Ischemic and Traumatic Brain and Spinal Cord Injuries Book

Ischemic and Traumatic Brain and Spinal Cord Injuries


  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2018-03-21
  • Genre: Medical
  • Pages : 484
  • ISBN 10 : 9780128135976

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Ischemic and Traumatic Brain and Spinal Cord Injuries Excerpt :

Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The book integrates and consolidates knowledge on neurotraumatic diseases, with the hope of bringing forth more dramatic advances and developments, not only on molecular mechanisms, but also on the causes of, and treatments for, neurotraumatic diseases. Offers a clearly written, logically organized, comprehensive overview on the molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for ischemic, spinal cord, severe and mild brain injuries Provides cutting-edge research information on the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries Presents chapters that are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy

Mechanisms of Secondary Brain Damage Book

Mechanisms of Secondary Brain Damage


  • Author : Alexander Baethmann
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 165
  • ISBN 10 : 9783709192665

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Mechanisms of Secondary Brain Damage Excerpt :

Great progress has been made in the understanding and prevention of secondary brain damage from acute cerebral disorders, such as trauma and ischemia. Advances may be concerned in particular with better organization and logistics of preclinical emergency care, including rapid arrival of well-trained medical staff on the scene of an accident and of transportation to a competent hospital. Nevertheless, it is a safe assumption that development of secondary brain damage from both intra- and extracranial causes still represents a major factor for the final outcome in severe head injury. Thus, exchanges of experiences and information between various disciplines involved with this important clinical problem - trauma still assumes the number one position as a cause of morbidity and mortality up to an age of 45 years - may provide a basis for in-depth analysis of remaining problems as well as of methods of their solution. This exactly is the purpose of the present publication on concepts and findings pertinent for the general subject of secondary brain damage from various experimental as well as clinical viewpoints. An internationally high-ranking group of experts has been contributing to this collection of reviews on cerebral trauma and ischemia and its adverse sequelae, including cerebral exploration by most modern technologies, such as NMR spectroscopy or PET scanning, among others.

Animal Models of Acute Neurological Injuries Book

Animal Models of Acute Neurological Injuries


  • Author : Jun Chen
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-12-16
  • Genre: Medical
  • Pages : 498
  • ISBN 10 : 9781603271851

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Animal Models of Acute Neurological Injuries Excerpt :

Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.

Traumatic Brain and Spinal Cord Injury Book

Traumatic Brain and Spinal Cord Injury


  • Author : Cristina Morganti-Kossmann
  • Publisher : Cambridge University Press
  • Release Date : 2012-07-19
  • Genre: Medical
  • Pages : 360
  • ISBN 10 : 9781107007437

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Traumatic Brain and Spinal Cord Injury Excerpt :

Presents the most up-to-date clinical and experimental research in neurotrauma in an illustrated, accessible, comprehensive volume.

Acute Brain and Spinal Cord Injury Book

Acute Brain and Spinal Cord Injury


  • Author : Anish Bhardwaj
  • Publisher : Unknown
  • Release Date : 2008
  • Genre: Brain
  • Pages : 464
  • ISBN 10 : 036780641X

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Acute Brain and Spinal Cord Injury Excerpt :

The clinical management of patients with acute brain and spinal cord injury has evolved significantly with the advent of new diagnostic and therapeutic modalities. Editors Bhardwaj, Ellegala, and Kirsch present Acute Brain and Spinal Cord Injury, a new stand-alone reference to help today's neurologists and neurosurgeons keep abreast of all the recent advancements in brain and spinal cord injury. Divided into five sections, traumatic brain injury, ischemic stroke, intracerebral and subarachnoid hemorrhage, and spinal cord injury, this text offers the most current medical science and highlights controversies in the clinical management of patients with acute brain and spinal cord injuries.Acute Brain and Spinal Cord Injury:each section delineates diagnostic and monitoring tools, pharmacotherapies, and interventional and surgical treatments are coveredexamines and explores recently published laboratory trials and researchincorporates over 50 diagrams and figures for concise communication of scientific information.

Mechanisms of Secondary Brain Damage from Trauma and Ischemia Book

Mechanisms of Secondary Brain Damage from Trauma and Ischemia


  • Author : A. Baethmann
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 132
  • ISBN 10 : 9783709106037

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Mechanisms of Secondary Brain Damage from Trauma and Ischemia Excerpt :

Top level clinical and laboratory scientists present their most recent clinical and experimental findings and concepts. The well balanced contributions illustrate the enormous significance of the dialogue between both laboratory and clinic, ultimately for the benefit of the patients, and contribute to a better understanding of secondary brain damage from trauma and ischemia as basis to develop more effective treatment including drugs.

Acute Brain Impairment Book

Acute Brain Impairment


  • Author : Philip V Peplow
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-11-17
  • Genre: Science
  • Pages : 348
  • ISBN 10 : 9781788013376

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Acute Brain Impairment Excerpt :

A rise in the number of young and old patients suffering from a stroke or traumatic brain injury has led to the need for better drug development and treatment, as well as diagnosis and prevention of ischemic stroke and traumatic brain injury. This book provides a comprehensive overview of scientific advancements in these areas. Chapters provide the latest knowledge in neuroscience, biotechnology, and personalized medicine applicable to acute brain injuries. Development of neuroprotective drugs is treated in detail. Chemical biomarkers for detection, imaging and preventative strategies are covered to provide medicinal chemists with a broad view of translational aspects of the field. This book will be useful to postgraduate students and researchers in medicinal chemistry and pharmacology as well as specialists in the acute brain injury field.

Immunological Mechanisms and Therapies in Brain Injuries and Stroke Book

Immunological Mechanisms and Therapies in Brain Injuries and Stroke


  • Author : Jun Chen
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-09
  • Genre: Medical
  • Pages : 386
  • ISBN 10 : 9781461489153

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Immunological Mechanisms and Therapies in Brain Injuries and Stroke Excerpt :

Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.​

Therapeutic Hypothermia in Brain Injury Book

Therapeutic Hypothermia in Brain Injury


  • Author : Farid Sadaka
  • Publisher : Unknown
  • Release Date : 2013
  • Genre: Uncategoriezed
  • Pages : 162
  • ISBN 10 : 9535153501

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Therapeutic Hypothermia in Brain Injury Excerpt :

This book describes the evidence behind the application of Therapeutic Hypothermia on patients with injury to the brain and spinal cord, that includes ischemia reperfusion after cardiac arrest or asphyxiation, traumatic brain injury, acute ischemic stroke, hemorrhagic stroke, refractory intracranial hypertension, cerebral edema in acute liver failure, subarachnoid hemorrhage, as well as spinal cord injury. This book discusses the mechanisms by which therapeutic hypothermia can mitigate the pathophysiologies responsible for secondary brain injury, and provides information to help guide this treatment with regard to timing, depth, duration, and management of side-effects. The book also discusses the methods and technologies used to induce and maintain therapeutic hypothermia. It also describes how hypothermia can influence the ability to prognosticate these injured patients and provides grounds for future directions in the application of and research with therapeutic hypothermia.

Vascular Mechanisms in CNS Trauma Book

Vascular Mechanisms in CNS Trauma


  • Author : Eng H. Lo
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-04
  • Genre: Medical
  • Pages : 518
  • ISBN 10 : 9781461486909

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Vascular Mechanisms in CNS Trauma Excerpt :

While there are a number of books on the market that deal with neuronal mechanisms and targets, the proposed book will be the only one to cover the vascular aspects of CNS trauma. The contributing authors will present basic mechanisms, explain cutting-edge experimental models and techniques, and provide several clinical chapters that provide treating physicians with some insight on the cases that they see in the ICU. The table of contents is diverse and comprehensive with chapters on molecular mechanisms, physiology, pharmacology, stem cells, genomics and proteomics, in vivo MRI and PET, as well as the clinical management of vascular parameters.​

Cell Therapy Against Cerebral Stroke Book

Cell Therapy Against Cerebral Stroke


  • Author : Kiyohiro Houkin
  • Publisher : Springer
  • Release Date : 2017-01-06
  • Genre: Medical
  • Pages : 156
  • ISBN 10 : 9784431560593

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Cell Therapy Against Cerebral Stroke Excerpt :

This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity. Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy. The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan.

Acute Stroke Treatment Book

Acute Stroke Treatment


  • Author : Julien Bogousslavsky
  • Publisher : CRC Press
  • Release Date : 1997-09-04
  • Genre: Medical
  • Pages : 320
  • ISBN 10 : 1853174130

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Acute Stroke Treatment Excerpt :

Owing to the increased interest in brain ischemia and the new therapeutic options from pharmaceutical companies for the treatment of acute stroke, Professor Julien Bogousslavsky, one of the world's stroke experts, has revised his best-selling book. It is the emergence of huge possibilities in the management of stroke - ultra-early diagnosis, intensive care, surgical and other interventional therapies, thrombolysis, anti-ischemic drugs and prevention of immediate recurrence - which necessiates this timely update.

Brain Neurotrauma Book

Brain Neurotrauma


  • Author : Firas H. Kobeissy
  • Publisher : CRC Press
  • Release Date : 2015-02-25
  • Genre: Science
  • Pages : 725
  • ISBN 10 : 9781466565999

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Brain Neurotrauma Excerpt :

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Equine Fracture Repair Book

Equine Fracture Repair


  • Author : Alan J. Nixon
  • Publisher : John Wiley & Sons
  • Release Date : 2020-01-09
  • Genre: Medical
  • Pages : 928
  • ISBN 10 : 9780813815862

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Equine Fracture Repair Excerpt :

Offers a long-awaited Second Edition of this comprehensive, state-of-the-art reference for fracture repair in horses The Second Edition of Equine Fracture Repair has been thoroughly revised and updated to present the most current information on fracture repair in horses. Written to be accessible, the text is logically arranged, presenting the most authoritative information on equine fracture repair with explanations of the expected outcomes. The book provides valuable insight as to whether a fracture should be repaired, the degree of difficulty of the procedure, and a wealth of practical information on surgical techniques. This fully revised Second Edition offers a valuable tool for veterinarians making clinical decisions when faced with horse fractures, covering emergency care and splinting, the most current innovative techniques in equine fracture repair, and new implant systems. With contributions from leading experts in the field, the revised edition continues to be the essential reference to the subject. This essential resource: Offers a revised edition of the most comprehensive reference on the repair of fracture in horses, with complete information on patient assessment, emergency splinting and casting, and guidance in treatment choices Includes contributions from leading experts in the field Presents information organized by fracture type for quick access Provides valuable outcome assessment with helpful discussions of the degree of difficulty to aid in case management, incorporating information on the newest techniques and implant systems Concludes with extensive information on the identification and management of complications associated with fractures and repair methods This revised and updated edition of Equine Fracture Repair continues to provide a comprehensive resource for understanding the most effective and current techniques available for the treatment of fractures in horses.

Magnesium in the Central Nervous System Book

Magnesium in the Central Nervous System


  • Author : Robert Vink
  • Publisher : University of Adelaide Press
  • Release Date : 2011
  • Genre: Medical
  • Pages : 342
  • ISBN 10 : 9780987073051

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Magnesium in the Central Nervous System Excerpt :

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have