Cancer Signaling  Enhanced Edition Book

Cancer Signaling Enhanced Edition


  • Author : Christoph Wagener
  • Publisher : John Wiley & Sons
  • Release Date : 2017-01-27
  • Genre: Science
  • Pages : 360
  • ISBN 10 : 9783527800476

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Cancer Signaling Enhanced Edition Excerpt :

Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online.

Molecular Targeting and Signal Transduction Book

Molecular Targeting and Signal Transduction


  • Author : Rakesh Kumar
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-04-18
  • Genre: Medical
  • Pages : 331
  • ISBN 10 : 9781402078477

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Molecular Targeting and Signal Transduction Excerpt :

Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.

Therapeutic Strategies in Cancer Biology and Pathology Book

Therapeutic Strategies in Cancer Biology and Pathology


  • Author : Gajanan V. Sherbet
  • Publisher : Elsevier
  • Release Date : 2013-07-26
  • Genre: Medical
  • Pages : 310
  • ISBN 10 : 9780124165908

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Therapeutic Strategies in Cancer Biology and Pathology Excerpt :

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies. Identifies molecular targets and their accessibility for therapeutic intervention Provides information on biological features of tumor development and dissemination Background information provided for each topic

Cellular Signal Processing Book

Cellular Signal Processing


  • Author : Friedrich Marks
  • Publisher : Garland Science
  • Release Date : 2017-05-17
  • Genre: Medical
  • Pages : 640
  • ISBN 10 : 9781351677219

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Cellular Signal Processing Excerpt :

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.

Signal Transduction Book

Signal Transduction


  • Author : Bastien D. Gomperts
  • Publisher : Gulf Professional Publishing
  • Release Date : 2003-10-29
  • Genre: Medical
  • Pages : 424
  • ISBN 10 : 0122896327

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Signal Transduction Excerpt :

Signal Transduction now in paperback, is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix, etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particulary cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources key observations and experiments that set the scence for recent and current work. * Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine * Conceptual colour artwork assists with the comprehension of key topics * Extensive referencing provides an invaluable link to the core and historical literature * Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms

Signal Transduction in Cancer Book

Signal Transduction in Cancer


  • Author : David A. Frank
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-04-18
  • Genre: Medical
  • Pages : 357
  • ISBN 10 : 9780306481581

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Signal Transduction in Cancer Excerpt :

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Cell Surface GRP78  a New Paradigm in Signal Transduction Biology Book

Cell Surface GRP78 a New Paradigm in Signal Transduction Biology


  • Author : Salvatore V. Pizzo
  • Publisher : Academic Press
  • Release Date : 2018-03-20
  • Genre: Science
  • Pages : 144
  • ISBN 10 : 9780128123522

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Cell Surface GRP78 a New Paradigm in Signal Transduction Biology Excerpt :

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies Presents an in-depth treatment of the biological underpinnings of GRP78 and its connection to disease Provides four-color illustrations that facilitate the narrative

Cancer Signaling  Enhanced Edition Book

Cancer Signaling Enhanced Edition


  • Author : Christoph Wagener
  • Publisher : John Wiley & Sons
  • Release Date : 2016-08-17
  • Genre: Science
  • Pages : 360
  • ISBN 10 : 9783527800469

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Cancer Signaling Enhanced Edition Excerpt :

Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.

Synergistic Interactions of Targeted Therapy Within Signal Transduction Pathways Book

Synergistic Interactions of Targeted Therapy Within Signal Transduction Pathways


  • Author : Sharon Glaysher
  • Publisher : Unknown
  • Release Date : 2012
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : OCLC:847540502

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Synergistic Interactions of Targeted Therapy Within Signal Transduction Pathways Excerpt :

Introduction: Cancer of the same origin show considerable heterogeneity in sensitivity to chemotherapy both clinically and in vitro, and show rapid adaptation to chemotherapy based on gene expression. This study tested the hypothesis that anticancer drug exposure could render tumour-derived cells more susceptible to second agents, particularly those with specific molecular targets in survival pathways and with the knowledge of cellular pathways, determine new more effective molecularly designed regimens. Materials and Methods: Single agent, combinational and sequential chemosensitivity of a series of cell lines and tumours was assessed using the ATP-based tumour chemosensitivity assay (ATP-TCA). Sensitivity data was correlated with gene expression, measured by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) in a TaqMan Array following extraction of mRNA from cell samples and standardisation to the housekeeping gene (PBGD). Mutation analysis kits utilising Amplification Refractory Mutation System (ARMS) and scorpion technology were used to establish the presence of activating mutations in EGFR, KRAS, BRAF and PI3K. Results: Heterogeneity in cellular sensitivity to cytotoxic and targeted agents was observed. While gene expression was seen to show some correlation with sensitivity to signalling pathway combination targets, the complexity associated with cellular adaptation prevented the prediction of response to second agent sequential treatment. Discussion: This study has identified potential novel combinations for use in ovarian cancer. This combination of EGFR and PI3K inhibitors has shown greater sensitivity in cell based assays compared with single agent activity and could become the focus of future clinical trials. Successful application of 384 well ATP-based chemosensitivity assays has shown to be a valuable tool for future cell based research. The quantity of viable tumour derived cellular material is diminishing; therefore, methods devel

Molecular Mechanisms of Signal Transduction Book

Molecular Mechanisms of Signal Transduction


  • Author : Johannes Lukas Bos
  • Publisher : Unknown
  • Release Date : 2000
  • Genre: Cell adhesion molecules
  • Pages : 285
  • ISBN 10 : WISC:89074947979

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Molecular Mechanisms of Signal Transduction Excerpt :

This book contains overviews of topics that have been discussed. It includes contributions from leading experts in the field on small GTPases, protein kinases and transcription factors. A particular focus was the influence of oxygen radicals on signalling processes. It also contains the contribution of scientists early in their career, who have made an exccellent contribution to the institute."

Molecular Pathomechanisms and New Trends in Drug Research Book

Molecular Pathomechanisms and New Trends in Drug Research


  • Author : Gyorgy Keri
  • Publisher : CRC Press
  • Release Date : 2002-11-14
  • Genre: Medical
  • Pages : 664
  • ISBN 10 : 9780203219973

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Molecular Pathomechanisms and New Trends in Drug Research Excerpt :

Knowledge of the basic mechanisms of human disease is essential for any student or professional engaged in drug research and development. Functional gene analysis (genomics), protein analysis (proteomics), and other molecular biological techniques have made it possible to understand these cellular processes, opening up exciting opportunities for no

Medicinal Chemistry of Anticancer Drugs Book

Medicinal Chemistry of Anticancer Drugs


  • Author : Carmen Avendano
  • Publisher : Elsevier
  • Release Date : 2015-06-11
  • Genre: Science
  • Pages : 768
  • ISBN 10 : 9780444626677

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Medicinal Chemistry of Anticancer Drugs Excerpt :

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Cancer Cell Signaling Book

Cancer Cell Signaling


  • Author : Kasirajan Ayyanathan
  • Publisher : CRC Press
  • Release Date : 2014-06-20
  • Genre: Medical
  • Pages : 410
  • ISBN 10 : 9781482299458

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Cancer Cell Signaling Excerpt :

This title includes a number of Open Access chapters. Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developing new treatments. The current volume provides an overview of the field and how various cell biology techniques are used to better understand cancer on a cellular level. This easily accessible reference volume offers a comprehensive look at the field of cancer cell signaling. Edited by a researcher from Florida Atlantic University, Cancer Cell Signaling: Targeting Signaling Pathways Towards Therapeutic Approaches to Cancer is an authoritative and easy-to-use reference.

New Molecular Targets for Cancer Chemotherapy Book
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New Molecular Targets for Cancer Chemotherapy


  • Author : David J. Kerr
  • Publisher : CRC Press
  • Release Date : 1994-06-27
  • Genre: Medical
  • Pages : 236
  • ISBN 10 : 0849349052

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New Molecular Targets for Cancer Chemotherapy Excerpt :

This book covers a wide range of novel biochemical targets that appear to be the best leads in terms of designing novel targets for anticancer drug design. New Molecular Targets for Cancer Chemotherapy is a unique, multi-disciplinary effort, with internationally respected authors from the fields of growth factor-receptor interaction, phosphoinositide and phospholipase signal transduction, and DNA-drug binding interactions. The science is placed in clinical context and illustrations explain how clinicians can incorporate a mechanistic, pharmacodynamic approach into early clinical trial design.