Nano Pharmacokinetics and Theranostics Book

Nano Pharmacokinetics and Theranostics


  • Author : Nanasaheb D. Thorat
  • Publisher : Academic Press
  • Release Date : 2021-07-28
  • Genre: Business & Economics
  • Pages : 324
  • ISBN 10 : 9780323859820

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Nano Pharmacokinetics and Theranostics Excerpt :

Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy addresses from a comprehensive and multidisciplinary approach the translational aspects and clinical perspectives of nano-pharmacokinetics using cancer as a model disease. Nano-pharmacokinetics is emerging as an important sub discipline of nanoscience and medical sciences because of the increasing safety issues of nanosystems on living organisms. This book reports the dynamics of nanosystems in living organisms for better understanding of nanotoxicity, pharmacology, biochemistry, physiology and medicine perspectives. It further examines current progress of state-of-the art pharmacokinetics mechanisms, which will be of great help to develop more clinical-oriented nanosystems with a wide safety margin. The book is divided into three sections: the first section focuses on the concept of pharmacokinetics with state-of-the-art Nano-Pharmacokinetics (NPK). The second section looks at the engineering of nanoparticles and pharmacokinetics clinical development. The final section focuses on Nano-Pharmacokinetics and Theranostics, elaborating the basic question of how pharmacokinetics of nanomaterials relate to their end applications such as cancer therapy. Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy will be useful to researchers in the field of nanoparticle based targeted drug delivery including pharmaceutical scientists, material scientists, chemists, nanotechnologists, biomedical scientists, and clinicians. Includes contributions from highly qualified scientists, regulatory entities, enterprises and medical practitioners to explain the long and inherently multidisciplinary pathway of nano-pharmacokinetics Describes assessment methods of nano-pharmacokinetics Examines the interface between nanomedicine and pharmacokinetics to diagnose and treat cancer

External Field and Radiation Stimulated Breast Cancer Nanotheranostics Book

External Field and Radiation Stimulated Breast Cancer Nanotheranostics


  • Author : Nanasaheb D. Thorat
  • Publisher : Iop Expanding Physics
  • Release Date : 2019-09-26
  • Genre: Science
  • Pages : 450
  • ISBN 10 : 0750324147

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External Field and Radiation Stimulated Breast Cancer Nanotheranostics Excerpt :

Nano drug-delivery systems responding to cellular local stimuli, such as pH, temperature and reductive agent's activation, i.e. enzymes, could effectively provide passive-mode desirable release but fail in disease treatment following the biological rhythms of brain tumor. This book is a compilation of research development lead by expert researchers and it establishes a single reference module. It addresses, for the first time, all translational aspects and clinical perspectives of physically stimulated breast-cancer nanotheranostics from a wide-ranging and multidisciplinary perception providing unrivalled and comprehensive knowledge in the field.

Multifunctional Theranostic Nanomedicines in Cancer Book

Multifunctional Theranostic Nanomedicines in Cancer


  • Author : Malay K. Das
  • Publisher : Academic Press
  • Release Date : 2021-03-26
  • Genre: Business & Economics
  • Pages : 426
  • ISBN 10 : 9780128217009

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Multifunctional Theranostic Nanomedicines in Cancer Excerpt :

Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer. Provides a comprehensive resource of recent scientific progress and novel applications of theranostic nanomedicines Discusses treatment options from a pharmaceutical sciences perspective Includes translational science and targeted CNS cancer treatment

Colloids for Nanobiotechnology Book

Colloids for Nanobiotechnology


  • Author : Wolfgang Parak
  • Publisher : Frontiers of Nanoscience, Volu
  • Release Date : 2020-04-30
  • Genre: Technology & Engineering
  • Pages : 208
  • ISBN 10 : 9780081028285

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Colloids for Nanobiotechnology Excerpt :

Colloids for Nanobiotechnology: Synthesis, Characterization and Potential Applications, Volume 17, offers a range of perspectives on emerging nano-inspired colloidal applications. With an emphasis on biomedical and environmental opportunities and challenges, the book outlines how nanotechnology is being used to increase the uses and impact of colloid science. Nanotechnology offers new horizons for colloidal research and synthesis routes that allow for the production of highly reproducible and defined materials. This book presents new characterization methods and a fundamental understanding of basic physicochemical, physical and chemical properties.

Nano  and Microscale Drug Delivery Systems Book

Nano and Microscale Drug Delivery Systems


  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release Date : 2017-03-27
  • Genre: Medical
  • Pages : 514
  • ISBN 10 : 9780323527286

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Nano and Microscale Drug Delivery Systems Excerpt :

Nano- and Microscale Drug Delivery Systems: Design and Fabrication presents the developments that have taken place in recent years in the field of micro- and nanoscale drug delivery systems. Particular attention is assigned to the fabrication and design of drug delivery systems in order to i) reduce the side effects of therapeutic agents, ii) increase their pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. This book is designed to offer a cogent, concise overview of current scholarship in this important area of research through its focus on the characterization and fabrication of a variety of nanomaterials for drug delivery applications. It is an invaluable reference source for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems. Shows how micro- and nanomaterials can be engineered to create more effective drug delivery systems Summarizes current nanotechnology research in the field of drug delivery systems Explores the pros and cons of using particular nanomaterials as therapeutic agents Serves as a valuable reference for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids Book

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids


  • Author : Surendra Nimesh
  • Publisher : Woodhead Publishing
  • Release Date : 2017-04-04
  • Genre: Science
  • Pages : 256
  • ISBN 10 : 9780081005637

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Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids Excerpt :

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies

Nanomedicines for Breast Cancer Theranostics Book

Nanomedicines for Breast Cancer Theranostics


  • Author : Nanasaheb D. Thorat
  • Publisher : Elsevier
  • Release Date : 2020-03-08
  • Genre: Science
  • Pages : 438
  • ISBN 10 : 9780128200179

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Nanomedicines for Breast Cancer Theranostics Excerpt :

Nanomedicines for Breast Cancer Theranostics addresses the translational aspects and clinical perspectives of breast cancer nanomedicine from a multidisciplinary perspective. The book summarizes research efforts at the preclinical and clinical stage of nanostructures and nanomedicine for dealing with the important challenge of nanomedicine translation in breast cancer theranostics. This book is an important resource for those working in both academia and industry, focusing on hot topics in biomaterials, biomedical engineering, drug delivery and oncology. Shows how the discovery of new nanomedicines is leading directly to an increase in the early-stage diagnosis of breast cancer Includes coverage of breast cancer nanomedicine standardization and characterization, highlighting newly developed treatments, diagnostics and treatment monitoring tools Explains why the design of nanobiomaterials make them effective drug carriers when treating breast cancer

Nanotechnologies in Preventive and Regenerative Medicine Book

Nanotechnologies in Preventive and Regenerative Medicine


  • Author : Vuk Uskokovic
  • Publisher : Elsevier
  • Release Date : 2017-11-22
  • Genre: Medical
  • Pages : 616
  • ISBN 10 : 9780323480642

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Nanotechnologies in Preventive and Regenerative Medicine Excerpt :

Nanotechnologies in Preventative and Regenerative Medicine demonstrates how control at the nanoscale can help achieve earlier diagnoses and create more effective treatments. Chapters take a logical approach, arranging materials by their area of application. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications-orientated book is a valuable resource for researchers in biomedical science who want to gain a greater understanding on how nanotechnology can help create more effective vaccines and treatments, and to nanomaterials researchers seeking to gain a greater understanding of how these materials are applied in medicine. Demonstrates how nanotechnology can help achieve more successful diagnoses at an earlier stage Explains how nanomaterials can be manipulated to create more effective drug treatments Offers suggestions on how the use of nanotechnology might have future applications to create even more effective treatments

Biopharmaceutics and Pharmacokinetics Considerations Book

Biopharmaceutics and Pharmacokinetics Considerations


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-07-07
  • Genre: Medical
  • Pages : 752
  • ISBN 10 : 9780128144268

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Biopharmaceutics and Pharmacokinetics Considerations Excerpt :

Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce. Examines the most recent developments in biopharmaceutics and pharmacokinetics for pharmaceutical sciences Covers the principles, methodologies and technologies of biopharmaceutics and pharmacokinetics Focuses on the pharmaceutical sciences, but also encompasses aspects of toxicology, neuroscience, environmental sciences and nanotechnology

Design of Nanostructures for Theranostics Applications Book

Design of Nanostructures for Theranostics Applications


  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release Date : 2018-01-15
  • Genre: Science
  • Pages : 692
  • ISBN 10 : 9780128136706

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Design of Nanostructures for Theranostics Applications Excerpt :

Design of Nanostructures for Theranostics Applications focuses on the theranostics applications of nanostructures. In particular, multifunctional nanoparticles for diagnostics and treatment of different diseases, including those relating to the blood-brain barrier, are discussed in detail. Chapters explore different type of nanostructures, covering design, fabrication, functionalization and optimization, helping readers obtain the desired properties. Written by a diverse range of international academics, this book is a valuable reference resource for those working in both nanoscience and the pharmaceutical industry. Explores how the design of a range of nanomaterials make them effective theranostic agents, including multifunctional core-shell nanostructures, mesoporous silica nanoparticles, and quantum dots Shows how nanomaterials are used effectively for a range of diseases, including breast cancer, prostate cancer and neurological disorders Assesses the pros and cons of using different nanomaterials for different types of treatment

Nanotoxicology Book
Score: 5
From 1 Ratings

Nanotoxicology


  • Author : Nancy A. Monteiro-Riviere
  • Publisher : CRC Press
  • Release Date : 2007-07-25
  • Genre: Medical
  • Pages : 392
  • ISBN 10 : 9781420045154

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Nanotoxicology Excerpt :

Nanomaterials - structures with characteristic dimensions between 1 and 100 nm -exhibit a variety of unique and tunable chemical and physical properties that have made engineered nanoparticles central components in an array of emerging technologies. The use of nanotechnology is increasing; however its potential adverse effects on human health are n

Nanostructures for Cancer Therapy Book

Nanostructures for Cancer Therapy


  • Author : Alexandru Mihai Grumezescu
  • Publisher : Elsevier
  • Release Date : 2017-04-11
  • Genre: Technology & Engineering
  • Pages : 920
  • ISBN 10 : 9780323461504

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Nanostructures for Cancer Therapy Excerpt :

Nanostructures for Cancer Therapy discusses the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy, including current trends and developments in the use of nanostructured materials in chemotherapy and chemotherapeutics. In particular, coverage is given to the applications of gold nanoparticles and quantum dots in cancer therapies. In addition to the multifunctional nanomaterials involved in the treatment of cancer, other topics covered include nanocomposites that can target tumoral cells and the release of antitumoral therapeutic agents. The book is an up-to-date overview that covers the inorganic and organic nanostructures involved in the diagnostics and treatment of cancer. Provides an examination of nanoparticle delivery systems for cancer treatment, illustrating how the use of nanotechnology can help provide more effective chemotherapeutic treatments Examines, in detail, the different types of nanomaterials used in cancer therapy, also explaining the effect of each Provides a cogent overview of recent developments in the use of nanostructured materials in chemotherapeutics, allowing readers to quickly familiarize themselves with this area

Pharmacokinetics and Toxicokinetic Considerations   Vol II Book

Pharmacokinetics and Toxicokinetic Considerations Vol II


  • Author : Rakesh Kumar Tekade
  • Publisher : Academic Press
  • Release Date : 2022-02-17
  • Genre: Business & Economics
  • Pages : 814
  • ISBN 10 : 9780323913164

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Pharmacokinetics and Toxicokinetic Considerations Vol II Excerpt :

Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists. Allows readers to systematically integrate up-to-date research findings into their laboratory work Presents focused explorations of bioanalytical methods for bioavailability and bioequivalence assessment Provides clinical applications of concepts

Intracellular Delivery III Book

Intracellular Delivery III


  • Author : Aleš Prokop
  • Publisher : Springer
  • Release Date : 2016-10-31
  • Genre: Medical
  • Pages : 453
  • ISBN 10 : 9783319435251

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Intracellular Delivery III Excerpt :

A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes and most recently “nanomaterials” have been said to “show promise” but none of these promises have so far been “reduced” to human clinical practice. The focus of this volume is on cancer indication since the majority of published research relates to this application; within that, we focus on solid tumors (solid malignancies). Our aim is critically to evaluate whether nanomaterials, both non-targeted and targeted to specific cells, could be of therapeutic benefit in clinical practice. The emphasis of this volume will be on pharmacokinetics (PK) and pharmacodynamics (PD) in animal and human studies. Apart from the case of exquisitely specific antibody-based drugs, the development of target-specific drug–carrier delivery systems has not yet been broadly successful at the clinical level. It can be argued that drugs generated using the conventional means of drug development (i.e., relying on facile biodistribution and activity after (preferably) oral administration) are not suitable for a target-specific delivery and would not benefit from such delivery even when a seemingly perfect delivery system is available. Therefore, successful development of site-selective drug delivery systems will need to include not only the development of suitable carriers, but also the development of drug entities that meet the required PK/PD profile.