Molecules to Medicine with mTOR Book

Molecules to Medicine with mTOR

  • Author : Kenneth Maiese
  • Publisher : Academic Press
  • Release Date : 2016-02-21
  • Genre: Medical
  • Pages : 472
  • ISBN 10 : 9780128027554

Molecules to Medicine with mTOR Excerpt :

Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. Covers the role of mTOR by internationally recognized expert contributors in the field. Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. Includes analysis of the role of mTOR and in both health and disease. Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.

Molecules to Medicine with MTOR Book

Molecules to Medicine with MTOR

  • Author : Department of Neurology School of Medicine Kenneth Maiese
  • Publisher : Academic Press
  • Release Date : 2016-05-15
  • Genre: Uncategoriezed
  • Pages : 512
  • ISBN 10 : 0128027339

Molecules to Medicine with MTOR Excerpt :

mTOR in Human Diseases Book

mTOR in Human Diseases

  • Author : Olivier Dormond
  • Publisher : MDPI
  • Release Date : 2019-06-18
  • Genre: Medical
  • Pages : 480
  • ISBN 10 : 9783039210602

mTOR in Human Diseases Excerpt :

The mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protein, lipid, and nucleotide synthesis, as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified, including in cancer, hamartoma, neurological, and metabolic diseases. Through a series of articles, this book focuses on the role played by mTOR in cellular processes, metabolism in particular, and highlights a panel of human diseases for which mTOR inhibition provides or might provide benefits. It also addresses future studies needed to further characterize the role of mTOR in selected disorders, which will help design novel therapeutic approaches. It is therefore intended for everyone who has an interest in mTOR biology and its application in human pathologies.

mTOR Signaling in Metabolism and Cancer Book

mTOR Signaling in Metabolism and Cancer

  • Author : Shile Huang
  • Publisher : MDPI
  • Release Date : 2020-12-03
  • Genre: Science
  • Pages : 204
  • ISBN 10 : 9783039435531

mTOR Signaling in Metabolism and Cancer Excerpt :

The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this Special Issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting mTOR pathway is a promising strategy to fight against certain human diseases.

Resveratrol Book


  • Author : Farid A. Badria
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-02-06
  • Genre: Medical
  • Pages : 168
  • ISBN 10 : 9781789849943

Resveratrol Excerpt :

This book intends to strike a balance between developments in research and the fact that researchers must absorb and link to scientific advances with clinical practice so that the management of diseases can be based on sound physiological concepts. This book addresses several controversial issues regarding a natural molecule with fascinating pharmacological and therapeutic effects. The book contains three sections: Section 1: Pharmacology and Therapeutic Applications of Resveratrol; Section 2: Bioavailability, Metabolism, and Mode of Action of Resveratrol; Section 3: Resveratrol and Its Role in Chronic and Degenerative Diseases. Does it Add Life to Years or Years to Life? It is our hope that this book will motivate readers to approach the evidence on the use resveratrol and thereby spark an interest in making further contributions to the current scientific debate and treatment development efforts.

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging Book

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging

  • Author : M. A. Hayat
  • Publisher : Academic Press
  • Release Date : 2016-12-28
  • Genre: Medical
  • Pages : 430
  • ISBN 10 : 9780128094273

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging Excerpt :

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Molecular Basis and Emerging Strategies for Anti aging Interventions Book

Molecular Basis and Emerging Strategies for Anti aging Interventions

  • Author : Syed Ibrahim Rizvi
  • Publisher : Springer
  • Release Date : 2018-11-02
  • Genre: Medical
  • Pages : 386
  • ISBN 10 : 9789811316999

Molecular Basis and Emerging Strategies for Anti aging Interventions Excerpt :

This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.

Autophagy  Biology and Diseases Book

Autophagy Biology and Diseases

  • Author : Zheng-Hong Qin
  • Publisher : Springer Nature
  • Release Date : 2019-11-27
  • Genre: Science
  • Pages : 727
  • ISBN 10 : 9789811506024

Autophagy Biology and Diseases Excerpt :

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.

Molecular Medicine Book
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Molecular Medicine

  • Author : Jens Kurreck
  • Publisher : John Wiley & Sons
  • Release Date : 2016-02-16
  • Genre: Science
  • Pages : 404
  • ISBN 10 : 9783527331895

Molecular Medicine Excerpt :

Easy to read, yet comprehensive, this is the perfect introduction into the molecular basis of disease and the novel treatment options that have become available. The authors, Jens Kurreck and Cy Stein, have both long-standing teaching experience on the subject, one from a biologist's angle, the other with a medical background. Together, they have produced a modern textbook for courses in Molecular Medicine that incorporates modules from immunology to signaling, from virology to gene therapy, and the latest development in personalized medicine.

Inflammation  Advancing Age and Nutrition Book

Inflammation Advancing Age and Nutrition

  • Author : Irfan Rahman
  • Publisher : Academic Press
  • Release Date : 2013-09-03
  • Genre: Technology & Engineering
  • Pages : 394
  • ISBN 10 : 9780123978073

Inflammation Advancing Age and Nutrition Excerpt :

The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field. Includes models of aging, including worm, mouse and human Explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health Encompasses a variety of lifestyle impacts, including diet, exercise and nutrition Includes suggested nutritional interventions

T Cell Development Book

T Cell Development

  • Author : Remy Bosselut
  • Publisher : Humana Press
  • Release Date : 2016-10-28
  • Genre: Medical
  • Pages : 312
  • ISBN 10 : 1493948431

T Cell Development Excerpt :

This volume provides simple and accessible experiment protocols to explore thymus biology. "T-Cell Development: Methods and Protocols" is divided into three parts presenting short reviews on T cell development, analysis strategies, protocols for cell preparation, flow cytometry analyses, and multiple aspects of thymocyte biology. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, "T-Cell Development: Methods and Protocols" aims to ensure successful results in the further study of this vital field."

mTOR Pathway and mTOR Inhibitors in Cancer Therapy Book

mTOR Pathway and mTOR Inhibitors in Cancer Therapy

  • Author : Vitaly A. Polunovsky
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-07-23
  • Genre: Medical
  • Pages : 304
  • ISBN 10 : 9781603272711

mTOR Pathway and mTOR Inhibitors in Cancer Therapy Excerpt :

The main objective of this book is to provide an up-to-date survey of the rapidly advancing eld of cancer therapy. Moreover, since our knowledge in this area rapidly evolves, some data have got obsolete during the process of book editing. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer treatment – targeted therapy. The surge in this area results in no small part from studies conducted jointly by basic health scientists and clinical investigators. It is our hope that this book will help foster even further collaboration between investigators in these two disciplines. The target of rapamycin (TOR) was rst identi ed in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. In mammalian cells, mTOR exists in at least two multi-protein complexes that have critical roles in regulating cellular homeostasis and survival. As with many other areas of science, discovery of TOR signaling was fortuitous. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identi ed in a soil sample taken from the island of Rapa Nui (Easter Island). Rapamycin was rst discovered to be a potent antifungal agent and next as an immune suppressive drug. It was only later that it was found to be active as an antitumor agent in non-clinical models; although it was not developed for this indication. The history of rapamycin presents one of the rst examples of chemical genetics.

Nutrition and Enhanced Sports Performance Book

Nutrition and Enhanced Sports Performance

  • Author : Debasis Bagchi
  • Publisher : Academic Press
  • Release Date : 2013-07-26
  • Genre: Technology & Engineering
  • Pages : 568
  • ISBN 10 : 9780123964779

Nutrition and Enhanced Sports Performance Excerpt :

Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength provides a comprehensive overview to understanding the integrated impact of nutrition on performance. The book is divided into five main themes: An introductory overview of the role of nutrition in human health Various types of physical exercises, including cardiovascular training, resistance training, aerobic and anaerobic exercise, bioenergetics, and energy balance. This section also covers the nutritional requirements associated with various fitness programs, as well as exercise and nutritional requirements in special populations, including the pre-pubertal, young, elderly, and disabled. Sports and nutritional requirements. The molecular mechanisms involved in muscle building A thorough review of various food, minerals, supplements, phytochemicals, amino acids, transition metals, small molecules and other ergogenic agents that have been implicated in muscle building and human performance This book is an ideal resource for nutritionists, dietitians, exercise physiologists, health practitioners, researchers, students, athletes, trainers, and all those who wish to broaden their knowledge of nutrition and its role in human performance. Discusses the impact of nutrition, including food, minerals, vitamins, hormones, trace elements, etc., that can significantly attenuate/improve human performance and sports Addresses the molecular and cellular pathways involved in the physiology of muscle growth and the mechanisms by which nutrients affect muscle health, growth and maintenance Encompasses multiple forms of sports/performance and the salient contribution of appropriate nutrition on special populations, including nutritional guidelines and recommendations to athletes Strong focus on muscle building

Breast Cancer Metastasis and Drug Resistance Book

Breast Cancer Metastasis and Drug Resistance

  • Author : Aamir Ahmad
  • Publisher : Springer Nature
  • Release Date : 2019-08-27
  • Genre: Medical
  • Pages : 427
  • ISBN 10 : 9783030203016

Breast Cancer Metastasis and Drug Resistance Excerpt :

Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Cancer Signaling  Enhanced Edition Book

Cancer Signaling Enhanced Edition

  • Author : Christoph Wagener
  • Publisher : John Wiley & Sons
  • Release Date : 2017-01-27
  • Genre: Science
  • Pages : 360
  • ISBN 10 : 9783527800476

Cancer Signaling Enhanced Edition Excerpt :

Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online.