strongly consider picking up Greely’s The End of Sex and the Future of Human Reproduction...[It has] the potential to empower readers to make informed decisions about the implementation of advancements in genetics technologies.” —Dov Greenbaum, Science “[Greely] provides an extraordinarily sophisticated analysis of the practical, political, legal, and ethical implications of the new world of human reproduction. His book is a model of highly informed, rigorous, thought-provoking speculation about an immensely important topic.” —Glenn C. Altschuler, Psychology Today

Nonhuman Primates in Biomedical Research Book

Nonhuman Primates in Biomedical Research


  • Author : Christian R. Abee
  • Publisher : Academic Press
  • Release Date : 2012-03-29
  • Genre: Medical
  • Pages : 537
  • ISBN 10 : 9780123813657

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Nonhuman Primates in Biomedical Research Excerpt :

A comprehensive, up-to-date review of the use of nonhuman primates in biomedical research, emphasising the biology and management, diseases, and biomedical models for nonhuman primate species most commonly used in research.

Textbook of Assisted Reproductive Techniques Book

Textbook of Assisted Reproductive Techniques


  • Author : David K. Gardner
  • Publisher : CRC Press
  • Release Date : 2017-11-09
  • Genre: Medical
  • Pages : 1040
  • ISBN 10 : 9781498740104

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Textbook of Assisted Reproductive Techniques Excerpt :

Already established as a classic comprehensive reference for the whole team at the IVF clinic, this new edition has been extensively revised, with the addition of several important new contributions on laboratory ( including advanced sperm selection techniques for ICSI, human embryo biopsy procedures, oocyte activation, managing an oocyte bank, artificial gametes, and epigenetics) as well as on clinical topics (including GnRH agonist triggering, segmentation of IVF treatment, uterus transplantation, and risk and safety management). As previously, methods, protocols, and techniques of choice are presented by eminent contributors internationally.