Long Non Coding RNA Biology Book

Long Non Coding RNA Biology

  • Author : M.R.S. Rao
  • Publisher : Springer
  • Release Date : 2017-08-16
  • Genre: Medical
  • Pages : 323
  • ISBN 10 : 9789811052033

Long Non Coding RNA Biology Excerpt :

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Long Non coding RNA Book

Long Non coding RNA

  • Author : Antonin Morillon
  • Publisher : Elsevier
  • Release Date : 2018-02-01
  • Genre: Science
  • Pages : 190
  • ISBN 10 : 9780081023556

Long Non coding RNA Excerpt :

The dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms. This book offers a large review about the long non-coding RNA It presents the broad functional diversities of those molecules It presents pioneer works from the field Provides a comprehensive review of the field Presents fundamental and therapeutic interests

Long Non Coding RNA Book

Long Non Coding RNA

  • Author : Syed Mudasir Andrabi
  • Publisher : Cambridge Scholars Publishing
  • Release Date : 2020-09-03
  • Genre: Science
  • Pages : 201
  • ISBN 10 : 9781527559103

Long Non Coding RNA Excerpt :

Long non-coding RNAs (LncRNAs) were originally regarded as “noise” in the genome due to their lack of protein-encoding capacity. However, their roles are now understood to cover various biological functions like gene regulation, cell proliferation, survival, differentiation, and chromatin remodeling. As an emerging group of non-coding RNA molecules, LncRNAs are involved in diverse diseases like cancer, cardiovascular, autoimmune, hormonal disorders, neurodegeneration, and infection, among others. However, knowledge of the mechanisms by which they act is still ambiguous. As such, this book meets the essential need for a textbook dedicated to this topic and provides a comprehensive and captivating account of lncRNA research.

Long Noncoding RNAs in Plants Book

Long Noncoding RNAs in Plants

  • Author : Santosh Kumar Upadhyay
  • Publisher : Academic Press
  • Release Date : 2020-11-13
  • Genre: Science
  • Pages : 390
  • ISBN 10 : 9780128214633

Long Noncoding RNAs in Plants Excerpt :

The growth of human population has increased the demand for improved yield and quality of crops and horticultural plants. However, plant productivity continues to be threatened by stresses such as heat, cold, drought, heavy metals, UV radiations, bacterial and fungal pathogens, and insect pests. Long noncoding RNAs are associated with various developmental pathways, regulatory systems, abiotic and biotic stress responses and signaling, and can provide an alternative strategy for stress management in plants. Long Noncoding RNAs in Plants: Roles in development and stress provides the most recent advances in LncRNAs, including identification, characterization, and their potential applications and uses. Introductory chapters include the basic features and brief history of development of lncRNAs studies in plants. The book then provides the knowledge about the lncRNAs in various important agricultural and horticultural crops such as cereals, legumes, fruits, vegetables, and fiber crop cotton, and their roles and applications in abiotic and biotic stress management. Includes the latest advances and research in long noncoding RNAs in plants Provides alternative strategies for abiotic and biotic stress management in horticultural plants and agricultural crops Focuses on the application and uses of long noncoding RNAs

Long Non Coding RNAs in Cancer Book

Long Non Coding RNAs in Cancer

  • Author : Alfons Navarro
  • Publisher : Unknown
  • Release Date : 2021
  • Genre: Cancer
  • Pages : 387
  • ISBN 10 : 1071615815

Long Non Coding RNAs in Cancer Excerpt :

This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field. .

Cancer and Noncoding RNAs Book
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Cancer and Noncoding RNAs

  • Author : Jayprokas Chakrabarti
  • Publisher : Academic Press
  • Release Date : 2017-10-13
  • Genre: Medical
  • Pages : 576
  • ISBN 10 : 9780128134375

Cancer and Noncoding RNAs Excerpt :

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field

Gene Expression Profiling in Cancer Book

Gene Expression Profiling in Cancer

  • Author : Dimitrios Vlachakis
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-06-19
  • Genre: Medical
  • Pages : 79
  • ISBN 10 : 9781838801755

Gene Expression Profiling in Cancer Excerpt :

The contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new techniques for treating various diseases that affect humanity. Methods for finding and analyzing the profile of gene expression of infected cells give scientists the ability to develop more targeted and effective treatments, especially for diseases such as cancer. The development of gene expression profiling is one of the most important achievements in cancer genetics in our time. It is essentially the driving force behind personalized and precision medicine. This book highlights recent developments, applications, and breakthroughs in the field of gene expression profiling in cancer.

Computational Non coding RNA Biology Book

Computational Non coding RNA Biology

  • Author : Yun Zheng
  • Publisher : Academic Press
  • Release Date : 2018-09-14
  • Genre: Science
  • Pages : 320
  • ISBN 10 : 9780128143667

Computational Non coding RNA Biology Excerpt :

Computational Non-coding RNA Biology is a resource for the computation of non-coding RNAs. The book covers computational methods for the identification and quantification of non-coding RNAs, including miRNAs, tasiRNAs, phasiRNAs, lariat originated circRNAs and back-spliced circRNAs, the identification of miRNA/siRNA targets, and the identification of mutations and editing sites in miRNAs. The book introduces basic ideas of computational methods, along with their detailed computational steps, a critical component in the development of high throughput sequencing technologies for identifying different classes of non-coding RNAs and predicting the possible functions of these molecules. Finding, quantifying, and visualizing non-coding RNAs from high throughput sequencing datasets at high volume is complex. Therefore, it is usually possible for biologists to complete all of the necessary steps for analysis. Presents a comprehensive resource of computational methods for the identification and quantification of non-coding RNAs Introduces 23 practical computational pipelines for various topics of non-coding RNAs Provides a guide to assist biologists and other researchers dealing with complex datasets Introduces basic computational methods and provides guidelines for their replication by researchers Offers a solution to researchers approaching large and complex sequencing datasets

Plant Long Non Coding RNAs Book

Plant Long Non Coding RNAs

  • Author : Julia A. Chekanova
  • Publisher : Humana Press
  • Release Date : 2019-04-20
  • Genre: Science
  • Pages : 480
  • ISBN 10 : 1493990446

Plant Long Non Coding RNAs Excerpt :

This volume focuses on various approaches to studying long non-coding RNAs (lncRNAs), including techniques for finding lncRNAs, localization, and observing their functions. The chapters in this book cover how to catalog lncRNAs in various plant species; determining subcellular localization; protein interactions; structures; and RNA modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and innovative, Plant Long Non-Coding RNAs: Methods and Protocols is a valuable resource that aids researchers in understanding the functions of lncRNAs in different plant species, and helps them explore currently uncharted facets of plant biology.

Molecular Biology of Long Non coding RNAs Book

Molecular Biology of Long Non coding RNAs

  • Author : Ahmad Khalil
  • Publisher : Springer
  • Release Date : 2016-08-23
  • Genre: Medical
  • Pages : 227
  • ISBN 10 : 1493945289

Molecular Biology of Long Non coding RNAs Excerpt :

​Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. ​So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.

Non Coding RNAs Book

Non Coding RNAs

  • Author : Lütfi Tutar
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-03-04
  • Genre: Medical
  • Pages : 150
  • ISBN 10 : 9781789856552

Non Coding RNAs Excerpt :

Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.

Long Non Coding RNAs Book

Long Non Coding RNAs

  • Author : Lin Zhang
  • Publisher : Humana
  • Release Date : 2021-08-21
  • Genre: Medical
  • Pages : 308
  • ISBN 10 : 107161696X

Long Non Coding RNAs Excerpt :

This second edition provides a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Chapters guide readers through studies used to circular RNAs, RNA splicing, and findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Long Non-Coding RNAs: Methods and Protocols,Second Edition aims to ensure successful results in the further study of this vital field.

Non coding RNAs in Cardiovascular Diseases Book

Non coding RNAs in Cardiovascular Diseases

  • Author : Junjie Xiao
  • Publisher : Springer Nature
  • Release Date : 2020-04-13
  • Genre: Science
  • Pages : 426
  • ISBN 10 : 9789811516719

Non coding RNAs in Cardiovascular Diseases Excerpt :

This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.

Applications of RNA Seq and Omics Strategies Book

Applications of RNA Seq and Omics Strategies

  • Author : Fabio Marchi
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-09-13
  • Genre: Medical
  • Pages : 330
  • ISBN 10 : 9789535135036

Applications of RNA Seq and Omics Strategies Excerpt :

The large potential of RNA sequencing and other "omics" techniques has contributed to the production of a huge amount of data pursuing to answer many different questions that surround the science's great unknowns. This book presents an overview about powerful and cost-efficient methods for a comprehensive analysis of RNA-Seq data, introducing and revising advanced concepts in data analysis using the most current algorithms. A holistic view about the entire context where transcriptome is inserted is also discussed here encompassing biological areas with remarkable technological advances in the study of systems biology, from microorganisms to precision medicine.