Models of Seizures and Epilepsy Book

Models of Seizures and Epilepsy


  • Author : Asla Pitkänen
  • Publisher : Academic Press
  • Release Date : 2017-06-14
  • Genre: Science
  • Pages : 1178
  • ISBN 10 : 9780128040676

DOWNLOAD BOOK
Models of Seizures and Epilepsy Excerpt :

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Seizures and Epilepsy Book

Seizures and Epilepsy


  • Author : Jerome Engel Jr
  • Publisher : Oxford University Press
  • Release Date : 2013-01-31
  • Genre: Medical
  • Pages : 737
  • ISBN 10 : 9780195328547

DOWNLOAD BOOK
Seizures and Epilepsy Excerpt :

This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.

Jasper s Basic Mechanisms of the Epilepsies Book

Jasper s Basic Mechanisms of the Epilepsies


  • Author : Jeffrey Noebels
  • Publisher : Oxford University Press
  • Release Date : 2012-06-01
  • Genre: Medical
  • Pages : 1264
  • ISBN 10 : 9780199842599

DOWNLOAD BOOK
Jasper s Basic Mechanisms of the Epilepsies Excerpt :

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamu

Epileptic Seizures and the EEG Book

Epileptic Seizures and the EEG


  • Author : Andrea Varsavsky
  • Publisher : CRC Press
  • Release Date : 2016-04-19
  • Genre: Medical
  • Pages : 370
  • ISBN 10 : 9781439812044

DOWNLOAD BOOK
Epileptic Seizures and the EEG Excerpt :

A study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, it addresses the fundamental question: can seizures be predicted? Based on the authors' extensive research, the book concludes by exploring a range of future possibilities in seizure prediction.

Epilepsy Book

Epilepsy


  • Author : Philip A. Schwartzkroin
  • Publisher : Cambridge University Press
  • Release Date : 1993-06-17
  • Genre: Medical
  • Pages : 560
  • ISBN 10 : 9780521392983

DOWNLOAD BOOK
Epilepsy Excerpt :

This book considers a number of major concepts and models in epilepsy research, to advance understanding of the basic mechanisms involved.

Animal Models of Epilepsy Book

Animal Models of Epilepsy


  • Author : Scott C. Baraban
  • Publisher : Humana Press
  • Release Date : 2009-05-29
  • Genre: Medical
  • Pages : 276
  • ISBN 10 : 1603272623

DOWNLOAD BOOK
Animal Models of Epilepsy Excerpt :

In this book, investigators examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species. This is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.

Introduction to Epilepsy Book

Introduction to Epilepsy


  • Author : Gonzalo Alarcón
  • Publisher : Cambridge University Press
  • Release Date : 2012-04-26
  • Genre: Medical
  • Pages : 641
  • ISBN 10 : 9780521691581

DOWNLOAD BOOK
Introduction to Epilepsy Excerpt :

Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.

Encyclopedia of Basic Epilepsy Research Book

Encyclopedia of Basic Epilepsy Research


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2009-05-27
  • Genre: Medical
  • Pages : 4224
  • ISBN 10 : 9780123739612

DOWNLOAD BOOK
Encyclopedia of Basic Epilepsy Research Excerpt :

As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research

Computational Neuroscience in Epilepsy Book

Computational Neuroscience in Epilepsy


  • Author : Ivan Soltesz
  • Publisher : Academic Press
  • Release Date : 2011-09-02
  • Genre: Science
  • Pages : 624
  • ISBN 10 : 0080559530

DOWNLOAD BOOK
Computational Neuroscience in Epilepsy Excerpt :

Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering. Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures Contributors are top experts at the forefront of computational epilepsy research Chapter contents are highly relevant to both basic and clinical epilepsy researchers

Epilepsy Book

Epilepsy


  • Author : Jong Rho
  • Publisher : CRC Press
  • Release Date : 2010-06-18
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9781420085600

DOWNLOAD BOOK
Epilepsy Excerpt :

Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervo

Epilepsy Book

Epilepsy


  • Author : David W. McCandless
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-11-02
  • Genre: Medical
  • Pages : 532
  • ISBN 10 : 1461403618

DOWNLOAD BOOK
Epilepsy Excerpt :

The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7‐9 years, and the “success” rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.

Astrocytes and Epilepsy Book

Astrocytes and Epilepsy


  • Author : Jacqueline A. Hubbard
  • Publisher : Academic Press
  • Release Date : 2016-07-05
  • Genre: Medical
  • Pages : 394
  • ISBN 10 : 9780128026243

DOWNLOAD BOOK
Astrocytes and Epilepsy Excerpt :

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron i

Atlas of Epilepsies Book

Atlas of Epilepsies


  • Author : S.R. Benbadis
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-09-20
  • Genre: Medical
  • Pages : 1966
  • ISBN 10 : 9781848821279

DOWNLOAD BOOK
Atlas of Epilepsies Excerpt :

Atlas of Epilepsies is a landmark, all-encompassing, illustrated reference work and hands-on guide to the diagnosis, management and treatment of epilepsy in all its forms and across all age groups. The premier text in the field with over one thousand images, the Atlas’s highly illustrative approach tackles the difficult subject of epileptic seizures and epileptic syndromes, accompanied by sequential photographs of each management step. Intraoperative photographs are accompanied by detailed figure legends describing nuances, subtleties, and the thought processes involved in each step, providing a fuller understanding of each procedure. The Atlas draws on the expertise of over 300 internationally-renowned experts, and is liberally interspersed with clinical insights and personal vignettes that offer helpful tips, technical advice and critical knowledge to the clinician and scholar. The thorough and complete table of contents includes dedicated sections or chapters on important topics such as neonatal and pediatric seizures; imitators of epilepsy; EEG and neuroimaging; psychiatric and quality of life aspects of epilepsy; and a complete guide to treatment options including current and up-to-date chapters on pharmaceuticals, surgical procedures, and additional and alternative treatments. No other publication addresses epilepsies as thoroughly and completely as the Atlas of Epilepsies. Exhaustive and illustrative, convenient and current, this reference is sure to be the premier text on epilepsy for many years to come.

Models of Seizures and Epilepsy Book

Models of Seizures and Epilepsy


  • Author : Asla Pitkänen
  • Publisher : Academic Press
  • Release Date : 2017-06-16
  • Genre: Medical
  • Pages : 1178
  • ISBN 10 : 0128040661

DOWNLOAD BOOK
Models of Seizures and Epilepsy Excerpt :

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy Book

Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy


  • Author : Divya Vohora
  • Publisher : Unknown
  • Release Date : 2021
  • Genre: Anticonvulsants
  • Pages : 250
  • ISBN 10 : 1071612549

DOWNLOAD BOOK
Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy Excerpt :

This volume discusses the latest experimental and clinical approaches to study seizures and epilepsy. Chapters in this book cover detailed protocols for ex vivo and in vitro experimental models and widely-used in vivo (acute and chronic seizure) models in epilepsy research. Chapters also cover techniques to screen the effective leads for the treatment of refractory seizures of pharmacoresistant epilepsy and invertebrate, non-mammalian models. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy is a valuable resource for researchers, in both industry and academia, interested in learning about this important and developing field.