Neurobiology of Depression Book
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Neurobiology of Depression


  • Author : Joao Luciano de Quevedo
  • Publisher : Academic Press
  • Release Date : 2019-01-03
  • Genre: Medical
  • Pages : 471
  • ISBN 10 : 9780128133347

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Neurobiology of Depression Excerpt :

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

Neurobiology of Depression Book

Neurobiology of Depression


  • Author : Francisco Lopez-Munoz
  • Publisher : CRC Press
  • Release Date : 2011-09-09
  • Genre: Medical
  • Pages : 526
  • ISBN 10 : 9781439838501

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Neurobiology of Depression Excerpt :

Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

Systems Neuroscience in Depression Book

Systems Neuroscience in Depression


  • Author : Thomas Frodl
  • Publisher : Academic Press
  • Release Date : 2016-09-01
  • Genre: Psychology
  • Pages : 420
  • ISBN 10 : 9780128026281

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Systems Neuroscience in Depression Excerpt :

Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry. Knowledge covering the whole life span from early to later life Comprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscience Understanding the neurobiology of major depressive disorder Integrating stress and environmental factors with molecular underpinnings More than 25 illustrations and tables

The Neurobiological Basis of Suicide Book

The Neurobiological Basis of Suicide


  • Author : Yogesh Dwivedi
  • Publisher : CRC Press
  • Release Date : 2012-06-25
  • Genre: Medical
  • Pages : 482
  • ISBN 10 : 9781439838815

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The Neurobiological Basis of Suicide Excerpt :

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Rapid Acting Antidepressants Book

Rapid Acting Antidepressants


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-06-29
  • Genre: Medical
  • Pages : 402
  • ISBN 10 : 9780128201909

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Rapid Acting Antidepressants Excerpt :

The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Neuropsychology of Depression Book

Neuropsychology of Depression


  • Author : Shawn M. McClintock
  • Publisher : Guilford Publications
  • Release Date : 2022-02-20
  • Genre: Psychology
  • Pages : 464
  • ISBN 10 : 9781462549337

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Neuropsychology of Depression Excerpt :

Timely and authoritative, this unique volume focuses on neurocognitive aspects of depression and their implications for assessment, evaluation, clinical management, and research. Experts in the field explore the impact of depression on executive function, learning and memory, working memory, and other critical capacities, and present cutting-edge assessment tools and procedures. The neurocognitive effects of widely used antidepressant treatments are reviewed, from psychotropic medications and evidence-based psychotherapies to established and emerging neuromodulation technologies. Practical aspects of working with adults across the lifespan with depression are addressed, including ways to strengthen treatment engagement and adherence, and to incorporate cultural considerations.

Charney   Nestler s Neurobiology of Mental Illness Book

Charney Nestler s Neurobiology of Mental Illness


  • Author : Dennis S. Charney
  • Publisher : Oxford University Press
  • Release Date : 2018-01-12
  • Genre: Medical
  • Pages : 1024
  • ISBN 10 : 9780190681425

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Charney Nestler s Neurobiology of Mental Illness Excerpt :

Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.

Understanding Depression Book

Understanding Depression


  • Author : Yong-Ku Kim
  • Publisher : Springer
  • Release Date : 2018-01-02
  • Genre: Medical
  • Pages : 333
  • ISBN 10 : 9789811065774

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Understanding Depression Excerpt :

This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression, the clinical manifestations, and the development of more effective treatments. This second volume is devoted specifically to clinical and management issues. Readers will find detailed information on a wide range of frequently encountered and more complicated clinical presentations, with examination of risk factors and links to other conditions. Diagnostic aspects, including progress toward biological classification and the role of neuroimaging, are explored. Current trends in therapy are examined at length, drawing on the latest evidence and covering not only antidepressant medications but also the roles of neurostimulation, combined pharmacotherapy and psychotherapy, mindfulness-based cognitive therapy, and complementary and alternative medicine. The companion volume is dedicated to the underlying biomedical and neurobiological basis of depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.

The Neuroscience of Depression Book

The Neuroscience of Depression


  • Author : Colin R. Martin
  • Publisher : Academic Press
  • Release Date : 2021-03-05
  • Genre: Medical
  • Pages : 592
  • ISBN 10 : 9780128179345

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The Neuroscience of Depression Excerpt :

The Neuroscience of Depression: Features, Diagnosis and Treatment, is a comprehensive reference to the diagnosis and treatment of depression. This book provides readers with the mechanisms of depression reflecting on the interplay between depression and the biological and psychosocial processes. A detailed introduction to various episodes of depression, from PTSD to post-partum depression is provided, followed by a thorough discussion on biomarkers in depression and how to diagnose depression including the Hamilton Depression Rating scale. This book also includes three full sections on treatment options for depression, including pharmacological, behavioral and other novel regimes. The Neuroscience of Depression: Features, Diagnosis and Treatment is the only resource for researchers and practitioners studying, diagnosis and treating of depression. Covers a pharmacological and behavioral treatment options Features sections on diagnosis and biomarkers of depression Discusses depression in children, teens and adults Contains information on comorbidity of physical and mental conditions Includes more than 250 illustrations and tables

Stress  the Brain and Depression Book

Stress the Brain and Depression


  • Author : H. M. van Praag
  • Publisher : Cambridge University Press
  • Release Date : 2004-05-20
  • Genre: Medical
  • Pages : 300
  • ISBN 10 : 1139451243

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Stress the Brain and Depression Excerpt :

Can traumatic life events cause depression? Studies generally point to a connection between adverse life events and depression. However, establishing a causal rather than associative connection, the key concern of this book, is more problematic. What neurobiological changes may be induced by stress and depression, and to what extent do these changes correspond? The authors structure their examination around three major themes: the pathophysiological role of stress in depression; whether or not a subtype of depression exists that is particularly stress-inducible; and, finally, how best to diagnose and treat depression in relation to its biological underpinnings.

Ketamine for Treatment Resistant Depression Book

Ketamine for Treatment Resistant Depression


  • Author : Gustavo H. Vazquez
  • Publisher : Academic Press
  • Release Date : 2020-09-16
  • Genre: Medical
  • Pages : 168
  • ISBN 10 : 9780128210345

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Ketamine for Treatment Resistant Depression Excerpt :

Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. Provides efficacy research on ketamine as a treatment for depression Identifies best practices for clinical use, both long-term and acute Discusses the molecular mechanisms and neurobiology of action

Neurobiology of Mental Illness Book
Score: 5
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Neurobiology of Mental Illness


  • Author : Dennis S. Charney
  • Publisher : Oxford University Press
  • Release Date : 2013-07-04
  • Genre: Medical
  • Pages : 1222
  • ISBN 10 : 9780199934959

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Neurobiology of Mental Illness Excerpt :

Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

The Bipolar Book Book

The Bipolar Book


  • Author : Aysegül Yildiz
  • Publisher : Oxford University Press, USA
  • Release Date : 2015-05-28
  • Genre: Manic-depressive illness
  • Pages : 704
  • ISBN 10 : 9780199300532

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The Bipolar Book Excerpt :

As a major mainstay of clinical focus and research today, bipolar disorder affects millions of individuals across the globe with its extreme and erratic shifts of mood, thinking and behavior. Edited by a team of experts in the field, The Bipolar Book: History, Neurobiology, and Treatment is a testament and guide to diagnosing and treating this exceedingly complex, highly prevalent disease. Featuring 45 chapters from an expert team of contributors from around the world, The Bipolar Book delves deep into the origins of the disorder and how it informs clinical practice today by focusing on such topics as bipolar disorder occurring in special populations, stigmatization of the disease, the role genetics play, postmortem studies, psychotherapy, treatments and more. Designed to be the definitive reference volume for clinicians, students and researchers, Aysegül Yildiz, Pedro Ruiz and Charles Nemeroff present The Bipolar Book as a "must have" for those caregivers who routinely deal with this devastating disease.

Melancholia  A Disorder of Movement and Mood Book

Melancholia A Disorder of Movement and Mood


  • Author : Gordon Parker
  • Publisher : Cambridge University Press
  • Release Date : 1996-03-29
  • Genre: Medical
  • Pages : 356
  • ISBN 10 : 052147275X

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Melancholia A Disorder of Movement and Mood Excerpt :

Describes the development of a new approach to the diagnosis and pathogenesis of melancholic depression.

Depression Book

Depression


  • Author : Charles Foster
  • Publisher : Oxford University Press
  • Release Date : 2017-08-25
  • Genre: Law
  • Pages : 320
  • ISBN 10 : 9780192522139

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Depression Excerpt :

Depression is amorphous. It defies easy generalization, and eludes medical and legal categories. Is it part of the self, or its predator? Can a sufferer be held responsible for their actions? This edited collection provides a holistic study of a protean illness. If the law is to regulate the lives of those who suffer from depression, it is vital that lawyers understand the condition. Drawing upon a wide-ranging expertise, this volume looks at depression from four viewpoints: that of the sufferer, the clinician, the ethicist, and the lawyer. Topics covered include the cultural history of depression; causes, epidemiology, and diagnosis; the autonomy debate; criminal responsibility; public health law; depression in the workplace; depression and children; and assisted suicide. First-hand accounts from sufferers are followed by contributions from clinicians who say what depression is, outline its demography and therapeutic options, and indicate the legal and ethical problems that trouble them the most. The essays then go on to explore legal and ethical questions in depth. This collection is essential reading for lawyers seeking a broader understanding of depression, and non-lawyers seeking an insight into the difficulty law has engaging with the condition.