Molecular Targets in Protein Misfolding and Neurodegenerative Disease Book

Molecular Targets in Protein Misfolding and Neurodegenerative Disease


  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2014-10-09
  • Genre: Medical
  • Pages : 295
  • ISBN 10 : 0128001860

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Molecular Targets in Protein Misfolding and Neurodegenerative Disease Excerpt :

Aimed at "drug discoverers" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a "drug discovery" application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

Molecular Targets in Protein Misfolding and Neurodegenerative Disease Book

Molecular Targets in Protein Misfolding and Neurodegenerative Disease


  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2018-11-13
  • Genre: Science
  • Pages : 314
  • ISBN 10 : 0128103183

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Molecular Targets in Protein Misfolding and Neurodegenerative Disease Excerpt :

Aimed at "drug discoverers" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a "drug discovery” application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease Book

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease


  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2015-01-12
  • Genre: Medical
  • Pages : 260
  • ISBN 10 : 0128019441

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Chemical Modulators of Protein Misfolding and Neurodegenerative Disease Excerpt :

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. • Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds; • Provides discipline-specific chapters that cover medicinal chemistry and clinical applications; • Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder; • Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery.

The Molecular and Cellular Basis of Neurodegenerative Diseases Book

The Molecular and Cellular Basis of Neurodegenerative Diseases


  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release Date : 2018-03-29
  • Genre: Medical
  • Pages : 560
  • ISBN 10 : 9780128113059

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The Molecular and Cellular Basis of Neurodegenerative Diseases Excerpt :

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Molecular Targets in Protein Misfolding and Neurodegenerative Disease Book

Molecular Targets in Protein Misfolding and Neurodegenerative Disease


  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2014-10-07
  • Genre: Science
  • Pages : 314
  • ISBN 10 : 9780128004999

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Molecular Targets in Protein Misfolding and Neurodegenerative Disease Excerpt :

Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease Book

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease


  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2015-01-14
  • Genre: Science
  • Pages : 260
  • ISBN 10 : 9780128019597

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Chemical Modulators of Protein Misfolding and Neurodegenerative Disease Excerpt :

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer’s and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds Provides discipline-specific chapters that cover medicinal chemistry and clinical applications Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery

Protein and Peptide Folding  Misfolding  and Non Folding Book

Protein and Peptide Folding Misfolding and Non Folding


  • Author : Reinhard Schweitzer-Stenner
  • Publisher : John Wiley & Sons
  • Release Date : 2012-02-08
  • Genre: Science
  • Pages : 576
  • ISBN 10 : 9781118183359

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Protein and Peptide Folding Misfolding and Non Folding Excerpt :

Sheds new light on intrinsically disordered proteins andpeptides, including their role in neurodegenerative diseases With the discovery of intrinsically disordered proteins andpeptides (IDPs), researchers realized that proteins do notnecessarily adopt a well defined secondary and tertiary structurein order to perform biological functions. In fact, IDPs playbiologically relevant roles, acting as inhibitors, scavengers, andeven facilitating DNA/RNA-protein interactions. Due to theirpropensity for self-aggregation and fibril formation, some IDPs areinvolved in neurodegenerative diseases such as Parkinson's andAlzheimer's. With contributions from leading researchers, this text reviewsthe most recent studies, encapsulating our understanding of IDPs.The authors explain how the growing body of IDP research isbuilding our knowledge of the folding process, the binding ofligands to receptor molecules, and peptide self-aggregation.Readers will discover a variety of experimental, theoretical, andcomputational approaches used to better understand the propertiesand function of IDPs. Moreover, they'll discover the role of IDPsin human disease and as drug targets. Protein and Peptide Folding, Misfolding, and Non-Folding beginswith an introduction that explains why research on IDPs hassignificantly expanded in the past few years. Next, the book isdivided into three sections: Conformational Analysis of Unfolded States Disordered Peptides and Molecular Recognition Aggregation of Disordered Peptides Throughout the book, detailed figures help readers understandthe structure, properties, and function of IDPs. References at theend of each chapter serve as a gateway to the growing body ofliterature in the field. With the publication of Protein and Peptide Folding, Misfolding,and Non-Folding, researchers now have a single place to discoverIDPs, their diverse biological functions, and the many disciplinesthat have contributed to our evolving understanding of them.

Protein Chaperones and Protection from Neurodegenerative Diseases Book

Protein Chaperones and Protection from Neurodegenerative Diseases


  • Author : Stephan N. Witt
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-09
  • Genre: Science
  • Pages : 444
  • ISBN 10 : 9781118063897

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Protein Chaperones and Protection from Neurodegenerative Diseases Excerpt :

How protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases. Examining how different protein chaperones ameliorate the toxicity of proteins that are known to cause neurodegenerative damage, the book addresses both research and clinical perspectives on chaperone and anti-chaperone properties. The intersection of molecular chaperones and neurodegeneration is an intensely studied area, partly because of the potential for manipulating the expression of molecular chaperones to thwart the progression of debilitating diseases, and partly because of the ever-aging global population. Discussing the potential to harness the power of protein chaperones, and future directions for research, discovery, and therapeutics, this book is essential reading for scientists working in the fields of biochemistry, molecular medicine, pharmacology and drug discovery, biotechnology and pharmaceutical companies, advanced students, and anyone interested in this cutting-edge topic.

Protein Misfolding Book

Protein Misfolding


  • Author : Rossen Donev
  • Publisher : Academic Press
  • Release Date : 2020-01-13
  • Genre: Science
  • Pages : 450
  • ISBN 10 : 9780128177518

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Protein Misfolding Excerpt :

Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein misfolding, how Genetic and environmental factors interact to disrupt proteostasis and trigger protein misfolding diseases, Formation of oligomers and large amorphous aggregates by intrinsically disordered proteins, Protein misfolding in ER stress with applications to cardiovascular and renal disease, and much more. Integrates methods for studying protein misfolding, factors that trigger this process and its role in a wide spectrum of diseases and disorders Contains timely chapters written by well-renowned authorities in their field Provides data that is well supported by a number of high quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students

Neurodegenerative Diseases Book

Neurodegenerative Diseases


  • Author : Uday Kishore
  • Publisher : BoD – Books on Demand
  • Release Date : 2013-05-15
  • Genre: Medical
  • Pages : 642
  • ISBN 10 : 9789535110880

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Neurodegenerative Diseases Excerpt :

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.

Molecular Chaperones in Health and Disease Book

Molecular Chaperones in Health and Disease


  • Author : Matthias Gaestel
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-01-18
  • Genre: Science
  • Pages : 442
  • ISBN 10 : 9783540297178

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Molecular Chaperones in Health and Disease Excerpt :

Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.

Genotype   Proteotype   Phenotype Relationships in Neurodegenerative Diseases Book

Genotype Proteotype Phenotype Relationships in Neurodegenerative Diseases


  • Author : J. Cummings
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-03-30
  • Genre: Medical
  • Pages : 166
  • ISBN 10 : 9783540265221

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Genotype Proteotype Phenotype Relationships in Neurodegenerative Diseases Excerpt :

Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships. Experts from international laboratories contributed to the current volume to produce a comprehensive overview of the role of protein misfolding in neurodegeneration. Links between genotype and protein characteristics and between proteotype and clinical phenomenology were discussed across diseases categories. Progress in understanding the role of abnormalities of protein metabolism may lead to the identification of biological markers relevant to disease monitoring and to the development of new therapeutic agents capable of modifying and ameliorating basic neurodegenerative mechanisms.

Protein Misfolding in Neurodegenerative Diseases Book

Protein Misfolding in Neurodegenerative Diseases


  • Author : Robert D. E. Sewell
  • Publisher : CRC Press
  • Release Date : 2007-12-03
  • Genre: Science
  • Pages : 592
  • ISBN 10 : 1420007149

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Protein Misfolding in Neurodegenerative Diseases Excerpt :

Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS. A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.

TDP 43 and Neurodegeneration Book

TDP 43 and Neurodegeneration


  • Author : Vijay Kumar
  • Publisher : Academic Press
  • Release Date : 2021-10-23
  • Genre: Medical
  • Pages : 270
  • ISBN 10 : 9780128204405

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TDP 43 and Neurodegeneration Excerpt :

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathology Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases Presents a systems and precision biology perspective of TDP-43 Discusses therapeutics of TDP-43 proteinopathies Translates bench research to application bedside

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging Book

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging


  • Author : M. A. Hayat
  • Publisher : Academic Press
  • Release Date : 2016-12-28
  • Genre: Medical
  • Pages : 430
  • ISBN 10 : 9780128094273

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Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging Excerpt :

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available