Molecular Mechanisms of Synaptogenesis Book
Score: 4
From 1 Ratings

Molecular Mechanisms of Synaptogenesis


  • Author : Alexander Dityatev
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-11-24
  • Genre: Medical
  • Pages : 497
  • ISBN 10 : 9780387325620

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Molecular Mechanisms of Synaptogenesis Excerpt :

This book provides a new compilation of information that link changes in the basic structure of synapses and brain diseases. The book shows that specific secreted proteins, and short peptide mimicking the function of neural cell adhesion molecules can significantly enhance the formation of synapses in the brain. It describes recent advances in research that lay necessary scientific groundwork to develop pharmacological treatments.

Molecular Mechanisms of Synaptogenesis Book

Molecular Mechanisms of Synaptogenesis


  • Author : Alexander Dityatev
  • Publisher : Springer
  • Release Date : 2006-08-16
  • Genre: Medical
  • Pages : 497
  • ISBN 10 : 0387325603

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Molecular Mechanisms of Synaptogenesis Excerpt :

This book provides a new compilation of information that link changes in the basic structure of synapses and brain diseases. The book shows that specific secreted proteins, and short peptide mimicking the function of neural cell adhesion molecules can significantly enhance the formation of synapses in the brain. It describes recent advances in research that lay necessary scientific groundwork to develop pharmacological treatments.

Neural Plasticity and Memory Book

Neural Plasticity and Memory


  • Author : Federico Bermudez-Rattoni
  • Publisher : CRC Press
  • Release Date : 2007-04-17
  • Genre: Science
  • Pages : 368
  • ISBN 10 : 1420008412

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Neural Plasticity and Memory Excerpt :

A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniques have been used to investigate how cellular and brain circuits may be modified by experience. In each chapter, researchers present findings and explain their innovative methodologies. The book begins by introducing key issues and providing a historical overview of the field of memory consolidation. The following chapters review the putative genetic and molecular mechanisms of cell plasticity, elaborating on how experience could induce gene and protein expression and describing their role in synaptic plasticity underlying memory formation. They explore how putative modifications of brain circuits and synaptic elements through experience can become relatively permanent and hence improve brain function. Interdisciplinary reviews focus on how nerve cell circuitry, molecular expression, neurotransmitter release, and electrical activity are modified during the acquisition and consolidation of long-term memory. The book also covers receptor activation/deactivation by different neurotransmitters that enable the intracellular activation of second messengers during memory formation. It concludes with a summary of current research on the modulation and regulation that different neurotransmitters and stress hormones have on formation and consolidation of memory.

Textbook of Neural Repair and Rehabilitation Book

Textbook of Neural Repair and Rehabilitation


  • Author : Michael Selzer
  • Publisher : Cambridge University Press
  • Release Date : 2014-04-24
  • Genre: Medical
  • Pages : 688
  • ISBN 10 : 9781107011670

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Textbook of Neural Repair and Rehabilitation Excerpt :

Volume 1 of the Textbook of Neural Repair and Rehabilitation covers the basic sciences relevant to recovery of function following injury to the nervous system.

The Synapse Book

The Synapse


  • Author : Virginia M. Pickel
  • Publisher : Elsevier
  • Release Date : 2013-11-16
  • Genre: Science
  • Pages : 512
  • ISBN 10 : 9780124186828

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The Synapse Excerpt :

The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations. Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function. Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings. A comprehensive reference focused on the structure and function of the synapse Covers the links between the synapse and neural plasticity and the cellular basis of neurologic disease Detailed coverage of dendritic spines and associated perisynaptic glia—the tripartite synapse Includes in-depth coverage of synapse degeneration due to aging or hormonal decline related to severe cognitive impairment

Synapse Development and Maturation Book

Synapse Development and Maturation


  • Author : Pasko Rakic
  • Publisher : Academic Press
  • Release Date : 2020-05-29
  • Genre: Science
  • Pages : 558
  • ISBN 10 : 9780128236734

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Synapse Development and Maturation Excerpt :

Synapse Development and Maturation, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. The book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the synaptogenesis and developmental sequences in the maturation of intrinsic and synapse-driven patterns. Features leading experts in various subfields as section editors and article authors Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship Includes coverage of mechanisms which regulate synapse formation and maintenance during development Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity

Synaptogenesis in the Mammalian Central Inhibitory Synapse Book

Synaptogenesis in the Mammalian Central Inhibitory Synapse


  • Author : Alexandros Poulopoulos
  • Publisher : Sudwestdeutscher Verlag Fur Hochschulschriften AG
  • Release Date : 2010-12
  • Genre: Uncategoriezed
  • Pages : 172
  • ISBN 10 : 3838122666

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Synaptogenesis in the Mammalian Central Inhibitory Synapse Excerpt :

The establishment of accurate synaptic transmission underlies neural network processing and nervous system function. The organized deployment of specialized synaptic machinery is a key cellular process that shapes the synapse and its transmission properties, yet the molecular mechanisms involved in assembling the synaptic apparatus are largely unknown. This work has focused on the role of Neuroligins, a family of postsynaptic adhesion molecules, in mediating differentiation of inhibitory, GABAergic and glycinergic, postsynapses.

Neurotransmitter Release Book

Neurotransmitter Release


  • Author : Hugo J. Bellen
  • Publisher : Oxford University Press, USA
  • Release Date : 1999
  • Genre: Science
  • Pages : 437
  • ISBN 10 : UOM:39015048547338

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Neurotransmitter Release Excerpt :

Begins by providing a comprehensive introduction to the features and properties of synapses. It then describes key techniques used to study neurotransmitter release, from calcium entry to exocytosis. This is followed by chapters covering the identification and function of proteins involved in neurotransmitter release, the role of phospholipids in neurosecretion, and neurotransmitter transporter proteins. Subsequent chapters concentrate on approaches to unravel the function of specific proteins in vivo using toxins that affect neurotransmitter release, giant squit axons, C. elegans, Drosophila, and mice.

Investigation of the Molecular Mechanisms that Mediate Neural Circuit Formation Book

Investigation of the Molecular Mechanisms that Mediate Neural Circuit Formation


  • Author : Katherine Watters
  • Publisher : Unknown
  • Release Date : 2016
  • Genre: Neural circuitry
  • Pages : 38
  • ISBN 10 : OCLC:961833371

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Investigation of the Molecular Mechanisms that Mediate Neural Circuit Formation Excerpt :

Thought, perception, and behavior rely on the faithful transfer of information between neurons, the cells of the nervous system. To ensure proper neural circuit formation, neurons must form connections with the proper neuronal partner, a process called synaptic partner recognition. Next, the neuron must recruit synaptic components to the correct membrane, a process called synaptic assembly. These two processes must be tightly linked for proper nervous system function, and defects in either may result in developmental neurological disorders. The VanHoven laboratory uses the genetic model organism Caenhorabditis elegans and the transgenic fluorescent marker NLG-1 GRASP. NLG-1 GRASP fluorescently labels synapses that form between the PHB chemosensory neurons and the AVA interneurons in vivo. Previously the VanHoven laboratory revealed that the ligand-receptor pair UNC-6/Netrin and UNC-40/DCC act in a juxtacrine manner to specify synaptic partner recognition between PHB and AVA neurons. Here, we study two other genes required in neural circuit formation: the transmembrane receptor clr-1/Receptor Protein Tyrosine Phosphatase (RPTP) and the small vesicle transporter protein unc-69/Small Coiled-Coil (SCOCO). We find that both CLR-1/RPTP and UNC-69/SCOCO are required for proper PHB to AVA synaptogenesis, act in the previously described UNC-6/Netrin UNC-40/DCC pathway, and likely function downstream of UNC-6/Netrin. Further characterization of how CLR-1/RPTP and UNC-69/SCOCO mediate nervous system development will help us to understand the logic of neural circuit formation as well as aid in the development of treatments for neurological disorders.

Cellular Migration and Formation of Neuronal Connections Book

Cellular Migration and Formation of Neuronal Connections


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2013-05-06
  • Genre: Science
  • Pages : 1080
  • ISBN 10 : 9780123973474

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Cellular Migration and Formation of Neuronal Connections Excerpt :

The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity.

From Neurons to Neighborhoods Book
Score: 5
From 1 Ratings

From Neurons to Neighborhoods


  • Author : Division of Behavioral and Social Sciences and Education
  • Publisher : National Academies Press
  • Release Date : 2000-11-13
  • Genre: Social Science
  • Pages : 612
  • ISBN 10 : 9780309069885

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From Neurons to Neighborhoods Excerpt :

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Neurogenesis and Neural Plasticity Book

Neurogenesis and Neural Plasticity


  • Author : Catherine Belzung
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-07-08
  • Genre: Medical
  • Pages : 401
  • ISBN 10 : 9783642362323

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Neurogenesis and Neural Plasticity Excerpt :

This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.

Mechanisms of Neural Circuit Formation Book

Mechanisms of Neural Circuit Formation


  • Author : Joshua A. Weiner
  • Publisher : Frontiers Media SA
  • Release Date : 2015-01-30
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889194032

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Mechanisms of Neural Circuit Formation Excerpt :

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Regulation of Filopodia Dynamics is Critical for Proper Synapse Formation Book

Regulation of Filopodia Dynamics is Critical for Proper Synapse Formation


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2004
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:680289650

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Regulation of Filopodia Dynamics is Critical for Proper Synapse Formation Excerpt :

Despite the importance of proper synaptogenesis in the CNS, the molecular mechanisms that regulate the formation and development of synapses remain poorly understood. Indeed, the mechanisms through which initial synaptic contacts are established and modified during synaptogenesis have not been fully determined and a precise understanding of these mechanisms may shed light on synaptic development, plasticity and many CNS developmental diseases. The development and formation of spiny synapses has been thought to occur via filopodia shortening followed by the recruitment of proper postsynaptic proteins, however the precise function of filopodia remains controversial. Thus the goal of this study was to investigate the dynamics of dendritic filopodia and determine their role in the development of synaptic contacts. We initially define and characterize short lipidated motifs that are sufficient to induce process outgrowth. Indeed, the palmitoylated protein motifs of GAP-43 and paralemmin are sufficient to induce filopodial extensions in heterologous cells and to increase the number of filopodia and dendritic branches in neurons. We showed that the morphological changes induced by these FIMs (filopodia inducing motifs) require on-going protein palmitoylation and are modulated by a specific GTPase, Cdc42, that regulates actin dynamics. We also show that their function is palmitoylation dependent and is dynamically regulated by reversible protein palmitoylation. Significantly, our work suggests a general role for those palmitoylated motifs in the development of structures important for synapse formation and maturation. We combined several approaches to monitor the formation and development of filopodia. We show that filopodia continuously explore the environment and probe for appropriate contacts with presynaptic partners. We find that shortly after establishing a contact with axons, filopodia induce the recruitment of presynaptic elements. Remarkably, we find that expressio

Discovering the Brain Book

Discovering the Brain


  • Author : National Academy of Sciences
  • Publisher : National Academies Press
  • Release Date : 1992-01-01
  • Genre: Medical
  • Pages : 194
  • ISBN 10 : 9780309045292

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Discovering the Brain Excerpt :

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brain--an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attention--and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniques--what various technologies can and cannot tell us--and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakers--and many scientists as well--with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."