Neural Stem Cells and Adult Neurogenesis Book

Neural Stem Cells and Adult Neurogenesis


  • Author : Arie S. Mobley
  • Publisher : Academic Press
  • Release Date : 2019-02-28
  • Genre: Science
  • Pages : 241
  • ISBN 10 : 9780128110157

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Neural Stem Cells and Adult Neurogenesis Excerpt :

Neural Stem Cells and Adult Neurogenesis provides graduate students and neuroscientists with a basic understanding of what neural stem cells are and the cell types they produce. This early graduate level reference describes their physiology and potential for medicine and provides students with fundamental stem cell information. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research. For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons’ contribution to normal and diseased brain function. The level of information is appropriate for early graduate students, introducing technology and molecular biology in an accessible format. Provides a basic understanding of what a stem cell is, the different types, and their potential in health and research Details adult neurogenesis and its role in behavior, stroke and disease Includes walkthrough and technology boxes that illustrate experimental concepts, new approaches and techniques

Stem Cells and Regenerative Medicine Book

Stem Cells and Regenerative Medicine


  • Author : Philippe Taupin
  • Publisher : Nova Publishers
  • Release Date : 2008
  • Genre: Developmental neurobiology
  • Pages : 186
  • ISBN 10 : 1604564725

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Stem Cells and Regenerative Medicine Excerpt :

The subject of this book is stem cell research and regenerative medicine. Stem cells are undifferentiated cells that have the ability to differentiate into different lineages of the body. Stem cells carry tremendous potential for the treatment of a broad range of disease and injuries. Stem cells exist in embryonic, fetal, and adult tissues, including the adult central nervous system. This book aims at, in depth, the recent developments in stem cell research and regenerative medicine. Though this book encompasses all the fields of stem cell research and regenerative medicine, it emphasises adult neurogenesis and neural stem cell research and therapy.

Neural Stem Cells and Therapy Book

Neural Stem Cells and Therapy


  • Author : Tao Sun
  • Publisher : BoD – Books on Demand
  • Release Date : 2012-02-15
  • Genre: Science
  • Pages : 456
  • ISBN 10 : 9789533079585

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Neural Stem Cells and Therapy Excerpt :

This book is a collective work of international experts in the neural stem cell field. The book incorporates the characterization of embryonic and adult neural stem cells in both invertebrates and vertebrates. It highlights the history and the most advanced discoveries in neural stem cells, and summarizes the mechanisms of neural stem cell development. In particular, this book provides strategies and discusses the challenges of utilizing neural stem cells for therapy of neurological disorders and brain and spinal cord injuries. It is suitable for general readers, students, doctors and researchers who are interested in understanding the principles of and new discoveries in neural stem cells and therapy.

Adult Neurogenesis and Neural Stem Cells in Mammals Book

Adult Neurogenesis and Neural Stem Cells in Mammals


  • Author : Philippe Taupin
  • Publisher : Nova Publishers
  • Release Date : 2006
  • Genre: Medical
  • Pages : 222
  • ISBN 10 : 1594548560

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Adult Neurogenesis and Neural Stem Cells in Mammals Excerpt :

This title contains a book and CD. The brain has a number of nerve cells estimated at a magnitude of 10 to 100 billion, and 1014 to 1015 synapses, and therefore is the most complex organ of the human body. During fetal development the foundations of the brain are laid as billions of neurons form appropriate connections and patterns. In the adult mammalian brain, most neurons are post-mitotic, and therefore at risk for irreversible damage. As we age, atrophy of the brain occurs. As brain weight declines the volume of the brain in the 8th decade is reduced by 6 per cent -10 per cent versus the third decade, and neuronal loss occurs, up to 10,000 to 100,000 neurons are lost per day, though this estimation is being revised downward with the advance of more sophisticated measurements.

Adult neurogenesis twenty years later  physiological function versus brain repair Book

Adult neurogenesis twenty years later physiological function versus brain repair


  • Author : Paolo Peretto
  • Publisher : Frontiers Media SA
  • Release Date : 2015-05-01
  • Genre: Neurosciences. Biological psychiatry. Neuropsychiatry
  • Pages : 121
  • ISBN 10 : 9782889194940

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Adult neurogenesis twenty years later physiological function versus brain repair Excerpt :

The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes.

Adult Neurogenesis Book
Score: 5
From 1 Ratings

Adult Neurogenesis


  • Author : Fred Gage
  • Publisher : CSHL Press
  • Release Date : 2008
  • Genre: Medical
  • Pages : 667
  • ISBN 10 : 9780879697846

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Adult Neurogenesis Excerpt :

The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this monograph provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesis includes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.

Stem Cells and Regenerative Medicine Book

Stem Cells and Regenerative Medicine


  • Author : Philippe Taupin
  • Publisher : Nova Publishers
  • Release Date : 2008
  • Genre: Medical
  • Pages : 104
  • ISBN 10 : 1604564733

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Stem Cells and Regenerative Medicine Excerpt :

Annotation. The subject of this book is stem cell research and regenerative medicine. Stem cells are undifferentiated cells that have the ability to differentiate into different lineages of the body. Stem cells carry tremendous potential for the treatment of a broad range of disease and injuries. Stem cells exist in embryonic, foetal, and adult tissues, including the adult central nervous system. This book aims at, in depth, the recent developments in stem cell research and regenerative medicine. Though this book encompasses all the fields of stem cell research and regenerative medicine, it emphasises embryonic and adult stem cells.

The ventricular subventricular zone  a source of oligodendrocytes in the adult brain Book

The ventricular subventricular zone a source of oligodendrocytes in the adult brain


  • Author : Oscar Gonzalez-Perez
  • Publisher : Frontiers E-books
  • Release Date : 2014-09-30
  • Genre: Brain
  • Pages : 251
  • ISBN 10 : 9782889192687

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The ventricular subventricular zone a source of oligodendrocytes in the adult brain Excerpt :

Demyelinating diseases are characterized by an extensive loss of oligodendrocytes and myelin sheaths from axolemma, which commonly result in disability in young adults. To date, there is no effective treatment against these neurological disorders. In the adult brain, there are neural stem cells (NSCs) that reside within a niche denominated ventricular-subventricular zone (V-SVZ) in the lateral wall of the cerebral ventricles. NSCs give rise to neurons and oligodendrocytes that help preserve cellular homeostasis. Growing evidence indicates that V-SVZ progenitor cells may represent an endogenous source of oligodendrocytes that can be useful to treat demyelinating diseases. This e-Book “The ventricular-subventricular zone as a source of oligodendrocytes in the adult brain” collected the most recent evidence regarding the mechanisms that modulate the proliferation, migration, quiescence, cell-fate choices and survival of oligodendrocyte precursors generated in the V-SVZ. Herein, we compiled information about the role of Sonic hedgehog, NMDA receptors, ErbB proteins, hemopressin, erythropoietin, osmolarity and microglia in the oligodendrocyte production. Some chapters also describe the role of oligodendrocyte precursors in the preservation of cellular homeostasis, aging and white matter repair. All these information is presented as novel research findings, short communications, and review articles, which were written by experts in the field of oligodendrocyte generation, myelin production and white matter re-myelination.

Adult Neurogenesis Book

Adult Neurogenesis


  • Author : Gerd Kempermann
  • Publisher : Oxford University Press, USA
  • Release Date : 2006
  • Genre: Medical
  • Pages : 464
  • ISBN 10 : 0195179714

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Adult Neurogenesis Excerpt :

The discovery of adult neurogenesis and of stem cells in the brain has changed our view of the mature brain. Though we now know that the adult brain can make new neurons, it normally does so only in two privileged regions, the olfactory bulb and the hippocampus. Yet stem cells, which have the potential to produce new neurons, can be found throughout the adult brain. So why does the brain not make wider use of its potential for neurogenesis? And what is the function of new neurons and of neural stem cells in areas where they occur? After all, the brain regenerates poorly and many neurological and psychiatric disorders are chronic because cell replacement has not taken place. This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience. It begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias. For graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research, this book is a unique resource that sifts through the evidence for exciting scientific ideas and fosters a realistic view of the therapeutic possibilities for the use of stem cells in the adult brain.

Neurogenesis in the Adult Brain I Book

Neurogenesis in the Adult Brain I


  • Author : Tatsunori Seki
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-06-15
  • Genre: Medical
  • Pages : 413
  • ISBN 10 : 9784431539339

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Neurogenesis in the Adult Brain I Excerpt :

The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

Adult Neurogenesis in the Hippocampus Book

Adult Neurogenesis in the Hippocampus


  • Author : Juan J. Canales
  • Publisher : Academic Press
  • Release Date : 2016-05-23
  • Genre: Science
  • Pages : 298
  • ISBN 10 : 9780128019924

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Adult Neurogenesis in the Hippocampus Excerpt :

Neurogenesis in the adult brain has emerged as one of the most dynamic and rapidly moving fields in modern neuroscience research. The implications of adult neurogenesis for health and well-being are wide-ranging, with findings in this area having distinct relevance for treatment and rehabilitation in neurology and psychopathology. Adult Neurogenesis in the Hippocampus addresses these implications by providing an up-to-date account on how neurogenesis in the adult hippocampus contributes to critical psychological and physiological processes, such as learning and memory, and how it is modified by life experiences, such as aging, environmental enrichment, exercise, and dieting. The book also provides the most current reviews of how adult hippocampal neurogenesis influences the pathogenesis of mood disorders, addiction, and key neurological disorders. This book is the ideal resource for researchers and advanced graduates seeking focused knowledge on the role of adult neurogenesis in brain health and disease. Provides a unique overview of how adult hippocampal neurogenesis contributes to adaptive processes, brain psychopathology, and disease Includes state-of-the-art reviews by leading world experts in adult neurogenesis

Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory Book

Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory


  • Author : Aaron R. Friedman
  • Publisher : Unknown
  • Release Date : 2014-04-01
  • Genre: Medical
  • Pages : 40
  • ISBN 10 : 1615044760

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Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory Excerpt :

Approximately 50 years ago, newly generated neurons were discovered in the adult hippocampus of the rat brain. This discovery contradicted a key principle in mammalian developmental neurobiology - that all the neurons of the brain are made during early development - and led to intensive study to find out how new neurons are generated and how the process of neurogenesis is regulated. Since then, a unique population of adult neural stem cells has been identified, and many of the molecular pathways that control their self-renewal, proliferation, and cell fate have been elucidated. However, the presence of new neurons in the adult brain also poses intriguing functional questions that have, as yet, gone largely unanswered. Why is adult neurogenesis restricted to select brain regions? What functional benefit do these new cells confer? Indeed, the field of adult neurogenesis offers a unique opportunity to study naive neurons as they mature, form connections with existing neural networks, and begin to participate in information processing. We review the basics of adult NSC biology and the maturation of newborn neurons. In particular, we focus on new neurons in the hippocampus, and how they contribute to function in this key memory-forming structure of the brain."

Neural Stem Cells in Development  Adulthood and Disease Book

Neural Stem Cells in Development Adulthood and Disease


  • Author : H. Georg Kuhn
  • Publisher : Springer
  • Release Date : 2014-11-22
  • Genre: Science
  • Pages : 202
  • ISBN 10 : 9781493919086

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Neural Stem Cells in Development Adulthood and Disease Excerpt :

This comprehensive volume is the first to specifically target developing, adult and diseased neural stem cells. It explores recent advances in the understanding of neural stem cell biology along with strategies that use these cells to tackle neurological diseases and brain aging. Ten inclusive chapters discuss a wide range of topics including neurogenesis, neurodegeneration, demyelinating disease, mood regulation, and spinal cord regeneration, among others. Written by world-renowned scientists in the field, Neural Stem Cells in Development, Adulthood and Disease presents cutting-edge studies of interest to both established neurogenesis researchers and readers with general interests in nervous system science. It is an authoritative addition to the Stem Cell Biology and Regenerative Medicine series.

Neurogenesis and Neural Plasticity Book

Neurogenesis and Neural Plasticity


  • Author : Catherine Belzung
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-07-08
  • Genre: Medical
  • Pages : 401
  • ISBN 10 : 9783642362323

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Neurogenesis and Neural Plasticity Excerpt :

This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.