Mesenchymal Stem Cells in Human Health and Diseases Book

Mesenchymal Stem Cells in Human Health and Diseases


  • Author : Ahmed H.K. El-Hashash
  • Publisher : Academic Press
  • Release Date : 2020-01-07
  • Genre: Science
  • Pages : 228
  • ISBN 10 : 9780128205334

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Mesenchymal Stem Cells in Human Health and Diseases Excerpt :

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world

Lung Stem Cells in Development  Health and Disease Book

Lung Stem Cells in Development Health and Disease


  • Author : Nikolic, Marko Z.
  • Publisher : European Respiratory Society
  • Release Date : 2021-04-01
  • Genre: Medical
  • Pages : 392
  • ISBN 10 : 9781849841344

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Lung Stem Cells in Development Health and Disease Excerpt :

Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science

Stem Cell Innovation in Health   Disease  The Lung  Volume 2 Book

Stem Cell Innovation in Health Disease The Lung Volume 2


  • Author : Ahmed El-Hashash
  • Publisher : Academic Press
  • Release Date : 2021-06-10
  • Genre: Medical
  • Pages : 174
  • ISBN 10 : 9780128212073

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Stem Cell Innovation in Health Disease The Lung Volume 2 Excerpt :

In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world. Provides intensive scientific background and most recent information on cutting edge research to understand respiratory stem cell functions and develop methods to bring stem cells from bench to bedside for different lung diseases Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and iPSC-derived alveolar epithelia cell therapy in the lung Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the

Stem Cells and Human Diseases Book

Stem Cells and Human Diseases


  • Author : Rakesh K. Srivastava
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-02-01
  • Genre: Medical
  • Pages : 630
  • ISBN 10 : 9789400728004

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Stem Cells and Human Diseases Excerpt :

The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.

Mesenchymal Stem Cell Therapy Book

Mesenchymal Stem Cell Therapy


  • Author : Lucas G. Chase
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-12
  • Genre: Science
  • Pages : 456
  • ISBN 10 : 9781627032001

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Mesenchymal Stem Cell Therapy Excerpt :

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the real

Developmental and Stem Cell Biology in Health and Disease Book

Developmental and Stem Cell Biology in Health and Disease


  • Author : Ahmed El-Hashash
  • Publisher : Bentham Science Publishers
  • Release Date : 2016-07-14
  • Genre: Science
  • Pages : 260
  • ISBN 10 : 9781681082196

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Developmental and Stem Cell Biology in Health and Disease Excerpt :

Research into stem cells started in the 1960s with experiments on spleen cultures. Evans and Kaufman made a breakthrough in mouse embryo culturing and embryonic stem cell extraction in 1981, followed by the work of Thomson in 1998 on the technique for extracting human embryonic stem cells. Since then, stem cell research has rapidly expanded as a therapeutic avenue for different diseases in humans. This book explains the basic developmental biology of stem cells including the development of stem cells during the implantation stage in utero to the regulation of stem cell division. Medical applications of stem cells in the therapy of diseases such as cancer, neurodegenerative diseases, and bone diseases are also explained in subsequent chapters. The book also explains the effect of parasitic cells on stem cell growth. Concepts in the book are explained in a simple clear manner, making this book an informative reference for non-experts, students and professionals in the field of biology and medicine.

Update on Mesenchymal and Induced Pluripotent Stem Cells Book

Update on Mesenchymal and Induced Pluripotent Stem Cells


  • Author : Khalid Ahmed Al-Anazi
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-04-22
  • Genre: Science
  • Pages : 148
  • ISBN 10 : 9781789238075

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Update on Mesenchymal and Induced Pluripotent Stem Cells Excerpt :

This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders.

Pluripotent Stem Cells Book

Pluripotent Stem Cells


  • Author : Minoru Tomizawa
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-07-20
  • Genre: Science
  • Pages : 532
  • ISBN 10 : 9789535124719

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Pluripotent Stem Cells Excerpt :

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

Mesenchymal Stromal Cells Book

Mesenchymal Stromal Cells


  • Author : Peiman Hematti
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-01-16
  • Genre: Science
  • Pages : 695
  • ISBN 10 : 9781461457114

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Mesenchymal Stromal Cells Excerpt :

Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs. This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs. Features include: Coverage of the biology of MSCs, latest understanding of mechanisms of action, and role in tissue homeostasis and regeneration Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues.

Tissue Barriers in Disease  Injury and Regeneration Book

Tissue Barriers in Disease Injury and Regeneration


  • Author : Nikolai V. Gorbunov
  • Publisher : Elsevier
  • Release Date : 2021-07-07
  • Genre: Science
  • Pages : 206
  • ISBN 10 : 9780128185612

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Tissue Barriers in Disease Injury and Regeneration Excerpt :

Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more. Focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers to damaging impacts and exposure to pathogens and engineered nano-materials Is a special emphasis on role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid, and reticuloendothelial cells in development of reactions that bridge effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions and in metabolic status Examines the role of progenitor cells of different origins in remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, mucosa and external epithelium will be also addressed and discussed

Autophagy in Health and Disease Book

Autophagy in Health and Disease


  • Author : Kursad Turksen
  • Publisher : Springer
  • Release Date : 2018-10-06
  • Genre: Science
  • Pages : 177
  • ISBN 10 : 9783319981468

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Autophagy in Health and Disease Excerpt :

This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.

Neural Stem Cells in Health and Disease Book

Neural Stem Cells in Health and Disease


  • Author : Ashok K Shetty
  • Publisher : World Scientific Publishing Company
  • Release Date : 2015-08-28
  • Genre: Science
  • Pages : 572
  • ISBN 10 : 9789814623193

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Neural Stem Cells in Health and Disease Excerpt :

This book is a comprehensive guide on neural stem cell behavior in health and disease. The book confers the altered behavior of endogenous neural stem cells in neurodegenerative disease conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders. Neural stem cell activity and neurogenesis in the adult brain is now confirmed in virtually all mammalian species including humans. Hence, a series of chapters in the first half of the book discusses the current knowledge on mechanisms of neural stem cell activity, the extent and functional significance of neurogenesis in the adult brain under normal, aged and disease environments, the susceptibility of neural stem cells and the plasticity of neurogenesis to alcohol, drugs of abuse and anesthetic agents, and advanced techniques that trigger neurogenesis in non-neurogenic regions. A second series of chapters in this book are focused on discussing the promise and efficacy of grafting of neural stem cells and/or other stem cells for treating neurological disorders such as Parkinson's disease, stroke, temporal lobe epilepsy, Alzheimer's disease and spinal cord injury. The final chapter confers on advances that are made in manufacturing a variety of neural cell types from human pluripotent stem cells that can be used as donor cells for cell transplantation.

Guidelines for Stem Cell Research and Therapy Book

Guidelines for Stem Cell Research and Therapy


  • Author : India. Department of Biotechnology
  • Publisher : Unknown
  • Release Date : 2007
  • Genre: Stem cells
  • Pages : 66
  • ISBN 10 : LCCN:2009346305

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Guidelines for Stem Cell Research and Therapy Excerpt :

Stem cell research holds great promise for improving human health by control of degenerative diseases and restoration of damage to organs by various injuries; but at the same time it also raises several ethical and social issues such as destruction of human embryos to create human embryonic stem (hES) cell lines, potential for introducing commodification in human tissues and organs with inherent barriers of access to socioeconomically deprived and possible use of technology for germ-line engineering and reproductive cloning. The research in this field, therefore, needs to be regulated to strike a balance. Of utmost importance is assurance of safety, and rights of those donating gametes/ blastocysts/ somatic cells for derivation of stem cells; or fetal tissues/umbilical cord cells/ adult tissue (or cells) for use as stem cells. Safeguards have also to be in place to protect research participants receiving stem cell transplants, and patients at large from unproven therapies/remedies. With success of growing human embryonic stem cells without feeder layer, derivation of histocompatible hES from embryos created by Somatic Cell Nuclear Transfer (SCNT) and tissue specific differentiation of umbilical cord/bone marrow derived mesenchymal and haematopoeitic stem cells, there is a need to generate public confidence in potential benefit of stem cell research to human health and disease. As stem cell therapy is poised to enter into clinical practice, there is an urgent need to formulate guidelines for Stem cell Research and Therapy (SCRT). The aims and scope of this document are to lay down general principles for stem cell research and therapy keeping in view the ethical issues. To formulate specific guidelines for derivation, propagation, differentiation, characterization, banking, and use of human stem cells for research and therapy. These guidelines provide a mechanism to ensure that research with human stem cells is conducted in a responsible and ethically sensitive manner

Novel Concepts in iPSC Disease Modeling Book

Novel Concepts in iPSC Disease Modeling


  • Author : Alexander Birbrair
  • Publisher : Academic Press
  • Release Date : 2022-01-25
  • Genre: Science
  • Pages : 336
  • ISBN 10 : 9780128238837

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Novel Concepts in iPSC Disease Modeling Excerpt :

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs - Novel Concepts, Volume 15 addresses how important induced pluripotent stems cells are and how can they can help treat certain diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different disorders, such as liver disease, type-1 diabetes, Parkinson’s disease, macular degeneration of the retina and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers spinal cord injuries, type-1 diabetes, liver disease, Parkinson’s disease, graft vs. host disease, and much more Contributed by world-renown experts in the field

Human Mesenchymal Stem Cells Book

Human Mesenchymal Stem Cells


  • Author : Mitchell Khan
  • Publisher : Nova Science Publishers
  • Release Date : 2021
  • Genre: Science
  • Pages : 134
  • ISBN 10 : 1536192244

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Human Mesenchymal Stem Cells Excerpt :

"In Chapter 1, the COVID-19 pandemic and the damage mechanisms on the cellular level which can be ameliorated with the cellular therapies is thoroughly evaluated. Previous and ongoing stem cell clinical trial data from diseases with similar symptoms is gathered. All this accumulated data and current clinical trial results indicate that the cellular therapies could be the most effective treatment option for COVID-19 patients to ameliorate the damaged tissues and save lives. In Chapter 2, the authors examine activated mesenchymal stem cells for stroke repair. Stem Cell treatment has shown recovery in animal models of stroke, indicating an improved regenerative and repair potential. Though stem cells are still being used in clinical trials, there is no evidence that they enhance recovery in ischemic stroke patients. Nevertheless, the multipotent mesenchymal stem has widely been explored for stroke recovery. An'Activated MSC' as a therapeutic alternative to tackling ischemic stroke is proposed, thereby the activation of MSCs by cytokines, growth factors, hypoxia, pharmacological drugs, etc., could be a novel approach to improving stroke patients' responses to receiving MSCs. In Chapter 3, the potential benefits of in vitro culture of therapeutic stem cells in the presence of HB along with the ketogenic diet, whereby higher physiological concentrations of ketone bodies can be achieved in vivo, as an adjuvant to stem cell transplantation is assessed"--