Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases Book

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases


  • Author : Christophe Wiart
  • Publisher : Academic Press
  • Release Date : 2013-12-16
  • Genre: Medical
  • Pages : 416
  • ISBN 10 : 9780123983831

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Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases Excerpt :

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases. This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development. Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration

Phytochemicals as Lead Compounds for New Drug Discovery Book

Phytochemicals as Lead Compounds for New Drug Discovery


  • Author : Chukwuebuka Egbuna
  • Publisher : Elsevier
  • Release Date : 2019-09-07
  • Genre: Science
  • Pages : 378
  • ISBN 10 : 9780128178911

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Phytochemicals as Lead Compounds for New Drug Discovery Excerpt :

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Lead Compounds from Medicinal Plants for the Treatment of Cancer Book

Lead Compounds from Medicinal Plants for the Treatment of Cancer


  • Author : Christophe Wiart
  • Publisher : Academic Press
  • Release Date : 2013
  • Genre: Medical
  • Pages : 410
  • ISBN 10 : 9780123983718

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Lead Compounds from Medicinal Plants for the Treatment of Cancer Excerpt :

Lead Compounds from Medicinal Plants for the Treatment of Cancer is the first volume in the series, Pharmaceutical Leads from Medicinal Plants. The plant species described in this reference have been carefully selected based on pharmacological evidence and represent today's most promising sources of natural products for the discovery of anti-cancer drugs. Containing references to primary source material, over a hundred botanical illustrations, a table of chemical structures and much more, this book is an essential starting point for cancer researchers and those involved in anti-cancer drug discovery helping you identify the best novel lead molecules for further anti-cancer drug development. Provides a compilation of hundreds of medicinal plants from Europe, Asia, North and South America and Africa that contain prominent lead candidates for anti-cancer drug discovery Contains primary source references and hundreds of the most relevant citations from the current literature for additional research Offers cancer researchers and pharmaceutical scientists valuable tools such as chemical structures and promising pharmacological data to help them select the novel lead compounds that will best aid drug discovery.

Phytomedicine and Alzheimer   s Disease Book

Phytomedicine and Alzheimer s Disease


  • Author : Atanu Bhattacharjee
  • Publisher : CRC Press
  • Release Date : 2020-10-25
  • Genre: Health & Fitness
  • Pages : 332
  • ISBN 10 : 9781000171365

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Phytomedicine and Alzheimer s Disease Excerpt :

Alzheimer's disease, one of the most rapidly growing neurodegenerative disorders, is characterized by a progressive loss of memory. Despite several advances in the field of medical therapeutics, a viable treatment for Alzheimer's disease would be of great importance. Medicinal plants represent a largely untapped reservoir of natural medicines and potential sources of anti-Alzheimer’s drugs. The structural diversity of their phytoconstituents makes these plants a valuable source of novel lead compounds in the quest for drugs to treat Alzheimer's disease. Based on traditional literature and up-to-date research, various new therapeutically active compounds have been identified from phytoextracts, which could be useful in the treatment of cognitive disorders. Phytomedicine and Alzheimer’s Disease presents information on Mechanistic aspects of neurodegeneration in Alzheimer’s disease and the role of phytochemicals as restorative agents Understanding the complex biochemical aspects of Alzheimer’s disease Pre-clinical approaches to evaluating drugs to target Alzheimer’s disease Assessing alternative approaches to treating Alzheimer’s disease and the role of alternative medicine to delay the symptomatic progression of this disease Epigenetic changes in Alzheimer’s disease and possible therapeutic or dietary interventions This book serves as an excellent resource for scientific investigators, academics, biochemists, botanists, and alternative medicine practitioners who work to advance the role of phytomedicines in treating Alzheimer’s disease.

Phytomedicine and Alzheimer s Disorder Book

Phytomedicine and Alzheimer s Disorder


  • Author : Atanu Bhattacharjee
  • Publisher : CRC Press
  • Release Date : 2020-09-04
  • Genre: Uncategoriezed
  • Pages : 328
  • ISBN 10 : 0367332027

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Phytomedicine and Alzheimer s Disorder Excerpt :

Alzheimer's disease, one of the most rapidly growing neurodegenerative disorders, is characterized by progressive loss of memory. Despite several advancements in the field of medicinal therapeutics, a viable treatment for Alzheimer's disease is the need of great importance. Medicinal plants represent a great deal of untapped reservoir of natural medicines and potential source of anti-Alzheimer's drug. The structural diversity of their phytoconstituents makes them a valuable source of novel lead compounds for the quest of drugs to treat Alzheimer's disease. Based on the traditional literature, various new therapeutically active compounds have been isolated from phytoextracts useful in cognitive disorders. The book "Phytomedicine and Alzheimer's disorder"presents information on Mechanistic aspects of neurodegeneration in Alzheimer's disease and role of phytochemicals as restorative agents Helps in understanding the complex biochemical aspects of Alzheimer's disorder Pre-clinical approaches to evaluate drugs targeting Alzheimer's disease Aternative approach to encounter Alzheimer's disease and role of alternative medicine to delay the symptomatic progression of the same Epigenetic alterations in Alzheimer's disease and its therapeutic, dietary interventions This book serves as an excellent resource for scientific investigators, academician, biochemists, botanists, alternative medicine practitioners who are intended to emphasize the role of phytomedicines to treat Alzheimer's disease.

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health Book

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health


  • Author : Kavita Sharma
  • Publisher : BoD – Books on Demand
  • Release Date : 2021-04-07
  • Genre: Health & Fitness
  • Pages : 356
  • ISBN 10 : 9781838808877

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Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health Excerpt :

Bioactive compounds are abundant in nature, particularly in plants, which have the capacity to synthesize phenolics, flavonoids, caffeine, carotenoids, and much more. Different bioactive compounds can change or alter the life process due to their different biological activities. This book examines bioactive compounds and their sources, structures, and potential uses in various industries, including pharmaceuticals, medicine, cosmetics, and food processing.

Plant Extracts in Neurodegenerative Diseases Book

Plant Extracts in Neurodegenerative Diseases


  • Author : Magisetty Obulesu
  • Publisher : Academic Press
  • Release Date : 2022-08-01
  • Genre: Medical
  • Pages : 148
  • ISBN 10 : 9780323957632

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Plant Extracts in Neurodegenerative Diseases Excerpt :

Plant Extracts in Neurodegenerative Disease examines the therapeutic efficacy of plant extracts and the lead compounds contained therein that can significantly improve symptoms of diseases of the brain. Providing insights into the protective mechanisms of these bioactive plant compounds to treat Alzheimer’s Disease, Parkinson’s Disease, motor neuron disease, and other neurodegenerative diseases, the book also discusses the pros and cons of using these types of treatments, along with perspectives to overcome current challenges. With chapters looking at individual diseases, readers will learn about studies unique to each condition, including Huntington’s Disease, spinocerebellar ataxia, SMA, ALS and prion disease. Discusses the therapeutic efficacy of plant extracts and their lead bioactive compounds to treat neurodegenerative disease Describes protective mechanisms, pros and cons, and future perspectives Contains individual diseases in each chapter, including Alzheimer’s, Parkinson’s, Huntington’s, motor neuron disease, spinocerebellar ataxia, prion disease, SMA and ALS

Medicinal Plants Book

Medicinal Plants


  • Author : Mallappa Kumara Swamy
  • Publisher : CRC Press
  • Release Date : 2019-05-10
  • Genre: Medical
  • Pages : 238
  • ISBN 10 : 9780429535604

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Medicinal Plants Excerpt :

This book details several important medicinal plants, their occurrence, plant compounds and their chemical structures, and pharmacological properties against various human diseases. It also gives information on isolation and structural elucidation of phytocompounds, bio-assays, metabolomic studies, and therapeutical applications of plant compounds.

Studies in Natural Products Chemistry Book

Studies in Natural Products Chemistry


  • Author : Atta-ur-Rahman
  • Publisher : Elsevier
  • Release Date : 2016-09-30
  • Genre: Science
  • Pages : 434
  • ISBN 10 : 9780444637567

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Studies in Natural Products Chemistry Excerpt :

Studies in Natural Products Chemistry: Bioactive Natural Products (Part XIII) is the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Evidence Based Validation of Herbal Medicine Book

Evidence Based Validation of Herbal Medicine


  • Author : Pulok K. Mukherjee
  • Publisher : Elsevier
  • Release Date : 2015-02-17
  • Genre: Medical
  • Pages : 556
  • ISBN 10 : 9780128009963

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Evidence Based Validation of Herbal Medicine Excerpt :

Evidence-Based Validation of Herbal Medicines brings together current thinking and practice in the areas of characterization and validation of natural products. This book reviews all aspects of evaluation and development of medicines from plant sources, including their cultivation, collection, phytochemical and phyto-pharmacological evaluation, and therapeutic potential. Emphasis is placed on describing the full range of evidence-based analytical and bio-analytical techniques used to characterize natural products, including –omic technologies, phyto-chemical analysis, hyphenated techniques, and many more. Includes state-of-the-art methods for detecting, isolating, and performing structure elucidation by degradation and spectroscopic techniques Covers biosynthesis, synthesis, and biological activity related to natural products Consolidates information to save time and money in research Increases confidence levels in quality and validity of natural products

Medicinal Natural Products  A Disease Focused Approach Book

Medicinal Natural Products A Disease Focused Approach


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-09-21
  • Genre: Science
  • Pages : 530
  • ISBN 10 : 9780128210208

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Medicinal Natural Products A Disease Focused Approach Excerpt :

Medicinal Natural Products: A Disease-Focused Approach, Volume 55 in the Annual Reports in Medicinal Chemistry series, highlights the applications of natural products as medicines or prospective medicinal leads for the treatment of various human ailments. Each chapter covers a particular disease area or medical condition, with chapters in this new release covering Medicinal Natural Products – An Introduction, Anticancer Natural Products, Antimicrobial Natural Products, Antimalarial and Antiparasitic Natural Products, Anti-inflammatory Natural Products, Neuroprotective Natural Products, Hepatoprotective Natural Products, Nephroprotective Natural Products, Cancer Chemopreventive Natural Products, Antipsoriatic Natural Products, Medicinal Natural Products in Osteoporosis, Antidiabetic Natural Products, Anti-obesity Natural Products, and much more. Presents a disease-focused perspective Includes the latest on the medicinal chemistry of natural products Covers natural products in drug delivery

Ethnopharmacology Book

Ethnopharmacology


  • Author : Michael Heinrich
  • Publisher : John Wiley & Sons
  • Release Date : 2015-07-29
  • Genre: Medical
  • Pages : 464
  • ISBN 10 : 9781118930731

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Ethnopharmacology Excerpt :

Ethnopharmacology is one of the world’s fastest-growing scientific disciplines encompassing a diverse range of subjects. It links natural sciences research on medicinal, aromatic and toxic plants with socio-cultural studies and has often been associated with the development of new drugs. The Editors of Ethnopharmacology have assembled an international team of renowned contributors to provide a critical synthesis of the substantial body of new knowledge and evidence on the subject that has emerged over the past decade. Divided into three parts, the book begins with an overview of the subject including a brief history, ethnopharmacological methods, the role of intellectual property protection, key analytical approaches, the role of ethnopharmacology in primary/secondary education and links to biodiversity and ecological research. Part two looks at ethnopharmacological contributions to modern therapeutics across a range of conditions including CNS disorders, cancer, bone and joint health and parasitic diseases. The final part is devoted to regional perspectives covering all continents, providing a state-of-the –art assessment of the status of ethnopharmacological research globally. A comprehensive, critical synthesis of the latest developments in ethnopharmacology. Includes a section devoted to ethnopharmacological contributions to modern therapeutics across a range of conditions. Contributions are from leading international experts in the field. This timely book will prove invaluable for researchers and students across a range of subjects including ethnopharmacology, ethnobotany, medicinal plant research and natural products research. Ethnopharmacology- A Reader is part of the ULLA Series in Pharmaceutical Sciences www.ullapharmsci.org

The Benefits of Natural Products for Neurodegenerative Diseases Book

The Benefits of Natural Products for Neurodegenerative Diseases


  • Author : M. Mohamed Essa
  • Publisher : Springer
  • Release Date : 2016-09-20
  • Genre: Medical
  • Pages : 496
  • ISBN 10 : 9783319283838

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The Benefits of Natural Products for Neurodegenerative Diseases Excerpt :

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.