Key Heterocycle Cores for Designing Multitargeting Molecules Book

Key Heterocycle Cores for Designing Multitargeting Molecules


  • Author : Om Silakari
  • Publisher : Elsevier
  • Release Date : 2018-06-11
  • Genre: Science
  • Pages : 436
  • ISBN 10 : 9780081021057

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Key Heterocycle Cores for Designing Multitargeting Molecules Excerpt :

Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research. Emphasizes the chemical development of heterocyclic nuclei, from single to multitargeting molecules Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multitargeting agents Outlines current trends and future developments in multitarget molecule design for the treatment of various diseases

Advances in Heterocyclic Chemistry Book

Advances in Heterocyclic Chemistry


  • Author : Eric Scriven
  • Publisher : Academic Press
  • Release Date : 2020-05
  • Genre: Uncategoriezed
  • Pages : 314
  • ISBN 10 : 9780128211687

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Advances in Heterocyclic Chemistry Excerpt :

Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

Surfactants from Renewable Raw Materials Book

Surfactants from Renewable Raw Materials


  • Author : Divya Bajpai Tripathy
  • Publisher : CRC Press
  • Release Date : 2021-12-22
  • Genre: Science
  • Pages : 272
  • ISBN 10 : 9781000511895

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Surfactants from Renewable Raw Materials Excerpt :

Surfactants are often completely invisible to us and yet they are present in almost every chemical that we use in our daily life. They are found in toothpastes, cosmetics, sunscreens, mayonnaise, detergents, and an array of cleaning products. Traditional surfactants are known to have adverse environmental impacts spurring research into eco-friendly and cost-effective surfactants from renewable resources. Surfactants from Renewable Raw Materials examines the class of surfactants synthesized using plant-based raw materials detailing their properties, applications, bioavailability, and biodegradability. The concluding chapter reviews patent activity over the last decade. Additional features include: Addresses the tremendous variation found in the raw materials used to synthesize commercially available surfactants. Explores the selection of raw materials based upon the desired hydrophobic group or hydrophilic group to be incorporated into the product. Examines the characteristics and medicinal applications of pulmonary surfactants in preterm babies as well as their probable contribution in COVID-19 Discusses the biodegradability of surfactants to assist with the determination of truly green surfactants. This comprehensive reference will prove indispensable for professional and academic researchers creating or working with bio-based surfactants.

Greener Synthesis of Organic Compounds Book

Greener Synthesis of Organic Compounds


  • Author : Ahindra Nag
  • Publisher : CRC Press
  • Release Date : 2022-03-03
  • Genre: Science
  • Pages : 272
  • ISBN 10 : 9781000545128

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Greener Synthesis of Organic Compounds Excerpt :

This book provides an interdisciplinary, integrative overview of environmental problem-solving using mild reaction conditions, green reagents, waste free and energy efficient synthesis in both industry and academic world. Discussions include a broad, integrated perspective on sustainability, integrated risk, multi-scale changes and impacts taking place within ecosystems worldwide. Features: This book serves as a reference book for scientific investigators who need to do greener synthesis of organic compounds, drugs and natural products under mild reaction condition using green reagents, eco-friendly catalysts and benign reaction mediums over traditional synthetic processes which is a key driving force of scientists. Greener synthesis of multiple value-added heterocycles opens up a new horizon towards the organic catalysis and for this purpose, development of natural resources acts as an effective catalyst. Using environmentally friendly reaction medium e.g. ACC, WETSA, WEBSA have been used for the synthesis of some crucial heterocyclic scaffolds such as bisenols and 2-amino-4H-pyrans, tetraketones, pyrans, and biaryls. This book can also be used as a textbook for graduate and post graduate level courses for students. Furthermore, the problems with answers in book will add better understanding for students.

Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book

Green Approaches in Medicinal Chemistry for Sustainable Drug Design


  • Author : Bimal K. Banik
  • Publisher : Elsevier
  • Release Date : 2020-03-27
  • Genre: Medical
  • Pages : 1044
  • ISBN 10 : 9780128175934

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design Excerpt :

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis

Green Synthetic Approaches for Biologically Relevant Heterocycles Book

Green Synthetic Approaches for Biologically Relevant Heterocycles


  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release Date : 2021-03-20
  • Genre: Science
  • Pages : 646
  • ISBN 10 : 9780323851305

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Green Synthetic Approaches for Biologically Relevant Heterocycles Excerpt :

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability

Privileged Scaffolds in Medicinal Chemistry Book

Privileged Scaffolds in Medicinal Chemistry


  • Author : Stefan Bräse
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-20
  • Genre: Drug development
  • Pages : 468
  • ISBN 10 : 9781782620303

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Privileged Scaffolds in Medicinal Chemistry Excerpt :

One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular fragments. The first of the benzodiazepines, a class of drugs that is powerful for treating anxiety, may not have been discovered had it not been for a chance experiment on the contents of a discarded flask found during a lab clean-up. Some years later, scientists discovered that benzodiazepine derivatives were also effective in treating other diseases. This class of molecules was the first to be described as privileged in the sense that it is especially effective at altering the course of disease. Other privileged molecular structures have since been discovered, and since these compounds are so effective at interacting with numerous classes of proteins, they may be an effective starting point to look for new drugs against the supposedly "undruggable" proteins. Following introductory chapters presenting an overview, a historical perspective and the theoretical background and findings, main chapters describe the structure of privileged structures in turn and discuss major drug classes associated with them and their syntheses. This book provides comprehensive coverage of the subject through chapters contributed by expert authors from both academia and industry and will be an excellent reference source for medicinal chemists of a range of disciplines and experiences.

Green Sustainable Process for Chemical and Environmental Engineering and Science Book

Green Sustainable Process for Chemical and Environmental Engineering and Science


  • Author : Dr Inamuddin
  • Publisher : Elsevier
  • Release Date : 2021-11-26
  • Genre: Technology & Engineering
  • Pages : 240
  • ISBN 10 : 9780128198513

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Green Sustainable Process for Chemical and Environmental Engineering and Science Excerpt :

Green Sustainable Process for Chemical and Environmental Engineering and Science: Switchable Solvents explores the preparation, properties, chemical processes and applications of this class of green solvents. The book provides an in-depth overview on the area of switchable solvents in various industrial applications, focusing on the purification and extraction of chemical compounds utilizing green chemistry protocols that include liquid-liquid, solid-liquid, liquid-gas and lipids separation technologies. In addition, it includes recent advances in greener extraction and separation processes. This book will be an invaluable guide to students, professors, scientists and R&D industrial specialists working in the field of sustainable chemistry, organic, analytical, chemical engineering, environmental and pharmaceutical sciences. Provides a broad overview of switchable solvents in sustainable chemical processes Compares the use of switchable solvents as greener solvents over conventional solvents Outlines eco-friendly organic synthesis and chemical processes using switchable solvents Lists various industrial separations/extraction processes using switchable solvents

Deep Eutectic Solvents Book

Deep Eutectic Solvents


  • Author : Diego J. Ramón
  • Publisher : John Wiley & Sons
  • Release Date : 2019-11-25
  • Genre: Science
  • Pages : 384
  • ISBN 10 : 9783527345182

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Deep Eutectic Solvents Excerpt :

A useful guide to the fundamentals and applications of deep eutectic solvents Deep Eutectic Solvents contains a comprehensive review of the use of deep eutectic solvents (DESs) as an environmentally benign alternative reaction media for chemical transformations and processes. The contributors cover a range of topics including synthesis, structure, properties, toxicity and biodegradability of DESs. The book also explores myriad applications in various disciplines, such as organic synthesis and (bio)catalysis, electrochemistry, extraction, analytical chemistry, polymerizations, (nano)materials preparation, biomass processing, and gas adsorption. The book is aimed at organic chemists, catalytic chemists, pharmaceutical chemists, biochemists, electrochemists, and others involved in the design of eco-friendly reactions and processes. This important book: -Explores the promise of DESs as an environmentally benign alternative to hazardous organic solvents -Covers the synthesis, structure, properties (incl. toxicity) as well as a wide range of applications -Offers a springboard for stimulating critical discussion and encouraging further advances in the field Deep Eutectic Solvents is an interdisciplinary resource for researchers in academia and industry interested in the many uses of DESs as an environmentally benign alternative reaction media.

Handbook of Heterocyclic Chemistry Book

Handbook of Heterocyclic Chemistry


  • Author : Alan R. Katritzky
  • Publisher : Elsevier
  • Release Date : 2017-01-31
  • Genre: Science
  • Pages : 568
  • ISBN 10 : 9781483293424

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Handbook of Heterocyclic Chemistry Excerpt :

Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.

Structural Bioinformatics  Applications in Preclinical Drug Discovery Process Book

Structural Bioinformatics Applications in Preclinical Drug Discovery Process


  • Author : C. Gopi Mohan
  • Publisher : Springer
  • Release Date : 2019-01-10
  • Genre: Science
  • Pages : 406
  • ISBN 10 : 9783030052829

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Structural Bioinformatics Applications in Preclinical Drug Discovery Process Excerpt :

This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery. The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.

Heterocyclic Organic Corrosion Inhibitors Book

Heterocyclic Organic Corrosion Inhibitors


  • Author : Mumtaz A. Quraishi
  • Publisher : Elsevier
  • Release Date : 2020-03-07
  • Genre: Technology & Engineering
  • Pages : 298
  • ISBN 10 : 9780128196946

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Heterocyclic Organic Corrosion Inhibitors Excerpt :

Heterocyclic Organic Corrosion Inhibitors: Principles and Applications aims to comprehend the synthesis and application of organic heterocyclic compounds as corrosion inhibitors in various corrosive environments. Considering the high importance of corrosion inhibitor development for different industries, the book provides the fundamentals and most recent advancements in this field. The book is an indispensable reference tool for industrialists and academicians working in the field of corrosion protection. Provides a systematic overview of fundamentals and current advancements Acts as a primary reference for beginner researchers in this arena Presents a handy reference tool to different chemical industries Covers fundamentals, industrial applications and most recent advancements in this area

Design of Hybrid Molecules for Drug Development Book

Design of Hybrid Molecules for Drug Development


  • Author : Michael Decker
  • Publisher : Elsevier
  • Release Date : 2017-04-05
  • Genre: Science
  • Pages : 352
  • ISBN 10 : 9780081011188

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Design of Hybrid Molecules for Drug Development Excerpt :

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied Compares the advantages and disadvantages of these compounds Includes the very latest developments, such as photoactivatable and photo-responsive drugs

Quality Control and Evaluation of Herbal Drugs Book

Quality Control and Evaluation of Herbal Drugs


  • Author : Pulok K. Mukherjee
  • Publisher : Unknown
  • Release Date : 2018-10
  • Genre: Science
  • Pages : 700
  • ISBN 10 : 0128133740

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Quality Control and Evaluation of Herbal Drugs Excerpt :

Quality Control and Evaluation of Herbal Drugs: Approaches for Evaluating Natural Products and Traditional Medicine brings together current thinking and practice in the quality control and standardization of herbal drugs. As the use of herbal medicine in therapeutics is rising in both developed and developing countries, this book facilitates the development of quality standards for these medicines. Written by Pulok K. Mukherjee, a leader in the field, the book describes methods, techniques and approaches for evaluating their purity, quality, safety and efficacy. Particular attention is paid to methods that assess activity, the compounds responsible, and their underlying mechanisms of action. The book describes the quality control parameters followed in India and other countries, including Japan, China, Bangladesh, Srilanka and other Asian countries, as well as the regulatory profiles of the European Union and North America. Users will find it to be a comprehensive resource on bio-prospecting for traditional-medicine-inspired drug discovery and development. Provides new information on the research and development of natural remedies Includes essential reading on the study and use of natural resources for preventative or healing purposes References global organizations, such as the WHO, USFDA, CDSCO, TCM and others to serve as a comprehensive document for enforcement agencies, NGOS and regulatory authorities Aids in developing basic knowledge of the various techniques of quality evaluation, such as macroscopy, microscopy, HPTLC, HPLC and LC-MS

Bioactive Heterocycles Book

Bioactive Heterocycles


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2022-07-07
  • Genre: Bioactive compounds
  • Pages : null
  • ISBN 10 : OCLC:123293103

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Bioactive Heterocycles Excerpt :