Modelling Methodology for Physiology and Medicine Book

Modelling Methodology for Physiology and Medicine


  • Author : Ewart Carson
  • Publisher : Newnes
  • Release Date : 2013-12-05
  • Genre: Science
  • Pages : 588
  • ISBN 10 : 9780124095250

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Modelling Methodology for Physiology and Medicine Excerpt :

Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems

Introduction to Modeling in Physiology and Medicine Book

Introduction to Modeling in Physiology and Medicine


  • Author : Claudio Cobelli
  • Publisher : Elsevier
  • Release Date : 2008-02-06
  • Genre: Technology & Engineering
  • Pages : 337
  • ISBN 10 : 9780080559988

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Introduction to Modeling in Physiology and Medicine Excerpt :

This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises

Computational Modeling in Biomedical Engineering and Medical Physics Book

Computational Modeling in Biomedical Engineering and Medical Physics


  • Author : Alexandru Morega
  • Publisher : Academic Press
  • Release Date : 2020-09-15
  • Genre: Science
  • Pages : 314
  • ISBN 10 : 9780128178980

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Computational Modeling in Biomedical Engineering and Medical Physics Excerpt :

Mathematical and numerical modelling of engineering problems in medicine is aimed at unveiling and understanding multidisciplinary interactions and processes and providing insights useful to clinical care and technology advances for better medical equipment and systems. When modelling medical problems, the engineer is confronted with multidisciplinary problems of electromagnetism, heat and mass transfer, and structural mechanics with, possibly, different time and space scales, which may raise concerns in formulating consistent, solvable mathematical models. Computational Medical Engineering presents a number of engineering for medicine problems that may be encountered in medical physics, procedures, diagnosis and monitoring techniques, including electrical activity of the heart, hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave hyperthermia, ablation, EMF dosimetry, and bioimpedance methods. The authors discuss the core approach methodology to pose and solve different problems of medical engineering, including essentials of mathematical modelling (e.g., criteria for well-posed problems); physics scaling (homogenization techniques); Constructal Law criteria in morphing shape and structure of systems with internal flows; computational domain construction (CAD and, or reconstruction techniques based on medical images); numerical modelling issues, and validation techniques used to ascertain numerical simulation results. In addition, new ideas and venues to investigate and understand finer scale models and merge them into continuous media medical physics are provided as case studies. Presents the fundamentals of mathematical and numerical modeling of engineering problems in medicine Discusses many of the most common modelling scenarios for Biomedical Engineering, including, electrical activity of the heart hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave h

Introduction to Modeling in Physiology and Medicine Book

Introduction to Modeling in Physiology and Medicine


  • Author : Claudio Cobelli
  • Publisher : Academic Press
  • Release Date : 2019-08-01
  • Genre: Computers
  • Pages : 384
  • ISBN 10 : 9780128158050

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Introduction to Modeling in Physiology and Medicine Excerpt :

Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear understanding of the fundamental principles of good modeling methodology. Sections show how to create valid mathematical models that are fit for a range of purposes. These models are supported by detailed explanation, extensive case studies, examples and applications. This updated edition includes clearer guidance on the mathematical prerequisites needed to achieve the maximum benefit from the material, a greater detail regarding basic approaches to modeling, and discussions on non-linear and stochastic modeling. The range of case study material has been substantially extended, with examples drawn from recent research experience. Key examples include a cellular model of insulin secretion and its extension to the whole-body level, a model of insulin action during a meal/oral glucose tolerance test, a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials. Covers the underlying principles of good quantitative modeling methodology, with applied biomedical engineering and bioscience examples to ensure relevance to students, current research and clinical practice Includes modeling data, modeling systems, linear and non-linear systems, model identification, parametric and non-parametric models, and model validation Presents clear, step-by-step working plus examples and extensive case studies that relate concepts to real world applications Provides end-of-chapter exercises and assignments to reinforce learning

Quantitative Physiology Book

Quantitative Physiology


  • Author : Shangbin Chen
  • Publisher : Springer Nature
  • Release Date : 2021-02-09
  • Genre: Medical
  • Pages : 237
  • ISBN 10 : 9789813340336

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Quantitative Physiology Excerpt :

Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics

Applied Biomechatronics Using Mathematical Models Book

Applied Biomechatronics Using Mathematical Models


  • Author : Jorge Garza Ulloa
  • Publisher : Academic Press
  • Release Date : 2018-06-16
  • Genre: Technology & Engineering
  • Pages : 662
  • ISBN 10 : 9780128125953

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Applied Biomechatronics Using Mathematical Models Excerpt :

Applied Biomechatronics Using Mathematical Models provides an appropriate methodology to detect and measure diseases and injuries relating to human kinematics and kinetics. It features mathematical models that, when applied to engineering principles and techniques in the medical field, can be used in assistive devices that work with bodily signals. The use of data in the kinematics and kinetics analysis of the human body, including musculoskeletal kinetics and joints and their relationship to the central nervous system (CNS) is covered, helping users understand how the complex network of symbiotic systems in the skeletal and muscular system work together to allow movement controlled by the CNS. With the use of appropriate electronic sensors at specific areas connected to bio-instruments, we can obtain enough information to create a mathematical model for assistive devices by analyzing the kinematics and kinetics of the human body. The mathematical models developed in this book can provide more effective devices for use in aiding and improving the function of the body in relation to a variety of injuries and diseases. Focuses on the mathematical modeling of human kinematics and kinetics Teaches users how to obtain faster results with these mathematical models Includes a companion website with additional content that presents MATLAB examples

Basic Science Methods for Clinical Researchers Book

Basic Science Methods for Clinical Researchers


  • Author : Morteza Jalali
  • Publisher : Academic Press
  • Release Date : 2017-03-31
  • Genre: Science
  • Pages : 382
  • ISBN 10 : 9780128030783

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Basic Science Methods for Clinical Researchers Excerpt :

Basic Science Methods for Clinical Researchers addresses the specific challenges faced by clinicians without a conventional science background. The aim of the book is to introduce the reader to core experimental methods commonly used to answer questions in basic science research and to outline their relative strengths and limitations in generating conclusive data. This book will be a vital companion for clinicians undertaking laboratory-based science. It will support clinicians in the pursuit of their academic interests and in making an original contribution to their chosen field. In doing so, it will facilitate the development of tomorrow’s clinician scientists and future leaders in discovery science. Serves as a helpful guide for clinical researchers who lack a conventional science background Organized around research themes pertaining to key biological molecules, from genes, to proteins, cells, and model organisms Features protocols, techniques for troubleshooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data Appendices provide resources for practical research methodology, including legal frameworks for using stem cells and animals in the laboratory, ethical considerations, and good laboratory practice (GLP)

Models of Calcium Signalling Book

Models of Calcium Signalling


  • Author : Geneviève Dupont
  • Publisher : Springer
  • Release Date : 2016-06-07
  • Genre: Mathematics
  • Pages : 436
  • ISBN 10 : 9783319296470

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Models of Calcium Signalling Excerpt :

This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism. Geneviève Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Université Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbrück Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.

A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences Book

A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences


  • Author : Riccardo Sacco
  • Publisher : Academic Press
  • Release Date : 2019-07-18
  • Genre: Technology & Engineering
  • Pages : 854
  • ISBN 10 : 9780128125199

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A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences Excerpt :

A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences provides a systematic methodology to the formulation of problems in biomedical engineering and the life sciences through the adoption of mathematical models based on physical principles, such as the conservation of mass, electric charge, momentum, and energy. It then teaches how to translate the mathematical formulation into a numerical algorithm that is implementable on a computer. The book employs computational models as synthesized tools for the investigation, quantification, verification, and comparison of different conjectures or scenarios of the behavior of a given compartment of the human body under physiological and pathological conditions. Presents theoretical (modeling), biological (experimental), and computational (simulation) perspectives Features examples, exercises, and MATLAB codes for further reader involvement Covers basic and advanced functional and computational techniques throughout the book

Metabolic Engineering Book

Metabolic Engineering


  • Author : Jens Nielsen
  • Publisher : Springer
  • Release Date : 2003-07-03
  • Genre: Science
  • Pages : 184
  • ISBN 10 : 9783540453000

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Metabolic Engineering Excerpt :

Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.

Multidisciplinary Computational Anatomy Book

Multidisciplinary Computational Anatomy


  • Author : Makoto Hashizume
  • Publisher : Springer Nature
  • Release Date : 2022-01-01
  • Genre: Medical
  • Pages : 398
  • ISBN 10 : 9789811643255

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Multidisciplinary Computational Anatomy Excerpt :

This volume thoroughly describes the fundamentals of a new multidisciplinary field of study that aims to deepen our understanding of the human body by combining medical image processing, mathematical analysis, and artificial intelligence. Multidisciplinary Computational Anatomy (MCA) offers an advanced diagnosis and therapeutic navigation system to help detect or predict human health problems from the micro-level to macro-level using a four-dimensional, dynamic approach to human anatomy: space, time, function, and pathology. Applying this dynamic and “living” approach in the clinical setting will promote better planning for – and more accurate, effective, and safe implementation of – medical management. Multidisciplinary Computational Anatomy will appeal not only to clinicians but also to a wide readership in various scientific fields such as basic science, engineering, image processing, and biomedical engineering. All chapters were written by respected specialists and feature abundant color illustrations. Moreover, the findings presented here share new insights into unresolved issues in the diagnosis and treatment of disease, and into the healthy human body.

Evaluation of Human Work  2nd Edition Book

Evaluation of Human Work 2nd Edition


  • Author : E. N. Corlett
  • Publisher : CRC Press
  • Release Date : 1995-10-13
  • Genre: Technology & Engineering
  • Pages : 1152
  • ISBN 10 : 0748400834

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Evaluation of Human Work 2nd Edition Excerpt :

Comprising a compendium of ergonomics methods and techniques, this text covers every aspect of human work. This edition provides a reworking of existing chapters on the framework and context of methodology, the observation of performance, task analysis, experimental and study design, data collection, product assessment, environmental assessments, measurement of work and the evaluation of work systems. New chapters cover topics including: the human-computer interface; computer-aided design; work stress; psychophysiological function; risk evaluation; fieldwork; and participatory work design.

Cost Effectiveness in Health and Medicine Book

Cost Effectiveness in Health and Medicine


  • Author : Peter J. Neumann
  • Publisher : Oxford University Press
  • Release Date : 2016-10-03
  • Genre: Medical
  • Pages : 496
  • ISBN 10 : 9780190492953

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Cost Effectiveness in Health and Medicine Excerpt :

A COMPLETE UPDATE AND REVISION OF THE CLASSIC TEXT "At last, a manual of operations for comparing the cost-effectiveness of a preventive service with a treatment intervention." --American Journal of Preventive Medicine Twenty years after the first edition of COST-EFFECTIVENESS IN HEALTH AND MEDICINE established the practical benchmark for cost-effectiveness analysis, this completely revised edition of the classic text provides an essential resource to a new generation of practitioners, students, researchers, and policymakers. Produced by the Second Panel on Cost-Effectiveness in Health and Medicine--a team of 13 experts from fields including decision science, economics, ethics, psychology, and medicine--this new edition is a comprehensive guide to the use of cost-effectiveness analysis as an evaluative tool at the institutional and policy levels. As health care systems face increasing pressure to derive maximum value from expenditures, the guidelines in this new text represent not just the best information available, but a vital guide to health care decision-making in a challenging new era. Completely revised and enriched with examples and expanded coverage, this second edition of COST-EFFECTIVENESS IN HEALTH AND MEDICINE builds on its predecessor's excellence, offering required reading for both analysts and decision makers.

Building a Better Delivery System Book

Building a Better Delivery System


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2005-10-20
  • Genre: Medical
  • Pages : 277
  • ISBN 10 : 9780309096430

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Building a Better Delivery System Excerpt :

In a joint effort between the National Academy of Engineering and the Institute of Medicine, this books attempts to bridge the knowledge/awareness divide separating health care professionals from their potential partners in systems engineering and related disciplines. The goal of this partnership is to transform the U.S. health care sector from an underperforming conglomerate of independent entities (individual practitioners, small group practices, clinics, hospitals, pharmacies, community health centers et. al.) into a high performance "system" in which every participating unit recognizes its dependence and influence on every other unit. By providing both a framework and action plan for a systems approach to health care delivery based on a partnership between engineers and health care professionals, Building a Better Delivery System describes opportunities and challenges to harness the power of systems-engineering tools, information technologies and complementary knowledge in social sciences, cognitive sciences and business/management to advance the U.S. health care system.

Prognosis Research in Healthcare Book

Prognosis Research in Healthcare


  • Author : Richard D. Riley
  • Publisher : Oxford University Press
  • Release Date : 2019-01-17
  • Genre: Medical
  • Pages : 384
  • ISBN 10 : 9780192516657

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Prognosis Research in Healthcare Excerpt :

"What is going to happen to me?" Most patients ask this question during a clinical encounter with a health professional. As well as learning what problem they have (diagnosis) and what needs to be done about it (treatment), patients want to know about their future health and wellbeing (prognosis). Prognosis research can provide answers to this question and satisfy the need for individuals to understand the possible outcomes of their condition, with and without treatment. Central to modern medical practise, the topic of prognosis is the basis of decision making in healthcare and policy development. It translates basic and clinical science into practical care for patients and populations. Prognosis Research in Healthcare: Concepts, Methods and Impact provides a comprehensive overview of the field of prognosis and prognosis research and gives a global perspective on how prognosis research and prognostic information can improve the outcomes of healthcare. It details how to design, carry out, analyse and report prognosis studies, and how prognostic information can be the basis for tailored, personalised healthcare. In particular, the book discusses how information about the characteristics of people, their health, and environment can be used to predict an individual's future health. Prognosis Research in Healthcare: Concepts, Methods and Impact, addresses all types of prognosis research and provides a practical step-by-step guide to undertaking and interpreting prognosis research studies, ideal for medical students, health researchers, healthcare professionals and methodologists, as well as for guideline and policy makers in healthcare wishing to learn more about the field of prognosis.