Medical Applications of Mass Spectrometry Book

Medical Applications of Mass Spectrometry


  • Author : Karoly Vekey
  • Publisher : Elsevier
  • Release Date : 2011-08-11
  • Genre: Science
  • Pages : 606
  • ISBN 10 : 9780080554655

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Medical Applications of Mass Spectrometry Book Description :

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine. The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry. * Guides the reader from basic principles and methods to cutting edge applications. * There is NO comparable book on the market to fill this fast growing field.

Spectroscopic Analyses Book

Spectroscopic Analyses


  • Author : Eram Sharmin
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-12-06
  • Genre: Science
  • Pages : 240
  • ISBN 10 : 9789535136279

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Spectroscopic Analyses Book Description :

The book presents developments and applications of these methods, such as NMR, mass, and others, including their applications in pharmaceutical and biomedical analyses. The book is divided into two sections. The first section covers spectroscopic methods, their applications, and their significance as characterization tools; the second section is dedicated to the applications of spectrophotometric methods in pharmaceutical and biomedical analyses. This book would be useful for students, scholars, and scientists engaged in synthesis, analyses, and applications of materials/polymers.

Principles and Applications of Clinical Mass Spectrometry Book

Principles and Applications of Clinical Mass Spectrometry


  • Author : Nader Rifai
  • Publisher : Elsevier
  • Release Date : 2018-06-26
  • Genre: Science
  • Pages : 216
  • ISBN 10 : 9780128160640

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Principles and Applications of Clinical Mass Spectrometry Book Description :

Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well as pathogen identification. A thorough yet succinct guide to using mass spectrometry technology in the clinical laboratory, Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is an essential resource for chemists, pharmaceutical and biotech researchers, certain government agencies, and standardization groups. Provides concrete examples of the main applications of mass spectrometry technology Describes current capabilities of the LC- and MS-based analytical methods Details methods for successful analytical work in the field

Mass Spectrometry in Medicinal Chemistry Book

Mass Spectrometry in Medicinal Chemistry


  • Author : Klaus Wanner
  • Publisher : John Wiley & Sons
  • Release Date : 2007-06-27
  • Genre: Science
  • Pages : 460
  • ISBN 10 : 9783527610914

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Mass Spectrometry in Medicinal Chemistry Book Description :

This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.

Advancements of Mass Spectrometry in Biomedical Research Book

Advancements of Mass Spectrometry in Biomedical Research


  • Author : Alisa G. Woods
  • Publisher : Springer
  • Release Date : 2014-06-20
  • Genre: Science
  • Pages : 600
  • ISBN 10 : 9783319060682

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Advancements of Mass Spectrometry in Biomedical Research Book Description :

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine.

Quadrupole Mass Spectrometry and Its Applications Book

Quadrupole Mass Spectrometry and Its Applications


  • Author : Peter H. Dawson
  • Publisher : Elsevier
  • Release Date : 2013-10-22
  • Genre: Science
  • Pages : 372
  • ISBN 10 : 9781483165042

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Quadrupole Mass Spectrometry and Its Applications Book Description :

Quadrupole Mass Spectrometry and Its Applications provides a comprehensive discussion of quadrupoles and their applications. It proceeds from a general explanation of the action of radiofrequency quadrupole fields to the description of their utilization in mass analyzers—such as the quadrupole mass filter, the monopole, the three-dimensional quadrupole ion trap, and various time-of-flight spectrometers—and finally to the characteristic applications of quadrupoles. A multi-author format has been adopted to provide broader-than-usual viewpoint in the book. The book begins by explaining the principles of operation of quadrupole devices. These include ion trajectories and computer simulations of performance; analytical theory; numerical methods of calculation of performance, including the recently developed application of phase-space dynamics; and fringing fields and other field imperfections. Subsequent chapters provide design and performance evaluations of the mass filter, the monopole, ion traps, and time-of-flight instruments; and describe areas of application where quadrupole devices have made the greatest impact because of their particular advantages and disadvantages.

Mass Spectrometry for the Clinical Laboratory Book

Mass Spectrometry for the Clinical Laboratory


  • Author : Hari Nair
  • Publisher : Academic Press
  • Release Date : 2016-11-02
  • Genre: Medical
  • Pages : 304
  • ISBN 10 : 9780128009925

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Mass Spectrometry for the Clinical Laboratory Book Description :

Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Applications of Mass Spectrometry in Microbiology Book

Applications of Mass Spectrometry in Microbiology


  • Author : Plamen Demirev
  • Publisher : Springer
  • Release Date : 2016-01-12
  • Genre: Science
  • Pages : 336
  • ISBN 10 : 9783319260709

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Applications of Mass Spectrometry in Microbiology Book Description :

In the last quarter century, advances in mass spectrometry (MS) have been at the forefront of efforts to map complex biological systems including the human metabolome, proteome, and microbiome. All of these developments have allowed MS to become a well-established molecular level technology for microorganism characterization. MS has demonstrated its considerable advantage as a rapid, accurate, and cost-effective method for microorganism identification, compared to conventional phenotypic techniques. In the last several years, applications of MS for microorganism characterization in research, clinical microbiology, counter-bioterrorism, food safety, and environmental monitoring have been documented in thousands of publications. Regulatory bodies in Europe, the US, and elsewhere have approved MS-based assays for infectious disease diagnostics. As of mid-2015, more than 3300 commercial MS systems for microorganism identification have been deployed worldwide in hospitals and clinical labs. While previous work has covered broader approaches in using MS to characterize microorganisms at the species level or above, this book focuses on strain-level and subtyping applications. In twelve individual chapters, innovators, leaders and practitioners in the field from around the world have contributed to a comprehensive overview of current and next-generation approaches for MS-based microbial characterization at the subspecies and strain levels. Chapters include up-to-date reference lists as well as web-links to databases, recommended software, and other useful tools. The emergence of new, antibiotic-resistant strains of human or animal pathogens is of extraordinary concern not only to the scientific and medical communities, but to the general public as well. Developments of novel MS-based assays for rapid identification of strains of antibiotic-resistant microorganisms are reviewed in the book as well. Microbiologists, bioanalytical scientists, infectious disease specialists, cl

Proton Transfer Reaction Mass Spectrometry Book

Proton Transfer Reaction Mass Spectrometry


  • Author : Andrew M. Ellis
  • Publisher : John Wiley & Sons
  • Release Date : 2013-12-17
  • Genre: Science
  • Pages : 368
  • ISBN 10 : 9781118683576

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Proton Transfer Reaction Mass Spectrometry Book Description :

Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a rapidlygrowing analytical technique for detecting and identifying verysmall quantities of chemical compounds in air. It has seenwidespread use in atmospheric monitoring and food science and showsincreasing promise in applications such as industrial processmonitoring, medical science and in crime and securityscenarios. Written by leading researchers, this is the first book devoted toPTR-MS and it provides a comprehensive account of the basicprinciples, the experimental technique and various applications,thus making this book essential reading for researchers,technicians, postgraduate students and professionals inindustry. The book contains nine chapters and is divided into two parts.The first part describes the underlying principles of the PTR-MStechnique, including • the relevant ion-molecule chemistry • thermodynamics and reaction kinetics • a discussion of ion sources, drift tubes and massspectrometers • practical aspects of PTR-MS, includingcalibration. The second part of the book turns its attention to some of themany applications of PTR-MS, demonstrating the scope and benefits,as well as the limitations, of the technique. The chapters thatmake up the second part of the book build upon the materialpresented in the first part and are essentially self-containedreviews focusing on the following topics: • environmental science • food science • medicine • homeland security, and • applications of PTR-MS in liquid analysis.

Advances in Forensic Applications of Mass Spectrometry Book

Advances in Forensic Applications of Mass Spectrometry


  • Author : Jehuda Yinon
  • Publisher : CRC Press
  • Release Date : 2003-12-29
  • Genre: Law
  • Pages : 279
  • ISBN 10 : 0203998286

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Advances in Forensic Applications of Mass Spectrometry Book Description :

Recent developments in analytical instrumentation have had an enormous influence on forensic analysis. The mass spectrometer is now an integral part of every forensic laboratory, resulting in greater analytical accuracy, more reliable identification, and lower detection limits. As the instrumental method of choice among forensic analysts, the mass spectrometer continues to pave the way for innovative applications in forensic analysis. Exploring the latest developments in the field, Advances in Forensic Applications of Mass Spectrometry provides a comprehensive reference guide to forensic applications using modern mass spectrometry techniques. The book features methods developed from advanced instrumentation, drug detection and toxicological analysis, and methodology of applications of stable isotope ratios. The final chapters present approaches for identifying accelerants in fire debris and procedures for analyzing explosives in post-blast residues. Jehuda Yinon, Ph.D., is one of the top forensic chemists in the world. As the editor of this authoritative volume, he compiles the knowledge of leading experts to demonstrate the use of novel mass spectrometry techniques in a vast range of forensic applications.

Quadrupole Mass Spectrometry and Its Applications Book

Quadrupole Mass Spectrometry and Its Applications


  • Author : Peter H. Dawson
  • Publisher : Elsevier
  • Release Date : 2013-10-22
  • Genre: Science
  • Pages : 372
  • ISBN 10 : 9781483165042

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Quadrupole Mass Spectrometry and Its Applications Book Description :

Quadrupole Mass Spectrometry and Its Applications provides a comprehensive discussion of quadrupoles and their applications. It proceeds from a general explanation of the action of radiofrequency quadrupole fields to the description of their utilization in mass analyzers—such as the quadrupole mass filter, the monopole, the three-dimensional quadrupole ion trap, and various time-of-flight spectrometers—and finally to the characteristic applications of quadrupoles. A multi-author format has been adopted to provide broader-than-usual viewpoint in the book. The book begins by explaining the principles of operation of quadrupole devices. These include ion trajectories and computer simulations of performance; analytical theory; numerical methods of calculation of performance, including the recently developed application of phase-space dynamics; and fringing fields and other field imperfections. Subsequent chapters provide design and performance evaluations of the mass filter, the monopole, ion traps, and time-of-flight instruments; and describe areas of application where quadrupole devices have made the greatest impact because of their particular advantages and disadvantages.

Mass Spectrometry for the Novice Book

Mass Spectrometry for the Novice


  • Author : John Greaves
  • Publisher : CRC Press
  • Release Date : 2013-10-16
  • Genre: Medical
  • Pages : 309
  • ISBN 10 : 9781420094206

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Mass Spectrometry for the Novice Book Description :

With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers

Encyclopedia of Spectroscopy and Spectrometry Book

Encyclopedia of Spectroscopy and Spectrometry


  • Author :
  • Publisher : Academic Press
  • Release Date : 2016-09-22
  • Genre: Science
  • Pages : 3584
  • ISBN 10 : 9780128032251

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Encyclopedia of Spectroscopy and Spectrometry Book Description :

This third edition of the Encyclopedia of Spectroscopy and Spectrometry provides authoritative and comprehensive coverage of all aspects of spectroscopy and closely related subjects that use the same fundamental principles, including mass spectrometry, imaging techniques and applications. It includes the history, theoretical background, details of instrumentation and technology, and current applications of the key areas of spectroscopy. The new edition will include over 80 new articles across the field. These will complement those from the previous edition, which have been brought up-to-date to reflect the latest trends in the field. Coverage in the third edition includes: Atomic spectroscopy Electronic spectroscopy Fundamentals in spectroscopy High-Energy spectroscopy Magnetic resonance Mass spectrometry Spatially-resolved spectroscopic analysis Vibrational, rotational and Raman spectroscopies The new edition is aimed at professional scientists seeking to familiarize themselves with particular topics quickly and easily. This major reference work continues to be clear and accessible and focus on the fundamental principles, techniques and applications of spectroscopy and spectrometry. Incorporates more than 150 color figures, 5,000 references, and 300 articles for a thorough examination of the field Highlights new research and promotes innovation in applied areas ranging from food science and forensics to biomedicine and health Presents a one-stop resource for quick access to answers and an in-depth examination of topics in the spectroscopy and spectrometry arenas

Mass Spectrometry in Drug Discovery Book
Score: 5
From 1 Ratings

Mass Spectrometry in Drug Discovery


  • Author : David T. Rossi
  • Publisher : CRC Press
  • Release Date : 2001-11-07
  • Genre: Medical
  • Pages : 432
  • ISBN 10 : 1420002473

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Mass Spectrometry in Drug Discovery Book Description :

Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.

Mass Spectrometry Book

Mass Spectrometry


  • Author : Dominic M. Desiderio
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-06-29
  • Genre: Science
  • Pages : 359
  • ISBN 10 : 9781489917485

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Mass Spectrometry Book Description :

The current volume reviews novel instrumentation and techniques as applied to the analysis of diacylglycerylphospholipids, modifications to DNA, and the characterization of variant hemoglobins. It reflects the flexible, broad-based approaches mass spectroscopists apply to clinical and biomedical challenges.

Mass Spectrometry  An Issue of Clinics in Laboratory Medicine   E Book Book

Mass Spectrometry An Issue of Clinics in Laboratory Medicine E Book


  • Author : Nigel Clarke
  • Publisher : Elsevier Health Sciences
  • Release Date : 2011-10-03
  • Genre: Medical
  • Pages : 104
  • ISBN 10 : 9781455712014

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Mass Spectrometry An Issue of Clinics in Laboratory Medicine E Book Book Description :

This issue of Clinics in Laboratory Medicine, Guest Edited by Nigel Clarke, MD, and Andrew Hoofnagle, MD, will focus on Mass Spectrometry, with topics including: Proteins; Peptides; Small Molecules: Toxicology; Small Molecules: Diagnostics; and Regulatory Considerations.

Carbohydrate Chemistry  Biology and Medical Applications Book

Carbohydrate Chemistry Biology and Medical Applications


  • Author : Hari G. Garg
  • Publisher : Elsevier
  • Release Date : 2011-09-06
  • Genre: Science
  • Pages : 432
  • ISBN 10 : 0080558143

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Carbohydrate Chemistry Biology and Medical Applications Book Description :

The finding by Emil Fischer that glucose and fructose on treatment with phenylhydrazine gave the identical osazone led him to the elucidation of stereochemistry of carbohydrates. Since then, progress in the field of carbohydrates has been amazing with the unraveling their basic structure, biosynthesis, immunology, functions, and clinical uses, for pure carbohydrates and for protein-linked carbohydrates (glycoproteins and proteoglycans). The chapters in Carbohydrate Chemistry, Biology and Medical Applications present a logical sequence leading from the chemistry and biochemistry of carbohydrates, followed by their role in various pathological conditions, to carbohydrates as potential therapeutic and diagnostic agents. This book offers a detailed panoramic review of the chemistry and biology of carbohydrates for chemists, biologists and health professionals. Each chapter is authored by contributors expert in the particular area of research. Explains how carbohydrates are important to life Details the chemistry, biology and medical aspects of carbohydrates Interdisciplinary and international team of authors

Time Resolved Mass Spectrometry Book

Time Resolved Mass Spectrometry


  • Author : Pawel L. Urban
  • Publisher : John Wiley & Sons
  • Release Date : 2016-03-21
  • Genre: Science
  • Pages : 280
  • ISBN 10 : 9781118887325

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Time Resolved Mass Spectrometry Book Description :

Time is an important factor in physical and natural sciences. It characterizes the progress of chemical and biochemical processes. Mass spectrometry provides the means to study molecular structures by detecting gas-phase ions with the unique mass-to-charge ratios. Time-resolved mass spectrometry (TRMS) allows one to differentiate between chemical states that can be observed sequentially at different time points. Real-time mass spectrometric monitoring enables recording data continuously with a specified temporal resolution. The TRMS approaches – introduced during the past few decades – have shown temporal resolutions ranging from hours down to microseconds and beyond. This text covers the key aspects of TRMS. It introduces ion sources, mass analyzers, and interfaces utilized in time-resolved measurements; discusses the influence of data acquisition and treatment; finally, it reviews most prominent applications of TRMS – in the studies of reaction kinetics and mechanism, physicochemical phenomena, protein structure dynamics, biocatalysis, and metabolic profiling. It will assist science and engineering students to gain a basic understanding of the TRMS concept, and to recognize its usefulness. In addition, it may benefit scientists who conduct molecular studies in the areas of chemistry, physics and biology.

Liquid Chromatography   Mass Spectrometry Book

Liquid Chromatography Mass Spectrometry


  • Author : Robert E. Ardrey
  • Publisher : John Wiley & Sons
  • Release Date : 2003-04-02
  • Genre: Science
  • Pages : 300
  • ISBN 10 : 0471498017

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Liquid Chromatography Mass Spectrometry Book Description :

First explaining the basic principles of liquid chromatography and mass spectrometry and then discussing the current applications and practical benefits of LC-MS, along with descriptions of the basic instrumentation, this title will prove to be the indispensable reference source for everyone wishing to use this increasingly important tandem technique. * First book to concentrate on principles of LC-MS * Explains principles of mass spectrometry and chromatography before moving on to LC-MS * Describes instrumental aspects of LC-MS * Discusses current applications of LC-MS and shows benefits of using this technique in practice