Molecular and Cellular Therapies for Motor Neuron Diseases Book

Molecular and Cellular Therapies for Motor Neuron Diseases


  • Author : Nicholas M. Boulis
  • Publisher : Academic Press
  • Release Date : 2017-01-16
  • Genre: Motor neurons
  • Pages : 336
  • ISBN 10 : 0128022574

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Molecular and Cellular Therapies for Motor Neuron Diseases Excerpt :

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig's Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

Molecular and Cellular Therapies for Motor Neuron Diseases Book

Molecular and Cellular Therapies for Motor Neuron Diseases


  • Author : Nicholas M Boulis
  • Publisher : Academic Press
  • Release Date : 2017-01-18
  • Genre: Psychology
  • Pages : 336
  • ISBN 10 : 9780128025246

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Molecular and Cellular Therapies for Motor Neuron Diseases Excerpt :

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

Motor Neuron Disease in Adults Book

Motor Neuron Disease in Adults


  • Author : Mark Bromberg
  • Publisher : Oxford University Press
  • Release Date : 2014-10-02
  • Genre: Medical
  • Pages : 352
  • ISBN 10 : 9780199783168

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Motor Neuron Disease in Adults Excerpt :

Motor Neuron Disease in Adults reviews new information as it applies to all aspects of motor neuron disease (ALS, PLS, PMA). The choice of articles is for those that use evidence-based methods to ensure that the new information is solid and advances the topic or issue. The book can be used by anyone who provides any type of care to ALS patients. In particular, neurologists will find the latest information on diagnosis and management, as well as new information on genetics and frontotemporal lobe involvement. Allied health providers will find useful information for their discipline. Patients will also find both specific and general information to help understand what they are experiencing and how to help manage their symptoms.

The Future of Pharmaceuticals Book

The Future of Pharmaceuticals


  • Author : Sarfaraz K. Niazi
  • Publisher : CRC Press
  • Release Date : 2022-03-01
  • Genre: Medical
  • Pages : 620
  • ISBN 10 : 9781000458169

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The Future of Pharmaceuticals Excerpt :

Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future. Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development.

Gene and Cell Therapy Book

Gene and Cell Therapy


  • Author : Nancy Smyth Templeton
  • Publisher : CRC Press
  • Release Date : 2003-12-17
  • Genre: Science
  • Pages : 894
  • ISBN 10 : 9780824758608

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Gene and Cell Therapy Excerpt :

This reference is completely revised and expanded to reflect the most critical studies, controversies, and technologies impacting the medical field, including probing research on lentivirus, gutless adenovirus, bacterial and baculovirus vectors, retargeted viral vectors, in vivo electroporation, in vitro and in vivo gene detection systems, and all inducible gene expression systems. Scrutinizing every tool, technology, and issue impacting the future of gene and cell research, it is specifically written and organized for laymen, scholars, and specialists from varying backgrounds and disciplines to understand the current status of gene and cell therapy and anticipate future developments in the field.

The Molecular and Clinical Pathology of Neurodegenerative Disease Book

The Molecular and Clinical Pathology of Neurodegenerative Disease


  • Author : Patrick A. Lewis
  • Publisher : Academic Press
  • Release Date : 2018-11-16
  • Genre: Science
  • Pages : 274
  • ISBN 10 : 9780128110706

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The Molecular and Clinical Pathology of Neurodegenerative Disease Excerpt :

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

Molecular Bio Sensors and the Role of Metal Ions Book

Molecular Bio Sensors and the Role of Metal Ions


  • Author : Thomas J. Meade
  • Publisher : CRC Press
  • Release Date : 2022-09-27
  • Genre: Science
  • Pages : 407
  • ISBN 10 : 9781000647006

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Molecular Bio Sensors and the Role of Metal Ions Excerpt :

Volume 23, entitled Molecular Bio-Sensors and the Role of Metal Ions, of the series Metal Ions in Life Sciences (MILS) represents a milestone of contemporary progress and understanding of molecular bio-sensors for metal ions. It is bringing together the latest research in academia and industry, and it also emphasizes the spectrum of evolving regulations from regulatory bodies. This vibrant research area is covered by 31 internationally recognized experts. The impact of MILS-23 is manifested by more than 1300 references and close to 200 figures, more than 100 of them in color; further information is summarized in several tables. In conclusion, Volume 23 significantly advances our understanding of Molecular Bio-Sensors, it is therefore an essential resource for scientists working in the wide range from earth sciences, material sciences, physics, pharmacology, enzymology, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic. • It provides an understanding of the roles that metals play in living systems. • It offers an insight for the demands needed in the clinic. • It reveals the interplay between bio-sensors and therapies. The Series METAL IONS IN LIFE SCIENCES increases our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of Biological Inorganic Chemistry and coordinate the efforts of researchers in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, toxicology, environmental chemistry, biophysics, pharmacy, and medicine. The volumes deal with the formation, stability, structure, and reactivity of metal-containing biological compounds of low and high molecular weight. The metabolism and transport of metal ions and their complexes as well as new models of complicated natural structures and processes are in the focus. Consequently, the volumes are an essential source

Molecular and Cellular Therapeutics Book

Molecular and Cellular Therapeutics


  • Author : David Whitehouse
  • Publisher : John Wiley & Sons
  • Release Date : 2012-04-09
  • Genre: Science
  • Pages : 331
  • ISBN 10 : 9780470748145

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Molecular and Cellular Therapeutics Excerpt :

Molecular and Cellular Therapeutics aims to bring together key developments in the areas of molecular diagnostics, therapeutics and drug discovery. The book covers topics including diagnostics, therapeutics, model systems, clinical trials and drug discovery. The developing approaches to molecular and cellular therapies, diagnostics and drug discovery are presented in the context of the pathologies they are devised to treat.

TDP 43 and Neurodegeneration Book

TDP 43 and Neurodegeneration


  • Author : Vijay Kumar
  • Publisher : Academic Press
  • Release Date : 2021-10-23
  • Genre: Medical
  • Pages : 270
  • ISBN 10 : 9780128204405

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TDP 43 and Neurodegeneration Excerpt :

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathology Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases Presents a systems and precision biology perspective of TDP-43 Discusses therapeutics of TDP-43 proteinopathies Translates bench research to application bedside

Novel Aspects on Motor Neuron Disease Book

Novel Aspects on Motor Neuron Disease


  • Author : Humberto Foyaca Sibat
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-05-20
  • Genre: Medical
  • Pages : 120
  • ISBN 10 : 9781838807733

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Novel Aspects on Motor Neuron Disease Excerpt :

Dedicated to our readers, we include novel information (not reported in IntechOpen’s books before) about new contributions of aberrant astrocytes to MND damage and death in the SOD1G93A rat experimental model of ALS; novel genetic studies on ALS; an update of the structural and functional consequences of the spinal muscular atrophy-linked mutations of the survival motor neuron protein; stem cell therapy for MND; and the novel treatment for SMA and ALS in the introductory chapter. This book contains selected peer-reviewed chapters written by international researchers. In this publication, the readers will find a compilation of state-of-the-art reviews about etiology, therapies, investigations, the molecular basis of disease progression and clinical manifestations, and the genetic familial ALS, as well as novel therapeutic modalities. We look forward with confidence and pride to the remarkable role that this book will play for a new vision and mission.

Motor Neuron Disease  New Insights for the Healthcare Professional  2011 Edition Book

Motor Neuron Disease New Insights for the Healthcare Professional 2011 Edition


  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2012-01-09
  • Genre: Medical
  • Pages : 59
  • ISBN 10 : 9781464904424

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Motor Neuron Disease New Insights for the Healthcare Professional 2011 Edition Excerpt :

Motor Neuron Disease: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Motor Neuron Disease in a concise format. The editors have built Motor Neuron Disease: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Motor Neuron Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Motor Neuron Disease: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Motor Neuron Disease Research Progress Book

Motor Neuron Disease Research Progress


  • Author : Raffaele L. Mancini
  • Publisher : Nova Publishers
  • Release Date : 2008
  • Genre: Medical
  • Pages : 330
  • ISBN 10 : 1604561556

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Motor Neuron Disease Research Progress Excerpt :

The motor neuron diseases (or motor neuron diseases) (MND) are a group of progressive neurological disorders that destroy motor neurons, the cells that control voluntary muscle activity such as speaking, walking, breathing, and swallowing. Neurological examination presents specific signs associated with upper and lower motor neuron degeneration. Signs of upper motor neuron damage include spasticity, brisk reflexes and the Babinski sign. Signs of lower motor neuron damage include weakness and muscle atrophy. Every muscle group in the body requires both upper and lower motor neurons to function. It is a common misconception that "upper" motor neurons control the arms, while "lower" motor neurons control the legs. The signs described above can occur in any muscle group, including the arms, legs, torso, and bulbar region. Symptoms usually present between the ages of 50-70, and include progressive weakness, muscle wasting, and muscle fasciculations; spasticity or stiffness in the arms and legs; and overactive tendon reflexes. Patients may present with symptoms as diverse as a dragging foot, unilateral muscle wasting in the hands, or slurred speech. This new book presents the latest research from around the globe.

Dementia and Motor Neuron Disease Book

Dementia and Motor Neuron Disease


  • Author : Michael Strong
  • Publisher : CRC Press
  • Release Date : 2006-07-27
  • Genre: Medical
  • Pages : 256
  • ISBN 10 : 0415391660

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Dementia and Motor Neuron Disease Excerpt :

Dementia and Motor Neuron Disease is a single authoritative reference on the current understanding of frontotemporal dementia in amyotrophic lateral sclerosis (ALS). This comprehensive work is ideal for clinical and research groups focusing on dementia or ALS, as well as those working in the fields of neuroimaging and neuropsychology. Key topics covered include: • Frontotemporal dementia, including history, anatomy and impairment • Clinical phenomenology and treatment • Neuropathological, cognitive dysfunction and altered cognition spectrums • Neuroimaging • Molecular and cellular neuropathology • Genetics • Neurochemistry With contributions from international opinion leaders in dementia and motor neuron disease, this is a one-of-a-kind reference for established clinicians and researchers, as well as graduate students studying neurodegeneration.

The Molecular and Cellular Basis of Neurodegenerative Diseases Book

The Molecular and Cellular Basis of Neurodegenerative Diseases


  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release Date : 2018-03-29
  • Genre: Medical
  • Pages : 560
  • ISBN 10 : 9780128113059

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The Molecular and Cellular Basis of Neurodegenerative Diseases Excerpt :

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts