Multiple Action Based Design Approaches to Antibacterials Book

Multiple Action Based Design Approaches to Antibacterials

  • Author : John Bremner
  • Publisher : Springer Nature
  • Release Date : 2021-04-05
  • Genre: Technology & Engineering
  • Pages : 193
  • ISBN 10 : 9789811609992
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Multiple Action Based Design Approaches to Antibacterials Excerpt :

This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development.

Surveying Antimicrobial Resistance Approaches Issues and Challenges to Overcome Book

Surveying Antimicrobial Resistance Approaches Issues and Challenges to Overcome

  • Author : Gilberto Igrejas
  • Publisher : Frontiers Media SA
  • Release Date : 2017-03-29
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889451418
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Surveying Antimicrobial Resistance Approaches Issues and Challenges to Overcome Excerpt :

Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The “One Health” concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017

Post Genomic Approaches in Drug and Vaccine Development Book

Post Genomic Approaches in Drug and Vaccine Development

  • Author : Kishore R. Sakharkar
  • Publisher : River Publishers
  • Release Date : 2015-04-11
  • Genre: Medical
  • Pages : 450
  • ISBN 10 : 9788793102842
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Post Genomic Approaches in Drug and Vaccine Development Excerpt :

Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. This book focuses on some key advances in the field. Technical topics discussed in the book include: Drug discoveryTarget identification and prioritizationHypothesis driven multi-target drug designGenomics in vaccine developmentGene regulatory networks Vaccine design and developmentPrediction of drug side effects in silico

Antibacterial Agents Book

Antibacterial Agents

  • Author : Ranjith Kumavath
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-05-31
  • Genre: Science
  • Pages : 138
  • ISBN 10 : 9789535131991
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Antibacterial Agents Excerpt :

New drugs are frequently entering into the market along with the existing drugs. The antibacterial agents can be discussed in five major classes, i.e. classification based on the type of action, source, spectrum of activity, chemical structure and function. Resistance of bacteria to antibiotics is an urgent problem of the humanity, which leads us to the lack of therapy for serious bacterial infections. Development of new antibiotics has almost ceased in the last decades - even when a new antibiotic is launched, very soon the resistance of bacteria appears. Industrial textiles exposed as awnings, screens, tents; upholstery used in large public areas such as hospitals, hotels and stations; fabrics for transports; protective clothing and personal protective equipment; bed sheets and blankets; textiles left wet between processing steps; intimate apparel, underwear, socks and sportswear, disinfection of air and water for white rooms, hospitals and operating theatres, food and pharma industries, water depuration, drinkable water supplying and air conditioning systems. Many clinicians recommend alternative approaches to using antimicrobial substances. Moreover, the majority of bioagents demonstrate on antibiotics for treatment of a wide range of diseases in human sectors. However, the misuse and mishandling of drugs lead to microbial, particularly bacterial, resistance as well as result in the difficulty of treating microbial diseases. Hence, the proposed book will give more precise information on novel antibacterial compound(s).

Antibacterial Drug Discovery to Combat MDR Book

Antibacterial Drug Discovery to Combat MDR

  • Author : Iqbal Ahmad
  • Publisher : Springer Nature
  • Release Date : 2019-11-09
  • Genre: Medical
  • Pages : 680
  • ISBN 10 : 9789811398711
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Antibacterial Drug Discovery to Combat MDR Excerpt :

This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Antimicrobials Book

Antimicrobials

  • Author : Flavia Marinelli
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-04
  • Genre: Medical
  • Pages : 364
  • ISBN 10 : 9783642399688
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Antimicrobials Excerpt :

Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.

Sustainable Agriculture Reviews 46 Book

Sustainable Agriculture Reviews 46

  • Author : Harsh Panwar
  • Publisher : Springer Nature
  • Release Date : 2020-09-29
  • Genre: Technology & Engineering
  • Pages : 231
  • ISBN 10 : 9783030530242
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Sustainable Agriculture Reviews 46 Excerpt :

According to the World Health Organization, antimicrobial resistance is a major threat to global health because the number of alternative antibiotics is very limited. Antimicrobial resistance is a slow evolutionary process that has been accelerated by human activities in health, environment and agriculture sectors. Due to their wide application, antibiotics and their residues have been found in almost all food products and natural ecosystems. This book reviews the drivers, impact and mitigation of antimicrobial resistance, with focus on methods and targets.

Proceedings of 6th World Congress on Medicinal Chemistry and Drug Design 2017 Book

Proceedings of 6th World Congress on Medicinal Chemistry and Drug Design 2017

  • Author : ConferenceSeries
  • Publisher : ConferenceSeries
  • Release Date : 2017-06-01
  • Genre: Medical
  • Pages : 95
  • ISBN 10 : 978186723xxxx
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Proceedings of 6th World Congress on Medicinal Chemistry and Drug Design 2017 Excerpt :

June 07-08, 2017 Milan,. Italy Key Topics : Medicinal Chemistry, Synthetic Organic Chemistry, Drug Design and Drug Development, CADD (Computer Aided Drug Design), Bioorganic and Medicinal Chemistry, Pharmacology and toxicology, BioInorganic Chemistry, Organometallic Chemistry, Radiopharmaceuticals, Chemical Biology, Anticancer agents in Medicinal Chemistry, Pharmaceutical Industry, Clinical Pharmacology, Pharmaceutical Sciences, Bioisostere, Analytical Chemistry, Nanomedicine, Stereochemistry, Pharmacovigilance,

Antibacterials Book

Antibacterials

  • Author : Jed F. Fisher
  • Publisher : Springer
  • Release Date : 2018-06-28
  • Genre: Science
  • Pages : 194
  • ISBN 10 : 9783319680972
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Antibacterials Excerpt :

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors

Antimicrobial Resistance Multi Partner Trust Fund Forging Tripartite collaboration for urgent global and country action against antimicrobial resistance AMR Book

Antimicrobial Resistance Multi Partner Trust Fund Forging Tripartite collaboration for urgent global and country action against antimicrobial resistance AMR

  • Author : Food and Agriculture Organization of the United Nations
  • Publisher : Food & Agriculture Org.
  • Release Date : 2021-07-15
  • Genre: Science
  • Pages : 54
  • ISBN 10 : 9789251345849
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Antimicrobial Resistance Multi Partner Trust Fund Forging Tripartite collaboration for urgent global and country action against antimicrobial resistance AMR Excerpt :

In 2019, the Tripartite Joint Secretariat (FAO, OIE, and WHO) launched the AMR Multi-Partner Trust Fund (MPTF) to scale up action in low- and lower-middle-income countries to address antimicrobial resistance (AMR) as well as set up joint, global-level activities. In 2020, the Tripartite put in place the necessary frameworks, tools, and standards to select countries and develop global programmes that will be supported by the MPTF. The following report will provide an overview of the country and global projects, their current implementation status, the fund’s financial resources as well as the next steps.

Prokaryotic Antimicrobial Peptides Book

Prokaryotic Antimicrobial Peptides

  • Author : Djamel Drider
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-03-08
  • Genre: Science
  • Pages : 451
  • ISBN 10 : 9781441976925
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Prokaryotic Antimicrobial Peptides Excerpt :

The book will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products. Antimicrobial peptides stand as potentially great alternatives to current antibiotics, and most research in this newly-created area has been published in journals and other periodicals. It is the editors’ opinion that it is timely to sum up the most important achievements in the field and provide the scientific community in a reference book. The goals of this project include illustrating the achievements made so far, debating the state of the art, and drawing new perspectives.

Antimicrobial Peptides Book

Antimicrobial Peptides

  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2022-03-01
  • Genre: Science
  • Pages : 390
  • ISBN 10 : 9780323901598
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Antimicrobial Peptides Excerpt :

Antimicrobial Peptides, Volume 663 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on Unifying the classification of antimicrobial peptides in the Antimicrobial Peptide Database, Optimizing peptide library creation for PepSAVI-MS (RP libraries, etc.), Discovery of novel Antimicrobial peptides using BioProspecting, Screening for cysteine-stabilized scaffolds for developing protelytic-resistant AMPs, Exploring synergy and its role in antimicrobial peptide biology, Colorimetric assays for the rapid and high-throughput screening of antimicrobial peptide activity against diverse bacterial pathogens, and much more. Other chapters cover Liquid chromatography-mass spectrometry-based analysis of naturally occurring neuropeptide diastereomers, Multiplexed Quantitative Neuropeptidomics via DiLeu Isobaric Tagging, In vitro evaluation of antibiotic resistance via proteomics, Molecular networking-based strategies in mass spectrometry, Development of Macrocyclic antimicrobial peptides and peptoids, and a host of other timely topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Updated release includes the latest information on Antimicrobial Peptides

Antibacterial Surfaces Thin Films and Nanostructured Coatings Book

Antibacterial Surfaces Thin Films and Nanostructured Coatings

  • Author : Daniele Valerini
  • Publisher : MDPI
  • Release Date : 2021-09-08
  • Genre: Science
  • Pages : 182
  • ISBN 10 : 9783036516325
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Antibacterial Surfaces Thin Films and Nanostructured Coatings Excerpt :

Creating antibacterial surfaces is the primary approach in preventing the occurrence and diffusion of clinical infections and foodborne diseases as well as in contrasting the propagation of pandemics in everyday life. Proper surface engineering can inhibit microorganism spread and biofilm formation, can contrast antimicrobial resistance (AMR), and can avoid cross-contamination from a contaminated surface to another and eventually to humans. For these reasons, antibacterial surfaces play a key role in many applications, ranging from biomedicine to food and beverage materials, textiles, and objects with frequent human contact. The incorporation of antimicrobial agents within a surface or their addition onto a surface are very effective strategies to achieve this aim and to properly modify many other surface properties at the same time. In this framework, this Special Issue collects research studying several materials and methods related to the antibacterial properties of surfaces for different applications and discussions about the environmental and human-safety aspects.