Ischemic and Traumatic Brain and Spinal Cord Injuries Book

Ischemic and Traumatic Brain and Spinal Cord Injuries

  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2018-03-21
  • Genre: Medical
  • Pages : 484
  • ISBN 10 : 9780128135976
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Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The book integrates and consolidates knowledge on neurotraumatic diseases, with the hope of bringing forth more dramatic advances and developments, not only on molecular mechanisms, but also on the causes of, and treatments for, neurotraumatic diseases. Offers a clearly written, logically organized, comprehensive overview on the molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for ischemic, spinal cord, severe and mild brain injuries Provides cutting-edge research information on the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries Presents chapters that are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy

Mechanisms of Secondary Brain Damage from Trauma and Ischemia Book

Mechanisms of Secondary Brain Damage from Trauma and Ischemia

  • Author : A. Baethmann
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 126
  • ISBN 10 : 9783709106037
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Top level clinical and laboratory scientists present their most recent clinical and experimental findings and concepts. The well balanced contributions illustrate the enormous significance of the dialogue between both laboratory and clinic, ultimately for the benefit of the patients, and contribute to a better understanding of secondary brain damage from trauma and ischemia as basis to develop more effective treatment including drugs.

Acute Brain and Spinal Cord Injury Book

Acute Brain and Spinal Cord Injury

  • Author : Anish Bhardwaj
  • Publisher : CRC Press
  • Release Date : 2018-09-10
  • Genre: Brain
  • Pages : 460
  • ISBN 10 : 1138381381
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The clinical management of patients with acute brain and spinal cord injury has evolved significantly with the advent of new diagnostic and therapeutic modalities. Acute Brain and Spinal Cord Injury presents the latest medical science and highlights controversies in the clinical management of patients with acute brain and spinal cord injuries. Divided into five sections--traumatic brain injury, ischemic stroke, intracerebral and subarachnoid hemorrhage, and spinal cord injury--this text: Delineates diagnostic and monitoring tools, pharmacotherapies, and interventional and surgical treatments Examines and explores recently published laboratory trials and research Incorporates over 50 diagrams and figures for concise communication of scientific information This stand-alone reference is a powerful tool in helping today's neurologists and neurosurgeons keep abreast of current advancements in brain and spinal cord injury.

Mechanisms of Secondary Brain Damage Book

Mechanisms of Secondary Brain Damage

  • Author : A. Baethmann
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-09
  • Genre: Science
  • Pages : 403
  • ISBN 10 : 9781468452037
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A distinction between primary and secondary brain damage of vari ous origin, particularly in acute lesions, such as head injury and ische mia is not entirely new. The concept is of practical significance, be cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent scientists and clinicians from various fields to pro vide a competent introduction and survey of the various aspects involved in secondary brain damage. It was attempted to provide criteria for the distinction between the primary and secondary phenomena on a morpho logical and functional level, on the basis of the kinetics involved and, most importantly, regarding the different specific manifestations, such as disturbances of microcirculation, aspects of the blood-brain barrier, and of cellular structure and function at a molecular level. Although it was not expected that a grand unifying hypothesis will be reached recon cilable with the many, occasionally opposing views on such a complex subject, nevertheless, the present volume attains an appropriate result. It can best be described as a mosaic of many different pieces which only as an ensemble reflect the current state of the art.

Animal Models of Acute Neurological Injuries II Book

Animal Models of Acute Neurological Injuries II

  • Author : Jun Chen
  • Publisher : Humana Press
  • Release Date : 2012-04-11
  • Genre: Medical
  • Pages : 0
  • ISBN 10 : 1617797812
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The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury Book

Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury

  • Author : Donald G. Stein
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 386
  • ISBN 10 : 9781461309277
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Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar macological treatment is currently available. Considering the enormity of the problem in terms of human tragedy as well as the economic burden to families and societies alike, it is surprising that so little effort is being made to develop treatments for these disorders. Although no one can become inured to the victims of brain or spinal cord injuries, one reason that insufficient time and effort have been devoted to research on recovery is that it is a generally held medical belief that nervous system injuries are simply not amenable to treatment. At best, current therapies are aimed at providing symptomatic relief or focus on re habilitative measures and the teaching of alternative behavioral strategies to help patients cope with their impairments, with only marginal results in many cases. Only within the last decade have neuroscientists begun to make serious inroads into understanding and examining the inherent "plasticity" found in the adult CNS. Ten years or so ago, very few researchers or clinicians would have thought that damaged central neurons could sprout new terminals or that intact nerve fibers in a damaged pathway could proliferate to replace inputs from neurons that died as a result of injury.

Neurotrauma New Insights into Pathology and Treatment Book

Neurotrauma New Insights into Pathology and Treatment

  • Author : John T. Weber
  • Publisher : Elsevier
  • Release Date : 2007-07-27
  • Genre: Medical
  • Pages : 460
  • ISBN 10 : 0080548873
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Neurotrauma is the leading cause of death and disability in young adults, and the incidence in older patients is increasing. Neurotrauma is also a field in medicine with one of the highest unmet needs. Concentrated, focused and multidisciplinary efforts are required to combat this important disease. Exciting findings from basic research open opportunities for improving treatment results. This volume presents a unique and comprehensive overview of the latest findings and insights on translational research in neurotrauma. This book should be a must for any TBI or SCI researcher interested in translating their work to the clinic, as well as to clinicians interested in the latest research findings which could provide novel treatment strategies for their patients. • Integrates results from research on traumatic brain injury and spinal cord injury, bridging basic science and clinical research • Includes contributions from a worldwide panel of leading researchers and clinicians in the fields of TBI and SCI

Immunological Mechanisms and Therapies in Brain Injuries and Stroke Book

Immunological Mechanisms and Therapies in Brain Injuries and Stroke

  • Author : Jun Chen
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-09
  • Genre: Medical
  • Pages : 386
  • ISBN 10 : 9781461489153
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Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.​

Central Nervous System Trauma Book

Central Nervous System Trauma

  • Author : S. Tsuyoshi Ohnishi
  • Publisher : CRC Press
  • Release Date : 1995-07-27
  • Genre: Science
  • Pages : 610
  • ISBN 10 : 0849380944
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Central nervous system trauma, which encompasses stroke, subarachnoid hemorrhage, head injury, and spinal cord injury, is a leading cause of death in developed countries. In the search for underlying mechanisms, membrane involvement has been the common link. This fourth volume in the Membrane-Linked Diseases series is therefore dedicated to research on CNS trauma. Focusing on the mechanism of membrane damage, Central Nervous System Trauma: Research Techniques presents a variety of experimental techniques to study the mechanism of CNS trauma. Animal and tissue culture models provide the bulk of the research findings in this area. Possible pharmacological interventions are analyzed. This volume offers numerous illustrative examples, including full color figures. This book serves as a valuable resource for students and researchers, assisting in the comprehension of current trends in CNS trauma and helping to stimulate the discovery of new research areas.

Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma Book

Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma

  • Author : Alexander Baethmann
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 124
  • ISBN 10 : 9783709194652
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The publication of the Vth International Symposium 1995 on "Mechanisms of Secondary Brain Damage" in Mauls/ltaly is a collection of focused reviews reaching from novel molecular- and cell biological findings to aspects of clinical management in head injury and cerebral ischemia. A specific purpose of these series of meetings introduced in 1984 is for an exchange on problems of mutual interest by international high ranking experts from the basic sciences and related clinical disciplines, such as intensive care medicine, neurology, or neurosurgery. The present volume covers three major areas: (a) Molecular and cell biological mechanisms including inflammation (b) Novel findings on mechanisms and treatment in cerebral ischemia (c) Secondary processes in head injury, regeneration and treatment Molecular-and cell biology is currently attracting attention towards activation of genomic processes associated with the demise of cells referred to as "programmed cell death" and "apoptosis" which, actually, might be distinguished from each other. Thus, the phenomenon of delayed neuronal death in selectively vulnerable brain areas following brief interruption of blood flow is scrutinized as to the contribution of the activation of suicide genes. The physiological role of such a response, among others, is removal of surplus neurons during ontogenesis of the brain. Yet, evidence is accumulating that similar mechanisms playa role in cerebral ischemia, probably also trauma, where nerve-and other cells demonstrate features of apoptosis. Observations on protection of neurons by administration of protein synthesis inhibitors in cerebral ischemia provide more direct support.

Animal Models of Acute Neurological Injuries Book

Animal Models of Acute Neurological Injuries

  • Author : Jun Chen
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-12-16
  • Genre: Medical
  • Pages : 498
  • ISBN 10 : 9781603271851
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Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.

Animal Models of Acute Neurological Injury Book

Animal Models of Acute Neurological Injury

  • Author : Jun Chen
  • Publisher : Springer
  • Release Date : 2019-07-23
  • Genre: Medical
  • Pages : 544
  • ISBN 10 : 9783030160821
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Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. Animal Models of Acute Neurological Injuries, Second Edition, provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models have become obsolete, some have stood the test of time, and newer models have emerged to enhance our knowledge of acute neurological injuries. The second edition continues to offer the research community tested approaches for this area of investigation. As with the first edition, top experts have developed and contributed these animal models. The book’s focus remains hands-on, practical applications of the models, rather than a theoretical approach. Each chapter contains a proven procedure enhanced by clear figures, illustrations, or videos. This new edition presents its readily reproducible protocols with clarity and consistency to best aid neuroscientists and neurobiologists. As with the first edition, the second edition is comprehensive and cutting-edge. Animal Models of Acute Neurological Injuries, Second Edition, is an ideal guide for research professionals, at all stages of their careers, who wish to pursue this vital course of study with the proficiency and precision required by the field.

Brain Edema XIII Book

Brain Edema XIII

  • Author : Julian T. Hoff
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-06-22
  • Genre: Medical
  • Pages : 460
  • ISBN 10 : 9783211307144
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This volume contains 93 papers from internationally recognized experts in the field of brain edema and brain injury. The papers include human and animal studies on edema following stroke, cerebral hemorrhage, traumatic brain injury, spinal cord injury and hydrocephalus. Papers also address fluid dynamics in the brain (including the role of aquaporins).

Traumatic Brain and Spinal Cord Injury Book

Traumatic Brain and Spinal Cord Injury

  • Author : Cristina Morganti-Kossmann
  • Publisher : Cambridge University Press
  • Release Date : 2012-07-19
  • Genre: Medical
  • Pages : 361
  • ISBN 10 : 9781107007437
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Presents the most up-to-date clinical and experimental research in neurotrauma in an illustrated, accessible, comprehensive volume.

Neurological Regeneration Book

Neurological Regeneration

  • Author : Phuc Van Pham
  • Publisher : Unknown
  • Release Date : 2017
  • Genre: Biomedical engineering
  • Pages : 258
  • ISBN 10 : 3319337211
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