Medical Applications of Mass Spectrometry Book

Medical Applications of Mass Spectrometry

  • Author : Karoly Vekey
  • Publisher : Elsevier
  • Release Date : 2011-08-11
  • Genre: Science
  • Pages : 606
  • ISBN 10 : 9780080554655

Medical Applications of Mass Spectrometry Excerpt :

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine. The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry. * Guides the reader from basic principles and methods to cutting edge applications. * There is NO comparable book on the market to fill this fast growing field.

Mass Spectrometry for the Clinical Laboratory Book

Mass Spectrometry for the Clinical Laboratory

  • Author : Hari Nair
  • Publisher : Academic Press
  • Release Date : 2016-11-02
  • Genre: Medical
  • Pages : 304
  • ISBN 10 : 9780128009925

Mass Spectrometry for the Clinical Laboratory Excerpt :

Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Quadrupole Mass Spectrometry and Its Applications Book

Quadrupole Mass Spectrometry and Its Applications

  • Author : Peter H. Dawson
  • Publisher : Elsevier
  • Release Date : 2013-10-22
  • Genre: Science
  • Pages : 372
  • ISBN 10 : 9781483165042

Quadrupole Mass Spectrometry and Its Applications Excerpt :

Quadrupole Mass Spectrometry and Its Applications provides a comprehensive discussion of quadrupoles and their applications. It proceeds from a general explanation of the action of radiofrequency quadrupole fields to the description of their utilization in mass analyzers—such as the quadrupole mass filter, the monopole, the three-dimensional quadrupole ion trap, and various time-of-flight spectrometers—and finally to the characteristic applications of quadrupoles. A multi-author format has been adopted to provide broader-than-usual viewpoint in the book. The book begins by explaining the principles of operation of quadrupole devices. These include ion trajectories and computer simulations of performance; analytical theory; numerical methods of calculation of performance, including the recently developed application of phase-space dynamics; and fringing fields and other field imperfections. Subsequent chapters provide design and performance evaluations of the mass filter, the monopole, ion traps, and time-of-flight instruments; and describe areas of application where quadrupole devices have made the greatest impact because of their particular advantages and disadvantages.

Advancements of Mass Spectrometry in Biomedical Research Book

Advancements of Mass Spectrometry in Biomedical Research

  • Author : Alisa G. Woods
  • Publisher : Springer
  • Release Date : 2014-06-20
  • Genre: Science
  • Pages : 600
  • ISBN 10 : 9783319060682

Advancements of Mass Spectrometry in Biomedical Research Excerpt :

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine.

Spectroscopic Analyses Book

Spectroscopic Analyses

  • Author : Eram Sharmin
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-12-06
  • Genre: Science
  • Pages : 242
  • ISBN 10 : 9789535136279

Spectroscopic Analyses Excerpt :

The book presents developments and applications of these methods, such as NMR, mass, and others, including their applications in pharmaceutical and biomedical analyses. The book is divided into two sections. The first section covers spectroscopic methods, their applications, and their significance as characterization tools; the second section is dedicated to the applications of spectrophotometric methods in pharmaceutical and biomedical analyses. This book would be useful for students, scholars, and scientists engaged in synthesis, analyses, and applications of materials/polymers.

Mass Spectrometry in Chemical Biology Book

Mass Spectrometry in Chemical Biology

  • Author : Norberto Peporine Lopes
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-11-16
  • Genre: Science
  • Pages : 298
  • ISBN 10 : 9781788013468

Mass Spectrometry in Chemical Biology Excerpt :

Mass spectrometry is one of the most widespread technologies in chemistry and has been increasingly used in biology with the rise of omics sciences. This book summarizes some important methodological approaches in mass spectrometry and applications in the field of chemical biology. The core chapters build on basic concepts introduced in the opening chapter and explore established fields such as high throughput screening, proteomics and metabolomics. Emerging applications of mass spectrometry in elucidating biosynthetic pathways, enzyme mechanisms and protein-protein interactions are then presented. Connections between these diverse research fields are highlighted throughout. The book concludes with a discussion of databases and future perspectives. This book will be a useful tool to early chemical biology researchers wishing to incorporate mass spectrometry as a tool in their research.

Applications of Mass Spectrometry in Microbiology Book

Applications of Mass Spectrometry in Microbiology

  • Author : Plamen Demirev
  • Publisher : Springer
  • Release Date : 2016-01-12
  • Genre: Science
  • Pages : 336
  • ISBN 10 : 9783319260709

Applications of Mass Spectrometry in Microbiology Excerpt :

In the last quarter century, advances in mass spectrometry (MS) have been at the forefront of efforts to map complex biological systems including the human metabolome, proteome, and microbiome. All of these developments have allowed MS to become a well-established molecular level technology for microorganism characterization. MS has demonstrated its considerable advantage as a rapid, accurate, and cost-effective method for microorganism identification, compared to conventional phenotypic techniques. In the last several years, applications of MS for microorganism characterization in research, clinical microbiology, counter-bioterrorism, food safety, and environmental monitoring have been documented in thousands of publications. Regulatory bodies in Europe, the US, and elsewhere have approved MS-based assays for infectious disease diagnostics. As of mid-2015, more than 3300 commercial MS systems for microorganism identification have been deployed worldwide in hospitals and clinical labs. While previous work has covered broader approaches in using MS to characterize microorganisms at the species level or above, this book focuses on strain-level and subtyping applications. In twelve individual chapters, innovators, leaders and practitioners in the field from around the world have contributed to a comprehensive overview of current and next-generation approaches for MS-based microbial characterization at the subspecies and strain levels. Chapters include up-to-date reference lists as well as web-links to databases, recommended software, and other useful tools. The emergence of new, antibiotic-resistant strains of human or animal pathogens is of extraordinary concern not only to the scientific and medical communities, but to the general public as well. Developments of novel MS-based assays for rapid identification of strains of antibiotic-resistant microorganisms are reviewed in the book as well. Microbiologists, bioanalytical scientists, infectious disease specialists, cl

Encyclopedia of Spectroscopy and Spectrometry Book

Encyclopedia of Spectroscopy and Spectrometry

  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2016-09-22
  • Genre: Science
  • Pages : 3584
  • ISBN 10 : 9780128032251

Encyclopedia of Spectroscopy and Spectrometry Excerpt :

This third edition of the Encyclopedia of Spectroscopy and Spectrometry provides authoritative and comprehensive coverage of all aspects of spectroscopy and closely related subjects that use the same fundamental principles, including mass spectrometry, imaging techniques and applications. It includes the history, theoretical background, details of instrumentation and technology, and current applications of the key areas of spectroscopy. The new edition will include over 80 new articles across the field. These will complement those from the previous edition, which have been brought up-to-date to reflect the latest trends in the field. Coverage in the third edition includes: Atomic spectroscopy Electronic spectroscopy Fundamentals in spectroscopy High-Energy spectroscopy Magnetic resonance Mass spectrometry Spatially-resolved spectroscopic analysis Vibrational, rotational and Raman spectroscopies The new edition is aimed at professional scientists seeking to familiarize themselves with particular topics quickly and easily. This major reference work continues to be clear and accessible and focus on the fundamental principles, techniques and applications of spectroscopy and spectrometry. Incorporates more than 150 color figures, 5,000 references, and 300 articles for a thorough examination of the field Highlights new research and promotes innovation in applied areas ranging from food science and forensics to biomedicine and health Presents a one-stop resource for quick access to answers and an in-depth examination of topics in the spectroscopy and spectrometry arenas

Proton Transfer Reaction Mass Spectrometry Book

Proton Transfer Reaction Mass Spectrometry

  • Author : Andrew M. Ellis
  • Publisher : John Wiley & Sons
  • Release Date : 2013-12-17
  • Genre: Science
  • Pages : 368
  • ISBN 10 : 9781118683576

Proton Transfer Reaction Mass Spectrometry Excerpt :

Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a rapidlygrowing analytical technique for detecting and identifying verysmall quantities of chemical compounds in air. It has seenwidespread use in atmospheric monitoring and food science and showsincreasing promise in applications such as industrial processmonitoring, medical science and in crime and securityscenarios. Written by leading researchers, this is the first book devoted toPTR-MS and it provides a comprehensive account of the basicprinciples, the experimental technique and various applications,thus making this book essential reading for researchers,technicians, postgraduate students and professionals inindustry. The book contains nine chapters and is divided into two parts.The first part describes the underlying principles of the PTR-MStechnique, including • the relevant ion-molecule chemistry • thermodynamics and reaction kinetics • a discussion of ion sources, drift tubes and massspectrometers • practical aspects of PTR-MS, includingcalibration. The second part of the book turns its attention to some of themany applications of PTR-MS, demonstrating the scope and benefits,as well as the limitations, of the technique. The chapters thatmake up the second part of the book build upon the materialpresented in the first part and are essentially self-containedreviews focusing on the following topics: • environmental science • food science • medicine • homeland security, and • applications of PTR-MS in liquid analysis.

The Encyclopedia of Mass Spectrometry Book

The Encyclopedia of Mass Spectrometry

  • Author : Anonim
  • Publisher : Newnes
  • Release Date : 2015-12-04
  • Genre: Science
  • Pages : 406
  • ISBN 10 : 9780080913254

The Encyclopedia of Mass Spectrometry Excerpt :

Volume 9: Historical Perspectives, Part A: The Development of Mass Spectrometry of The Encyclopedia of Mass Spectrometry describes and analyzes the development of many aspects of Mass Spectrometry. Beginning with the earliest types of Mass Analyzers, Historical Perspectives explores the development of many different forms of analytical processes and methods. The work follows various instruments and interfaces, to the current state of detectors and computerization. It traces the use of Mass Spectrometry across many different disciplines, including Organic Chemistry, Biochemistry, and Proteomics; Environmental Mass Spectrometry; Forensic Science; Imaging; Medical Monitoring and Diagnosis; Earth and Planetary Sciences; and Nuclear Science. Finally, the book covers the history of manufacturers and societies as well as the professionals who form the Mass Spectrometry community. Also available: Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry briefly reviews the lives and works of many of the major people who carried out this development. Preserves the history and development of Mass Spectrometry for use across scientific fields Written and edited by Mass Spectrometry experts Coordinates with Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry, a collection of short biographies on many of the major people who carried out this development

Mass Spectrometry of Nucleosides and Nucleic Acids Book

Mass Spectrometry of Nucleosides and Nucleic Acids

  • Author : Joseph H. Banoub
  • Publisher : CRC Press
  • Release Date : 2009-12-21
  • Genre: Science
  • Pages : 504
  • ISBN 10 : 1420044036

Mass Spectrometry of Nucleosides and Nucleic Acids Excerpt :

Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustrates the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers, nucleosides, nucleotides, and adducts. It describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry (MS/MS). Next, the contributors examine mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. They analyze urinary modified nucleosides and explore DNA adducts. They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and examine various uses of electrospray ionization mass spectrometry (ESI-MS). The book reviews recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explores the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examines quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry. The book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates, and concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids. The exciting developments in mass spectrometry technology have fueled incredible advances in our understanding of nucleic acids and their complexes. The contributions presented in this volume capture the range of these advances, helping to inspire new findings and avenues of research.

Aptamers for Medical Applications Book

Aptamers for Medical Applications

  • Author : Yiyang Dong
  • Publisher : Springer Nature
  • Release Date : 2021
  • Genre: Biochemical engineering
  • Pages : 462
  • ISBN 10 : 9789813348387

Aptamers for Medical Applications Excerpt :

This book outlines comprehensively the main medical uses of aptamers, from diagnosis to therapeutics in fourteen chapters. Pioneering topics covered include aptamer pharmaceuticals, aptamers for malign tumors, aptamers for personalized therapeutics and aptamers for point-of-care testing. The book offers an essential guide for medical scientists interested in developing aptamer-based schemes for better theranostics. It is therefore of interest for not only academic researchers, but also practitioners and medical researchers in various fields of medical science, medical research and bio-analytical chemistry.

Mass Spectrometry for the Novice Book

Mass Spectrometry for the Novice

  • Author : John Greaves
  • Publisher : CRC Press
  • Release Date : 2013-10-16
  • Genre: Medical
  • Pages : 309
  • ISBN 10 : 9781420094206

Mass Spectrometry for the Novice Excerpt :

With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers

Mass Spectrometry in Drug Metabolism and Pharmacokinetics Book

Mass Spectrometry in Drug Metabolism and Pharmacokinetics

  • Author : Ragu Ramanathan
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-20
  • Genre: Science
  • Pages : 390
  • ISBN 10 : 9781118211571

Mass Spectrometry in Drug Metabolism and Pharmacokinetics Excerpt :

This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.